Nitric oxide, chronic iron and copper overloads and regulation of redox homeostasis in rat liver

2021 ◽  
Author(s):  
Fabiana Lairion ◽  
Christian Saporito-Magriñá ◽  
Rosario Musacco-Sebio ◽  
Julian Fuda ◽  
Horacio Torti ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Liver ◽  
Redox Homeostasis

Role of nitric oxide in hepatic and pulmonary injury following ischemia-reperfusion of rat liver

2003 ◽  
Vol 124 (4) ◽  
pp. A719-A720
Author(s):  
Yuji Takamatsu ◽  
Kazuo Shimada ◽  
Koji Yamaguchi ◽  
Kazuo Chijiiwa ◽  
Masao Tanaka
Keyword(s):  
Nitric Oxide ◽  
Rat Liver ◽  
Ischemia Reperfusion ◽  
Pulmonary Injury

Role of nitric oxide in oxygen transport in rat liver sinusoids during endotoxemia

Hepatology ◽  
1997 ◽  
Vol 26 (2) ◽  
pp. 336-342 ◽  
Author(s):  
T Huang ◽  
T Nishida ◽  
W Kamike ◽  
H Kosaka ◽  
A Seiyama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Liver ◽  
Oxygen Transport ◽  
Liver Sinusoids

scholarly journals Nitric oxide production by the regenerating rat liver

1995 ◽  
Vol 11 (2) ◽  
pp. 76-81
Author(s):  
M. Yu. Obolenskaya ◽  
A. F. Vanin ◽  
P. I. Mordvintcev ◽  
K. Decker
Keyword(s):  
Nitric Oxide ◽  
Rat Liver ◽  
Nitric Oxide Production ◽  
Oxide Production ◽  
Regenerating Rat Liver

scholarly journals Alimentary induced fatty liver and adjuvant therapy with effective natural bioactive molecules

2011 ◽  
Vol 152 (26) ◽  
pp. 1035-1042 ◽  
Author(s):  
Viktor Hegedüs ◽  
Domokos Gerő ◽  
Zoltán Mihály ◽  
Attila Szijártó ◽  
Tivadar Zelles ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Fatty Liver ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Redox Homeostasis ◽  
Mrna Levels ◽  
Factor Α ◽  
Oxide Synthase ◽  
Necrosis Factor ◽  
Inducible Nitric Oxide

Changes of redox-homeostasis generate cytokines, and free radicals influence many intracellular signaling pathways in different liver diseases. Liophylised table beet and carrot powder (GPS Powder Kft. 1361/004/2003BFÁÉÉÁ) containing bioactive components such as betaine, betanins, betaxanthins, flavonoids, polyphenols, glutamine, beta carotene, vitamins and folic acid may produce changes various cellular pathways. Aim: The aim of this study was to determine the protecting effects of bioactive agents of the liophylised table beet and carrot powder on fatty liver in a “short term” experiment. Method: Male Wistar rats were fed with chow with or without high fat (2% cholesterol, 0.5% cholic acid, 20% sunflower oil) and treated with 0.1 or 1 g/bwkg/day natural product for ten days parallel with the feedings. Cyclooxygenase-2, inducible nitric oxide synthase and tumor necrosis factor-α mRNA levels were determined using molecular biologic methods. Free radicals, H-donating activity, reducing power and free SH-group concentrations were determined by luminometry and spectrophotometry. Mobilized methyl groups were assayed by over pressure liquid chromatography method in liver homogenates. Results: It was found that the higher dose of the natural product better decreased the induced free radical reactions, cyclooxygenase-2, inducible nitric oxide synthase and tumor necrosis factor-α mRNA-levels both in normal and fatty liver tissues. Although treatments failed to exert significant changes in all global antioxidant parameters, mobilized methyl group concentrations were higher after treatments in fatty liver. Favorable tendencies were also noted in the redox-homeostasis of the fatty liver after treatment. Conclusions: As expected, lyophylised table beet and carrot proved to be a “functional food” in rats with alimentary fat induced fatty liver. It cannot be ruled out that this beneficial effect may have clinical relevance. Orv. Hetil., 2011, 152, 1035–1042.

Effect of peroxynitrite on glutaredoxin

2001 ◽  
Vol 20 (7) ◽  
pp. 373-376 ◽  
Author(s):  
G Aykaç-Toker ◽  
S Bulgurcuogélu ◽  
N Koçak-Toker
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Ascorbic Acid ◽  
Rat Liver ◽  
Dehydroascorbate Reductase ◽  
Active Elements ◽  
Thiol Homeostasis ◽  
Important Enzyme

Glutaredoxin is an important enzyme in thiol homeostasis. As a thioltransferase, it reduces oxidized thiols. It also has dehydroascorbate reductase (DHAR) activity to reduce dehydroascorbate (DHA) to ascorbic acid. Peroxynitrite (ONOO-) is one of the most active elements of oxidative stress that can be formed wherever nitric oxide and superoxide are produced simultaneously. ONOO- is known to react with free thiols easily. To observe the effect of ONOO- on glutaredoxin, rat liver cytosolic fractions were incubated with 0–250 MONOO -. Thioltransferase activity was found to be decreased as ONOO- concentration increased. The inhibition was not reversible with dithiothreitol (DTT). In cytosol besides glutaredoxin, another enzyme with DHAR activity is also present. In our study, the cytosolic DHAR activity which consisted both enzymes, was also inhibited by ONOO-, but DTT was able to return the activity almost completely.

Protective Role of the L-Arginine-Nitric Oxide Synthase Pathway on Preservation Injury after Rat Liver Transplantation

2001 ◽  
Vol 25 (3) ◽  
pp. 142-147 ◽  
Author(s):  
David A. Geller ◽  
Stanley H. Chia ◽  
Yoshihito Takahashi ◽  
Gautam P. Yagnik ◽  
George Tsoulfas ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Transplantation ◽  
Nitric Oxide Synthase ◽  
Rat Liver ◽  
Protective Role ◽  
Rat Liver Transplantation ◽  
Preservation Injury ◽  
Oxide Synthase

Iron-induced changes in nitric oxide and superoxide radical generation in rat liver after lindane or thyroid hormone treatment

2001 ◽  
Vol 119 (2) ◽  
pp. 87-93 ◽  
Author(s):  
Pamela Cornejo ◽  
Gladys Tapia ◽  
Susana Puntarulo ◽  
Mónica Galleano ◽  
Luis A. Videla ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Thyroid Hormone ◽  
Rat Liver ◽  
Superoxide Radical ◽  
Hormone Treatment ◽  
Radical Generation ◽  
Induced Changes
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