The effect of topical anal captopril on resting anal pressure in healthy volunteers: the first human pilot study

2013 ◽  
Vol 18 (1) ◽  
pp. 39-43 ◽  
Author(s):  
M. Khaikin ◽  
B. Bashankaev ◽  
D. Sands ◽  
E. G. Weiss ◽  
A. Zbar ◽  
...  
Keyword(s):  
Pilot Study ◽  
Healthy Volunteers ◽  
Anal Pressure ◽  
Resting Anal Pressure

scholarly journals Aortic Function’s Adaptation in Response to Exercise-Induced Stress Assessing by 1.5T MRI: A Pilot Study in Healthy Volunteers

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0157704 ◽  
Author(s):  
Laurence Bal-Theoleyre ◽  
Alain Lalande ◽  
Frank Kober ◽  
Roch Giorgi ◽  
Frederic Collart ◽  
...  
Keyword(s):  
Pilot Study ◽  
Healthy Volunteers ◽  
Induced Stress ◽  
Exercise Induced ◽  
Response To Exercise

scholarly journals Anal sphincter dysfunction in multiple sclerosis: an observation manometric study

Open Medicine ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. 509-517 ◽  
Author(s):  
Silvia Marola ◽  
Alessia Ferrarese ◽  
Enrico Gibin ◽  
Marco Capobianco ◽  
Antonio Bertolotto ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Fecal Incontinence ◽  
Anal Pressure ◽  
Before And After ◽  
Group A ◽  
The Difference ◽  
Resting Anal Pressure ◽  
Group B ◽  
Multiple Sclerosis Patients ◽  
Group D

AbstractConstipation, obstructed defecation, and fecal incontinence are frequent complaints in multiple sclerosis. The literature on the pathophysiological mechanisms underlying these disorders is scant. Using anorectal manometry, we compared the anorectal function in patients with and without multiple sclerosis.136 patients referred from our Center for Multiple Sclerosis to the Coloproctology Outpatient Clinic, between January 2005 and December 2011, were enrolled. The patients were divided into four groups: multiple sclerosis patients with constipation (group A); multiple sclerosis patients with fecal incontinence (group B); non-multiple sclerosis patients with constipation (group C); non-multiple sclerosis patients with fecal incontinence (group D). Anorectal manometry was performed to measure: resting anal pressure; maximum squeeze pressure; rectoanal inhibitory reflex; filling pressure and urge pressure. The difference between resting anal pressure before and after maximum squeeze maneuvers was defined as the change in resting anal pressure calculated for each patient.ResultsGroup A patients were noted to have greater sphincter hypotonia at rest and during contraction compared with those in group C (p=0.02); the rectal sensitivity threshold was lower in group B than in group D patients (p=0.02). No voluntary postcontraction sphincter relaxation was observed in either group A or group B patients (p=0.891 and p=0.939, respectively).ConclusionsThe decrease in the difference in resting anal pressure before and after maximum squeeze maneuvers suggests post-contraction sphincter spasticity, indicating impaired pelvic floor coordination in multiple sclerosis patients. A knowledge of manometric alterations in such patients may be clinically relevant in the selection of patients for appropriate treatments and for planning targeted rehabilitation therapy.

scholarly journals Exhaled Breath Condensate: Pilot Study of the Method and Initial Experience in Healthy Subjects

2018 ◽  
Vol 61 (1) ◽  
pp. 8-16
Author(s):  
Eva Peterová ◽  
Jaroslav Chládek ◽  
Darina Kohoutová ◽  
Veronika Knoblochová ◽  
Paula Morávková ◽  
...  
Keyword(s):  
Pilot Study ◽  
Healthy Volunteers ◽  
Coefficient Of Variation ◽  
Healthy Subjects ◽  
Lung Diseases ◽  
Exhaled Breath Condensate ◽  
Exhaled Breath ◽  
Initial Experience ◽  
Major Disadvantage ◽  
Breath Condensate

Analysis of Exhaled breath condensate (EBC) is a re-discovered approach to monitoring the course of the disease and reduce invasive methods of patient investigation. However, the major disadvantage and shortcoming of the EBC is lack of reliable and reproducible standardization of the method. Despite many articles published on EBC, until now there is no clear consensus on whether the analysis of EBC can provide a clue to diagnosis of the diseases. The purpose of this paper is to investigate our own method, to search for possible standardization and to obtain our own initial experience. Thirty healthy volunteers provided the EBC, in which we monitored the density, pH, protein, chloride and urea concentration. Our results show that EBC pH is influenced by smoking, and urea concentrations are affected by the gender of subjects. Age of subjects does not play a role. The smallest coefficient of variation between individual volunteers is for density determination. Current limitations of EBC measurements are the low concentration of many biomarkers. Standardization needs to be specific for each individual biomarker, with focusing on optimal condensate collection. EBC analysis has a potential become diagnostic test, not only for lung diseases.

Detection of fatty acid composition of trabecular bone marrow by localized iDQC MRS at 3 T: A pilot study in healthy volunteers

2021 ◽  
Vol 77 ◽  
pp. 28-35
Author(s):  
Jianfeng Bao ◽  
Yuchuan Zhuang ◽  
Zhong Chen ◽  
Jingliang Cheng ◽  
Jianhui Zhong
Keyword(s):  
Bone Marrow ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Pilot Study ◽  
Healthy Volunteers ◽  
Trabecular Bone ◽  
Acid Composition

scholarly journals Effects of Nigella sativa seeds (black cumin) on insulin secretion and lipid profile: A pilot study in healthy volunteers

2019 ◽  
Vol 85 (7) ◽  
pp. 1607-1611
Author(s):  
Sophie Pelegrin ◽  
Florence Galtier ◽  
Anne Chalançon ◽  
Jean‐Pierre Gagnol ◽  
Anne‐Marie Barbanel ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Pilot Study ◽  
Healthy Volunteers ◽  
Lipid Profile ◽  
Nigella Sativa ◽  
Black Cumin

How reliable are pain scores? a pilot study of 20 healthy volunteers

2003 ◽  
Vol 29 (4) ◽  
pp. 322-325 ◽  
Author(s):  
Timothy J. Mader ◽  
Fidela S.J. Blank ◽  
Howard A. Smithline ◽  
Jeannette M. Wolfe
Keyword(s):  
Pilot Study ◽  
Healthy Volunteers ◽  
Pain Scores
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