Determination of teicoplanin trough concentration target and appropriate total dose during the first 3 days: a retrospective study in patients with MRSA infections

ABSTRACT Objective: To discuss the implementation of technical advances in laboratory diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria for validation of high-sensitivity flow cytometry protocols. Methods: A retrospective study based on analysis of laboratory data from 745 patient samples submitted to flow cytometry for diagnosis and/or monitoring of paroxysmal nocturnal hemoglobinuria. Results: Implementation of technical advances reduced test costs and improved flow cytometry resolution for paroxysmal nocturnal hemoglobinuria clone detection. Conclusion: High-sensitivity flow cytometry allowed more sensitive determination of paroxysmal nocturnal hemoglobinuria clone type and size, particularly in samples with small clones.

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Determination of pregnancy-associated glycoprotein concentrations in goats (capra hircus) with unsuccessful pregnancies: a retrospective study

Theriogenology ◽

10.1016/s0093-691x(99)00076-x ◽

1999 ◽

Vol 51 (7) ◽

pp. 1321-1331 ◽

Cited By ~ 28

Author(s):

A. Zarrouk ◽

I. Engeland ◽

J. Sulon ◽

J.F. Beckers

Keyword(s):

Retrospective Study ◽

Capra Hircus

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Can Determination of Circulating Endothelial Cells and Serum Caspase-Cleaved CK18 Predict for Response and Survival in Patients with Advanced Non–Small-Cell Lung Cancer Receiving Endostatin and Paclitaxel–Carboplatin Chemotherapy? A Retrospective Study

Journal of Thoracic Oncology ◽

10.1097/jto.0b013e3182725fe0 ◽

2012 ◽

Vol 7 (12) ◽

pp. 1781-1789 ◽

Cited By ~ 11

Author(s):

Tian-Qing Chu ◽

Hao Ding ◽

David H. Garfield ◽

Ai-Qin Gu ◽

Jun Pei ◽

...

Keyword(s):

Lung Cancer ◽

Endothelial Cells ◽

Retrospective Study ◽

Small Cell Lung Cancer ◽

Cell Lung Cancer ◽

Small Cell ◽

Circulating Endothelial Cells ◽

Small Cell Lung

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Concomitant Treatment with Voriconazole and Flucloxacillin: A Combination to Avoid

Antibiotics ◽

10.3390/antibiotics10091112 ◽

2021 ◽

Vol 10 (9) ◽

pp. 1112

Author(s):

Ruth Van Daele ◽

Joost Wauters ◽

Pieter De Cock ◽

Franky Buyle ◽

John Leys ◽

...

Keyword(s):

Cytochrome P450 ◽

Retrospective Study ◽

Trough Concentration ◽

Multivariate Analyses ◽

Independent Effect ◽

Concomitant Treatment ◽

Cytochrome P450 Enzymes ◽

First Line ◽

Trough Concentrations ◽

Exposure Methods

Background: Voriconazole is an antifungal drug used as one of the first-line treatments for invasive aspergillosis. This drug is extensively metabolized, predominantly via cytochrome P450 enzymes. An interaction between flucloxacillin and voriconazole, leading to subtherapeutic voriconazole concentrations, has previously been reported. We aimed to demonstrate that flucloxacillin independently influences voriconazole exposure. Methods: Patients from three Belgian hospitals, treated with a combination of voriconazole and flucloxacillin, were included in this retrospective study. Voriconazole concentrations were collected both in a timeframe with and without flucloxacillin co-treatment. Multivariate analyses were performed to study the independent effect of flucloxacillin treatment on voriconazole exposure and the possible influence of the flucloxacillin dose. Results: Thirty-three patients were included in this study and 145 trough concentrations (51 with, and 94 without concomitant flucloxacillin treatment) were analyzed. The median (IQR) voriconazole trough concentration sampled during flucloxacillin co-treatment was 0.5 (0–1.8) mg/L, whereas samples without flucloxacillin co-treatment had a median (IQR) voriconazole trough concentration of 3.5 (1.7–5.1) mg/L (p = 0.002), while receiving similar voriconazole doses. Subtherapeutic concentrations (<1 mg/L) were observed in 69% and 7% of the samples with flucloxacillin co-treatment versus samples without flucloxacillin co-treatment, respectively. Conclusion: This study shows that flucloxacillin co-treatment independently decreases voriconazole exposure. Caution is needed when these two drugs are administered simultaneously.

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The Effect of Guilu Erxian Jiao on Osteoporosis Patients: A Retrospective Study

10.21203/rs.3.rs-685272/v1 ◽

2021 ◽

Author(s):

Yuan-Xin Lai ◽

Chu-Yao Tseng ◽

Huang-Yu Yang ◽

Sien-Hung Yang ◽

Tsung-Hsien Yang

Keyword(s):

Retrospective Study ◽

Total Dose ◽

Cumulative Incidence ◽

Rank Test ◽

Chang Gung Memorial Hospital ◽

Fracture Rate ◽

T Score ◽

Significant Difference ◽

Cumulative Rate ◽

Student’S T

Abstract Background: This retrospective study aimed to evaluate whether the Chinese herbal medicine formula Guilu Erxian Jiao can improve T-score in osteoporosis patients diagnosed by dual energy x-ray absorptiometry (DXA) and even decrease fracture rate.Method: Osteoporosis participants were collected through the Chang Gung Memorial Hospital (CGMH) database from 2000 to 2019. Intervention was taking Guilu Erxian Jiao pills. We analyzed the change of T-score and the following cumulative incidence of fracture. The Student’s T-test, Cox’s proportional hazard model, Kaplan-Meier method and log-rank test were conducted using SAS software.Results: There was no significant difference about the baseline between the Guilu Erxian Jiao group and non-Guilu Erxian Jiao group. Guilu Erxian Jiao can improve the osteoporosis of the vertebrate of lumbar. However, there is no significant diffidence about the vertebrate of lumbar and femoral neck between the Guilu Erxian Jiao group and non-Guilu Erxian Jiao group. The cumulative rate of fracture between these two groups is no significant difference. However, if patients took the total dose of Guilu Erxian Jiao over 600 pill*days, the fracture rate would decrease.Conclusion: Usage of Guilu Erxian Jiao would improve the osteoporosis of vertebrate of lumbar, but does not improve the cumulative incidence of fracture, unless they took the total dose of Guilu Erxian Jiao over 600 pill*days.

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Retrospective study of allometric relationship between heart rate, electrocardiographic parameters and bodyweight in dogs

Arquivo Brasileiro de Medicina Veterinária e Zootecnia ◽

10.1590/1678-4162-10407 ◽

2019 ◽

Vol 71 (6) ◽

pp. 1800-1804

Author(s):

A.S.C. Aleixo ◽

A. Alfonso ◽

M.G. Fillippi ◽

S.B. Chiacchio ◽

M.L.G. Lourenço

Keyword(s):

Heart Rate ◽

Retrospective Study ◽

The Body ◽

Weak Correlation ◽

Allometric Relationship ◽

Domestic Species ◽

Electrocardiographic Parameters ◽

The Relationship ◽

Weight Groups

ABSTRACT The allometric relationship between bodyweight (BW) and heart rate (HR) has been described as inversely proportional in domestic species, but that has been refuted. The relationship between HR and electrocardiographic variables is described in literature. However, studies about the variation and influence of factors on the hemodynamic and electrocardiographic parameters in dogs are not abundant. As the metabolic rate is defined as the production and dissipation of heat by the body surface area (BSA) in m², it is essential to define that relationship. A retrospective study was conducted to analyze the correlation between HR, ECG parameters and BW in dogs. One thousand electrocardiographic tracings were analyzed in addition to the ECG parameters and clinical data such as gender, age and bodyweight. The determination of BSA was performed as follows: BSA (m2) = (10.1 x bodyweight 0.67) X 10-4. When the unified groups were analyzed, there was a negative but weak correlation (r= -0.14, P< 0.0001) between bodyweight and HR. There were differences between weight groups regarding electrocardiographic variables. There is no allometric relationship between BW and HR in dogs. Weight was associated with changes in ECG variables.

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