Study of kinetics of 19F-MRI using a fluorinated imaging agent (19FIT) on a 3T clinical MRI system

2018 ◽  
Vol 32 (1) ◽  
pp. 97-103 ◽  
Author(s):  
Xin Liu ◽  
Zhong-Xing Jiang ◽  
Bruce Y. Yu ◽  
Eun-Kee Jeong
Keyword(s):  
Imaging Agent ◽  
19F Mri ◽  
Kinetics Of ◽  
Clinical Mri

scholarly journals Paired-Agent Fluorescence Molecular Imaging of Sentinel Lymph Nodes Using Indocyanine Green as a Control Agent for Antibody-Based Targeted Agents

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Chengyue Li ◽  
Xiaochun Xu ◽  
Nathan McMahon ◽  
Omar Alhaj Ibrahim ◽  
Husain A. Sattar ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Lymph Nodes ◽  
Indocyanine Green ◽  
Metastatic Breast ◽  
Control Agent ◽  
Sentinel Lymph Nodes ◽  
Imaging Agent ◽  
Binding Potential ◽  
Cancer Spread ◽  
Kinetics Of

Purpose. Paired-agent molecular imaging methods, which employ coadministration of an untargeted, “control” imaging agent with a targeted agent to correct for nonspecific uptake, have been demonstrated to detect 200 cancer cells in a mouse model of metastatic breast cancer. This study demonstrates that indocyanine green (ICG), which is approved for human use, is an ideal control agent for future paired-agent studies to facilitate eventual clinical translation. Methods. The kinetics of ICG were compared with a known ideal control imaging agent, IRDye-700DX-labeled antibody in both healthy and metastatic rat popliteal lymph nodes after coadministration, intradermally in the footpad. Results. The kinetics of ICG and antibody-based imaging agent in tumor-free rat lymph nodes demonstrated a strong correlation with each other (r = 0.98, p<0.001) with a measured binding potential of −0.102 ± 0.03 at 20 min postagent injection, while the kinetics of ICG and targeted imaging agent shows significant separation in the metastatic lymph nodes. Conclusion. This study indicated a potential for microscopic sensitivity to cancer spread in sentinel lymph nodes using ICG as a control agent for antibody-based molecular imaging assays.

scholarly journals HL91-technetium-99m: Kinetics of a new hypoxia avid imaging agent in normal and ischemic myocardium as assessed by gamma camera images

1996 ◽  
Vol 27 (2) ◽  
pp. 407
Author(s):  
Gerald Johnson ◽  
Kiem N. Nguyen ◽  
Zhonglin Liu ◽  
Ping Gao ◽  
Barbara Edwards ◽  
...  
Keyword(s):  
Gamma Camera ◽  
Ischemic Myocardium ◽  
Imaging Agent ◽  
Technetium 99M ◽  
Kinetics Of

Design and Synthesis of Fluorinated Amphiphile as 19F MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly

2015 ◽  
Vol 80 (12) ◽  
pp. 6360-6366 ◽  
Author(s):  
Shaowei Bo ◽  
Cong Song ◽  
Yu Li ◽  
Weijiang Yu ◽  
Shizhen Chen ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Imaging Agent ◽  
Design And Synthesis ◽  
19F Mri ◽  
Dual Imaging

A CoII complex for 19F MRI-based detection of reactive oxygen species

2016 ◽  
Vol 52 (96) ◽  
pp. 13885-13888 ◽  
Author(s):  
Meng Yu ◽  
Da Xie ◽  
Khanh P. Phan ◽  
José S. Enriquez ◽  
Jeffrey J. Luci ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
High Spin ◽  
Reactive Oxygen ◽  
Imaging Agent ◽  
Oxygen Species ◽  
Mri Imaging ◽  
Turn On ◽  
19F Mri ◽  
Coii Complex

A fluorinated, cobalt(ii)-based 19F MRI imaging agent switches from a paramagnetic high spin CoII state to a diamagnetic low spin CoIII state following oxidation by H2O2 and other reactive oxygen species, resulting in a turn-on response via both 19F NMR and MRI.

Kinetics of Formation for Lanthanide (III) Complexes of DTPA-(Me-Trp)2 used as Imaging Agent

2011 ◽  
Vol 77 (5) ◽  
pp. 388-392 ◽  
Author(s):  
Anjani K. Tiwari ◽  
Deepa Sinha ◽  
Anupama Datta ◽  
Dipti Kakkar ◽  
Anil K. Mishra
Keyword(s):  
Imaging Agent ◽  
Kinetics Of Formation ◽  
Kinetics Of

Direct observations of radiation-enhanced transformations in glass

1983 ◽  
Vol 41 ◽  
pp. 354-355
Author(s):  
J. F. DeNatale ◽  
D. G. Howitt
Keyword(s):  
Glass Matrix ◽  
Diffusion Mechanism ◽  
Bubble Formation ◽  
Silicate Glasses ◽  
Phase Decomposition ◽  
Direct Observations ◽  
Thin Foils ◽  
Oxygen Bubble ◽  
Electron Energy Loss ◽  
Kinetics Of

The electron irradiation of silicate glasses containing metal cations produces various types of phase separation and decomposition which includes oxygen bubble formation at intermediate temperatures figure I. The kinetics of bubble formation are too rapid to be accounted for by oxygen diffusion but the behavior is consistent with a cation diffusion mechanism if the amount of oxygen in the bubble is not significantly different from that in the same volume of silicate glass. The formation of oxygen bubbles is often accompanied by precipitation of crystalline phases and/or amorphous phase decomposition in the regions between the bubbles and the detection of differences in oxygen concentration between the bubble and matrix by electron energy loss spectroscopy cannot be discerned (figure 2) even when the bubble occupies the majority of the foil depth.The oxygen bubbles are stable, even in the thin foils, months after irradiation and if van der Waals behavior of the interior gas is assumed an oxygen pressure of about 4000 atmospheres must be sustained for a 100 bubble if the surface tension with the glass matrix is to balance against it at intermediate temperatures.

Irradiation behavior of pyrolytic silicon carbide

1983 ◽  
Vol 41 ◽  
pp. 72-73
Author(s):  
R. J. Lauf
Keyword(s):  
Silicon Carbide ◽  
Fission Products ◽  
Thermodynamics And Kinetics ◽  
Neutron Fluences ◽  
Fuel Particles ◽  
Sic Coatings ◽  
Irradiation Behavior ◽  
Kinetics Of ◽  
Htgr Fuel

Fuel particles for the High-Temperature Gas-Cooled Reactor (HTGR) contain a layer of pyrolytic silicon carbide to act as a miniature pressure vessel and primary fission product barrier. Optimization of the SiC with respect to fuel performance involves four areas of study: (a) characterization of as-deposited SiC coatings; (b) thermodynamics and kinetics of chemical reactions between SiC and fission products; (c) irradiation behavior of SiC in the absence of fission products; and (d) combined effects of irradiation and fission products. This paper reports the behavior of SiC deposited on inert microspheres and irradiated to fast neutron fluences typical of HTGR fuel at end-of-life.

The Ordered Phase Formation in Ti-Al-Ga Alloys

1970 ◽  
Vol 28 ◽  
pp. 440-441
Author(s):  
Shiro Fujishiro ◽  
Harold L. Gegel
Keyword(s):  
Thermal Stability ◽  
High Temperature ◽  
Titanium Alloys ◽  
Growth Kinetics ◽  
Stoichiometric Composition ◽  
Good Potential ◽  
Alpha Titanium ◽  
Cold Rolled ◽  
Kinetics Of ◽  
Thermal Stability Of

Ordered-alpha titanium alloys having a DO19 type structure have good potential for high temperature (600°C) applications, due to the thermal stability of the ordered phase and the inherent resistance to recrystallization of these alloys. Five different Ti-Al-Ga alloys consisting of equal atomic percents of aluminum and gallium solute additions up to the stoichiometric composition, Ti3(Al, Ga), were used to study the growth kinetics of the ordered phase and the nature of its interface.The alloys were homogenized in the beta region in a vacuum of about 5×10-7 torr, furnace cooled; reheated in air to 50°C below the alpha transus for hot working. The alloys were subsequently acid cleaned, annealed in vacuo, and cold rolled to about. 050 inch prior to additional homogenization

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