scholarly journals A Qualitative Study to Identify Perceptual Barriers to Antiretroviral Therapy (ART) Uptake and Adherence in HIV Positive People from UK Black African and Caribbean Communities

2019 ◽  
Vol 23 (9) ◽  
pp. 2514-2521
Author(s):  
Elizabeth Glendinning ◽  
◽  
Johanna Spiers ◽  
Jonathan A. Smith ◽  
Jane Anderson ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Adverse Effects ◽  
Hiv Positive ◽  
Long Term Effects ◽  
Structured Interviews ◽  
Framework Analysis ◽  
Black African ◽  
Black Caribbean ◽  
Feeling Overwhelmed

Abstract To inform the development of interventions to increase uptake and adherence to antiretroviral therapy (ART), we explored perceptions of ART in semi-structured interviews with 52 men and women from UK black African and black Caribbean communities. Verbatim transcripts were analyzed using framework analysis. Perceptions of ART could be grouped into two categories: doubts about the personal necessity for ART and concerns about potential adverse effects. Doubts about necessity stemmed from feeling well, doubts about the efficacy of ART, religious beliefs and the belief that treatment was futile because it could not cure HIV. Concerns about adverse effects included the fear that attending HIV services and taking treatment would lead to disclosure of HIV, feeling overwhelmed at the prospect of starting treatment soon after diagnosis, fears about side effects and potential long-term effects, and physical repulsion. The findings will facilitate the development of interventions to increase uptake and adherence to ART.

Explosions and Human Health: The Long-Term Effects of Blast Injury

2012 ◽  
Vol 27 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Sarah E. Finlay ◽  
Michelle Earby ◽  
David J. Baker ◽  
Virginia S.G. Murray
Keyword(s):  
Human Health ◽  
Well Being ◽  
Blast Injury ◽  
Mass Casualties ◽  
Long Term Effects ◽  
Structured Interviews ◽  
National Guidelines ◽  
Emergency Responders ◽  
Response Strategies

AbstractThe immediate patterns of injury from explosions are well documented, from both military and civil experience. However, few studies have focused on less immediately apparent health consequences and latent effects of explosions in survivors, emergency responders and the surrounding community. This review aimed to analyze the risks to health following an explosion in a civil setting.A comprehensive review of the open literature was conducted, and data on 10 relevant military, civilian and industrial events were collected. Events were selected according to availability of published studies and involvement of large numbers of people injured. In addition, structured interviews with experts in the field were conducted, and existing national guidelines reviewed.The review revealed significant and potentially long-term health implications affecting various body systems and psychological well-being following exposure to an explosion. An awareness of the short- and long-term health effects of explosions is essential in screening for blast injuries, and identifying latent pathologies that could otherwise be overlooked in stressful situations with other visually distracting injuries and, often, mass casualties. Such knowledge would guide responsible medical staff in implementing early appropriate interventions to reduce the burden of long-term sequelae. Effective planning and response strategies would ensure accessibility of appropriate health care resources and evidence-based information in the aftermath of an explosion.Finlay SE, Earby M, Baker DJ, Murray VSG. Explosions and human health: the long-term effects of blast injury. Prehosp Disaster Med. 2012;27(4):1-7.

Long-term effect of highly active antiretroviral therapy on cervical lesions in HIV-positive women

AIDS ◽  
2003 ◽  
Vol 17 (14) ◽  
pp. 2136-2138 ◽  
Author(s):  
Caterina Uberti-Foppa ◽  
Davide Ferrari ◽  
Sara Lodini ◽  
Salvatore Reina ◽  
Franco Ameglio ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Term Effect ◽  
Hiv Positive ◽  
Cervical Lesions ◽  
Highly Active ◽  
Hiv Positive Women ◽  
Long Term Effect

Incest: What do we Really Know about It?

1987 ◽  
Vol 21 (4) ◽  
pp. 430-440 ◽  
Author(s):  
R. Kosky
Keyword(s):  
Adverse Effects ◽  
Sexual Activity ◽  
Sexual Intercourse ◽  
Current Knowledge ◽  
Epidemiological Studies ◽  
Scientific Basis ◽  
Long Term Effects ◽  
Clinical Series ◽  
General Populations

The literature on incest is reviewed. Current knowledge rests on a very insecure scientific basis and has been mainly derived from small, highly selected clinical series. Recently, some important epidemiological studies of general populations have been reported, but the results of prevalence are inconsistent. Overall, however, it appears that incest, when defined in terms of sexual intercourse, occurs in less than 1% of the population, but other forms of intrafamilial sexual activity may affect 10% of females before they are 16 years of age. Some children are more at risk than others. Because information has generally been derived from court or treatment samples, we are unclear about the long-term effects of incest experiences but, overall, the impression is that incest has markedly adverse effects, especially if it is accompanied by violence and threats and is directed, as it usually is, at the young pre-pubescent child.

scholarly journals Long-Term Consequences of Adolescent Exposure to THC-Rich/CBD-Poor and CBD-Rich/THC-Poor Combinations: A Comparison with Pure THC Treatment in Female Rats

2021 ◽  
Vol 22 (16) ◽  
pp. 8899
Author(s):  
Marina Gabaglio ◽  
Erica Zamberletti ◽  
Cristina Manenti ◽  
Daniela Parolaro ◽  
Tiziana Rubino
Keyword(s):  
Adverse Effects ◽  
Chronic Administration ◽  
Female Rats ◽  
Acid Decarboxylase ◽  
Long Term Effects ◽  
Gabaergic Neurotransmission ◽  
Long Term Consequences ◽  
Adolescent Exposure ◽  
Long Term Adverse Effects

Cannabis is the most-used recreational drug worldwide, with a high prevalence of use among adolescents. In animal models, long-term adverse effects were reported following chronic adolescent exposure to the main psychotomimetic component of the plant, delta-9-tetrahydrocannabinol (THC). However, these studies investigated the effects of pure THC, without taking into account other cannabinoids present in the cannabis plant. Interestingly, cannabidiol (CBD) content seems to mitigate some of the side effects of THC, at least in adult animals. Thus, in female rats, we evaluated the long-term consequences of a co-administration of THC and CBD at a 3:1 ratio, chosen based on the analysis of recently confiscated illegal cannabis samples in Europe. CBD content is able to mitigate some of the long-term behavioral alterations induced by adolescent THC exposure as well as long-term changes in CB1 receptor and microglia activation in the prefrontal cortex (PFC). We also investigated, for the first time, possible long-term effects of chronic administration of a THC/CBD combination reminiscent of “light cannabis” (CBD:THC in a 33:1 ratio; total THC 0.3%). Repeated administration of this CBD:THC combination has long-term adverse effects on cognition and leads to anhedonia. Concomitantly, it boosts Glutamic Acid Decarboxylase-67 (GAD67) levels in the PFC, suggesting a possible lasting effect on GABAergic neurotransmission.

Long-term effects of interferon-α in five HIV-positive patients with chronic hepatitis B

1996 ◽  
Vol 3 (5) ◽  
pp. 253-260 ◽  
Author(s):  
V. Martino ◽  
F. Lunel ◽  
J.F. Cadranel ◽  
C. Hoang ◽  
Y. Parlier ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hiv Positive ◽  
Interferon Α ◽  
Long Term Effects

scholarly journals Long-Term Effects of Highly Active Antiretroviral Therapy in Pretreated, Vertically HIV Type 1-Infected Children: 6 Years of Follow-Up

2006 ◽  
Vol 42 (6) ◽  
pp. 862-869 ◽  
Author(s):  
S. Resino ◽  
R. Resino ◽  
D. Micheloud ◽  
D. Gurbindo-Gutierrez ◽  
J. A. Leon ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Long Term Effects ◽  
Highly Active ◽  
Hiv Type 1

scholarly journals Long-term durability of responses to 2 or 3 doses of hepatitis A vaccination in HIV-positive adults on antiretroviral therapy

2016 ◽  
pp. jiw605 ◽  
Author(s):  
Aristine Cheng ◽  
Sui-Yuan Chang ◽  
Hsin-Yun Sun ◽  
Mao-Song Tsai ◽  
Wen-Chun Liu ◽  
...  
Keyword(s):  
Antiretroviral Therapy ◽  
Hepatitis A ◽  
Hiv Positive ◽  
Hiv Positive Adults

scholarly journals A Cohort Study on Long-Term Adverse Effects of Parental Drinking: Background and Study Design

2015 ◽  
Vol 9s2 ◽  
pp. SART.S23329 ◽  
Author(s):  
Ingunn Olea Lund ◽  
Anne Bukten ◽  
Elisabet E. Storvoll ◽  
Inger Synnøve Moan ◽  
Svetlana Skurtveit ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Adverse Outcomes ◽  
Registry Data ◽  
Long Term Effects ◽  
Risk Levels ◽  
General Population Cohort ◽  
Parental Drinking ◽  
The Rich ◽  
Long Term Adverse Effects

Although many studies have addressed adverse outcomes in children of parents with alcohol abuse/dependence, less is known about the possible long-term effects of more normative patterns of parental alcohol consumption, including drinking at lower risk levels and heavy episodic or binge drinking. The extent of harm from parental drinking may therefore be underestimated. With this research proposal, we describe a project that aims to assess possible long-term adverse effects of parental drinking by combining survey and nationwide registry data. Advantages of a longitudinal general population cohort design include that it allows for detailed information on parental drinking through survey data and identification of possible negative long-term health and social outcomes from exposure to parental drinking 1–19 years after exposure through continuously updated nationwide registers. The rich information available from combining survey and registry data allows us to take into account important confounders, mediators, and moderators.

scholarly journals A Qualitative Study Exploring the Impact and Effects Following Hospital Discharge of COVID-19

2021 ◽  
Vol 1 (3) ◽  
pp. 216-222
Author(s):  
Abigail Reay ◽  
Avinash Aujayeb ◽  
Catherine Dotchin ◽  
Ellen Tullo ◽  
John Steer ◽  
...  
Keyword(s):  
Qualitative Study ◽  
Hospital Discharge ◽  
Psychological Effects ◽  
Functional Abilities ◽  
Long Term Effects ◽  
Structured Interviews ◽  
Discharge From Hospital ◽  
The Impact

Introduction: Research into the long-term effects of coronavirus disease 2019 (COVID-19) continues at an unprecedented pace. Many physical long-term symptoms of COVID-19 have been reported and include headache, fatigue, muscle pain and breathlessness, etc. Psychological effects are not dissimilar to survivors of SARS. There is limited qualitative research exploring the mental health impacts and experiences of hospitalized COVID-19 inpatients. Methods: A prospective qualitative study is planned to explore patient experiences post hospital discharge following a diagnosis of COVID-19. The research aims to gain an understanding of how COVID-19 affects quality of life (QoL) and functional abilities. Patients discharged from the hospital will be invited to take part in semi-structured interviews discussing their experiences of hospitalization and the impact of COVID-19 on their QoL. Interviews will be conducted at three and six months following discharge from hospital. This study will provide important qualitative insight and may inform clinical interventions and commissioning decisions. Trial registration: The study has Research Ethics Committee (REC) and Health Research Authority (HRA) approvals obtained from Health and Care Research Wales (HCRW) [IRAS project ID 293196].

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