CYP3A Polymorphism and Chronic Mercury Intoxication

2020 ◽  
Vol 168 (4) ◽  
pp. 492-495
Author(s):  
Yu. I. Chernyak ◽  
A. P. Merinova
Keyword(s):  
Mercury Intoxication ◽  
Chronic Mercury Intoxication

The interrelation of neurophysiological, psychological, and biochemical indicators in patients with occupational chronic mercury intoxication suffering from insomnia

2020 ◽  
Vol 60 (12) ◽  
pp. 904-910
Author(s):  
Elena V. Katamanova ◽  
Elena N. Korchuganova ◽  
Natalia V. Slivnitsyna ◽  
Irina V. Kudaeva ◽  
Oleg L. Lakhman
Keyword(s):  
Cerebral Cortex ◽  
Work Experience ◽  
Sleep Time ◽  
Serotonin Level ◽  
Complex Activity ◽  
Equivalent Dipole ◽  
Mercury Intoxication ◽  
Psychological Examination ◽  
Reticular System ◽  
Chronic Mercury Intoxication

Introduction. Despite the apparent connection of the existing neurological disorders and changes in the psycho-emotional sphere with sleep disorders in patients with chronic mercury intoxication (CRI), these relationships remain the least studied in the clinic neurointoxications. The study aimed to establish a connection between neurophysiological, biochemical, and psychopathological indicators in patients with occupational chronic mercury intoxication and insomnia. Materials and methods. Thirty-six patients took part in the examination in the remote period of CRI. The average age of patients in this group was 50.7±1.05 years, with an average work experience of 14.7±1.05. The authors carried out a psychological examination to determine the levels of depression, anxiety, asthenic state, computed electroencephalography (EEG), cognitive evoked potentials (CEP), polysomnography, the level of neurotransmitters. Results. The study showed that asthenization, when exposed to mercury, occurs due to a decrease in the limbic-hypothalamo-reticular complex activity (the presence of equivalent dipole sources of pathological activity in the area of diencephalic formations (thalamus, hypothalamus) in 56.2±5.6% of cases. The study showed a decrease in activity cerebral cortex, confirmed by weakening the coherent connections of the α-range in the occipital, central and frontal leads according to the data of coherent EEG analysis and changes on the part of the CEP. There was a direct correlation between the level of total sleep time and the serotonin level (rs=0.45), an inverse relationship between the level of depression and histamine level (rs=-0.56). Conclusion. The studies carried out to make it possible to establish the mechanisms of insomnia disorders in chronic mercury intoxication, which cause a weakening of the tone of the cerebral cortex and changes in neurotransmitter metabolism, as well as disorders of the reticular system with limbic structures. The study showed a close direct relationship between neurophysiological, psychological, and biochemical parameters in implementing insomnia in patients with chronic mercury intoxication.

scholarly journals PHENOTYPIC COMPOSITION OF PERIPHERAL BLOOD LYMPHOCYTES AND THEIR COOPERATION IN PATIENTS WITH CHRONIC MERCURY INTOXICATION IN A POST-CONTACT PERIOD

2019 ◽  
Vol 98 (10) ◽  
pp. 1091-1095
Author(s):  
Elena V. Boklazhenko ◽  
G. M. Bodienkova
Keyword(s):  
Immune System ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Contact Period ◽  
Blood Lymphocytes ◽  
Mercury Intoxication ◽  
System Functioning ◽  
Therapeutic Measures ◽  
Chronic Mercury Intoxication

Introduction. Based on the current understanding of the progression of professional chronic mercury intoxication, it is extremely important to study the regulatory activity of immunocompetent cells after the cessation contact with mercury to develop effective therapeutic measures. The purpose of the study was to study the population and subpopulation spectrum of peripheral blood lymphocytes and their cooperation in patients with chronic mercury intoxication in a distant postexposure period. Material and methods. Phenotyping of lymphocytes in the blood of the subjects was carried out by the method of indirect immunofluorescence using monoclonal antibodies to the molecules CD3+, CD4+, CD8+, CD9+, CD16+, CD20+, CD21+, CD23+, CD25+, CD95+. Results. In patients with chronic mercury intoxication in the long-term postexposure period, there were revealed features of the immune system functioning, indicating hyperactivation of both T- and B-components of the immune system. An increase in the total population of T-lymphocytes was established due to an increase in cells with receptors CD4+ (T-lymphocyte-helper cells) and CD16+ (killer cells), as well as an increase in the number of mature B-lymphocytes (CD20+) and pre-B-immature-lymphocytes (CD9+). Changes in the system of lymphocyte apoptosis, characterized by an increase in the number of cells expressing receptors for readiness for Fas-dependent apoptosis (CD95+), have been recorded. The established relationships between populations and subpopulations of lymphocytes indicate their importance in the implementation of the immune response, high activity and contingency between the components of the immune system in persons with chronic mercury intoxication after the termination of contact with the toxicant. Conclusion. The results obtained are the basis for long-term monitoring of the health status and improvement of the tactics of treating patients with neurointoxication with mercury in the postexposure period.

scholarly journals PSYCHOLOGICAL CORRELATES OF DISSOMNIC DISORDERS IN PATIENTS IN THE REMOTE PERIOD AFTER CHRONIC MERCURY INTOXICATION

2018 ◽  
Vol 97 (10) ◽  
pp. 925-929 ◽  
Author(s):  
Oksana I. Shevchenko ◽  
E. B. Katamanova ◽  
E. H. Korchuganova ◽  
O. L. Lakhman
Keyword(s):  
Negative Impact ◽  
Professional Activity ◽  
Control Group ◽  
Contact Period ◽  
Second Stage ◽  
Mercury Intoxication ◽  
Chronic Mercury Intoxication ◽  
Psychological Features ◽  
Relationship Of ◽  
General Time

Introduction. Need of carrying out a research is defined by insufficient study of retsiprokny relationship of psychological features with the course of insomnichesky frustration taking into account psychopathological symptomatology and features of displays of neurointoxication for the purpose of prevention of sleep disorders at patients with the chronic mercury intoxication (CMI). A research objective was identification of psychological features of formation of dissomnichesky frustration at patients in the remote post-contact period of HRI. Material and methods. Kliniko-diagnostic, polisomnografichesky and experimental and psychological examinations to 40 patients from HRI and to 15 healthy men of group of comparison which didn't have in professional activity of contact with harmful substances are conducted. Results. The Polisomnografichesky research of patients with HRI has revealed rough changes of indicators of structure of a night dream in comparison with control group in the form of reduction of duration of a dream, increase in the latent period of the first stage of a dream, the general time of wakefulness in a dream from time of its duration, total of activation shifts. Essential changes of structure of a dream were noted in his first cycle - in the form of reduction of duration. Reduction of duration of a cycle, time of the second stage, reduction representation of a delta dream is noted. The indicators characterizing the mnestiko-attentsionny sphere and an emotional condition of patients considerably differed from standard levels that demonstrated personal disintegration, formation of mental defect of asthenic, disturbing and hypochondriac, sensitive types with prevalence of affects of disturbing and depressive and explosive character. Discussion. The established correlation connection demonstrates negative impact of time of duration of a dream on levels of uneasiness, a depression, morbid depression, social disadaptation, intelligence quotient, indicators of short-term, figurative memory, concentration of attention Increase in duration of a somnolence promotes aggravation of paranoyalny manifestations and decrease in concentration of attention and is regarded as sign of strengthening of activity of stem structures. Conclusion. It is established that at professional neurointoxications permanent changes of polisomnografichesky activity in the form of insomnichesky violations of the mixed character are a consequence of chronic influence of vapors of metal mercury and also the reason of psychopathological violations.

scholarly journals Using of the biofeedback in rehabilitation of patients with mercury intoxication

2010 ◽  
Vol 9 (2) ◽  
pp. 59-62
Author(s):  
M. P. Diyakovich ◽  
P. V. Kazakova ◽  
Ye. V. Katamanova ◽  
D. V. Rusanova
Keyword(s):  
Functional State ◽  
Brain Activity ◽  
Life Quality ◽  
Study Results ◽  
Mercury Intoxication ◽  
Chronic Mercury Intoxication ◽  
Positive Effect

The study results of using the biological reverse connection training with the musical therapy in the rehabilitation of the patients with the chronic mercury intoxication are represented in this paper. The positive effect of the BRC-training on processes concentration of retention, some subscales of the life quality, the functional state of the central afferent conducting structures as well as the neurophysiologic balance of the bioelectrical brain activity have been indicated.

scholarly journals DIAGNOSTIC CRITERIA OF SLEEP DISORDERS IN PATIENTS WITH LONG-TERM CHRONIC MERCURY INTOXICATION

2019 ◽  
Vol 98 (10) ◽  
pp. 1155-1160 ◽  
Author(s):  
Elena V. Katamanova ◽  
N. V. Slivnitsyna ◽  
E. N. Korchuganova ◽  
O. I. Shevchenko
Keyword(s):  
Sleep Disorders ◽  
Diagnostic Criteria ◽  
Sleep Disturbances ◽  
Comparison Group ◽  
Total Sleep Time ◽  
Behavioral Therapy ◽  
Sleep Time ◽  
Mercury Intoxication ◽  
Chronic Mercury Intoxication

Introduction. In the Irkutsk region, chronic mercury intoxication (CRI) occupies a leading place among occupational neurointoxications. An organic personality disorder with insomnia is one of the manifestations of brain damage in CRI. The aim of the study was to establish diagnostic criteria for secondary insomnia in patients with professional CRI for the selection of effective treatment. Material and methods. The study involved 30 people in the long-term CRI and 30 people in the comparison group with sleep disorders that are not in contact with harmful factors. Electroencephalographic, polysomnographic research and questioning were carried out with the assessment of the subjective characteristics of sleep. Information was processed using the Statistika 6.0 application package. Results. It was shown that CRI patients were shown to complain statistically significantly more frequent sleep disturbances than in the comparison group (p = 0.0003), difficulty in maintaining sleep (p = 0.004). As a result of EEG in the group of patients in the long-term CRI, the integral index and the ratio α/β were statistically significantly different from those in the comparison group, and according to the results of polysomnography, more pronounced qualitative and quantitative violations of the night sleep pattern were found in CRI patients; as a decrease in total sleep time (p = 0.0001), increase in sleep time (p = 0.008), number of activations and total wakefulness inside sleep (p = 0.03), decrease in sleep efficiency index (p = 0.006) and increase in an integrative sleep quality index (p = 0.03). According to the discriminant analysis, 4 criteria for diagnosing insomnia in CRI were established: total sleep time (min.), duration of the first stage of slow sleep (%), rhythm ratio α/β, EEG (%) and integral EEG index (%). Conclusion. Considering the data obtained, it is possible to improve approaches to treating insomnia in CRI by prescribing a complex of treatment, including cognitive-behavioral therapy, antidepressants with a sedative effect, as well as alpha training using biofeedback.

scholarly journals Clinical management of chronic mercury intoxication secondary to skin lightening products: A proposed algorithm

2020 ◽  
Author(s):  
Fitri Fareez Ramli
Keyword(s):  
Chelation Therapy ◽  
Clinical Presentation ◽  
Toxic Substance ◽  
Delayed Diagnosis ◽  
Primary Treatment ◽  
Response To Treatment ◽  
Mercury Intoxication ◽  
History Of ◽  
Chronic Mercury Intoxication ◽  
Skin Lightening

Mercury is a toxic substance that is commonly used in skin lightening products. Various effects on humans have been observed, which affect both users and non-users. Many cases reported delayed diagnosis and treatment, even after weeks of hospitalization. The possible reasons are non-specific clinical manifestation and lack of awareness and knowledge regarding chronic mercury intoxication secondary to skin lightening products. A thorough history of mercury exposure is crucial. Physical assessment and relevant supporting tests are indicated to establish a diagnosis. Blood and urine mercury levels are an essential examination for diagnosis and monitoring of the progress and response to treatment. The primary treatment is the discontinuation of the skin lightening products. Chelation therapy is not mandatory and usually indicated for symptomatic patients. The prognosis depends on the duration of the product use, concentration of mercury in the skin product, and the severity of the clinical presentation.

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