The interrelation of neurophysiological, psychological, and biochemical indicators in patients with occupational chronic mercury intoxication suffering from insomnia

2020 ◽  
Vol 60 (12) ◽  
pp. 904-910
Author(s):  
Elena V. Katamanova ◽  
Elena N. Korchuganova ◽  
Natalia V. Slivnitsyna ◽  
Irina V. Kudaeva ◽  
Oleg L. Lakhman
Keyword(s):  
Cerebral Cortex ◽  
Work Experience ◽  
Sleep Time ◽  
Serotonin Level ◽  
Complex Activity ◽  
Equivalent Dipole ◽  
Mercury Intoxication ◽  
Psychological Examination ◽  
Reticular System ◽  
Chronic Mercury Intoxication

Introduction. Despite the apparent connection of the existing neurological disorders and changes in the psycho-emotional sphere with sleep disorders in patients with chronic mercury intoxication (CRI), these relationships remain the least studied in the clinic neurointoxications. The study aimed to establish a connection between neurophysiological, biochemical, and psychopathological indicators in patients with occupational chronic mercury intoxication and insomnia. Materials and methods. Thirty-six patients took part in the examination in the remote period of CRI. The average age of patients in this group was 50.7±1.05 years, with an average work experience of 14.7±1.05. The authors carried out a psychological examination to determine the levels of depression, anxiety, asthenic state, computed electroencephalography (EEG), cognitive evoked potentials (CEP), polysomnography, the level of neurotransmitters. Results. The study showed that asthenization, when exposed to mercury, occurs due to a decrease in the limbic-hypothalamo-reticular complex activity (the presence of equivalent dipole sources of pathological activity in the area of diencephalic formations (thalamus, hypothalamus) in 56.2±5.6% of cases. The study showed a decrease in activity cerebral cortex, confirmed by weakening the coherent connections of the α-range in the occipital, central and frontal leads according to the data of coherent EEG analysis and changes on the part of the CEP. There was a direct correlation between the level of total sleep time and the serotonin level (rs=0.45), an inverse relationship between the level of depression and histamine level (rs=-0.56). Conclusion. The studies carried out to make it possible to establish the mechanisms of insomnia disorders in chronic mercury intoxication, which cause a weakening of the tone of the cerebral cortex and changes in neurotransmitter metabolism, as well as disorders of the reticular system with limbic structures. The study showed a close direct relationship between neurophysiological, psychological, and biochemical parameters in implementing insomnia in patients with chronic mercury intoxication.

scholarly journals DIAGNOSTIC CRITERIA OF SLEEP DISORDERS IN PATIENTS WITH LONG-TERM CHRONIC MERCURY INTOXICATION

2019 ◽  
Vol 98 (10) ◽  
pp. 1155-1160 ◽  
Author(s):  
Elena V. Katamanova ◽  
N. V. Slivnitsyna ◽  
E. N. Korchuganova ◽  
O. I. Shevchenko
Keyword(s):  
Sleep Disorders ◽  
Diagnostic Criteria ◽  
Sleep Disturbances ◽  
Comparison Group ◽  
Total Sleep Time ◽  
Behavioral Therapy ◽  
Sleep Time ◽  
Mercury Intoxication ◽  
Chronic Mercury Intoxication

Introduction. In the Irkutsk region, chronic mercury intoxication (CRI) occupies a leading place among occupational neurointoxications. An organic personality disorder with insomnia is one of the manifestations of brain damage in CRI. The aim of the study was to establish diagnostic criteria for secondary insomnia in patients with professional CRI for the selection of effective treatment. Material and methods. The study involved 30 people in the long-term CRI and 30 people in the comparison group with sleep disorders that are not in contact with harmful factors. Electroencephalographic, polysomnographic research and questioning were carried out with the assessment of the subjective characteristics of sleep. Information was processed using the Statistika 6.0 application package. Results. It was shown that CRI patients were shown to complain statistically significantly more frequent sleep disturbances than in the comparison group (p = 0.0003), difficulty in maintaining sleep (p = 0.004). As a result of EEG in the group of patients in the long-term CRI, the integral index and the ratio α/β were statistically significantly different from those in the comparison group, and according to the results of polysomnography, more pronounced qualitative and quantitative violations of the night sleep pattern were found in CRI patients; as a decrease in total sleep time (p = 0.0001), increase in sleep time (p = 0.008), number of activations and total wakefulness inside sleep (p = 0.03), decrease in sleep efficiency index (p = 0.006) and increase in an integrative sleep quality index (p = 0.03). According to the discriminant analysis, 4 criteria for diagnosing insomnia in CRI were established: total sleep time (min.), duration of the first stage of slow sleep (%), rhythm ratio α/β, EEG (%) and integral EEG index (%). Conclusion. Considering the data obtained, it is possible to improve approaches to treating insomnia in CRI by prescribing a complex of treatment, including cognitive-behavioral therapy, antidepressants with a sedative effect, as well as alpha training using biofeedback.

scholarly journals Pharmacotherapy of insomnia in patients with occupational chronic mercury intoxication

2020 ◽  
Vol 99 (10) ◽  
pp. 1132-1138
Author(s):  
E. H. Korchuganova ◽  
E. V. Katamanova ◽  
N. V. Slivnitsyna
Keyword(s):  
Sleep Disorders ◽  
Statistical Processing ◽  
Sleep Time ◽  
Efficiency Index ◽  
Treatment Regimens ◽  
Falling Asleep ◽  
Mercury Intoxication ◽  
Leading Position ◽  
Chronic Mercury Intoxication

Introduction. Among occupational poisoning, chronic mercury intoxication (CMI) in the Irkutsk region occupies a leading position. Objective. To give a comparative analysis of the methods of pharmacotherapy of sleep disorders in patients in the long-term CRI. Material and methods. The study included 60 patients with long-term CRI, divided into two equal groups of 30 cases: in the first, the average age was 56.0 ± 0.7, in the second, the average age was 57.1 ± 3.0. Questionnaires were conducted using the hospital scale of anxiety and depression, electroencephalographic, polysomnographic studies before and after treatment. During the study, two treatment regimens for sleep disorders were implemented: the first regimen included the administration of an antidepressant (trazodone) and the chemical analog of melatonin (melaxen), and the second regimen was zolpidem. Statistical processing of the research results was carried out using the software package “Statistica 6.0”. Results. After treatment, in the first group there was an increase in the duration of the total sleep time (p = 0.0008), a decrease in the time of falling asleep (p = 0.004), a decrease in the total number of activations (p = 0.00005), and the time of wakefulness in bed (p = 0.0018), an increase in the representation of delta sleep (p = 0.03), and REM sleep (p = 0.004), an increase in the sleep efficiency index (p = 0.0008), and a decrease in the integrative sleep quality index (p = 0.001). In the second group, only a decrease in the latent period of stage 1 (time of falling asleep) was established (p = 0.05). Discussion. After treatment with trazodone in combination with melaxen, a decrease in the severity of presomnic and intrasomnic disorders was found, and in patients taking zolpidem, only the severity of presomnic disorders was reduced. The results confirm the hypothesized cause of dissominal disorders in CRI (changes in the activity of the limbic-reticular complex). Conclusion. The use of trazodone in combination with melaxen proves the improvement of the qualitative and quantitative indices of the structure of night sleep in patients in the long-term postexposure period of CRI.

Analysis of relationships between biochemical markers of endothelial dysfunction in chronic mercury exposure

2020 ◽  
Vol 60 (11) ◽  
pp. 834-836
Author(s):  
Olga V. Naumova ◽  
Olga A. Dyakovich
Keyword(s):  
Endothelial Dysfunction ◽  
Occupational Disease ◽  
Work Experience ◽  
Exposure Period ◽  
Biochemical Indicators ◽  
Production Factors ◽  
Mercury Intoxication ◽  
Chronic Mercury Intoxication ◽  
The Relationship

Introduction. The cause of the development of endothelial dysfunction (ED) and, as a result, the pathology of the cardiovascular system may be exposure to mercury. The aim of study is to study the relationship between ED markers in individuals exposed to mercury. Materials and methods. A survey was carried out using biochemical and statistical methods in persons exposed to mercury with more than five years of work experience, and in patients with chronic mercury intoxication in the long-term post-exposure period. Results. Relationships of biochemical indicators of ED of various directions have been established, indicating the presence of pathological changes in the endothelium of vessels in which its different links are involved. Conclusions. Associations were established between the exposition load and the concentration of ED markers in workers without occupational disease, which indicates the contribution of production factors to its formation during contact with the toxicant. The results of the study of the correlation of biochemical indicators of ED indicate the presence of complex associations that form a closed system between its markers at the stage before the formation of occupational disease, and their disunity in the distant period of chronic mercury intoxication, especially in the presence of CVD.

scholarly journals PHENOTYPIC COMPOSITION OF PERIPHERAL BLOOD LYMPHOCYTES AND THEIR COOPERATION IN PATIENTS WITH CHRONIC MERCURY INTOXICATION IN A POST-CONTACT PERIOD

2019 ◽  
Vol 98 (10) ◽  
pp. 1091-1095
Author(s):  
Elena V. Boklazhenko ◽  
G. M. Bodienkova
Keyword(s):  
Immune System ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Contact Period ◽  
Blood Lymphocytes ◽  
Mercury Intoxication ◽  
System Functioning ◽  
Therapeutic Measures ◽  
Chronic Mercury Intoxication

Introduction. Based on the current understanding of the progression of professional chronic mercury intoxication, it is extremely important to study the regulatory activity of immunocompetent cells after the cessation contact with mercury to develop effective therapeutic measures. The purpose of the study was to study the population and subpopulation spectrum of peripheral blood lymphocytes and their cooperation in patients with chronic mercury intoxication in a distant postexposure period. Material and methods. Phenotyping of lymphocytes in the blood of the subjects was carried out by the method of indirect immunofluorescence using monoclonal antibodies to the molecules CD3+, CD4+, CD8+, CD9+, CD16+, CD20+, CD21+, CD23+, CD25+, CD95+. Results. In patients with chronic mercury intoxication in the long-term postexposure period, there were revealed features of the immune system functioning, indicating hyperactivation of both T- and B-components of the immune system. An increase in the total population of T-lymphocytes was established due to an increase in cells with receptors CD4+ (T-lymphocyte-helper cells) and CD16+ (killer cells), as well as an increase in the number of mature B-lymphocytes (CD20+) and pre-B-immature-lymphocytes (CD9+). Changes in the system of lymphocyte apoptosis, characterized by an increase in the number of cells expressing receptors for readiness for Fas-dependent apoptosis (CD95+), have been recorded. The established relationships between populations and subpopulations of lymphocytes indicate their importance in the implementation of the immune response, high activity and contingency between the components of the immune system in persons with chronic mercury intoxication after the termination of contact with the toxicant. Conclusion. The results obtained are the basis for long-term monitoring of the health status and improvement of the tactics of treating patients with neurointoxication with mercury in the postexposure period.

scholarly journals PSYCHOLOGICAL CORRELATES OF DISSOMNIC DISORDERS IN PATIENTS IN THE REMOTE PERIOD AFTER CHRONIC MERCURY INTOXICATION

2018 ◽  
Vol 97 (10) ◽  
pp. 925-929 ◽  
Author(s):  
Oksana I. Shevchenko ◽  
E. B. Katamanova ◽  
E. H. Korchuganova ◽  
O. L. Lakhman
Keyword(s):  
Negative Impact ◽  
Professional Activity ◽  
Control Group ◽  
Contact Period ◽  
Second Stage ◽  
Mercury Intoxication ◽  
Chronic Mercury Intoxication ◽  
Psychological Features ◽  
Relationship Of ◽  
General Time

Introduction. Need of carrying out a research is defined by insufficient study of retsiprokny relationship of psychological features with the course of insomnichesky frustration taking into account psychopathological symptomatology and features of displays of neurointoxication for the purpose of prevention of sleep disorders at patients with the chronic mercury intoxication (CMI). A research objective was identification of psychological features of formation of dissomnichesky frustration at patients in the remote post-contact period of HRI. Material and methods. Kliniko-diagnostic, polisomnografichesky and experimental and psychological examinations to 40 patients from HRI and to 15 healthy men of group of comparison which didn't have in professional activity of contact with harmful substances are conducted. Results. The Polisomnografichesky research of patients with HRI has revealed rough changes of indicators of structure of a night dream in comparison with control group in the form of reduction of duration of a dream, increase in the latent period of the first stage of a dream, the general time of wakefulness in a dream from time of its duration, total of activation shifts. Essential changes of structure of a dream were noted in his first cycle - in the form of reduction of duration. Reduction of duration of a cycle, time of the second stage, reduction representation of a delta dream is noted. The indicators characterizing the mnestiko-attentsionny sphere and an emotional condition of patients considerably differed from standard levels that demonstrated personal disintegration, formation of mental defect of asthenic, disturbing and hypochondriac, sensitive types with prevalence of affects of disturbing and depressive and explosive character. Discussion. The established correlation connection demonstrates negative impact of time of duration of a dream on levels of uneasiness, a depression, morbid depression, social disadaptation, intelligence quotient, indicators of short-term, figurative memory, concentration of attention Increase in duration of a somnolence promotes aggravation of paranoyalny manifestations and decrease in concentration of attention and is regarded as sign of strengthening of activity of stem structures. Conclusion. It is established that at professional neurointoxications permanent changes of polisomnografichesky activity in the form of insomnichesky violations of the mixed character are a consequence of chronic influence of vapors of metal mercury and also the reason of psychopathological violations.

scholarly journals ELECTROMYOGRAPHY OF MUSCULOFACIAL REGION MUSCLES AND RESULTS OF PSYCHOLOGICAL EXAMINATIONS IN WORKERS WITH HAZARDOUS WORKING CONDITIONS

2021 ◽  
Vol 16 (4) ◽  
pp. 167-172
Author(s):  
Valentina Olesova ◽  
Dmitry Martynov ◽  
Egor Olesov ◽  
Evgeniya Ekusheva ◽  
Magomed Salamov ◽  
...  
Keyword(s):  
Working Conditions ◽  
Work Experience ◽  
Muscle Tone ◽  
Psychological Characteristics ◽  
Production Factor ◽  
Maxillofacial Region ◽  
Psychophysiological Examination ◽  
Psychological Examination ◽  
Dental Rehabilitation ◽  
Masticatory Apparatus

According to the data of targeted examinations of workers with hazardous working conditions, in particular, in the presence of a radiation factor, the dental status in terms of the prevalence and intensity of major dental diseases does not differ significantly from those working in normal working conditions. At the same time, during interviews and clinical examination, workers in hazardous industries often reveal hypertonicity of the muscles of the maxillofacial region, which is especially noticeable in people with long work experience. One of the reasons for the hypertonicity of the muscles of the maxillofacial region can be chronic stressful loads associated with hazardous working conditions. However, this section of functional dentistry has not been sufficiently studied in relation to workers in hazardous industries. It is required to compare the results of electromyography of the muscles of the maxillofacial region and the data of psychological examination of workers. The aim of the study is to compare the psychological characteristics and the results of electromyography of the muscles of the maxillofacial region in workers with hazardous working conditions and normal working conditions in the 45-55 age group. Material and Methods: A comparative analysis of electromyography data of masticatory and temporal muscles, "Hamburg testing" of the masticatory apparatus and psychological characteristics was carried out in 50 workers of hazardous industries (radiation production factor) and in 53 workers in normal working conditions. Results of the study: the study revealed differences in the results of psychophysiological examination, "Hamburg testing" of the chewing apparatus and electromyography of the muscles of the maxillofacial region in workers with hazardous working conditions and working in normal conditions. Employees of hazardous industries, according to psychological examination, are subject to chronic stress, which leads to a distortion of the tone of the muscles of the maxillofacial region, which, in turn, causes more frequent detection of dysfunction of the masticatory apparatus in workers. Conclusion: the results of the study should be taken into account in the complex dental rehabilitation of workers in hazardous industries, including measures aimed at normalizing the muscle tone of the maxillofacial region.

scholarly journals Comparative evaluation of the phenotypic composition of lymphocytes in patients with occupational pathology of various genesis

2020 ◽  
Vol 99 (10) ◽  
pp. 1067-1072
Author(s):  
Elena V. Boklazhenko ◽  
Galina M. Bodienkova
Keyword(s):  
Immune Responses ◽  
Work Experience ◽  
Lymphocyte Activation ◽  
Pathological Process ◽  
Combined Exposure ◽  
Local Vibration ◽  
Activation Markers ◽  
Mercury Intoxication ◽  
Chemical Factors ◽  
Physical And Chemical

Introduction. One important aspect of modern research is the study of the role of the phenotypic composition of lymphocytes in the development of a variety of pathological processes. The aim of the study was to compare the phenotypic composition of lymphocytes and their intercellular cooperation in patients with sensorineural hearing loss (SHL), with vibration disease (VD) from exposure to local vibration, with VD from combined exposure to general and local vibration, chronic mercury intoxication (CMI). Material and methods. The phenotypical structure of lymphocytes was estimated by the method of indirect immunofluorescence using monoclonal antibodies to molecules CD3+, CD4+, CD8+, CD16+, CD20+, CD25+, CD95+. Results. The general regularity of changes of an immunophenotype of lymphocytes in patients with the occupational pathology induced by the influence of physical and chemical factors was established to be the hyperactivation of immune responses characterized by an increase in the number of lymphocytes (CD3+, CD4+, CD20+) of the various degree of expressiveness. Differences between the compared groups were characterized by an elevation increase in the number of mature T-lymphocytes (CD3+) in persons with SHL concerning patients with the VD from the combined impact of the general and local vibration, increase of natural killers (CD16+) in comparison with the VD due to a local vibration. The latter showed lower levels of early lymphocyte activation markers (CD25+) than BB due to combined exposure to local and general vibration and CMI. Features of pathogenetically significant intercellular interactions, manifested by a difference in number and composition of correlation pairs, are revealed. Discussion. The results show a different degree of expression of immune responses, which can be due to many factors (severity of the disease course, an initial background of immunoreactivity before starting work in harmful working conditions, work experience, etc.). Conclusion. The detected changes in the phenotypic composition of lymphocytes and their cooperation in patients with occupational pathology formed under the influence of physical and chemical factors seem to be due to the specificity of the affecting occupational factors and, as a result, the degree of expression of the pathological process.

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