Visualization of Anatomical Structures of Biological Tissues by Optical Coherence Tomography with Digital Processing of Morphological Data

2020 ◽  
Vol 54 (1) ◽  
pp. 9-13 ◽  
Author(s):  
A. Yu. Potlov ◽  
S. V. Frolov ◽  
S. G. Proskurin
Keyword(s):  
Optical Coherence Tomography ◽  
Digital Processing ◽  
Biological Tissues ◽  
Morphological Data ◽  
Optical Coherence ◽  
Anatomical Structures

scholarly journals Utilization potential of intraluminal optical coherence tomography for the Eustachian tube

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hayoung Byun ◽  
Yeon Hoon Kim ◽  
Jingchao Xing ◽  
Su-Jin Shin ◽  
Seung Hwan Lee ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Eustachian Tube ◽  
Balloon Dilatation ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Anatomical Structures ◽  
Complex Anatomy ◽  
Before And After ◽  
Tubal Lumen ◽  
Oct Image

AbstractImaging the Eustachian tube is challenging because of its complex anatomy and limited accessibility. This study fabricated a fiber-based optical coherence tomography (OCT) catheter and investigated its potential for assessing the Eustachian tube anatomy. A customized OCT system and an imaging catheter, termed the Eustachian OCT, were developed for visualizing the Eustachian tube. Three male swine cadaver heads were used to study OCT image acquisition and for subsequent histologic correlation. The imaging catheter was introduced through the nasopharyngeal opening and reached toward the middle ear. The OCT images were acquired from the superior to the nasopharyngeal opening before and after Eustachian tube balloon dilatation. The histological anatomy of the Eustachian tube was compared with corresponding OCT images, The new, Eustachian OCT catheter was successfully inserted in the tubal lumen without damage. Cross-sectional images of the tube were successfully obtained, and the margins of the anatomical structures including cartilage, mucosa lining, and fat could be successfully delineated. After balloon dilatation, the expansion of the cross-sectional area could be identified from the OCT images. Using the OCT technique to assess the Eustachian tube anatomy was shown to be feasible, and the fabricated OCT image catheter was determined to be suitable for Eustachian tube assessment.

scholarly journals Foveal Exudative Macroaneurysm Treated with Intravitreal Ranibizumab

2015 ◽  
Vol 6 (2) ◽  
pp. 170-175 ◽  
Author(s):  
Carlos Menezes ◽  
Rui Carvalho ◽  
Carla Teixeira ◽  
José Alberto Lemos ◽  
Rita Gonçalves ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Macular Edema ◽  
Morphological Data ◽  
Foveal Avascular Zone ◽  
Optical Coherence ◽  
Intravitreal Ranibizumab ◽  
Corrected Visual Acuity ◽  
Retinal Macroaneurysm ◽  
Best Corrected Visual Acuity

Purpose: We report a case of a foveal macroaneurysm with long-standing macular edema in a rare location, successfully treated with intravitreal ranibizumab. Methods: We report the case of a 52-year-old man with left eye long-term visual loss due to macular edema caused by a retinal macroaneurysm, localized about 400 μm from the center of the fovea, and its response to 6 monthly ranibizumab intravitreal injections. His best-corrected visual acuity and morphological data evaluated by optical coherence tomography and fluorescein angiography are presented. Results: His best-corrected visual acuity improved from 1/10 to 3/10 after the 3rd injection, and from 1/10 to 4/10 after the 6th one. The central retinal thickness was evaluated by optical coherence tomography and improved from 310 to 233 μm, with the resolution of both the associated serous detachments and the cystoid macular edema; an almost complete reabsorption of the hard exudates at the end of the treatment was also observed. The macroaneurysm lumen almost obliterated after the 3rd injection and completely collapsed at the end of treatment. Conclusions: Intravitreal ranibizumab may be effective in the treatment of long-standing macular edema associated with foveal macroaneurysms. To the best of our knowledge, this is the first report of a retinal macroaneurysm located so close to the foveal avascular zone.

Polarization contrast imaging of biological tissues by polarization-sensitive Fourier-domain optical coherence tomography

2006 ◽  
Vol 45 (6) ◽  
pp. 1142 ◽  
Author(s):  
Shuichi Makita ◽  
Yoshiaki Yasuno ◽  
Takashi Endo ◽  
Masahide Itoh ◽  
Toyohiko Yatagai
Keyword(s):  
Optical Coherence Tomography ◽  
Biological Tissues ◽  
Fourier Domain ◽  
Optical Coherence ◽  
Contrast Imaging ◽  
Polarization Contrast

Differentiation between normal and tumor mammary glands with depth-resolved attenuation coefficient from optical coherence tomography

2021 ◽  
Author(s):  
Marino de Jesus Maciel ◽  
Hugo M Pereira ◽  
Sara Pimenta ◽  
Alice Miranda ◽  
Eduardo Jorge Nunes-Pereira ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Attenuation Coefficient ◽  
Light Attenuation ◽  
Biological Tissues ◽  
Mammary Glands ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Subjective Analysis ◽  
Coefficient Estimation ◽  
Cross Sectional Imaging

Abstract Optical coherence tomography (OCT) is a well-established imaging technology for high-resolution, cross-sectional imaging of biological tissues. Imaging processing and light attenuation coefficient estimation allows to further improve the OCT diagnostic capability. In this paper we use a commercial OCT system, Telesto II-1325LR from Thorlabs, and demonstrate its ability to differentiate normal and tumor mammary mouse glands with the OCT attenuation coefficient. Using several OCT images of normal and tumor mammary mouse glands (n=26), a statistical analysis was performed. The attenuation coefficient was calculated in depth, considering a slope of 0.5 mm. The normal glands present a median attenuation coefficient of 0.403 mm-1, comparatively to 0.561 mm-1 obtained for tumor mammary glands. This translates in an attenuation coefficient approximately 39 % higher for tumor mammary glands when compared to normal mammary glands. The OCT attenuation coefficient estimation eliminates the subjective analysis provided by direct visualization of the OCT images.

scholarly journals The Use of Optical Coherence Tomography in Dental Diagnostics: A State-of-the-Art Review

2017 ◽  
Vol 2017 ◽  
pp. 1-31 ◽  
Author(s):  
Monika Machoy ◽  
Julia Seeliger ◽  
Liliana Szyszka-Sommerfeld ◽  
Robert Koprowski ◽  
Tomasz Gedrange ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Time Delay ◽  
Internal Structure ◽  
State Of The Art ◽  
Biological Tissues ◽  
Tomographic Imaging ◽  
Optical Coherence ◽  
X Rays ◽  
Analytical Technology

Optical coherence tomography provides sections of tissues in a noncontact and noninvasive manner. The device measures the time delay and intensity of the light scattered or reflected from biological tissues, which results in tomographic imaging of their internal structure. This is achieved by scanning tissues at a resolution ranging from 1 to 15 μm. OCT enables real-time in situ imaging of tissues without the need for biopsy, histological procedures, or the use of X-rays, so it can be used in many fields of medicine. Its properties are not only particularly used in ophthalmology, in the diagnosis of all layers of the retina, but also increasingly in cardiology, gastroenterology, pulmonology, oncology, and dermatology. The basic properties of OCT, that is, noninvasiveness and low wattage of the used light, have also been appreciated in analytical technology by conservators, who use it to identify the quality and age of paintings, ceramics, or glass. Recently, the OCT technique of visualization is being tested in different fields of dentistry, which is depicted in the article.

scholarly journals A Mesh-Based Monte Carlo Study for Investigating Structural and Functional Imaging of Brain Tissue Using Optical Coherence Tomography

2019 ◽  
Vol 9 (19) ◽  
pp. 4008
Author(s):  
Luying Yi ◽  
Liqun Sun ◽  
Mingli Zou ◽  
Bo Hou
Keyword(s):  
Optical Coherence Tomography ◽  
Monte Carlo ◽  
Brain Imaging ◽  
Brain Tissue ◽  
Three Dimensional ◽  
Hemoglobin Concentration ◽  
Monte Carlo Study ◽  
Biological Tissues ◽  
Optical Coherence ◽  
Quantitative Accuracy

Optical coherence tomography (OCT) can obtain high-resolution three-dimensional (3D) structural images of biological tissues, and spectroscopic OCT, which is one of the functional extensions of OCT, can also quantify chromophores of tissues. Due to its unique features, OCT has been increasingly used for brain imaging. To support the development of the simulation and analysis tools on which OCT-based brain imaging depends, a model of mesh-based Monte Carlo for OCT (MMC-OCT) is presented in this work to study OCT signals reflecting the structural and functional activities of brain tissue. In addition, an approach to improve the quantitative accuracy of chromophores in tissue is proposed and validated by MMC-OCT simulations. Specifically, the OCT-based brain structural imaging was first simulated to illustrate and validate the MMC-OCT strategy. We then focused on the influences of different wavelengths on the measurement of hemoglobin concentration C, oxygen saturation Y, and scattering coefficient S in brain tissue. Finally, it is proposed and verified here that the measurement accuracy of C, Y, and S can be improved by selecting appropriate wavelengths for calculation, which contributes to the experimental study of brain functional sensing.

Novel methods for elasticity characterization using optical coherence tomography: Brief review and future prospects

2014 ◽  
Vol 3 (4) ◽  
Author(s):  
Lev A. Matveev ◽  
Vladimir Y. Zaitsev ◽  
Aleksander L. Matveev ◽  
Grigory V. Gelikonov ◽  
Valentin M. Gelikonov ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Rheological Properties ◽  
Biological Tissues ◽  
Optical Coherence ◽  
Future Prospects ◽  
Local Strains ◽  
Step Process ◽  
New Approaches ◽  
Novel Methods

AbstractIn this paper, a brief overview of several recently proposed approaches to elastographic characterization of biological tissues using optical coherence tomography is presented. A common feature of these “unconventional” approaches is that unlike most others, they do not rely on a two-step process of first reconstructing the particle displacements and then performing its error-prone differentiation in order to determine the local strains. Further, several variants of these new approaches were proposed and demonstrated essentially independently and are based on significantly different principles. Despite the seeming differences, these techniques open up interesting prospects not only for independent usage, but also for combined implementation to provide a multifunctional investigation of elasticity of biological tissues and their rheological properties in a wider sense.

Investigation of biological tissues using PM-fiber-based polarization sensitive optical coherence tomography

2004 ◽  
Author(s):  
Roman V. Kuranov ◽  
Veronika V. Sapozhnikova ◽  
Ludmila B. Snopova ◽  
Grigory V. Gelikonov ◽  
Andrew N. Morozov
Keyword(s):  
Optical Coherence Tomography ◽  
Biological Tissues ◽  
Optical Coherence

scholarly journals Non-Destructive Analysis of the Internal Anatomical Structures of Mosquito Specimens Using Optical Coherence Tomography

Sensors ◽  
2017 ◽  
Vol 17 (8) ◽  
pp. 1897 ◽  
Author(s):  
Naresh Ravichandran ◽  
Ruchire Wijesinghe ◽  
Seung-Yeol Lee ◽  
Kwang Choi ◽  
Mansik Jeon ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optical Coherence ◽  
Anatomical Structures ◽  
Destructive Analysis ◽  
Non Destructive
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