Inequalities in cancer incidence and mortality across medium to highly developed countries in the twenty-first century

Background: Breast cancer is the most common malignant disease among the female population of Kazakhstan like in many developed countries of the world (Canada, UK, US, Western Europe), and it accounts for every 5th tumor. We aimed to assess the epidemiological aspects of breast cancer incidence and mortality among Almaty and Astana (Now Nur-Sultan), Kazakhstan residents in 2009-2018. Methods: A retrospective study using modern descriptive and analytical methods of epidemiology was conducted to evaluate the breast cancer incidence and mortality in megapolises of Kazakhstan. Results: The average annual age-standardized incidence rate of breast cancer amounted to 61.90/0000 (95% CI=56.2-67.6) in Almaty and 61.20/0000 (95% CI=56.765.7) in Astana. The average age-standardized mortality was 19.20/0000 (95% CI=17.3-21.1) in Almaty and 19.30/0000 (95% CI=17.1-21.4) in Astana. The standardized incidence in the megapolises tended to increase (Тgr=+0.8% in Almaty and Тgr=+1.4% in Astana), while the mortality was decreasing (Тdec=−4.2% in Almaty and Тdec=−1.1% in Astana). According to the component analysis, the growth in the number of breast cancer cases was due to a population increase (ΔP=+130.4% in Almaty and ΔP=+93.2% in Astana), with a notable decrease of factors related to the risk of getting sick (ΔR=−27.9% in Almaty, ΔR=−6.1% in Astana). Conclusion: This is the first epidemiological study to assess the changes in incidence and mortality from breast cancer in megapolises of Kazakhstan because of screening. The results of this study can be used to improve the government program to combat breast cancer.

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Regional Variations in Potential Plant Habitat Changes in Response to Multiple Global Warming Scenarios*

Journal of Climate ◽

10.1175/jcli-d-13-00753.1 ◽

2015 ◽

Vol 28 (7) ◽

pp. 2884-2899 ◽

Cited By ~ 6

Author(s):

Chang-Eui Park ◽

Su-Jong Jeong ◽

Chang-Hoi Ho ◽

Jinwon Kim

Keyword(s):

Global Warming ◽

Land Surface ◽

Developed Countries ◽

Global Climate Models ◽

First Century ◽

Climate Projections ◽

Dynamic Global Vegetation Model ◽

Habitat Changes ◽

Twenty First Century ◽

Plant Habitat

Abstract This study examines the impacts of global warming on the timing of plant habitat changes in the twenty-first century using climate scenarios from multiple global climate models (GCMs). The plant habitat changes are predicted by driving the bioclimate rule in a dynamic global vegetation model using the climate projections from 16 coupled GCMs. The timing of plant habitat changes is estimated by the first occurrence of specified fractional changes (10%, 20%, and 30%). All future projections are categorized into three groups by the magnitude of the projected global-mean land surface temperature changes: low (<2.5 K), medium (2.5–3.5 K), and high (>3.5 K) warming. During the course of the twenty-first century, dominant plant habitat changes are projected in ecologically transitional (i.e., from tropical to temperate and temperate to boreal) regions. The timing of plant habitat changes varies substantially according to regions. In the low-warming group, habitat changes of 10% in southern Africa occur in 2028, earlier than in the Americas by more than 70 yr. Differences in the timing between regions increase with the increase in warming and fractional threshold. In the subtropics, fast plant habitat changes are projected for the Asia and Africa regions, where countries of relatively small gross domestic product (GDP) per capita are concentrated. Ecosystems in these regions will be more vulnerable to global warming, because countries of low economic power lack the capability to deal with the warming-induced habitat changes. Thus, it is important to establish international collaboration via which developed countries provide assistance to mitigate the impacts of global warming.

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Trends in Incidence and Mortality of Primary Liver Cancer in Lithuania 1998–2015

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18031191 ◽

2021 ◽

Vol 18 (3) ◽

pp. 1191

Author(s):

Audrius Dulskas ◽

Povilas Kavaliauskas ◽

Kestutis Zagminas ◽

Ligita Jancoriene ◽

Giedre Smailyte

Keyword(s):

Liver Cancer ◽

Cancer Incidence ◽

Ductal Carcinoma ◽

Primary Liver Cancer ◽

Age Groups ◽

Developed Countries ◽

Mortality Rates ◽

Incidence Rates ◽

Incidence And Mortality ◽

Cancer Incidence Rates

Background: Recently, reports have suggested that rates of liver cancer have increased during the last decades in developed countries; increasing hepatocellular carcinoma and cholangiocarcinoma rates were reported. The aim of this study was to examine time trends in incidence and mortality rates of liver cancer for the period of 1998–2015 in Lithuania by sex, age, and histology. Methods: We examined the incidence of liver cancer from 1998 to 2015 using data from the Lithuanian Cancer Registry. Age-standardized incidence rates were calculated by sex, age, and histology. Trends were analyzed using the Joinpoint Regression Program to estimate the annual percent change. Results: A total of 3086 primary liver cancer cases were diagnosed, and 2923 patients died from liver cancer. The total number of liver cancer cases changed from 132 in 1998 to 239 in 2015. Liver cancer incidence rates changed during the study period from 5.02/100,000 in 1998 to 10.54/100,000 in 2015 in men and from 2.43/100,000 in 1998 to 6.25/100,000 in 2015 in women. Annual percentage changes (APCs) in the age-standardized rates over this period were 4.5% for incidence and 3.6% for mortality. Hepatocellular cancer incidence rates were stable from 1998 to 2005 (APC −5.9, p = 0.1) and later increased by 6.7% per year (p < 0.001). Intrahepatic ductal carcinoma incidence increased by 8.9% per year throughout the study period. The rise in incidence was observed in all age groups; however, in age groups < 50 and between 70 and 79 years, observed changes were not statistically significant. For mortality, the significant point of trend change was detected in 2001, where after stable mortality, rates started to increase by 2.4% per year. Conclusions: Primary liver cancer incidence and mortality increased in both sexes in Lithuania. The rise om incidence was observed in both sexes and main histology groups. The increasing incidence trend may be related to the prevalence of main risk factors (alcohol consumption, hepatitis B and C infections. and diabetes).

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Epidemiology of the Incidence and Mortality of Pancreas Cancer and its Relationship with the Human Development Index (HDI) in the World: An Ecological Study in 2018

Current Pharmaceutical Design ◽

10.2174/1381612826666200713170047 ◽

2020 ◽

Vol 26 (40) ◽

pp. 5163-5173

Author(s):

Elham Goodarzi ◽

Ali Hassanpour Dehkordi ◽

Reza Beiranvand ◽

Hasan Naemi ◽

Zaher Khazaei

Keyword(s):

Pancreatic Cancer ◽

Human Development ◽

Cancer Incidence ◽

Pancreas Cancer ◽

Malignant Neoplasm ◽

Developed Countries ◽

Mortality Rates ◽

Incidence And Mortality ◽

The Impact ◽

Very High

Objective: Pancreatic cancer is one of the leading causes of mortality in developed countries and a lethal malignant neoplasm worldwide. This study aims to evaluate the epidemiology of pancreatic cancer incidence and mortality and its relationship with HDI. Methods: This is a descriptive cross-sectional study that is based on cancer incidence data and cancer mortality rates derived from the GLOBOCAN in 2018. : The incidence and mortality rates of Pancreas as well as Pancreas cancer distribution maps were derived for world countries. The data analysis was conducted using a correlation test, and regression tests were used to evaluate the correlation of the incidence and mortality of Pancreas with HDI. The statistical analysis was carried out by Stata-14, and a significance level of 0.05 was considered. Results: The highest incidence of pancreatic cancer was reported in Asia with 214499 (46.7%) cases and the lowest incidence was related to Oceania with 4529 cases (0.99%). The results showed a positive and significant correlation between incidence (r = 0.764, P <0.0001) and mortality (r = 0.771, P <0.0001) of pancreatic cancer and the HDI index. The results of ANOVA revealed that the highest mean incidence was related to the very high HDI (P <0.0001) and the highest mortality was connected to the very high human development (P <0.0001). The results exhibited that incidence was positively and significantly correlated with GNI (r = 0.497, P <0.0001), MYS (r = 0.746, P <0.0001), LEB (r = 0.676, <0.0001) and EYS (r = 0.738, P <0.0001). Also, a significant positive correlation was found between mortality and GNI (r = 0.507, P <0.0001), MYS (r = 0.745, P <0.0001), LEB (r = 0.679, <0.0001), and EYS (r = 0.748, P <0.0001). Conclusion: Given the higher incidence and mortality of pancreatic cancer in countries with HDI, it is necessary to pay a greater attention to risk factors and appropriate planning to reduce these factors and minimize the impact and mortality rate of this disease.

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