Sigma-1 Receptor Modulates Neuroinflammation After Traumatic Brain Injury

2015 ◽  
Vol 36 (5) ◽  
pp. 639-645 ◽  
Author(s):  
Hui Dong ◽  
Yunfu Ma ◽  
Zengxi Ren ◽  
Bin Xu ◽  
Yunhe Zhang ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Sigma 1 Receptor ◽  
Sigma 1

scholarly journals Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

2021 ◽  
Vol 22 (21) ◽  
pp. 11611
Author(s):  
Gundega Stelfa ◽  
Edijs Vavers ◽  
Baiba Svalbe ◽  
Rinalds Serzants ◽  
Anna Miteniece ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Glial Cells ◽  
Motor Coordination ◽  
Molecular Layer ◽  
Neurological Deficits ◽  
Sigma 1 Receptor ◽  
Gfap Expression ◽  
Bergmann Glial Cells ◽  
Sigma 1

Neuroprotective effects of Sigma-1 receptor (S1R) ligands have been observed in multiple animal models of neurodegenerative diseases. Traumatic brain injury (TBI)-related neurodegeneration can induce long-lasting physical, cognitive, and behavioral disabilities. The aim of our study was to evaluate the role of S1R in the development of neurological deficits after TBI. Adult male wild-type CD-1 (WT) and S1R knockout (S1R-/-) mice were subjected to lateral fluid percussion injury, and behavioral and histological outcomes were assessed for up to 12 months postinjury. Neurological deficits and motor coordination impairment were less pronounced in S1R-/- mice with TBI than in WT mice with TBI 24 h after injury. TBI-induced short-term memory impairments were present in WT but not S1R-/- mice 7 months after injury. Compared to WT animals, S1R-/- mice exhibited better motor coordination and less pronounced despair behavior for up to 12 months postinjury. TBI induced astrocyte activation in the cortex of WT but not S1R-/- mice. S1R-/- mice presented a significantly reduced GFAP expression in Bergmann glial cells in the molecular layer of the cerebellum compared to WT mice. Our findings suggest that S1R deficiency reduces TBI-induced motor coordination impairments by reducing GFAP expression in Bergmann glial cells in the cerebellum.

scholarly journals Sigma-1 Receptor: A Potential Therapeutic Target for Traumatic Brain Injury

2021 ◽  
Vol 15 ◽  
Author(s):  
Mingming Shi ◽  
Fanglian Chen ◽  
Zhijuan Chen ◽  
Weidong Yang ◽  
Shuyuan Yue ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Endoplasmic Reticulum ◽  
Brain Injury ◽  
Neurological Disorders ◽  
Inflammatory Responses ◽  
Current Knowledge ◽  
Glutamate Excitotoxicity ◽  
Sigma 1 Receptor ◽  
Beneficial Effects ◽  
Sigma 1

The sigma-1 receptor (Sig-1R) is a chaperone receptor that primarily resides at the mitochondria-associated endoplasmic reticulum (ER) membrane (MAM) and acts as a dynamic pluripotent modulator regulating cellular pathophysiological processes. Multiple pharmacological studies have confirmed the beneficial effects of Sig-1R activation on cellular calcium homeostasis, excitotoxicity modulation, reactive oxygen species (ROS) clearance, and the structural and functional stability of the ER, mitochondria, and MAM. The Sig-1R is expressed broadly in cells of the central nervous system (CNS) and has been reported to be involved in various neurological disorders. Traumatic brain injury (TBI)-induced secondary injury involves complex and interrelated pathophysiological processes such as cellular apoptosis, glutamate excitotoxicity, inflammatory responses, endoplasmic reticulum stress, oxidative stress, and mitochondrial dysfunction. Thus, given the pluripotent modulation of the Sig-1R in diverse neurological disorders, we hypothesized that the Sig-1R may affect a series of pathophysiology after TBI. This review summarizes the current knowledge of the Sig-1R, its mechanistic role in various pathophysiological processes of multiple CNS diseases, and its potential therapeutic role in TBI.

scholarly journals 299 PRE-084, A Sigma-1 Receptor Ligand, Protects Against Excitotoxic Perinatal Brain Injury in Newborn Mice

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A87-A88
Author(s):  
E. Griesmaier ◽  
A. Posod ◽  
M. Gross ◽  
V. Neubauer ◽  
K. Wegleiter ◽  
...  
Keyword(s):  
Brain Injury ◽  
Perinatal Brain Injury ◽  
Receptor Ligand ◽  
Newborn Mice ◽  
Sigma 1 Receptor ◽  
Sigma 1

scholarly journals 9 The Sigma-1 Receptor Agonist PRE-084 Attenuates Inflammation-Sensitized Nmdar-Mediated Excitotoxic Brain Injury in Newborn Mice

2012 ◽  
Vol 97 (Suppl 2) ◽  
pp. A3-A3
Author(s):  
A. Posod ◽  
K. Neumayer ◽  
V. Neubauer ◽  
M. Keller ◽  
K. Wegleiter ◽  
...  
Keyword(s):  
Brain Injury ◽  
Receptor Agonist ◽  
Newborn Mice ◽  
Sigma 1 Receptor ◽  
Sigma 1

Neuroprotective effects of the sigma-1 receptor ligand PRE-084 against excitotoxic perinatal brain injury in newborn mice

2012 ◽  
Vol 237 (2) ◽  
pp. 388-395 ◽  
Author(s):  
E. Griesmaier ◽  
A. Posod ◽  
M. Gross ◽  
V. Neubauer ◽  
K. Wegleiter ◽  
...  
Keyword(s):  
Brain Injury ◽  
Perinatal Brain Injury ◽  
Neuroprotective Effects ◽  
Receptor Ligand ◽  
Newborn Mice ◽  
Sigma 1 Receptor ◽  
Sigma 1

scholarly journals 195 The Selective Sigma-1 Receptor Agonist Pre-084 Reduces Ndmar- Mediated Excitotoxic Brain Injury in Newborn Mice

2010 ◽  
Vol 68 ◽  
pp. 102-102
Author(s):  
M Groß ◽  
K Medek ◽  
M Urbanek ◽  
U Kiechl-Kohlendorfer ◽  
M Keller ◽  
...  
Keyword(s):  
Brain Injury ◽  
Receptor Agonist ◽  
Newborn Mice ◽  
Sigma 1 Receptor ◽  
Sigma 1

Cognitive control constrains memory attributions

2019 ◽  
Vol 42 ◽  
Author(s):  
Colleen M. Kelley ◽  
Larry L. Jacoby
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Control

Abstract Cognitive control constrains retrieval processing and so restricts what comes to mind as input to the attribution system. We review evidence that older adults, patients with Alzheimer's disease, and people with traumatic brain injury exert less cognitive control during retrieval, and so are susceptible to memory misattributions in the form of dramatic levels of false remembering.

Lessons Learned From Coaching Postsecondary Students With Traumatic Brain Injury

2020 ◽  
Vol 5 (1) ◽  
pp. 88-96
Author(s):  
Mary R. T. Kennedy
Keyword(s):  
College Students ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Sense Of Self ◽  
Scientific Evidence ◽  
Sudden Onset ◽  
Lessons Learned ◽  
Speech Language Pathologists ◽  
The Brain ◽  
Exhaustive List

Purpose The purpose of this clinical focus article is to provide speech-language pathologists with a brief update of the evidence that provides possible explanations for our experiences while coaching college students with traumatic brain injury (TBI). Method The narrative text provides readers with lessons we learned as speech-language pathologists functioning as cognitive coaches to college students with TBI. This is not meant to be an exhaustive list, but rather to consider the recent scientific evidence that will help our understanding of how best to coach these college students. Conclusion Four lessons are described. Lesson 1 focuses on the value of self-reported responses to surveys, questionnaires, and interviews. Lesson 2 addresses the use of immediate/proximal goals as leverage for students to update their sense of self and how their abilities and disabilities may alter their more distal goals. Lesson 3 reminds us that teamwork is necessary to address the complex issues facing these students, which include their developmental stage, the sudden onset of trauma to the brain, and having to navigate going to college with a TBI. Lesson 4 focuses on the need for college students with TBI to learn how to self-advocate with instructors, family, and peers.

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