Methods of synthesis of natural indoloquinolines isolated from Cryptolepis sanguinolenta

We are investigating by Raman microprobe measurements the superconducting and related phases in the LnBa2Cu3O7-x (for x=0 to 1) system where yttrium has been replaced by several of the lanthanide (Ln = Nd,Sm,Eu,Ho,Er) elements. The aim is to relate the observed optical spectra (Raman and fluorescence) to the compositional and structural properties of these solids as part of comprehensive materials characterization. The results are correlated with the methods of synthesis, the processing techniques of these materials, and their superconducting properties. Of relevance is the substitutional chemistry of these isostructural systems, the differences in the spectra, and their microanalytical usefulness for the detection of impurity phases, and the assessment of compositional homogeneity. The Raman spectra of most of these compounds are well understood from accounts in the literature.The materials examined here are mostly ceramic powders prepared by conventional solid state reaction techniques. The bulk samples are of nominally single-phase composition as determined by x-ray diffraction.

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Tailoring microstructures of materials through biomimetics

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100148332 ◽

1993 ◽

Vol 51 ◽

pp. 500-501

Author(s):

Mehmet Sarikaya ◽

Ilhan A. Aksay

Keyword(s):

Chemical Properties ◽

Design And Synthesis ◽

Structure Sensitive ◽

Macro Scale ◽

Methods Of Synthesis ◽

Successive Level ◽

Engineering Materials ◽

Physical And Chemical ◽

And Chemical Properties ◽

Synthesis Of Materials

Biomimetics involves investigation of structure, function, and methods of synthesis of biological composite materials. The goal is to apply this information to the design and synthesis of materials for engineering applications.Properties of engineering materials are structure sensitive through the whole spectrum of dimensions from nanometer to macro scale. The goal in designing and processing of technological materials, therefore, is to control microstructural evolution at each of these dimensions so as to achieve predictable physical and chemical properties. Control at each successive level of dimension, however, is a major challenge as is the retention of integrity between successive levels. Engineering materials are rarely fabricated to achieve more than a few of the desired properties and the synthesis techniques usually involve high temperature or low pressure conditions that are energy inefficient and environmentally damaging.In contrast to human-made materials, organisms synthesize composites whose intricate structures are more controlled at each scale and hierarchical order.

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DEVELOPMENT OF PRINCIPLES FOR THE DESIGN OF COMPLEX TECHNICAL MEANS AND TECHNOLOGICAL PROCESSES OF CROP PRODUCTION

Vestnik of the Russian agricultural science ◽

10.30850/vrsn/2019/2/70-72 ◽

1970 ◽

pp. 70-72

Author(s):

D. N. Radnaev ◽

Yu. А. Sergeev ◽

А. А. Abiduev ◽

S. V. Petunov

Keyword(s):

Crop Production ◽

Design Methodology ◽

Systematic Approach ◽

Optimal Solution ◽

Agricultural Science ◽

Complex Objects ◽

Technological Processes ◽

Methods Of Synthesis ◽

Working Bodies ◽

Projected Process

Currently, agricultural science and practice has a large amount of experimental data that need to be taken into account in the development of new technological processes and working bodies. Therefore, there is a need to design technical processes in order to identify their effectiveness. In this regard, the use of methods of synthesis of technological processes based on the characteristics of tillage, seeding and production system of the economy, in which it is necessary to implement the projected process. In the General statement of the problem, the design of technological processes is one of the complex problems with the following characteristic feature: lack of knowledge about the methods of designing technological processes, suitable for system - structural modeling and algorithmization of design processes. To overcome this incompleteness, a systematic approach is needed. The system approach proceeds from the fact that the specificity of complex objects and processes is not limited to the features of its constituent parts and elements, but lies in the nature of relationships and relationships between them. In this paper, the design methodology is based on the formulated fundamental assumptions and principles of the whole system of more specific statements, revealing the structure and content of design operations, the synthesis of the choice of solutions. The principles of technological compatibility and emergence suitable for system-structural analysis of complex technical means and technological processes, consisting of statements having a hierarchical structure, where the degree of detail of the goals from level to level increases, and the approval of the last level determines the direction of the search for the optimal solution to the problem.

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State policy of maintaining the innovative forms of employment in the context of the economy digitalization

Regional Economy ◽

10.36818/1562-0905-2020-3-9 ◽

2020 ◽

pp. 81-90

Author(s):

Olha Mulska ◽

Olha Levytska ◽

Valentyna Kutsyk

Keyword(s):

Information And Communication Technologies ◽

System Analysis ◽

Employment Policy ◽

Socially Responsible ◽

State Budget ◽

Economic Relations ◽

Functional Flexibility ◽

Leading Role ◽

Methods Of Synthesis ◽

Information And Communication

The purpose of the study is to analyze current trends in the evolution of forms of employment under the influence of the economy digitalization, as well as to substantiate the directions and means of public policy to regulate the conditions of effective employment in the new realities. Methods of synthesis and system analysis, groupings, logical analysis, strategic management, and system analysis were used in the research. The most significant characteristics of the sphere of employment in the conditions of the economy digitalization, in particular quantitative flexibility, functional flexibility, and space-time flexibility, are defined. The spheres of economy in which new professions are most in demand in Ukraine in the conditions of development of digitalization processes of the national economy are identified, in particular information and communication technologies, biotechnologies, medicine, energy, and its accumulation, power networks and energy consumption management, transport, especially water and air transport, education, and ecology. The directions, spheres, branches, and concrete sub-branches where new professions are in demand in the conditions of the economy digitalization are defined. The paper emphasizes the leading role of the information and communication technology sector, the development of which largely determines the emergence of new professions. The paper provides the conclusion that in this situation the new forms of employment cover great innovative potential, as well as shadow aspects (informal agreements), which exacerbate the problem of insufficient filling of social funds and reduction of tax revenues to the state budget. The priorities of effective employment policy in Ukraine in the global digitalization of economic relations are outlined based on the principles of flexicurity, best practices, and implementation of innovative solutions in building mutually beneficial and socially responsible relations between employer and employee.

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ASSESSMENT OF TOXICITY OF GERMANIUM COORDINATION COMPOUNDS

Токсикологический вестник ◽

10.36946/0869-7922-2019-2-16-21 ◽

2019 ◽

pp. 16-21

Author(s):

A. V. Kadomtsevа ◽

I. V. Zhdanovich ◽

M. S. Piskunovа ◽

A. N. Lineva ◽

A. N. Novikova ◽

...

Keyword(s):

Coordination Compounds ◽

Organometallic Compounds ◽

Biologically Active ◽

Pharmacological Properties ◽

Toxicological Studies ◽

Methods Of Synthesis ◽

Promising Area

The synthesis of biologically active coordination compounds and the design on their basis of effective pharmacological preparations is currently the promising area. This paper presents the results of the toxicological studies on digermanium and its complex derivatives. It should be noted that the positive medical properties of organometallic compounds of germanium are confirmed by numerous studies, therefore, the development of the methods of synthesis, as well as investigations of physicochemical and pharmacological properties of these compounds are at the center of attention.

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Privileged Structures in the Design of Potential Drug Candidates for Neglected Diseases

Current Medicinal Chemistry ◽

10.2174/0929867324666171023163752 ◽

2019 ◽

Vol 26 (23) ◽

pp. 4323-4354 ◽

Cited By ~ 9

Author(s):

Ana Cristina Lima Leite ◽

José Wanderlan Pontes Espíndola ◽

Marcos Veríssimo de Oliveira Cardoso ◽

Gevanio Bezerra de Oliveira Filho

Keyword(s):

Biologically Active ◽

Neglected Diseases ◽

Financial Return ◽

Drug Candidates ◽

Lead Compounds ◽

Wide Range ◽

Methods Of Synthesis ◽

Current Therapies ◽

Resistant Strains ◽

Privileged Structures

Background: Privileged motifs are recurring in a wide range of biologically active compounds that reach different pharmaceutical targets and pathways and could represent a suitable start point to access potential candidates in the neglected diseases field. The current therapies to treat these diseases are based in drugs that lack of the desired effectiveness, affordable methods of synthesis and allow a way to emergence of resistant strains. Due the lack of financial return, only few pharmaceutical companies have been investing in research for new therapeutics for neglected diseases (ND). Methods: Based on the literature search from 2002 to 2016, we discuss how six privileged motifs, focusing phthalimide, isatin, indole, thiosemicarbazone, thiazole, and thiazolidinone are particularly recurrent in compounds active against some of neglected diseases. Results: It was observed that attention was paid particularly for Chagas disease, malaria, tuberculosis, schistosomiasis, leishmaniasis, dengue, African sleeping sickness (Human African Trypanosomiasis - HAT) and toxoplasmosis. It was possible to verify that, among the ND, antitrypanosomal and antiplasmodial activities were between the most searched. Besides, thiosemicarbazone moiety seems to be the most versatile and frequently explored scaffold. As well, phthalimide, isatin, thiazole, and thiazolidone nucleus have been also explored in the ND field. Conclusion: Some described compounds, appear to be promising drug candidates, while others could represent a valuable inspiration in the research for new lead compounds.

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Schiff Base Metal Complexes Precursor for Metal Oxide Nanomaterial: A Review

Current Nanoscience ◽

10.2174/1573413716999201127112204 ◽

2020 ◽

Vol 16 ◽

Author(s):

Meghshyam K. Patil ◽

Vijay H. Masand ◽

Atish K. Maldhure

Keyword(s):

Schiff Base ◽

Metal Complexes ◽

Metal Oxides ◽

Base Metal ◽

Carbonyl Compounds ◽

Organic Transformations ◽

Iron Cobalt ◽

Methods Of Synthesis ◽

Schiff Base Metal Complexes ◽

Nickel Manganese

: Schiff bases and their complexes are versatile compounds, which have been synthesized from the condensation of carbonyl compounds with amino compounds and exhibit a broad range of applications in biological, medicinal, catalysis, and industrial purposes. Furthermore, Schiff base-metal complexes have been used as a precursor for the synthesis of different metal oxides, which includes oxides of iron, cobalt, copper, nickel, manganese, vanadium, cadmium, zinc, mercury, etc. and ferrites such as Fe3O4, ZnFe2O4, and ZnCo2O4. These metal oxides have been utilized for several applications, which includes as a catalyst for several organic transformations and for biological activity. This review encompasses different methods of synthesis of metal oxides using Schiff base metal complexes precursor, their characterization, and various applications in detail.

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