scholarly journals Sphingosine-1-Phosphate Protects Intestinal Epithelial Cells from Apoptosis Through the Akt Signaling Pathway

2008 ◽  
Vol 54 (3) ◽  
pp. 499-510 ◽  
Author(s):  
Jose Greenspon ◽  
Ruiyun Li ◽  
Lan Xiao ◽  
Jaladanki N. Rao ◽  
Bernard S. Marasa ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Signaling Pathway ◽  
Intestinal Epithelial Cells ◽  
Akt Signaling ◽  
Intestinal Epithelial ◽  
Akt Signaling Pathway ◽  
Sphingosine 1 Phosphate

scholarly journals Spirulina Crude Protein Promotes the Migration and Proliferation in IEC-6 Cells by Activating EGFR/MAPK Signaling Pathway

Marine Drugs ◽  
2019 ◽  
Vol 17 (4) ◽  
pp. 205
Author(s):  
Su-Jin Jeong ◽  
Jeong-Wook Choi ◽  
Min-Kyeong Lee ◽  
Youn-Hee Choi ◽  
Taek-Jeong Nam
Keyword(s):  
Cell Cycle ◽  
Epithelial Cells ◽  
Signaling Pathway ◽  
Crude Protein ◽  
Cell Cycle Progression ◽  
Intestinal Epithelial Cells ◽  
Mapk Signaling ◽  
S Phase ◽  
Intestinal Epithelial ◽  
Cycle Progression

Spirulina is a type of filamentous blue-green microalgae known to be rich in nutrients and to have pharmacological effects, but the effect of spirulina on the small intestine epithelium is not well understood. Therefore, this study aims to investigate the proliferative effects of spirulina crude protein (SPCP) on a rat intestinal epithelial cells IEC-6 to elucidate the mechanisms underlying its effect. First, the results of wound-healing and cell viability assays demonstrated that SPCP promoted migration and proliferation in a dose-dependent manner. Subsequently, when the mechanisms of migration and proliferation promotion by SPCP were confirmed, we found that the epidermal growth factor receptor (EGFR) and mitogen-activated protein (MAPK) signaling pathways were activated by phosphorylation. Cell cycle progression from G0/G1 to S phase was also promoted by SPCP through upregulation of the expression levels of cyclins and cyclin-dependent kinases (Cdks), which regulate cell cycle progression to the S phase. Meanwhile, the expression of cyclin-dependent kinase inhibitors (CKIs), such as p21 and p27, decreased with SPCP. In conclusion, our results indicate that activation of EGFR and its downstream signaling pathway by SPCP treatment regulates cell cycle progression. Therefore, these results contribute to the research on the molecular mechanism for SPCP promoting the migration and proliferation of rat intestinal epithelial cells.

M1731 Sphingosine-1-Phosphate Regulates Barrier Function in Cultured Intestinal Epithelial Cells and Murine Intestinal Tissue

2008 ◽  
Vol 134 (4) ◽  
pp. A-407
Author(s):  
Ruiyun Li ◽  
Jose Greenspon ◽  
Emily Bellavance ◽  
Rex Sun ◽  
Lan Xiao ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Barrier Function ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Intestinal Tissue ◽  
Sphingosine 1 Phosphate

Tu1402 All-Trans Retinoic Acid (ATRA) Stimulates SLC26A3 Activity in Intestinal Epithelial Cells via a PI3K Signaling Pathway

2015 ◽  
Vol 148 (4) ◽  
pp. S-880 ◽  
Author(s):  
Shubha Priyamvada ◽  
Arivarasu Natarajan Anbazhagan ◽  
Anoop Kumar ◽  
Tarunmeet Gujral ◽  
Alip Borthakur ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Epithelial Cells ◽  
Signaling Pathway ◽  
Intestinal Epithelial Cells ◽  
Pi3k Signaling ◽  
Intestinal Epithelial ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Pi3k Signaling Pathway

Sphingosine-1-phosphate inhibits hydrogen peroxide-induced granulosa cell apoptosis via the PI3K/Akt signaling pathway

2012 ◽  
Vol 98 (3) ◽  
pp. S239
Author(s):  
T. Nakahara ◽  
A. Iwase ◽  
M. Kondo ◽  
T. Nakamura ◽  
M. Goto ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Signaling Pathway ◽  
Granulosa Cell ◽  
Cell Apoptosis ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Sphingosine 1 Phosphate

Allyl methyl disulfide inhibits IL-8 and IP-10 secretion in intestinal epithelial cells via the NF-кB signaling pathway

2015 ◽  
Vol 27 (1) ◽  
pp. 156-163 ◽  
Author(s):  
Yongchun Zhang ◽  
Ying Wang ◽  
Fang Zhang ◽  
Kaiming Wang ◽  
Guangpu Liu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Signaling Pathway ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial

M1614 Expression of Delta Ligands Is Regulated By Notch-Hes1 Signaling Pathway in Human Intestinal Epithelial Cells

2009 ◽  
Vol 136 (5) ◽  
pp. A-395
Author(s):  
Junko Akiyama ◽  
Ryuichi Okamoto ◽  
Kiichiro Tsuchiya ◽  
Tetsuya Nakamura ◽  
Mamoru Watanabe
Keyword(s):  
Epithelial Cells ◽  
Signaling Pathway ◽  
Intestinal Epithelial Cells ◽  
Intestinal Epithelial ◽  
Human Intestinal Epithelial Cells
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