Circulating microRNA-22-3p Predicts the Malignant Progression of Precancerous Gastric Lesions from Intestinal Metaplasia to Early Adenocarcinoma

2018 ◽  
Vol 63 (9) ◽  
pp. 2301-2308 ◽  
Author(s):  
Tsung-Hsing Chen ◽  
Cheng-Tang Chiu ◽  
Chieh Lee ◽  
Yin-Yi Chu ◽  
Hao-Tsai Cheng ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
Malignant Progression ◽  
Circulating Microrna ◽  
Gastric Lesions ◽  
Precancerous Gastric Lesions ◽  
Early Adenocarcinoma

scholarly journals Chronic atrophic gastritis: an update on diagnosis

2020 ◽  
Author(s):  
Adriana Botezatu ◽  
Nicolae Bodrug
Keyword(s):  
Atrophic Gastritis ◽  
Intestinal Metaplasia ◽  
Chronic Atrophic Gastritis ◽  
Diagnostic Methods ◽  
Digestive Endoscopy ◽  
Gastric Lesions ◽  
Inclusion Criteria ◽  
Non Invasive ◽  
Precancerous Gastric Lesions ◽  
Upper Digestive Endoscopy

Background and aim. Atrophic gastritis is a precancerous gastric lesion, therefore its early detection is a priority in preventing gastric cancer. The aim of the present paper is to develop a narrative synthesis of the present knowledge on diagnostic methods of chronic atrophic gastritis. Methods. A literature search was carried out on main databases: PubMed, Hinari, SpringerLink and Scopus (Elsevier) for the period 2000-2020. The searched keywords were: chronic atrophic gastritis, intestinal metaplasia and dysplasia + diagnosis. Inclusion criteria were focused on the articles about the invasive and non-invasive diagnosis of chronic atrophic gastritis and of precancerous gastric lesions, intestinal metaplasia and dysplasia; exclusion criteria were articles published before 2000 and those that did not include the proposed theme. Results. The search returned 575 papers addressing the topic of precancerous lesions. From these, 60 articles were qualified representative for the materials published on the topic of this synthesis article, being those that met the inclusion criteria. The data emphasize the need to use upper digestive endoscopy with biopsies for the diagnosis of chronic atrophic gastritis. However serological diagnosis is available as alternative mainly recommended in follow up. Conclusions. There are two main methodological approaches for the evaluation of chronic atrophic gastritis as a precancerous gastric lesions: invasive examination, which requires histological analysis of biopsy samples taken during upper digestive endoscopy, being the "gold standard" for diagnosis, and non-invasive serological examination using markers of gastric function.

scholarly journals Deregulation of Annexin-A1 and Galectin-1 Expression in Precancerous Gastric Lesions: Intestinal Metaplasia and Gastric Ulcer

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Ana Flávia Teixeira Rossi ◽  
Márcia Cristina Duarte ◽  
Ayla Blanco Poltronieri ◽  
Marina Curado Valsechi ◽  
Yvana Cristina Jorge ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Protein Expression ◽  
Intestinal Metaplasia ◽  
Normal Mucosa ◽  
Positive Staining ◽  
Annexin A1 ◽  
Gastric Lesions ◽  
Precancerous Gastric Lesions ◽  
Mrna And Protein Expression ◽  
Immunohistochemical Techniques

Objective.Annexin-A1 (ANXA1/AnxA1) and galectin-1 (LGALS1/Gal-1) are mediators that play an important role in the inflammatory response and are also associated with carcinogenesis. We investigated mRNA and protein expression in precancerous gastric lesions that participate in the progression cascade to gastric cancer, such as intestinal metaplasia (IM) and gastric ulcer (GU).Methods.Quantitative real-time PCR (qPCR) and immunohistochemical techniques were used to analyze the relative quantification levels (RQ) ofANXA1andLGALS1mRNA and protein expression, respectively.Results.Increased relative expression levels ofANXA1were found in 100% of cases, both in IM (meanRQ=6.22±0.06) and in GU (meanRQ=6.69±0.10). However, theLGALS1presented basal expression in both groups (IM: meanRQ=0.35±0.07; GU: meanRQ=0.69±0.09). Immunohistochemistry revealed significant positive staining for both the AnxA1 and Gal-1 proteins in the epithelial nucleus and cytoplasm as well as in the stroma of the IM and GU groups (P<0.05) but absence or low immunorectivity in normal mucosa.Conclusion. Our results bring an important contribution by evidencing that both the AnxA1 and Gal-1 anti-inflammatory proteins are deregulated in precancerous gastric lesions, suggesting their involvement in the early stages of gastric carcinogenesis, possibly due to an inflammatory process in the gastric mucosa.

Circulation Microrna-22-3P Could Predict Gastric Precancerous Lesions from Intestinal Metaplasia to Early Adenocarcinoma

2017 ◽  
Vol 152 (5) ◽  
pp. S256
Author(s):  
Tsung-Hsing Chen ◽  
Ta-Sen Yeh ◽  
Kwang-Huei Lin ◽  
Cheng-Tang Chiu
Keyword(s):  
Intestinal Metaplasia ◽  
Precancerous Lesions ◽  
Early Adenocarcinoma

Detection of precancerous gastric lesions and gastric cancer through exhaled breath

Gut ◽  
2015 ◽  
Vol 65 (3) ◽  
pp. 400-407 ◽  
Author(s):  
Haitham Amal ◽  
Marcis Leja ◽  
Konrads Funka ◽  
Roberts Skapars ◽  
Armands Sivins ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Exhaled Breath ◽  
Gastric Lesions ◽  
Precancerous Gastric Lesions

scholarly journals Association of Epstein–Barr virus antibody levels with precancerous gastric lesions in a high-risk cohort

2008 ◽  
Vol 99 (2) ◽  
pp. 350-354 ◽  
Author(s):  
Aaron J. Schetter ◽  
Wei-cheng You ◽  
Evelyne T. Lennette ◽  
Mitchell T. Gail ◽  
Charles S. Rabkin
Keyword(s):  
High Risk ◽  
Epstein Barr Virus ◽  
Gastric Lesions ◽  
Virus Antibody ◽  
Barr Virus ◽  
Precancerous Gastric Lesions ◽  
Epstein Barr ◽  
Antibody Levels ◽  
High Risk Cohort

scholarly journals Expression of Cancer Stem Cell Marker CD44 and Its Polymorphisms in Patients with Chronic Gastritis, Precancerous Gastric Lesion, and Gastric Cancer: A Cross-Sectional Multicenter Study in Thailand

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Taweesak Tongtawee ◽  
Wareeporn Wattanawongdon ◽  
Theeraya Simawaranon ◽  
Soraya Kaewpitoon ◽  
Sivamate Kaengpenkae ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Protein Expression ◽  
Cancer Patients ◽  
Chronic Gastritis ◽  
Stem Cell Marker ◽  
Gastric Lesions ◽  
Cd44 Expression ◽  
Precancerous Gastric Lesions ◽  
Significant Difference ◽  
Gastric Cancer Patients

Here we investigated CD44 protein expression and its polymorphisms in patients with chronic gastritis, precancerous gastric lesions, and gastric cancer; and we evaluated our result with the risk of CD44 protein expression and clinicopathological characteristics. Our results obtained by analyzing 162 gastric cancer patients, 125 chronic gastritis, and 165 precancerous gastric lesions from three study centers in Thailand showed that CD44 expression was significantly higher in patients with precancerous gastric lesions and gastric cancer while patients with chronic gastritis were negative for CD44 staining (p=0.036). We further observed the significant association of variant genotype; gastric cancer patients carrying AG or GG of CD44 rs187116 had more increased risk of CD44 expression than wild-type (WT) carriers (AG: odds ratio (OR) = 5.67; 95% CI = 1.57–7.23; p=0.024 and GG: OR = 8.32; 95% CI = 2.94–11.42; p=0.016), but no significant difference in the risk of CD44 expression due to polymorphism in patients with precancerous gastric lesions. Our results suggested that CD44 expression could be used as a marker for the prediction of gastric cancer development, particularly in patients with precancerous gastric lesions carrying AG or GG, who were selected to surveillance follow-up for gastric cancer prevention.

Sign in / Sign up

Export Citation Format

Share Document