Caffeic acid phenethyl ester exerts apoptotic and oxidative stress on human multiple myeloma cells

2018 ◽  
Vol 37 (5) ◽  
pp. 837-848 ◽  
Author(s):  
Elizabeth Hernandez Marin ◽  
Hana Paek ◽  
Mei Li ◽  
Yesung Ban ◽  
Marie Katie Karaga ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Myeloma ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Myeloma Cells ◽  
Human Multiple Myeloma ◽  
And Oxidative Stress

scholarly journals Caffeic acid phenethyl ester (CAPE) as a remedial agent for reproductive functions and oxidative stress-based pathologies of gonads

2015 ◽  
Vol 4 (2) ◽  
pp. 187 ◽  
Author(s):  
Sumeyya Akyol ◽  
Ali Akbas ◽  
Ilknur Butun ◽  
Muhsin Toktas ◽  
Huseyin Ozyurt ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
And Oxidative Stress

Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidatıve stress ın various cancer cell lines

2019 ◽  
Vol 94 (7) ◽  
pp. 491-497 ◽  
Author(s):  
F. Fırat ◽  
M. Özgül ◽  
E. Türköz Uluer ◽  
S. Inan
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cancer Cell Lines ◽  
Caffeic Acid Phenethyl Ester ◽  
And Oxidative Stress

A biochemical and immunohistochemical study of the effects of caffeic acid phenethyl ester on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis

2020 ◽  
Vol 95 (6) ◽  
pp. 456-463
Author(s):  
Alper Kızıldağ ◽  
Taner Arabacı ◽  
Mevlüt Albayrak ◽  
Havva Müge Balseven ◽  
Canan Aksu Kızıldağ ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bone Loss ◽  
Caffeic Acid ◽  
Alveolar Bone ◽  
Immunohistochemical Study ◽  
Caffeic Acid Phenethyl Ester ◽  
Diabetic Rats ◽  
Alveolar Bone Loss ◽  
Experimental Periodontitis ◽  
And Oxidative Stress

scholarly journals Modulation of Cell Metabolic Pathways and Oxidative Stress Signaling Contribute to Acquired Melphalan Resistance in Multiple Myeloma Cells

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0119857 ◽  
Author(s):  
Kamila Anna Zub ◽  
Mirta Mittelstedt Leal de Sousa ◽  
Antonio Sarno ◽  
Animesh Sharma ◽  
Aida Demirovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Myeloma ◽  
Metabolic Pathways ◽  
Stress Signaling ◽  
Myeloma Cells ◽  
And Oxidative Stress

scholarly journals The effect of caffeic acid phenethyl ester (CAPE) on hepatic histopathology and oxidative stress in rats treated with malathion

2018 ◽  
pp. 604
Author(s):  
Gokhan Nur ◽  
Mehmet Husunet ◽  
Izzettin Guler ◽  
Ayla Deveci ◽  
Evren Koc ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Caffeic Acid ◽  
Caffeic Acid Phenethyl Ester ◽  
Hepatic Histopathology ◽  
And Oxidative Stress

Lnc NEAT1/miR-29b-3p/Sp1 form a positive feedback loop and modulate bortezomib resistance in human multiple myeloma cells

2021 ◽  
Vol 891 ◽  
pp. 173752
Author(s):  
Feifei Che ◽  
Xuemei Ye ◽  
Yu Wang ◽  
Shuyue Ma ◽  
Xuemei Wang
Keyword(s):  
Multiple Myeloma ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Positive Feedback Loop ◽  
Myeloma Cells ◽  
Human Multiple Myeloma

scholarly journals Crosstalk between endoplasmic reticulum stress and oxidative stress: a dynamic duo in multiple myeloma

2021 ◽  
Author(s):  
Sinan Xiong ◽  
Wee-Joo Chng ◽  
Jianbiao Zhou
Keyword(s):  
Oxidative Stress ◽  
Multiple Myeloma ◽  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Cell Fate ◽  
Stress Responses ◽  
Plasma Cells ◽  
Reactive Oxygen Species Generation ◽  
Future Research ◽  
And Oxidative Stress

AbstractUnder physiological and pathological conditions, cells activate the unfolded protein response (UPR) to deal with the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum. Multiple myeloma (MM) is a hematological malignancy arising from immunoglobulin-secreting plasma cells. MM cells are subject to continual ER stress and highly dependent on the UPR signaling activation due to overproduction of paraproteins. Mounting evidence suggests the close linkage between ER stress and oxidative stress, demonstrated by overlapping signaling pathways and inter-organelle communication pivotal to cell fate decision. Imbalance of intracellular homeostasis can lead to deranged control of cellular functions and engage apoptosis due to mutual activation between ER stress and reactive oxygen species generation through a self-perpetuating cycle. Here, we present accumulating evidence showing the interactive roles of redox homeostasis and proteostasis in MM pathogenesis and drug resistance, which would be helpful in elucidating the still underdefined molecular pathways linking ER stress and oxidative stress in MM. Lastly, we highlight future research directions in the development of anti-myeloma therapy, focusing particularly on targeting redox signaling and ER stress responses.

Phosphoproteomic analysis of primary human multiple myeloma cells

2010 ◽  
Vol 73 (7) ◽  
pp. 1381-1390 ◽  
Author(s):  
Feng Ge ◽  
Chuan-Le Xiao ◽  
Xing-Feng Yin ◽  
Chun-Hua Lu ◽  
Hui-Lan Zeng ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Myeloma Cells ◽  
Human Multiple Myeloma
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