Marital status and prostate cancer incidence: a pooled analysis of 12 case–control studies from the PRACTICAL consortium

2021 ◽  
Author(s):  
Charlotte Salmon ◽  
Lixin Song ◽  
Kenneth Muir ◽  
Nora Pashayan ◽  
Alison M. Dunning ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Marital Status ◽  
Cancer Incidence ◽  
Pooled Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Prostate Cancer Incidence

The RTK/ERK pathway is associated with prostate cancer risk on the SNP level: A pooled analysis of 41 sets of data from case–control studies

Gene ◽  
2014 ◽  
Vol 534 (2) ◽  
pp. 286-297 ◽  
Author(s):  
Yang Chen ◽  
Tianyu Li ◽  
Xiaoqiang Yu ◽  
Jianfeng Xu ◽  
Jianling Li ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Pooled Analysis ◽  
Case Control ◽  
Erk Pathway ◽  
Case Control Studies

scholarly journals Marital Status and Prostate Cancer Incidence: A Pooled Analysis of 12 Case-Control Studies From the PRACTICAL Consortium

2021 ◽  
Author(s):  
Charlotte Salmon ◽  
Lixin Song ◽  
Kenneth R Muir ◽  
Nora Pashayan ◽  
Alison M Dunning ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Social Support ◽  
Cancer Risk ◽  
Marital Status ◽  
Prostate Cancer Risk ◽  
Case Control ◽  
Cancer Prognosis ◽  
Low Grade ◽  
High Grade ◽  
Case Control Studies

Abstract While being in a committed relationship is associated with a better prostate cancer prognosis, little is known about how marital status relates to its incidence. Social support provided by marriage/relationship could promote a healthy lifestyle and an increased healthcare seeking behavior.We investigated the association between marital status and prostate cancer risk using data from the PRACTICAL Consortium. Pooled analyses were conducted combining 12 case-control studies based on histologically-confirmed incident prostate cancers and controls with information on marital status prior to diagnosis/interview. Marital status was categorized as married/partner, separated/divorced, single, or widowed. Tumours with Gleason scores ≥8 defined high-grade cancers, and low-grade otherwise. NCI-SEER’s summary stages (local, regional, distant) indicated the extent of the cancer. Logistic regression was used to derive odds ratios (ORs) and 95% confidence intervals (CI) for the association between marital status and prostate cancer risk, adjusting for potential confounders. Overall, 14,760 cases and 12,019 controls contributed to analyses. Compared to men who were married/with a partner, widowed men had an OR of 1.19 (95%CI 1.03-1.35) of prostate cancer, with little difference between low- and high-grade tumours. Risk estimates among widowers were 1.14 (95%CI 0.97-1.34) for local, 1.53 (95%CI 1.22-1.92) for regional, and 1.56 (95%CI 1.05-2.32) for distant stage tumours. Single men had elevated risks of high-grade cancers. Our findings highlight elevated risks of incident prostate cancer among widowers, more often characterized by tumours that had spread beyond the prostate at the time of diagnosis. Social support interventions and closer medical follow-up in this sub-population are warranted.

scholarly journals The association between prostatitis and prostate cancer. Systematic review and meta-analysis

2017 ◽  
Vol 89 (4) ◽  
pp. 259 ◽  
Author(s):  
Gianpaolo Perletti ◽  
Elena Monti ◽  
Vittorio Magri ◽  
Tommaso Cai ◽  
Anne Cleves ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Odds Ratio ◽  
Chronic Prostatitis ◽  
Meta Analysis ◽  
Pooled Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Crude Odds Ratio ◽  
Funnel Plot ◽  
History Of

Objective: The main outcome of this review was the association between a history of clinical chronic prostatitis (NIH category II or III) and a histologically confirmed diagnosis of prostate cancer. Materials and methods: Crude odds ratios and 95% confidence intervals (CI) were calculated to analyze dichotomous data. For analysis of pooled data we adopted a random-effects model and the inverse variance weighing method. Heterogeneity was assessed by calculating the I2 value. Results: Out of 2794 screened records, we retrieved 16 full-text articles written in English, reporting the data of 15 case-control studies, involving 422.943 patients. Pooled analysis resulted in a significant crude odds ratio of 1.83 (95% CI: 1.43 to 2.35; P < 0.00001). The total set of data showed considerable heterogeneity (I2 = 91%). Both the Egger’s test and the Begg's test for funnel plot asymmetry did not reach statistical significance. The ‘trim and fill’ method applied to the funnel plot imputed 3 missing studies and the resulting adjusted estimate of the odds ratio was 2.12 (95% CI: 1.38 to 3.22). According to GRADE criteria, the overall quality of the meta-analysis data is low, mainly due to the presence of bias, confounders and extreme effect size outliers. Five among the included studies reported data assessed in 8015 African-American subjects. Pooled analysis resulted in a non-significant crude odds ratio of 1.59 (95% CI: 0.71 to 3.57; P = 0.26), and considerable heterogeneity (I2 = 90%). Conclusions: Meta-analysis of 15 case-control studies shows that a history of clinical chronic prostatitis can significantly increase the odds for prostate cancer in the general population, whereas such association in African-American individuals remains uncertain.

471: Biopsy Gleason 8-10 Prostate Cancer: Incidence of Downgrading and Outcome

2005 ◽  
Vol 173 (4S) ◽  
pp. 129-129
Author(s):  
John F. Donohue ◽  
Fernando J. Bianco ◽  
Kentaro Kuroiwa ◽  
Andrew J. Vickers ◽  
Thomas M. Wheeler ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Incidence ◽  
Prostate Cancer Incidence

Decade-long Trends in Prostate Cancer Incidence and Mortality in Poland, 1999–2012

2018 ◽  
Author(s):  
Urszula Wojciechowska ◽  
◽  
Lauren M. Hurwitz ◽  
Grzegorz Helicki ◽  
Jennifer Cullen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Incidence ◽  
Prostate Cancer Incidence ◽  
Incidence And Mortality

scholarly journals Social Jetlag and Prostate Cancer Incidence in Alberta’s Tomorrow Project: A Prospective Cohort Study

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3873
Author(s):  
Liang Hu ◽  
Andrew Harper ◽  
Emily Heer ◽  
Jessica McNeil ◽  
Chao Cao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Risk ◽  
Cancer Incidence ◽  
Repeated Measures ◽  
Prospective Cohort ◽  
Prostate Cancer Risk ◽  
Absolute Difference ◽  
Prostate Cancer Incidence ◽  
Social Jetlag ◽  
Increased Risk

We investigated the association of social jetlag (misalignment between the internal clock and socially required timing of activities) and prostate cancer incidence in a prospective cohort in Alberta, Canada. Data were collected from 7455 cancer-free men aged 35–69 years enrolled in Alberta’s Tomorrow Project (ATP) from 2001–2007. In the 2008 survey, participants reported usual bed- and wake-times on weekdays and weekend days. Social jetlag was defined as the absolute difference in waking time between weekday and weekend days, and was categorized into three groups: 0–<1 h (from 0 to anything smaller than 1), 1–<2 h (from 1 to anything smaller than 2), and 2+ h. ATP facilitated data linkage with the Alberta Cancer Registry in June 2018 to determine incident prostate cancer cases (n = 250). Hazard ratios (HR) were estimated using Cox proportional hazards regressions, adjusting for a range of covariates. Median follow-up was 9.57 years, yielding 68,499 person-years. Baseline presence of social jetlag of 1–<2 h (HR = 1.52, 95% CI: 1.10 to 2.01), and 2+ hours (HR = 1.69, 95% CI: 1.15 to 2.46) were associated with increased prostate cancer risk vs. those reporting no social jetlag (p for trend = 0.004). These associations remained after adjusting for sleep duration (p for trend = 0.006). With respect to chronotype, the association between social jetlag and prostate cancer risk remained significant in men with early chronotypes (p for trend = 0.003) but attenuated to null in men with intermediate (p for trend = 0.150) or late chronotype (p for trend = 0.381). Our findings suggest that greater than one hour of habitual social jetlag is associated with an increased risk of prostate cancer. Longitudinal studies with repeated measures of social jetlag and large samples with sufficient advanced prostate cancer cases are needed to confirm these findings.

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