Supramolecular nanofiber-reinforced Puerarin hydrogels as drug carriers with synergistic controlled release and antibacterial properties

2020 ◽  
Vol 55 (15) ◽  
pp. 6669-6677 ◽  
Author(s):  
Wan Li
Keyword(s):  
Controlled Release ◽  
Antibacterial Properties ◽  
Drug Carriers

scholarly journals Synthesis and Biomedical Application of Hydroxyapatite as Carrier for Loading and Controlled Delivery of Antibiotics

2019 ◽  
Vol 69 (12) ◽  
pp. 3400-3405
Author(s):  
Mariana Mateescu ◽  
Sanda Maria Doncea ◽  
Iuliana Raut ◽  
Cristina Lavinia Nistor ◽  
Ioneta Codrina Bujanca
Keyword(s):  
Controlled Release ◽  
Biomedical Application ◽  
Drug Loading ◽  
Antibacterial Properties ◽  
Drug Carriers ◽  
Chemical Precipitation ◽  
Controlled Delivery ◽  
Wet Chemical ◽  
Uv Visible ◽  
Wet Chemical Precipitation

The hydroxyapatite (HA) nano and microparticles were synthesized by wet-chemical precipitation in order to use them as drug carriers for biomedical applications. Scanning Electron Microscopy (SEM), Dynamic Light Scattering (DLS) and Fourier Transform Infrared Spectroscopy (FTIR) were performed to assess their size, external morphology and chemical composition. The properties of HA particles as drug carriers for antibiotics delivery were evaluated with doxycycline and chloramphenicol. The amount of drug loading and release was determined by UV-Visible spectrophotometry. The antibacterial properties of loaded HA particles were evaluated using gram-positive Bacillus subtilis bacteria and gram-negative Pseudomonas aeruginosa bacteria. The synthesized particles of HA exhibit a high adsorption capacity (around 99%) and good controlled release properties for doxycycline. The adsorption of chloramphenicol on HA was extremely low (about 2%). According to the results, the compatibility between the drug and substrate is an important factor in the absorption process, and the hydroxyapatite is a very promising carrier for controlled release of antibiotics.

scholarly journals Preparation and Sustained-Release Performance of PLGA Microcapsule Carrier System

Nanomaterials ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1758
Author(s):  
Shuaikai Ren ◽  
Chunxin Wang ◽  
Liang Guo ◽  
Congcong Xu ◽  
Yan Wang ◽  
...  
Keyword(s):  
Controlled Release ◽  
Biomedical Applications ◽  
Encapsulation Efficiency ◽  
Drug Carriers ◽  
Optimum Conditions ◽  
Carrier System ◽  
Preparation Conditions ◽  
Encapsulation Rate ◽  
Release Drug ◽  
Release Curve

Microcapsules have been widely studied owing to their biocompatibility and potential for application in various areas, particularly drug delivery. However, the size of microcapsules is difficult to control, and the size distribution is very broad via various encapsulation techniques. Therefore, it is necessary to obtain microcapsules with uniform and tailored size for the construction of controlled-release drug carriers. In this study, emulsification and solvent evaporation methods were used to prepare a variety of ovalbumin-loaded poly (lactic-co-glycolic acid) (PLGA) microcapsules to determine the optimal preparation conditions. The particle size of the PLGA microcapsules prepared using the optimum conditions was approximately 200 nm, which showed good dispersibility with an ovalbumin encapsulation rate of more than 60%. In addition, porous microcapsules with different pore sizes were prepared by adding a varying amount of porogen bovine serum albumin (BSA) to the internal water phase. The release curve showed that the rate of protein release from the microcapsules could be controlled by adjusting the pore size. These findings demonstrated that we could tailor the morphology and structure of microcapsules by regulating the preparation conditions, thus controlling the encapsulation efficiency and the release performance of the microcapsule carrier system. We envision that this controlled-release novel microcapsule carrier system shows great potential for biomedical applications.

scholarly journals The Application of Chitosan Nanostructures in Stomatology

Molecules ◽  
2021 ◽  
Vol 26 (20) ◽  
pp. 6315
Author(s):  
Shunli Chu ◽  
Jue Wang ◽  
Fengxiang Gao
Keyword(s):  
Positive Charge ◽  
Antibacterial Properties ◽  
Drug Carriers ◽  
Natural Polymer ◽  
Hard Tissue ◽  
Recent Developments ◽  
Potential Applications ◽  
Soft Tissue Diseases ◽  
Application Fields ◽  
Dental Restorative

Chitosan (CS) is a natural polymer with a positive charge, a deacetylated derivative of chitin. Chitosan nanostructures (nano-CS) have received increasing interest due to their potential applications and remarkable properties. They offer advantages in stomatology due to their excellent biocompatibility, their antibacterial properties, and their biodegradability. Nano-CSs can be applied as drug carriers for soft tissue diseases, bone tissue engineering and dental hard tissue remineralization; furthermore, they have been used in endodontics due to their antibacterial properties; and, finally, nano-CS can improve the adhesion and mechanical properties of dental-restorative materials due to their physical blend and chemical combinations. In this review, recent developments in the application of nano-CS for stomatology are summarized, with an emphasis on nano-CS’s performance characteristics in different application fields. Moreover, the challenges posed by and the future trends in its application are assessed.

Development and Characterization of Chitosan Membranes as a System for Controlled Release of Piperine

2016 ◽  
Vol 869 ◽  
pp. 864-868
Author(s):  
Imarally Vitor de Souza Ribeiro Nascimento ◽  
Mairly Karolyne da Silva Souza ◽  
Willams Teles Barbosa ◽  
Thiago Bizerra Fideles ◽  
Thais Maria Alves Marinho ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Carriers ◽  
Solvent Casting ◽  
X Ray Diffraction ◽  
Casting Method ◽  
Pharmacological Activities ◽  
X Ray ◽  
Natural Alkaloid ◽  
Chitosan Membranes

Among the variety of polymers used as drug carriers, chitosan has received attention in the fields of medicine and pharmacy by being a nontoxic, biocompatible and biodegradable copolymer. Piperine is a natural alkaloid, has various pharmacological activities such as anti-inflammatory, analgesic, antipyretic, hepatoprotective and antitumor when combined with chitosan has better bioavailability and more effectiveness. This work aims to prepare and characterize chitosan / piperine membranes obtained by the solvent casting method. The membranes were characterized by Spectroscopy Fourier Transform Infrared (FTIR), X-ray Diffraction (DRX) and Scanning Electron Microscopy (MEV). From the results obtained it can be concluded that the process described was effective in obtaining the system chitosan/piperine indicating its potential for studies of controlled release of drug.

Antibacterial properties and cytocompatibility of bio-based nanostructured carbon aerogels derived from silver nanoparticles deposited onto bacterial cellulose

RSC Advances ◽  
2015 ◽  
Vol 5 (118) ◽  
pp. 97467-97476 ◽  
Author(s):  
Ning Yan ◽  
Yabin Zhou ◽  
Yudong Zheng ◽  
Shuang Qiao ◽  
Qun Yu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Silver Nanoparticles ◽  
Controlled Release ◽  
Bacterial Cellulose ◽  
Antibacterial Properties ◽  
Carbon Aerogels ◽  
Nanostructured Carbon

p-BC/AgNP carbon aerogels with excellent reabsorption capacities and mechanical properties were prepared by in situ reduction and carbonization. The aerogels had better antibacterial behavior and biocompatibility due to their slow controlled release of silver.

scholarly journals Antimicrobial Effect of Drug Incorporated Nanoparticles Against Oral Pathogens

2020 ◽  
Vol 70 (12) ◽  
pp. 4445-4449
Keyword(s):  
Layered Double Hydroxides ◽  
Antibacterial Properties ◽  
Antimicrobial Effect ◽  
Drug Carriers ◽  
Antibiotics Resistance ◽  
Prolonged Release ◽  
Oral Infections ◽  
Oral Pathogens ◽  
Double Hydroxides ◽  
Antibiotic Efficacy

Last few years antibiotics resistance known a major problem that concerns the specialists in the dentistry field due to the improper usage of anti-infectious drugs. Administration of third generation quinolones, levofloxacin (Lev), in dental practice is preferred since has few nonhazardous adverse effects, is used once daily and can be successfully applied as intra-pocket films.This study investigated the possibility of preparing levofloxacin loaded layered double hydroxides nanoparticles in order to enhance antibiotic efficacy against oral pathogens. The nanoparticles obtained under optimal conditions were physico-chemically analyzed and intercalation efficiency was tested. The results of this work revealed that the use of these nanoparticles type levofloxacin loaded layered double hydroxides has the major advantage of prolonged release of the drug, thus allowing an increase of the period between administration and the diminution of side effects of the antibiotic. Further researches should focus on biocompatible properties and antibacterial effect as these nanomaterials supposed to be a sustainable drug delivery system. Keywords: nanoparticles, drug carriers, antibacterial properties, public health dentistry, oral infections

scholarly journals Controlled release of entrapped nanoparticles from thermoresponsive hydrogels with tunable network characteristics

Soft Matter ◽  
2020 ◽  
Vol 16 (20) ◽  
pp. 4756-4766 ◽  
Author(s):  
Yi Wang ◽  
Zhen Li ◽  
Jie Ouyang ◽  
George Em Karniadakis
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Controlled Drug Delivery ◽  
Drug Carriers ◽  
Network Characteristics ◽  
Thermoresponsive Hydrogels ◽  
Smart Drug

Thermoresponsive hydrogels have been studied intensively for creating smart drug carriers and controlled drug delivery.

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