Zirconium Based Nano Metal–Organic Framework UiO-67-NH2 with High Drug Loading for Controlled Release of Camptothecin

2019 ◽  
Vol 30 (2) ◽  
pp. 573-579
Author(s):  
DaoTong Chen ◽  
JiaRui Bi ◽  
Jian Wu ◽  
Abhinav Kumar
Keyword(s):  
Controlled Release ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
High Drug ◽  
Metal Organic ◽  
High Drug Loading ◽  
Organic Framework

A versatile and multifunctional metal–organic framework nanocomposite toward chemo-photodynamic therapy

2020 ◽  
Vol 49 (16) ◽  
pp. 5291-5301 ◽  
Author(s):  
Ying Pan ◽  
Zhidong Luo ◽  
Xiaoxiong Wang ◽  
Qianyi Chen ◽  
Junhao Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
Hybrid Scaffolds ◽  
High Drug Loading ◽  
Organic Framework

We synthesize a new carrier of ALA@UIO-66-NH-FAM/MTA to achieve efficient synergistic therapy, taking advantage of the targeting component of MTA and high drug-loading capacity of hybrid scaffolds of MOF.

A γ-cyclodextrin-based metal–organic framework embedded with graphene quantum dots and modified with PEGMA via SI-ATRP for anticancer drug delivery and therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (43) ◽  
pp. 20956-20967 ◽  
Author(s):  
Qiaojuan Jia ◽  
Zhenzhen Li ◽  
Chuanpan Guo ◽  
Xiaoyu Huang ◽  
Yingpan Song ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Graphene Quantum Dots ◽  
Tumor Growth Inhibition ◽  
High Drug ◽  
Anticancer Drug Delivery ◽  
Metal Organic ◽  
High Drug Loading

A biocompatible γ-CD-MOF based DDS with high drug loading and full drug release was prepared and effective tumor growth inhibition was achieved in vivo.

scholarly journals Metal Organic Framework@Polysilsesequioxane Core/Shell-Structured Nanoplatform for Drug Delivery

Pharmaceutics ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 98
Author(s):  
Liangyu Lu ◽  
Mengyu Ma ◽  
Chengtao Gao ◽  
Hongwei Li ◽  
Long Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Surface Area ◽  
Drug Loading ◽  
High Surface ◽  
High Surface Area ◽  
Loading Capacity ◽  
High Drug ◽  
Metal Organic ◽  
High Drug Loading

Modern pharmaceutics requires novel drug loading platforms with high drug loading capacity, controlled release, high stability, and good biocompacity. Metal–organic frameworks (MOFs) show promising applications in biomedicine owing to their extraordinarily high surface area, tunable pore size, and adjustable internal surface properties. However, MOFs have low stability due to weak coordinate bonding and limited biocompatibility, limiting their bioapplication. In this study, we fabricated MOFs/polysilsesquioxane (PSQ) nanocomposites and utilized them as drug carriers. Amine-functionalized MOF (UiO-66-NH2) nanoparticles were synthesized and encapsulated with epoxy-functionalized polysilsesquioxane layer on the surface via a facile process. MOFs possessed high surface area and regular micropores, and PSQs offered stability, inertness, and functionality. The obtained UiO-66-NH2@EPSQ nanocomposites were utilized as carriers for ibuprofen, a drug with carboxylic groups on the surface, and demonstrated high drug loading capacity and well-controlled release property. The UiO-66-NH2@EPSQ nanocomposite exhibited low cytotoxicity to HeLa cells within a wide concentration range of 10–100 µg/mL, as estimated by the MTT method. The UiO-66-NH2@EPSQ drug release system could be a potential platform in the field of controlled drug delivery.

scholarly journals Microwave-Assisted Synthesis, Characterization and Modeling of CPO-27-Mg Metal-Organic Framework for Drug Delivery

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 426
Author(s):  
Anton I. Kudelin ◽  
Konstantinos Papathanasiou ◽  
Vera Isaeva ◽  
Juergen Caro ◽  
Tapio Salmi ◽  
...  
Keyword(s):  
Density Functional ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Microwave Assisted Synthesis ◽  
Functional Theory ◽  
Microwave Assisted ◽  
The Density Functional Theory ◽  
Metal Organic ◽  
High Drug Loading ◽  
Organic Framework

The coordination polymer CPO-27-Mg was rapidly synthesized under microwave irradiation. This material exhibits a sufficiently high drug loading towards aspirin (~8% wt.) and paracetamol (~14% wt.). The binding of these two molecules with the inner surface of the metal-organic framework was studied employing the Gaussian and Plane Wave approach of the Density Functional Theory. The structure of CPO-27-Mg persists after the adsorption of aspirin or paracetamol and their desorption energies, being quite high, decrease under solvent conditions.

A novel anhydrous preparation of PEG hydrogels enables high drug loading with biologics for controlled release applications

2021 ◽  
Vol 147 ◽  
pp. 110286
Author(s):  
Christian E. Ziegler ◽  
Moritz Graf ◽  
Sebastian Beck ◽  
Achim M. Goepferich
Keyword(s):  
Controlled Release ◽  
Drug Loading ◽  
Peg Hydrogels ◽  
High Drug ◽  
High Drug Loading

scholarly journals Histidine polypeptide-hybridized nanoscale metal–organic framework to sense drug loading/release

2021 ◽  
Vol 205 ◽  
pp. 109741
Author(s):  
Yanan Xu ◽  
Zhenhua Li ◽  
Dan Xiu ◽  
Guotao Sun ◽  
Christopher D. Snow ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Drug Loading ◽  
Metal Organic ◽  
Organic Framework

Enhanced stability and Controlled Release of Menthol Using a β-Cyclodextrin Metal-Organic Framework

2021 ◽  
pp. 131760
Author(s):  
Ziman Hu ◽  
Miao Shao ◽  
Bin Zhang ◽  
Xiong Fu ◽  
Qiang Huang
Keyword(s):  
Controlled Release ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Enhanced Stability ◽  
Organic Framework

Photo-triggered release of 5-fluorouracil from a MOF drug delivery vehicle

2018 ◽  
Vol 54 (55) ◽  
pp. 7617-7620 ◽  
Author(s):  
Kristina Roth Stefaniak ◽  
Charity C. Epley ◽  
Joshua J. Novak ◽  
Margaret L. McAndrew ◽  
Hannah D. Cornell ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Small Molecules ◽  
Metal Organic Framework ◽  
Delivery Vehicle ◽  
Triggered Release ◽  
Drug Delivery Vehicle ◽  
Metal Organic ◽  
Organic Framework

A nano metal–organic-framework (nanoMOF) was employed as a first-of-its kind drug delivery vehicle (DDV) for the photo-controlled release of therapeutics with simultaneous breakdown of the carrier into small molecules.

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