Regularly grafted polymer brush with degradable PCL backbone by ring-opening polymerization and “click” reaction: synthesis and self-assembly

2016 ◽  
Vol 23 (2) ◽  
Author(s):  
Ruixue Chang ◽  
Jianglei Qin ◽  
Haijun Wang
Keyword(s):  
Self Assembly ◽  
Ring Opening ◽  
Click Reaction ◽  
Polymer Brush ◽  
Ring Opening Polymerization ◽  
Reaction Synthesis ◽  
Grafted Polymer

Efficient synthesis and self-assembly of hetero-grafted amphiphilic polypepide bottlebrushes

2012 ◽  
Vol 84 (12) ◽  
pp. 2569-2578 ◽  
Author(s):  
Chunhui Luo ◽  
Chongyi Chen ◽  
Zhibo Li
Keyword(s):  
Self Assembly ◽  
Ring Opening ◽  
Click Reaction ◽  
Ring Opening Polymerization ◽  
The Self ◽  
Molar Ratio ◽  
Efficient Synthesis ◽  
Poly Ethylene Glycol ◽  
New Type ◽  
Poly Ethylene

A new type of hetero-grafted molecular bottlebrush with polypeptide as backbone was synthesized using graft-onto strategy. Poly(γ-propargyl-L-glutamate) (PPLG) as backbone was firstly synthesized via ring-opening polymerization (ROP) of γ-propargyl-L-glutamate (PLG) N-carboxyanhydride (NCA). Next, polystyrene-N3 (PS-N3) and monomethoxy poly(ethylene glycol)-N3 (mPEG-N3) as side chains were grafted onto the PPLG backbone using copper-catalyzed click reaction, which afforded good grafting density and efficiency. Two polypeptide bottlebrushes with PS-to-mPEG molar ratio at 70/30 and 30/70 were prepared. The self-assembly behaviors of these two polypeptide bottlebrushes were investigated using the cosolvent method, and their supramolecular structures were characterized using light scattering (LS) and electron microscopy.

Ring-opening polymerization-induced self-assembly (ROPISA) of salicylic acid o-carboxyanhydride

2021 ◽  
Author(s):  
Qianqian Shi ◽  
Yibing Chen ◽  
Junjiao Yang ◽  
Jing Yang
Keyword(s):  
Salicylic Acid ◽  
Self Assembly ◽  
Ring Opening ◽  
Ring Opening Polymerization

Reported here is the first polyester-based bioactive nanoparticles accessed via ring-opening polymerization-induced self-assembly (ROPISA) of salicylic acid o-carboxyanhydride (SAOCA) monomers. Superfast ROPISA of SAOCA was completed in 30 seconds to form worm-like morphology.

Folic acid targeted pH-responsive amphiphilic polymer nanoparticles conjugated with near infrared fluorescence probe for imaging-guided drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (46) ◽  
pp. 40312-40322 ◽  
Author(s):  
Liyi Fu ◽  
Le Liu ◽  
Zheng Ruan ◽  
Houbing Zhang ◽  
Lifeng Yan
Keyword(s):  
Folic Acid ◽  
Ring Opening ◽  
Near Infrared ◽  
Fluorescence Probe ◽  
Click Reaction ◽  
Raft Polymerization ◽  
Ring Opening Polymerization ◽  
Amphiphilic Polymer ◽  
Polymer Nanoparticles ◽  
Ph Responsive

A novel folic acid targeted pH-responsive amphiphilic polymer conjugated with near infrared (NIR) probe has been synthesized by the combination of RAFT polymerization, ring-opening polymerization of N-carboxy anhydride (NCA) and click reaction.

Polysarcosine: The Best Alternative of Poly (Ethylene Glycol)

2020 ◽  
Vol 04 ◽  
Author(s):  
Manu Singhai ◽  
Sankha Bhattacharya
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Protein Delivery ◽  
Ring Opening ◽  
Biomedical Applications ◽  
High Vacuum ◽  
Ring Opening Polymerization ◽  
Poly Ethylene Glycol ◽  
Biologically Relevant ◽  
Poly Ethylene

Abstract:: Polysarcosine (psar) is a non-ionic hydrophilic polypeptoid with numerous biologically relevant properties. Polysarcosine is poly (n-methylated glycine) and has been reported first by wesley and co-workers in the 1920s. Polysarcosine was first synthesized via ring-opening polymerization (rop) of sarcosine n-carboxyanhydride, using high-vacuum techniques. Overall, findings highlight the potential of poly(sarcosine) as an alternative corona-forming polymer to poly (ethylene glycol)-based analogues of (polymerization-induced self-assembly) pisa assemblies for use in various pharmaceutical and biomedical applications. Numerous studies suggested that such polypeptoids hold enormous potential for many biomedical applications, including protein delivery, colloidal stabilization, and nanomedicine.

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