The Effect of Zinc supplementation on Ghrelin-Immunoreactive Cells and Lipid Parameters in Gastrointestinal Tissue of Streptozotocin-Induced Female Diabetic Rats

Diabetes is characterized by hyperglycaemia with alterations of lipid parameters. The effects of Aloe vera (A.V) gel extract on lipid profiles of streptozotocin-induced diabetic rats were investigated. Seventy-two male albino rats were randomly divided into six groups of 12 rats each; control, diabetic control, 4 ml/kg and 8 ml/kg body weight (b.w.) A.V, 10 mg/kg b.w. glibenclimide and non-diabetic 8 ml/kg b.w. A.V groups. They were treated for 14 and 28 days. The plasma and HDL lipid profiles (triacylglycerols, cholesterol and phospholipids) of the diabetic rats were significantly (p<0.05) increased, while those of the VLDL+LDL, RBC, RBC membrane and organs were observed to be significantly (p<0.05) reduced, when compared to the control after 14 and 28 days of treatment. A.V gel extract significantly (p<0.05) ameliorated the disruptions observed in the lipid profiles of the diabetic and thus provide a scientific rationale for the use of Aloe vera as a therapeutic agent.Bangladesh J Med Biochem 2016; 9(1): 11-26

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Oral Zinc Supplementation Protects Rat Kidney Tissue from Oxidative Stress in Diabetic Rats

Kafkas Universitesi Veteriner Fakultesi Dergisi ◽

10.9775/kvfd.2011.5650 ◽

2012 ◽

Author(s):

Nurten OZSOY ◽

Ayse CAN ◽

Ozgur MUTLU ◽

Nuriye AKEV ◽

Refiye YANARDAG

Keyword(s):

Oxidative Stress ◽

Zinc Supplementation ◽

Rat Kidney ◽

Kidney Tissue ◽

Diabetic Rats

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Zinc supplementation mitigates its dyshomeostasis in experimental diabetic rats by regulating the expression of zinc transporters and metallothionein

Metallomics ◽

10.1039/c7mt00210f ◽

2017 ◽

Vol 9 (12) ◽

pp. 1765-1777 ◽

Cited By ~ 9

Author(s):

Susmita Barman ◽

Seetur R. Pradeep ◽

Krishnapura Srinivasan

Keyword(s):

Zinc Supplementation ◽

Diabetic Rats ◽

Zinc Transporters ◽

Zinc Depletion ◽

Zinc Nutrition

Zinc depletion during diabetes projects a role for zinc nutrition in this condition.

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Ameliorative effect of zinc supplementation on compromised small intestinal health in streptozotocin-induced diabetic rats

Chemico-Biological Interactions ◽

10.1016/j.cbi.2019.04.018 ◽

2019 ◽

Vol 307 ◽

pp. 37-50

Author(s):

Susmita Barman ◽

Krishnapura Srinivasan

Keyword(s):

Zinc Supplementation ◽

Diabetic Rats ◽

Intestinal Health ◽

Ameliorative Effect ◽

Small Intestinal

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ANTIDIABETIC ACTIVITY OF BACOLEPIS NERVOSA (WIGHT AND ARN.) DECNE. EX MOQ. EXTRACT ON ALLOXAN INDUCED DIABETIC RATS

International Journal of Pharmacy and Pharmaceutical Sciences ◽

10.22159/ijpps.2016v8i11.14803 ◽

2016 ◽

Vol 8 (11) ◽

pp. 320

Author(s):

Arockia Jenecius Alphonse A. ◽

Mohan V. R. ◽

Doss A.

Keyword(s):

Blood Glucose ◽

Ethanol Extract ◽

Diabetic Rats ◽

Serum Enzymes ◽

Antidiabetic Activity ◽

Albino Rats ◽

Ethanol Extracts ◽

Wistar Albino Rats ◽

Alloxan Monohydrate ◽

Lipid Parameters

Objective: The aim of this study was to investigate the effect of ethanol extracts of stem and leaf of Bacolepis nervosa as antihyperglycemic, anti-hyperlipidemic and antioxidant activity in alloxan-induced diabetic rats. Methods: Diabetes was induced in wistar albino rats by administration of alloxan monohydrate (150 mg/kg). The ethanol extract of B. nervosa leaf and stem at a dose of 150 and 300 mg/kg body weight was administrated at a single dose per day to diabetes-induced rats for a period of 14 d. The effect of ethanol extract of B. nervosa leaf and stem on blood glucose, insulin, urea, creatinine, HbA1C, serum protein, albumin, globulin, serum enzymes, serum lipid profiles, lipid peroxidase (LPO) and antioxidant enzymes like superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH) were measured in the diabetic rats.Results: The ethanol extract of B. nervosa stem and leaf elicited significant reduction in blood glucose (p<0.001), serum enzymes (SGPT, SGOT, ALP) (p<0.01), lipid parameters (TC, TG, VLDL-LDL, PL) (p<0.01) except HDL-C and significantly increased insulin (p<0.01), HDL-C (p<0.05),, GPx, GSH, SOD and CAT (p<0.05) at the dose of 300 mg/kg when compared with the diabetic-induced control.Conclusion: From the above results, it is concluded that ethanol extracts of B. nervosa leaf and stem possesses significant antihyperglycemic, antihyperlipidemic and antioxidant effect in alloxan induced diabetic rats.

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Pregnane-Oximino-Alkyl-Amino-Ether Compound as a Novel Class of TGR5 Receptor Agonist Exhibiting Antidiabetic and Anti-Dyslipidemic Activities

Pharmacology ◽

10.1159/000519721 ◽

2021 ◽

pp. 1-15

Author(s):

Jyoti Gupta ◽

Dharmendra P. Singh ◽

Prem C. Verma ◽

Neha Rahuja ◽

Rohit Srivastava ◽

...

Keyword(s):

Skeletal Muscle ◽

Glucose Tolerance ◽

Glucose Utilization ◽

Glucose Production ◽

Muscle Cells ◽

Diabetic Rats ◽

Skeletal Muscle Cells ◽

Alkyl Ether ◽

High Fructose ◽

Lipid Parameters

Introduction: The present study deals with the synthesis of pregnane-oximino-amino-alkyl-ethers and their evaluation for antidiabetic and anti-dyslipidemic activities in validated animal and cell culture models. Methods: The effect on glucose tolerance was measured in sucrose-loaded rats; antidiabetic activity was evaluated in streptozotocin (STZ)-induced diabetic rats and genetically diabetic db/db mice; the anti-dyslipidemic effect was characterized in high-fructose, high-fat diet (HFD)-fed dyslipidemic hamsters. The effect on glucose production and glucose utilization was analyzed in HepG2 liver and L6 skeletal muscle cells, respectively. Results: From the synthesized molecules, pregnane-oximino-amino-alkyl-ether (compound 14b) improved glucose clearance in sucrose-loaded rats and exerted antihyperglycemic activity on STZ-induced diabetic rats. Further evaluation in genetically diabetic db/db mice showed temporal decrease in blood glucose, and improvement in glucose tolerance and lipid parameters, associated with mild improvement in the serum insulin level. Moreover, compound 14b treatment displayed an anti-dyslipidemic effect characterized by significant improvement in altered lipid parameters of the high-fructose, HFD-fed dyslipidemic hamster model. In vitro analysis in the cellular system suggested that compound 14b decreased glucose production in liver cells and stimulated glucose utilization in skeletal muscle cells. These beneficial effects of compound 14b were associated with the activation of the G-protein-coupled bile acid receptor TGR5. Conclusion: Compound 14b exhibits antidiabetic and anti-dyslipidemic activities through activating the TGR5 receptor system and can be developed as a lead for the management of type II diabetes and related metabolic complications.

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Effects of date seeds administration on anxiety and depressive symptoms in streptozotocin-induced diabetic rats: biochemical and behavioral evidences

Journal of Basic and Clinical Physiology and Pharmacology ◽

10.1515/jbcpp-2020-0225 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Samir Bikri ◽

Youssef Aboussaleh ◽

Assia Berrani ◽

Ismail Louragli ◽

Affaf Hafid ◽

...

Keyword(s):

Lipid Peroxidation ◽

Depressive Symptoms ◽

Aqueous Extract ◽

Diabetic Rats ◽

Behavioral Changes ◽

Oxidative Stress Marker ◽

Diabetic Patients ◽

Chronic Hyperglycemia ◽

Kidney Liver ◽

Lipid Parameters

Abstract Objectives Several epidemiological data indicate that chronic hyperglycemia is associated with behavioral changes such as anxiety and depressive symptoms. Date seeds, one of the most potent products with potential antioxidant activities and possess many benefits against hyperglycemia and its complication. The aim of the current study was to explore the potential effect of date seeds extract on biochemical and behavioral changes (anxiety and depression) in streptozotocin (STZ)-diabetic rats. Methods Rats were divided into four groups as follows: normal control, diabetic control, diabetic treated with the lyophilized aqueous extract of the date seed (2,000 mg/kg) (LAE-DS) and diabetics treated with insulin (4 UI/day). Experimental diabetes was induced by a single intraperitoneal injection of STZ (60 mg/kg). After 24 days treatment period, anxiety and depressive behaviors were evaluated using four behavioral tests. After sacrifice, blood samples were collected to evaluate lipid parameters. In addition, rat organs (kidney, liver and brain) were dissected out in order to estimate lipid peroxidation levels as oxidative stress marker. Results Oral administration of the lyophilized aqueous extract of date seeds and insulin injection for 30 days significantly decreased blood glucose levels in STZ-diabetic rats and protected them against undesirable changes in lipid parameters, including cholesterol, triglycerides, LDL cholesterol, VLDL cholesterol and atherosclerosis index. Compared to untreated diabetic rat, a significant decrease in lipid peroxidation levels in kidney, liver and brain (Hippocampus and prefrontal cortex) were observed after treatment with insulin or LAE-DS in diabetic rats. Furthermore, insulin and LAE-DS administration prevented anxiety-related behaviors in STZ-diabetic rats. Conclusions Therefore, it would be possible to combine this extract with insulin and use it as an antioxidant supplement for type 1 diabetic patients.

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Curative Effect of Catechin Isolated from Elaeagnus Umbellata Thunb. Berries for Diabetes and Related Complications in Streptozotocin-Induced Diabetic Rats Model

Molecules ◽

10.3390/molecules26010137 ◽

2020 ◽

Vol 26 (1) ◽

pp. 137

Author(s):

Nausheen Nazir ◽

Muhammad Zahoor ◽

Riaz Ullah ◽

Essan Ezzeldin ◽

Gamal A. E. Mostafa

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Blood Glucose Level ◽

Digestive Enzymes ◽

Fasting Blood Glucose ◽

Diabetic Rats ◽

Fasting Blood Glucose Level ◽

Elaeagnus Umbellata ◽

Liver And Kidney ◽

Lipid Parameters

In this study, catechin (CTN) isolated from Elaeagnus umbellata was evaluated for in vitro antioxidant potential and inhibition of carbohydrate digestive enzymes (α-amylase and α-glucosidase). The compound was also tested for its in vivo antidiabetic potential using Sprague-Dawley rats as experimental animals. The effects of various doses of catechin in STZ (Streptozotocin) induced diabetic rats on fasting blood glucose level, body weight, lipid parameters, hepatic enzymes, and renal functions were evaluated using the reported protocols. The CTN exhibited the highest percent antioxidant for free radical scavenging activity against DPPH and ABTS free radicals, and inhibited the activity of carbohydrate digestive enzymes (with percent inhibition values: 79 ± 1.5% α-amylase and 80 ± 1.1% α-glucosidase). Administration CTN and standard glibenclamide significantly decreased the fasting blood glucose level and increased the body weight in STZ-induced diabetic rats. CTN significantly decreased the different lipid parameters, hepatic, and renal function enzyme levels along with Hb1c level in diabetic rats, while significantly increasing the high-density lipoprotein (HDL) level with values comparable to the standard glibenclamide. Further, the altered levels of glutathione and lipid peroxides of liver and kidney tissues were restored (by CTN) to levels similar to the control group. CTN significantly increased the antioxidant enzyme activities, total content of reduced glutathione, and reduced the malondialdehyde (MDA) level in rat liver and kidney tissues homogenates, and also corrected the histopathological abnormalities, suggesting its antioxidant potential.

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