scholarly journals Curative Effect of Catechin Isolated from Elaeagnus Umbellata Thunb. Berries for Diabetes and Related Complications in Streptozotocin-Induced Diabetic Rats Model

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 137
Author(s):  
Nausheen Nazir ◽  
Muhammad Zahoor ◽  
Riaz Ullah ◽  
Essan Ezzeldin ◽  
Gamal A. E. Mostafa
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Digestive Enzymes ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Fasting Blood Glucose Level ◽  
Elaeagnus Umbellata ◽  
Liver And Kidney ◽  
Lipid Parameters

In this study, catechin (CTN) isolated from Elaeagnus umbellata was evaluated for in vitro antioxidant potential and inhibition of carbohydrate digestive enzymes (α-amylase and α-glucosidase). The compound was also tested for its in vivo antidiabetic potential using Sprague-Dawley rats as experimental animals. The effects of various doses of catechin in STZ (Streptozotocin) induced diabetic rats on fasting blood glucose level, body weight, lipid parameters, hepatic enzymes, and renal functions were evaluated using the reported protocols. The CTN exhibited the highest percent antioxidant for free radical scavenging activity against DPPH and ABTS free radicals, and inhibited the activity of carbohydrate digestive enzymes (with percent inhibition values: 79 ± 1.5% α-amylase and 80 ± 1.1% α-glucosidase). Administration CTN and standard glibenclamide significantly decreased the fasting blood glucose level and increased the body weight in STZ-induced diabetic rats. CTN significantly decreased the different lipid parameters, hepatic, and renal function enzyme levels along with Hb1c level in diabetic rats, while significantly increasing the high-density lipoprotein (HDL) level with values comparable to the standard glibenclamide. Further, the altered levels of glutathione and lipid peroxides of liver and kidney tissues were restored (by CTN) to levels similar to the control group. CTN significantly increased the antioxidant enzyme activities, total content of reduced glutathione, and reduced the malondialdehyde (MDA) level in rat liver and kidney tissues homogenates, and also corrected the histopathological abnormalities, suggesting its antioxidant potential.

scholarly journals GAMBARAN KADAR GLUKOSA DARAH PUASA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI ANGKATAN 2011 DENGAN INDEKS MASSA TUBUH ≥ 23 kg/m2

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Gracia Rorong ◽  
Stefana Kaligis ◽  
Diana Purwanto
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Body Mass ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Fasting Blood Glucose Level ◽  
Cross Sectional ◽  
Purposive Sampling

Abstract: Glucose is a main compound that has important role in preparation and development  of energy in human body. Blood glucose level is the amount of glucose in the blood. One of the factors that affects blood glucose level is body weight. Body weight is affected by several factors, such as aged, gender, and physical activities. Overweight may cause insulin resistance, results in increasing of the blood glucose level. This study aimed to describe the fasting blood glucose level at students Faculty of Medicine year 2011 Sam Ratulangi University with Body Mass Index (BMI) ≥23 kg/m2. Research method used for this study was cross sectional descriptive survey with purposive sampling method. From 26 respondents, 12 overweight (BMI ≥23 kg/m2) respondents (46,15%) had average fasting blood glucose level 85,4 mg/dL and 14 obese (BMI ≥25 kg/m2) respondents (53,85%) had average fasting blood glucose level 86 mg/dL. Conclusion: the description of fasting blood glucose level at students Faculty of Medicine year 2011 Sam Ratulangi University with Body Mass Index (BMI) ≥23 kg/m2 is at normal level (80-100 mg/dL). Keywords: BMI ≥23 kg/m2, Fasting blood glucose, students year 2011     Abstrak: Glukosa merupakan suatu molekul utama yang berperan penting dalam penyediaan dan pembentukan energi di dalam tubuh. Kadar glukosa darah adalah jumlah kandungan glukosa dalam darah. Salah satu faktor yang mempengaruhi kadar glukosa darah adalah berat badan. Berat badan dipengaruhi oleh beberapa faktor, antara lain usia, jenis kelamin, dan aktivitas fisik. Kelebihan berat badan dapat menyebabkan resistensi insulin sehingga kadar glukosa dalam darah meningkat. Peningkatan kadar glukosa darah merupakan salah satu penanda sindroma metabolik. Penelitian ini bertujuan untuk mengetahui gambaran kadar glukosa darah puasa pada mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi Angkatan 2011 dengan Indeks Massa Tubuh (IMT) ≥23 kg/m2. Jenis penelitian berupa penelitian survey deskriptif cross sectional dengan metode purposive sampling. Sampel penelitian sebanyak 26 orang responden. Hasil penelitian ini didapatkan 12 orang responden (46,15%) yang overweight (IMT ≥23 kg/m2) memiliki rata-rata kadar glukosa darah puasa 85,4 mg/dL dan 14 orang responden (53,85%) yang obesitas (IMT ≥25 kg/m2) memilki rata-rata kadar glukosa darah puasa 86 mg/dL. Simpulan: semua responden mahasiswa Fakultas Kedokteran Universitas Sam Ratulangi Angkatan 2011 memiliki kadar glukosa darah puasa normal (80-100 mg/dL). Kata Kunci: Glukosa darah puasa, IMT ≥23 kg/m2, mahasiswa angkatan 2011

scholarly journals Impact of Momordica Charantia (Karela) on the Fasting Blood Glucose level in the Streptozotocin-Induced Diabetic Rats

1970 ◽  
Vol 9 (1) ◽  
pp. 45-48
Author(s):  
S Mohal ◽  
DK Mondal ◽  
PK Chowdhury ◽  
A Khanom ◽  
KM Shamim
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Momordica Charantia ◽  
Key Words Diabetes ◽  
Fasting Blood Glucose Level ◽  
The Mean

Context: Scientific studies revealed the hypoglycaemic properties of momordica charantia. The present study was carried out to find out microscopically whether Momordica charantia (karela) has got any impact lowering of FBG (Fasting Blood Glucose) level in diabetes mellitus. Study type: an experiemental study. Setting: Anatomy department of the then IPGMR (Institute of Post Graduate Medicine and Research) at present BSMMU (Bangabandhu Sheikh Mujib Medical University) and BIRDEM (Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine & Metabolic Disorders). Subjects: Sixty five healthy young Long Evans rats of male sex weighing 150 to 280gm aged between 10 to 12 weeks were used in this study. Methods: The rats were divided into four equal groups depending on their different sorts of dietry feeding and drug treatment. Main outcome measures: variation of differential FBG level in different groups of rat. Result: Mean 'initial' and 'final' (on day 7 and day 51 from Streptozotocin/vehicle injection) fasting blood glucose (FBG) level in the control group (Group-A) was 7.872 ± 0.60 and 8.55 ± 0.82 respectively. Therefore the mean (FBG) increased by about 13% (P = 0.022*) which is higher than that of the initial value. In untreated diabetic group the mean initial (FBG) level was 25.95 ± 8.90 and the mean final was 24.02 ± 4.08. So here, the (FBG) level decreased by about 13% (P = 0.557). On the other hand, in the insulintreated diabetic rats the mean initial (FBG) level was 24.35 ± 6.81 and the mean final was 8.38 ± 5.02, which is lower (P = 0.000*) & in the karela–treated diabetic rats, the initial (FBG) level was 23.03 ± 5.70 and the mean final was 5.65 ± 1.29 which is lower* (P = 0.000*). The value in the insulin-treated diabetic rats & in the karela-treated diabetic rats were significantly lower than that of the untreated diabetic rats (P = 0.007) & (P= 0.005) respectively. But there was no significant difference between the insulin-treated diabetic rats & the karela-treated diabetic rats (P = 0.605) in this regard. Conclusion: Karela showed a tendency of acting against hyperglycemic effects of Streptozotocin-induced diabetes mellitus. However, further investigations are recommended for establishing karela as a safe, useful effective anti- hyperglycemic agent as well as antidiabetogenic agent. Key words: Diabetes mellitus; Hyperglycemia; Momordica charantia (karela) DOI: http://dx.doi.org/ 10.3329/bja.v9i1.8148 Bangladesh Journal of Anatomy January 2011, Vol. 9 No. 1 pp 45-48  

scholarly journals Effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. Hydro-alcoholic Extracts Either Alone or in Combination on Blood Glucose Level in Diabetic Rats

2020 ◽  
Vol 11 (4) ◽  
pp. 759-764
Author(s):  
Murtaza Haidari ◽  
Kawsar Alami ◽  
Arefa Hossaini ◽  
Sayed Yousof Mousavi
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Body Weight Loss ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Hibiscus Sabdariffa ◽  
Carum Carvi

Combination therapy is considered as a new and effective therapeutic strategy for control of hyperglycemia. The present study aimed to determine the hypoglycemic effect of Afghan Hibiscus sabdariffa L. and Carum Carvi L. hydro-alcoholic extracts either alone or in combination on diabetic rats. Streptozotocin-induced diabetic rats were administered intraperitoneally with hydro-alcoholic extracts of H. sabdariffa (75, 150 and 300 mg/kg), C. carvi (150, 300 and 500 mg/kg) and their combinations for 21 days. The Fasting blood glucose and body weight of rats were determined on 0, 7, 14 and 21st days. The results showed a significant (P<0.0001) hypoglycemic effect of H. sabdariffa extract (75, 150 and 300 mg/kg) on 7, 14 and 21th days, C. carvi extract (500 mg/kg), and their effective doses combination (75:25), especially on 7th day. Only 75 mg/kg of H. sabdariffa had positive effect on body weight loss of diabetic rats (P<0.05). One can conclude that Afghan H. sabdariffa and C. carvi hydro-alcoholic extracts and their combination have a hypoglycemic effect. However, their combinations do not have any synergic effects, so the hypoglycemic effect of H. sabdariffa was much greater and even normalized the blood glucose level.

scholarly journals Hypoglycemic Effects in Alloxan-Induced Diabetic Rats of the Phenolic Extract Enriching Ellagic Acid, Kaempferol and Their Derivatives from Mongolian Oak Cups

2018 ◽  
Author(s):  
Peipei Yin ◽  
Yu Wang ◽  
Lingguang Yang ◽  
Jinling Sui ◽  
Yujun Liu
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Ellagic Acid ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Protein Glycation ◽  
Fasting Blood Glucose Level ◽  
Mongolian Oak ◽  
Alpha Glucosidase

Our previous in vitro reports showed that crude extract prepared with 50% ethanol (ethanol crude extract, ECE) from Mongolian oak cups possessed excellent antioxidant capacities as well as inhibitory activities against &alpha;-glucosidase, &alpha;-amylase and protein glycation caused by its enrichment in phenolics, including mainly ellagic acid, kaempferol and their derivatives. Nevertheless, few in vivo studies on antidiabetic activities of these phenolics were conducted. The present study investigated hypoglycemic effects with normal and diabetic rats being administrated orally without or with ECE at 200 and 800 mg/kg for 15 days. In normal rats, no significant differences were exhibited after ECE administration in body weight, fasting blood glucose level, levels of chelesterol, triglyceride, LDL and AST in serum, organ indexes, and levels of GSH and MDA in organs. In diabetic rats, the fasting blood glucose level, indexes of heart and liver, and levels of chelesterol and triglyceride in serum and MDA in heart tissue were significantly decreased. Moreover, HDL levels in serum and SOD activities in the four organs of diabetic rats were significantly improved after ECE administration at 800 mg/kg. Thus, in addition to inhibiting &alpha;-glucosidase, &alpha;-amylase and protein glycation reported previously, oak cups might contain novel dietary phytonutrients in preventing abnormal changes in blood glucose and lipid profile and attenuating oxidant stress in vivo. The results also implied that it is ellagic acid, kaempferol and their derivatives enriched in ECE that might play vital roles in managing type 1 as well as type 2 diabetes.

scholarly journals Effects of ginger juice on blood glucose in alloxan induced diabetes mellitus in rats

2015 ◽  
Vol 23 (1) ◽  
pp. 14-17 ◽  
Author(s):  
Selima Sultana ◽  
Md Ismail Khan ◽  
Hasanur Rahman ◽  
Abu Sadat Mohammad Nurunnabi ◽  
Rokhsana Dil Afroz
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Zingiber Officinale ◽  
Control Group ◽  
Fasting Blood Glucose Level ◽  
Medical College ◽  
Group D

Objective: To find out the effects of ginger (Zingiber officinale) juice blood glucose in alloxan induced-diabetes mellitus in rats. Methods: This experimental study was done in the Department of Pharmacology & Therapeutics, Dhaka Medical College, Dhaka, in collaboration with the Departments of Pathology, Ibrahim Medical College, Dhaka between January and December 2009. This experimental animal study was divided into two parts, which were Experiment-1 and Experiment-2. Experiment 1 comprises of 12 rats and divided into 2 groups each group having 6 rats. Rats of group-A was non-diabetic normal control group and group-B was fed with ginger (Zingiber officinale) in a dose of 4ml/kg body weight orally through Ryle’s tube. Experiment-2 comprised of 12 rats divided into 2 groups each containing 6 rats labeled as group C, group D. Rats of groups C administered alloxan 150 mg/kg intraperitoneally on the 2nd day of the study. Rats of group D were administered alloxan 150mg /kg intraperitoneally and ginger (4ml/kg of body weight orally) on the 2nd day of the study. Results: The fasting blood glucose level at day 12 in the rats treated with ginger (Zingiber officinale) 4 ml /kg body weight orally daily for 12 days showed reduction in fasting blood glucose level as compared to control group, but not significant, which indicates that ginger has no effect in lowering blood glucose of normal rats. The fasting blood glucose levels at day 12 in the rats of group D (treated with ginger and alloxan) showed highly significant reduction in fasting blood glucose level as compared to diabetic control group (p<0.002). Conclusion: Consumption of ginger produced a significant antihyperglycemic effect in experimentally induced diabetic rats. DOI: http://dx.doi.org/10.3329/jdmc.v23i1.22687 J Dhaka Medical College, Vol. 23, No.1, April, 2014, Page 14-17

scholarly journals Antidiabetic Activity ofAcacia tortilis(Forsk.) Hayne ssp. raddiana Polysaccharide on Streptozotocin-Nicotinamide Induced Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Pradeep Kumar Bhateja ◽  
Randhir Singh
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Total Cholesterol ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Antidiabetic Activity ◽  
Control Group ◽  
Fasting Blood Glucose Level

The present study was designed to investigate the antidiabetic activity of aqueous extract ofAcacia tortilispolysaccharide (AEATP) from gum exudates and its role in comorbidities associated with diabetes in STZ-nicotinamide induced diabetic rats. Male albino Wistar rats were divided into control, diabetic control, glimepiride treated (10 mg/kg), and diabetic rats treated with 250, 500, and 1000 mg/kg dose of AEATP groups and fasting blood glucose, glycated hemoglobin, total cholesterol, triglyceride, LDL, VLDL, HDL, SGOT, and SGPT levels were measured. STZ significantly increased fasting blood glucose level, glycated hemoglobin, total cholesterol, triglyceride, LDL, VLDL, SGOT, and SGPT levels, whereas HDL level was reduced as compared to control group. After 7 days of administration, 500 and 1000 mg/kg dose of AEATP showed significant reduction(P<0.05)in fasting blood glucose level compared to diabetic control. AEATP has also reduced total cholesterol, triglyceride, LDL, VLDL, SGOT, and SGPT levels and improved HDL level as compared to diabetic control group. Our study is the first to report the normalization of fasting blood glucose level, lipid profile, and liver enzyme in AEATP treated diabetic rats. Thus, it can be concluded that AEATP may have potentials for the treatment of T2DM and its comorbidities.

scholarly journals Squalene decreased fasting blood glucose level of type ii diabetic rats

2021 ◽  
Vol 912 (1) ◽  
pp. 012088
Author(s):  
T Widyawati ◽  
S Syarifah ◽  
I B Sumantri
Keyword(s):  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Fasting Blood Glucose ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
High Dose ◽  
Type Ii ◽  
Fasting Blood Glucose Level ◽  
Group I

Abstract Squaleneis a chemical compound that has been reported to have antidiabetic activity. The present study aimed to investigate the effect of squalene on fasting blood glucose level (FBGL) in type 2 diabetic rats. Diabetes type II in rats was obtained by giving nicotinamide (120 mg/kg) before high dose streptozotocin (60 mg/kg) intraperitoneally. A total of 18 diabetic rats were divided into 3 groups and served once daily for 12 days as follows; Group I Aquades (Diabetic Control) 10 ml/kg, Group II (Metformin 45 mg/kg) and Group III (Squalene 160 mg/kg). FBGL was measured at day 0, day 6 and day 12. The results showed that FBGL in both Squalene- (194.67 ± 28.32 mg/dL) and Metformin- (178.50 ± 34.27 mg/dL) were significantly decreased after 12 days intervention compared to Diabetic Control-treated groups (438.33 ± 65.79 µmol/L) with p<0.001. This study concluded that squalene was able to decrease FBGL in type II diabetic rats.

Sign in / Sign up

Export Citation Format

Share Document