ADAM17 regulates prostate cancer cell proliferation through mediating cell cycle progression by EGFR/PI3K/AKT pathway

2011 ◽  
Vol 359 (1-2) ◽  
pp. 235-243 ◽  
Author(s):  
Ping Lin ◽  
Xicai Sun ◽  
Tian Feng ◽  
Haifeng Zou ◽  
Ying Jiang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Cell Cycle Progression ◽  
Prostate Cancer Cell ◽  
Akt Pathway ◽  
Cancer Cell Proliferation ◽  
Cycle Progression

scholarly journals Tectonic 1 accelerates gastric cancer cell proliferation and cell cycle progression in vitro

2015 ◽  
Vol 12 (4) ◽  
pp. 5897-5902 ◽  
Author(s):  
XINBAO WANG ◽  
QIMING YU ◽  
YINGLI ZHANG ◽  
ZHIQIANG LING ◽  
PENGFEI YU
Keyword(s):  
Gastric Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Cell Cycle Progression ◽  
Gastric Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cycle Progression ◽  
Gastric Cancer Cell Proliferation

scholarly journals LncRNA EPIC1 Promotes Cancer Cell Proliferation and Inhibits Apoptosis in Gallbladder Cancer Interacting with lncRNA LET

2020 ◽  
Author(s):  
Changbo Fu ◽  
Lei Nie ◽  
Tao Yin ◽  
Xuan Xu ◽  
weijun lu
Keyword(s):  
Cell Cycle ◽  
Cell Proliferation ◽  
Gallbladder Cancer ◽  
Cancer Cell ◽  
Cell Cycle Progression ◽  
Human Cancer ◽  
Cancer Cell Proliferation ◽  
Cycle Progression ◽  
Tumor Tissues ◽  
Proliferation And Apoptosis

Abstract Background: LncRNA EPIC1 is likely involved in human cancer by promoting cell cycle progression. Our study was carried out to investigate the involvement of EPIC1 in gallbladder cancer (GBC). Methods: Expression levels of EPIC1 in two types of tissues (GBC and paracancerous) and plasma were measured by performing qPCR. GBC-SD and SGC-996 cells were transfected with LET and EPIC1 expression vectors.Results: In the preset study we found that EPIC1 was upregulated in tumor tissues than in paracancerous tissues of GBC patients, and plasma levels of EPIC1 were significantly correlated with levels of EPIC1 in tumor tissues. LncRNA LET was downregulated in tumor tissues than in paracancerous tissues and was inversely correlated with EPIC1 in both tumor tissues and paracancerous tissues. Overexpression of EPIC1 led to downregulated LET, and LET overexpression also mediated the downregulation of EPIC1. EPIC1 led to accelerated GBC cell proliferation and inhibited apoptosis. Overexpression of LET played opposites roles. In addition, overexpression of LET also attenuated the effects of EPIC1 overexpression on cancer cell proliferation and apoptosis. Conclusion: Therefore, therefore, lncRNA EPIC1 may promote cancer cell proliferation and inhibit apoptosis in GBC by interacting with LET.

scholarly journals Knockdown of prostaglandin reductase 1 (PTGR1) suppresses prostate cancer cell proliferation by inducing cell cycle arrest and apoptosis

2016 ◽  
Vol 10 (2) ◽  
pp. 133-139 ◽  
Author(s):  
Li Xue ◽  
Zhen Zhu ◽  
Ziming Wang ◽  
Hecheng Li ◽  
Peng Zhang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Cycle ◽  
Cell Proliferation ◽  
Cell Cycle Arrest ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Cycle Arrest

scholarly journals AB044. AGE/RAGE/Akt pathway contributes to prostate cancer cell proliferation by promoting Rb phosphorylation and degradation

2016 ◽  
Vol 5 (S1) ◽  
pp. AB044-AB044 ◽  
Author(s):  
Jiming Bao ◽  
Yawei Bao ◽  
Shanchao Zhao ◽  
Minyi He ◽  
Haihua Luo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Akt Pathway ◽  
Cancer Cell Proliferation ◽  
Rb Phosphorylation
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