Regulatory Effects of Stevia Rebaudiana on NADPH Oxidase-Related Manifestations of Oxidative Stress in Diabetic Rats with Spinal Cord Injury

2021 ◽  
Author(s):  
K. V. Simonyan ◽  
V. A. Chavushyan ◽  
L. G. Avetisyan ◽  
R. M. Simonyan ◽  
A. S. Isoyan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nadph Oxidase ◽  
Stevia Rebaudiana ◽  
Diabetic Rats ◽  
Cord Injury ◽  
Regulatory Effects

NADPH Oxidase and Superoxide-Producing Associates in Cells of the Spinal Cord and Bone Marrow in Diabetic Rats with Spinal Cord Injury

2021 ◽  
Author(s):  
K. V. Simonyan ◽  
V. A. Chavushyan ◽  
A. G. Lorikyan ◽  
R. M. Simonyan ◽  
L. G. Avetisyan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Nadph Oxidase ◽  
Diabetic Rats ◽  
Cord Injury ◽  
In Cells

scholarly journals Inhibition of TREM1 reduces inflammation and oxidative stress after spinal cord injury (SCI) associated with HO-1 expressions

2019 ◽  
Vol 109 ◽  
pp. 2014-2021 ◽  
Author(s):  
Zhenhuan Li ◽  
Furong Wu ◽  
Dafeng Xu ◽  
Zhongzheng Zhi ◽  
Guanghui Xu
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury ◽  
And Oxidative Stress

Polydatin attenuates spinal cord injury in rats by inhibiting oxidative stress and microglia apoptosis via Nrf2/HO-1 pathway

Life Sciences ◽  
2019 ◽  
Vol 217 ◽  
pp. 119-127 ◽  
Author(s):  
Runxiao Lv ◽  
Lili Du ◽  
Lixin Zhang ◽  
Zhiqiang Zhang
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cord Injury

scholarly journals pH-responsive delivery of H2 through ammonia borane-loaded mesoporous silica nanoparticles improves recovery after spinal cord injury by moderating oxidative stress and regulating microglial polarization

2021 ◽  
Author(s):  
Yi Liu ◽  
Yeying Wang ◽  
Bing Xiao ◽  
Guoke Tang ◽  
Jiangming Yu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Ammonia Borane ◽  
Neural Regeneration ◽  
Dependent Manner ◽  
Cord Injury

Abstract Imbalance of oxidative and inflammatory regulation is the main contributor to neurofunctional deterioration and failure of rebuilding spared neural networks after spinal cord injury (SCI). As an emerging biosafe strategy for protecting against oxidative and inflammatory damage, hydrogen (H2) therapy is a promising approach for improving the microenvironment to allow neural regeneration. However, achieving release of H2 at sufficient concentrations specifically into the injured area is critical for the therapeutic effect of H2. Thus, we assembled SiO2@mSiO2 mesoporous silica nanoparticles and loaded them with ammonia borane (AB), which has abundant capacity and allows controllable release of H2 in an acid-dependent manner. The release of H2 from AB/SiO2@mSiO2 was satisfactory at pH 6.6, which is approximately equal to the microenvironmental acidity after SCI. After AB/SiO2@mSiO2 were intrathecally administered to rat models of SCI, continuous release of H2 from these nanoparticles synergistically enhanced neurofunctional recovery, reduced fibrotic scar formation and promoted neural regeneration by suppressing oxidative stress reaction. Furthermore, in the subacute phase of SCI, microglia were markedly polarized toward the M2 phenotype by H2 via inhibition of TLR9 expression in astrocytes. In conclusion, H2 delivery through AB/SiO2@mSiO2 has the potential to efficiently treat SCI through comprehensive modulation of the oxidative and inflammatory imbalance in the microenvironment.

Protective role of β-carotene against oxidative stress and neuroinflammation in a rat model of spinal cord injury

2018 ◽  
Vol 61 ◽  
pp. 92-99 ◽  
Author(s):  
Lihui Zhou ◽  
Lian Ouyang ◽  
Shuangzhi Lin ◽  
Song Chen ◽  
YingJie Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Protective Role ◽  
Cord Injury ◽  
Β Carotene

Protective effect of Oxymatrine against acute spinal cord injury in rats via modulating oxidative stress, inflammation and apoptosis

2019 ◽  
Vol 35 (1) ◽  
pp. 149-157
Author(s):  
Binggang Guan ◽  
Rongchun Chen ◽  
Mingliang Zhong ◽  
Ning Liu ◽  
Qin Chen
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Protective Effect ◽  
Acute Spinal Cord Injury ◽  
Cord Injury

The antioxidant effect of β-Glucan on oxidative stress status in experimental spinal cord injury in rats

2005 ◽  
Vol 28 (4) ◽  
pp. 298-302 ◽  
Author(s):  
Hakan Kayali ◽  
M. Fatih Ozdag ◽  
Serdar Kahraman ◽  
Ahmet Aydin ◽  
Engin Gonul ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Antioxidant Effect ◽  
Experimental Spinal Cord Injury ◽  
Cord Injury ◽  
Oxidative Stress Status
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