Inhibition of Nuclear Factor Erythroid 2-Related Factor 2 Exacerbates HIV-1 gp120-Induced Oxidative and Inflammatory Response: Role in HIV Associated Neurocognitive Disorder

2012 ◽  
Vol 37 (8) ◽  
pp. 1697-1706 ◽  
Author(s):  
Pichili Vijaya Bhaskar Reddy ◽  
Marisela Agudelo ◽  
Venkata S. R. Atluri ◽  
Madhavan P. Nair
Keyword(s):  
Inflammatory Response ◽  
Related Factor ◽  
Neurocognitive Disorder ◽  
Nuclear Factor ◽  
Hiv Associated Neurocognitive Disorder ◽  
Hiv 1

scholarly journals HIV-1 Tat increases BAG3 via NF-κB signaling to induce autophagy during HIV-associated neurocognitive disorder

Cell Cycle ◽  
2018 ◽  
Vol 17 (13) ◽  
pp. 1614-1623 ◽  
Author(s):  
Xiaoyan Wu ◽  
Huaqian Dong ◽  
Xiang Ye ◽  
Li Zhong ◽  
Tiantian Cao ◽  
...  
Keyword(s):  
Neurocognitive Disorder ◽  
Hiv Associated Neurocognitive Disorder ◽  
Hiv 1

scholarly journals Corrigendum: Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis

2022 ◽  
Vol 15 ◽  
Author(s):  
Huaqian Dong ◽  
Xiang Ye ◽  
Li Zhong ◽  
Jinhong Xu ◽  
Jinhua Qiu ◽  
...  
Keyword(s):  
Neuronal Apoptosis ◽  
Neurocognitive Disorder ◽  
Hiv Associated Neurocognitive Disorder ◽  
Hiv 1

scholarly journals Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling

2021 ◽  
Vol 15 ◽  
Author(s):  
Yue Fu ◽  
Jianping Jia
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Response ◽  
Molecular Mechanisms ◽  
Morphological Changes ◽  
No Production ◽  
Related Factor ◽  
Nuclear Factor ◽  
Qrt Pcr ◽  
Bv2 Cells ◽  
And Oxidative Stress

BackgroundNeuroinflammation and oxidative stress are two major pathological characteristics of Alzheimer’s disease (AD). Amyloid-β oligomers (AβO), a toxic form of Aβ, promote the neuroinflammation and oxidative stress in the development of AD. Isoliquiritigenin (ISL), a natural flavonoid isolated from the root of liquorice, has been shown to exert inhibitory effects on inflammatory response and oxidative stress.ObjectivesThe main purpose of this study is to assess the influence of ISL on inflammatory response and oxidative stress in BV2 cells stimulated with AβO, and to explore the underlying molecular mechanisms.Methods3-(4,5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-H- tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) cytotoxicity assays were used to assess the toxic or protective effects of ISL. The expression levels of interleukin-1β, interleukin-6, and tumor necrosis factor-α were assessed by quantitative real-time polymerase chain reaction (qRT-PCR) and enzyme-linked immunosorbent assays. Morphological changes in BV2 cells were assessed by immunofluorescence method. Nitric oxide (NO) assay kit was used to determinate the NO production. Western blot, qRT-PCR and immunofluorescence were used to explore the underlying molecular mechanisms.ResultsISL treatment reduced the production of inflammatory cytokines and NO, and alleviated the morphological changes in BV2 cells induced by AβO. ISL treatment further protected N2a cells from the toxic medium of AβO-stimulated BV2 cells. ISL activated nuclear factor erythroid-2 related factor 2 (Nrf2) signaling and suppressed nuclear factor-κB (NF-κB) signaling in BV2 cells.ConclusionISL suppresses AβO-induced inflammation and oxidative stress in BV2 cells via the regulation of Nrf2/NF-κB signaling. Therefore, ISL indirectly protects neurons from the damage of toxic conditioned media.

scholarly journals Protective role of nuclear factor erythroid 2-related factor 2 in the hemorrhagic shock-induced inflammatory response

2016 ◽  
Vol 37 (4) ◽  
pp. 1014-1022 ◽  
Author(s):  
HAIGE ZHAO ◽  
SIJING HAO ◽  
HONGFEI XU ◽  
LIANG MA ◽  
ZHENG ZHANG ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Hemorrhagic Shock ◽  
Protective Role ◽  
Related Factor ◽  
Nuclear Factor

scholarly journals HIV-1 Tat upregulates expression of histone deacetylase-2 (HDAC2) in human neurons: Implication for HIV-associated neurocognitive disorder (HAND)

2011 ◽  
Vol 58 (6) ◽  
pp. 656-664 ◽  
Author(s):  
Zainulabedin M. Saiyed ◽  
Nimisha Gandhi ◽  
Marisela Agudelo ◽  
Jessica Napuri ◽  
Thangavel Samikkannu ◽  
...  
Keyword(s):  
Histone Deacetylase ◽  
Neurocognitive Disorder ◽  
Histone Deacetylase 2 ◽  
Human Neurons ◽  
Hiv Associated Neurocognitive Disorder ◽  
Hiv 1

scholarly journals Preliminary Trichinella spiralis Infection Ameliorates Subsequent RSV Infection-Induced Inflammatory Response

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1314
Author(s):  
Ki-Back Chu ◽  
Hae-Ahm Lee ◽  
Hae-Ji Kang ◽  
Eun-Kyung Moon ◽  
Fu-Shi Quan
Keyword(s):  
Inflammatory Response ◽  
Trichinella Spiralis ◽  
Pulmonary Inflammation ◽  
High Rate ◽  
Related Factor ◽  
Nuclear Factor ◽  
Rsv Infection ◽  
Syncytial Virus ◽  
Helminth Therapy ◽  
Nrf2 Expression

Respiratory syncytial virus (RSV) infection affects the lives of neonates throughout the globe, causing a high rate of mortality upon hospital admission. Yet, therapeutic options to deal with this pulmonary pathogen are currently limited. Helminth therapy has been well received for its immunomodulatory role in hosts, which are crucial for mitigating a multitude of diseases. Therefore, in this study, we used the helminth Trichinella spiralis and assessed its capabilities for modulating RSV infection as well as the inflammatory response induced by it in mice. Our results revealed that RSV-specific antibody responses were enhanced by pre-existing T. spiralis infection, which also limited pulmonary viral replication. Diminished lung inflammation, indicated by reduced pro-inflammatory cytokines and inflammatory cell influx was confirmed, as well as through histopathological assessment. We observed that inflammation-associated nuclear factor kappa-light-chain enhancement of activated B cells (NF-κB) and its phosphorylated forms were down-regulated, whereas antioxidant-associated nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression was upregulated in mice co-infected with T. spiralis and RSV. Upregulated Nrf2 expression contributed to increased antioxidant enzyme expression, particularly NQO1 which relieved the host of oxidative stress-induced pulmonary inflammation caused by RSV infection. These findings indicate that T. spiralis can mitigate RSV-induced inflammation by upregulating the expression of antioxidant enzymes.

scholarly journals Effects of Launaea sarmentosa Extract on Lipopolysaccharide-Induced Inflammation via Suppression of NF-κB/MAPK Signaling and Nrf2 Activation

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2586 ◽  
Author(s):  
Thanh Q. C. Nguyen ◽  
Tran Duy Binh ◽  
Ryo Kusunoki ◽  
Tuan L. A. Pham ◽  
Yen D. H. Nguyen ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Inflammatory Response ◽  
Molecular Mechanisms ◽  
Inflammatory Diseases ◽  
Mapk Signaling ◽  
Mitogen Activated Protein Kinase ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Nuclear Factor ◽  
Akt Phosphorylation

Launaea sarmentosa has been extensively used as a nutrient herb in traditional Vietnamese remedies for the treatment of various diseases, especially inflammatory diseases. However, no detailed research has been conducted examining the molecular mechanisms involved in the suppression of inflammatory response. Here, we studied the effects of L. sarmentosa methanol extract on lipopolysaccharide (LPS)-induced inflammation using RAW 264.7 macrophages. The extract demonstrated potent antioxidant activity owing to the presence of polyphenolic and flavonoid components. Pretreatment with the extract inhibited LPS-mediated secretion of nitric oxide, reactive oxygen species, and tumor necrosis factor-α as well as the expression of inflammatory cytokines. Furthermore, the activation of the nuclear factor-kappa B pathway and phosphoinositide-3-kinase/protein kinase B pathways was blocked by the extract by inhibiting Akt phosphorylation. Additionally, the mitogen-activated protein kinase pathway was suppressed, and endoplasmic reticulum stress was attenuated. Furthermore, the extract promoted the activity of nuclear factor erythroid-2-related factor 2 resulting in the up-regulation of heme oxygenase-1 pathway, leading to the suppression of oxidative stress and inflammatory response. Taken together, the results indicate that L. sarmentosa exhibits anti-inflammatory effects, and hence, can be further developed as a novel drug for the treatment of diseases associated with excessive inflammation.

scholarly journals Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis

2019 ◽  
Vol 13 ◽  
Author(s):  
Huaqian Dong ◽  
Xiang Ye ◽  
Li Zhong ◽  
Jinhong Xu ◽  
Jinhua Qiu ◽  
...  
Keyword(s):  
Neuronal Apoptosis ◽  
Neurocognitive Disorder ◽  
Hiv Associated Neurocognitive Disorder ◽  
Hiv 1
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