Background:
Neuropathic pain responds poorly to drug treatments. The present study investigated
the therapeutic effect of Portulaca oleracea, in chronic constriction injury (CCI)-induced
neuropathic pain in rats.
Objective & Methods:
Neuropathic pain was performed by putting four loose ligatures around the sciatic
nerve. CCI resulted in the development of heat hyperalgesia, mechanical allodynia and cold allodynia
accompanied by an increase in the contents of TNF-α, IL1β, malondialdehyde, with a reduction
in total thiol content.
Results:
Administration of Portulaca oleracea (100 and 200 mg/kg intraperitoneal) for 14 days in CCI
rats significantly alleviated pain-related behaviors, oxidative damage and inflammatory cytokines in a
dose-dependent manner.
Conclusion:
In conclusion, it is suggested that the antinociceptive effects of Portulaca oleracea might
be due to antioxidant and anti-inflammatory properties.