Bray–Liebhafsky oscillatory reaction as the matrix system for the kinetic determination of microquantities of alizarin and purpurin

Objectives: Fentanyl is a potent synthetic opioid used for the management of chronic pain. A newer transdermal matrix system was developed and compared with a reservoir system used in the United States.Setting: An open-label, single-center, randomized, two-period crossover study was conducted to evaluate the bioequivalence of the transdermal matrix system to the transdermal reservoir system. Seventy-four subjects completed treatment with both the reservoir system (100 μg/h) and the matrix system (100 μg/h), each applied for 72 hours. After application of the first system, subjects completed a 9-day washout and then crossed over to receive the other system for another 72 hours.Main outcome measure: Blood samples for the determination of serum fentanyl concentrations were taken in each treatment period for up to 120 hours following application.Results: The ratios of geometric means for maximum fentanyl concentration (Cmax) and area under the concentration-time curve (AUClast and AUC∞ ) were 106 percent, 110 percent, and 110 percent, respectively. The 90% confidence intervals for the ratios of the geometric means were contained within the bioequivalence criteria of 80-125 percent. The matrix system adhered well to skin. Systemic and topical safety profiles were comparable between treatments.Conclusions: The transdermal fentanyl matrix system adhered well, was well tolerated, and produced systemic exposures of fentanyl that were bioequivalent to the reservoir system.

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Kinetic Determination of Microquantities of Rutin by Perturbation of the Bray-Liebhafsky Oscillatory Reaction in an Open System

Microchimica Acta ◽

10.1007/s00604-003-0071-8 ◽

2003 ◽

Vol 143 (4) ◽

pp. 261-267 ◽

Cited By ~ 11

Author(s):

Nata?a Pejic ◽

Slobodan Anic ◽

Vesna Kuntic ◽

Vladana Vukojevic ◽

Ljiljana Kolar-Anic

Keyword(s):

Open System ◽

Oscillatory Reaction ◽

Kinetic Determination

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Kinetic determination of morphine by means of Bray–Liebhafsky oscillatory reaction system using analyte pulse perturbation technique

Analytica Chimica Acta ◽

10.1016/j.aca.2006.09.026 ◽

2007 ◽

Vol 582 (2) ◽

pp. 367-374 ◽

Cited By ~ 22

Author(s):

Nataša D. Pejić ◽

Slavica M. Blagojević ◽

Slobodan R. Anić ◽

Vladana B. Vukojević ◽

Miroslav D. Mijatović ◽

...

Keyword(s):

Perturbation Technique ◽

Reaction System ◽

Oscillatory Reaction ◽

Kinetic Determination ◽

Pulse Perturbation ◽

Analyte Pulse Perturbation Technique

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Analysis of the results of thermal treatment of single crystals of silicon doped with boron impurity

Theory and practice of metallurgy ◽

10.34185/tpm.1.2019.10 ◽

2019 ◽

Vol 1 (1) ◽

pp. 77-80

Author(s):

Panchenko O ◽

Chervony I

Keyword(s):

Heat Treatment ◽

Single Crystals ◽

Self Control ◽

Matrix System ◽

Electric Resistance ◽

Technological Parameters ◽

The Matrix ◽

Specific Electric Resistance ◽

Silicon Doped

Two groups of plastins of single-crystals of silicon doped with boron, were preliminary grown by the method of Chochralsky and thermally treat. Got values of specific electric resistance at different terms realizations of heat treatment served as a weekend by data. On the basis of the obtained experimental data were conducted: analysis of variance of the matrix system, estimation of results on the criterion of Cochren and Student. Built mathematical models. Determination of values of optimal technological parameters allowed objectively, taking into account influence of factors, to educe the maximum-possible circle of values for the receipt of necessary results. For basis accepted the change of temperature of heat treatment and time of self-control. All got experimental job performances are recreated and real at the construction of matrix of planning.

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Lateral resolution of the electron microbeam analysis

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100109859 ◽

1978 ◽

Vol 36 (1) ◽

pp. 542-543

Author(s):

H.J. Dudek

Keyword(s):

Quantitative Analysis ◽

Depth Resolution ◽

Lateral Resolution ◽

Cylindrical Particle ◽

Correction Procedure ◽

X Ray ◽

Element Concentrations ◽

Microbeam Analysis ◽

The Matrix

The chemical inhomogenities in modern materials such as fibers, phases and inclusions, often have diameters in the region of one micrometer. Using electron microbeam analysis for the determination of the element concentrations one has to know the smallest possible diameter of such regions for a given accuracy of the quantitative analysis.In th is paper the correction procedure for the quantitative electron microbeam analysis is extended to a spacial problem to determine the smallest possible measurements of a cylindrical particle P of high D (depth resolution) and diameter L (lateral resolution) embeded in a matrix M and which has to be analysed quantitative with the accuracy q. The mathematical accounts lead to the following form of the characteristic x-ray intens ity of the element i of a particle P embeded in the matrix M in relation to the intensity of a standard S

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Determination of the phase structure of polymerblends by electron microscopy

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100109604 ◽

1978 ◽

Vol 36 (1) ◽

pp. 492-493

Author(s):

Dr. G. Kaemof

Keyword(s):

Screw Extruder ◽

Electron Microscopic ◽

Thin Sections ◽

Single Screw Extruder ◽

Transmission Electron ◽

The Matrix ◽

Twin Screw ◽

Special Case ◽

Microscopic Investigations

A mixture of polycarbonate (PC) and styrene-acrylonitrile-copolymer (SAN) represents a very good example for the efficiency of electron microscopic investigations concerning the determination of optimum production procedures for high grade product properties.The following parameters have been varied:components of charge (PC : SAN 50 : 50, 60 : 40, 70 : 30), kind of compounding machine (single screw extruder, twin screw extruder, discontinuous kneader), mass-temperature (lowest and highest possible temperature).The transmission electron microscopic investigations (TEM) were carried out on ultra thin sections, the PC-phase of which was selectively etched by triethylamine.The phase transition (matrix to disperse phase) does not occur - as might be expected - at a PC to SAN ratio of 50 : 50, but at a ratio of 65 : 35. Our results show that the matrix is preferably formed by the components with the lower melting viscosity (in this special case SAN), even at concentrations of less than 50 %.

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Polishing process effect on the image of dispersed precipitates

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100112646 ◽

1984 ◽

Vol 42 ◽

pp. 534-535

Author(s):

C.T. Hu ◽

C.W. Allen

Keyword(s):

Matrix Material ◽

Specimen Preparation ◽

Second Phase ◽

Precipitate Particle ◽

Polishing Process ◽

Second Phase Particles ◽

The Matrix ◽

Surface Profiles ◽

Thinning Process

One important problem in determination of precipitate particle size is the effect of preferential thinning during TEM specimen preparation. Figure 1a schematically represents the original polydispersed Ni3Al precipitates in the Ni rich matrix. The three possible type surface profiles of TEM specimens, which result after electrolytic thinning process are illustrated in Figure 1b. c. & d. These various surface profiles could be produced by using different polishing electrolytes and conditions (i.e. temperature and electric current). The matrix-preferential-etching process causes the matrix material to be attacked much more rapidly than the second phase particles. Figure 1b indicated the result. The nonpreferential and precipitate-preferential-etching results are shown in Figures 1c and 1d respectively.

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