Growth kinetics, metabolite yield, and expression analysis of biosynthetic pathway genes in friable callus cell lines of Rhodiola imbricata (Edgew)

Author(s):  
Shiv Rattan ◽  
Dinesh Kumar ◽  
Ashish R. Warghat
2014 ◽  
Vol 23 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Ch’ng Song Jin ◽  
Chan Lai Keng

Artemisinin, an important antimalarial drug against multidrug resistant strains of Plasmodium, can be produced in Artemisia annua L. Field production of artemisinin is affected by environmental condition and geographical location. In vitro production via cell suspension culture is an alternative mode and cell line selection is important to ensure sustainable production of biomass and artemisinin. Callus cell lines were derived from the leaf explants of five A. annua clones grown in two different locations in Vietnam. Thirty-four callus cell lines with consistent growth index (GI) were selected from these five clones and were categorized into fast (GI > 20), intermediate (GI 15 - 20) and slow (GI < 15) growing groups. The selected lines were found to have different morphology in term of colour and texture. The callus texture did affect the cell growth of A. annua in which the friable callus type showed faster, consistent and sustainable cell biomass production.D. O. I.http://dx.doi.org/10.3329/ptcb.v23i2.17507Plant Tissue Cult. & Biotech. 23(2): 157-163, 2013  (December)


Oncotarget ◽  
2017 ◽  
Vol 8 (30) ◽  
pp. 49944-49958 ◽  
Author(s):  
Radosław Januchowski ◽  
Karolina Sterzyńska ◽  
Piotr Zawierucha ◽  
Marcin Ruciński ◽  
Monika Świerczewska ◽  
...  

Marine Drugs ◽  
2019 ◽  
Vol 17 (11) ◽  
pp. 596 ◽  
Author(s):  
Zhaoming Liu ◽  
Zhen Fan ◽  
Zhanghua Sun ◽  
Hongxin Liu ◽  
Weimin Zhang

Dechdigliotoxins A–C (1–3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute configurations were unambiguously determined through quantum chemical calculations, as well as DP4+ probability simulations. The proposed biosynthetic pathway suggested 1–3 were generated from unusual L-Phe and D-Ser. All the isolates were evaluated for their cytotoxicity against four tumor cell lines.


Gene ◽  
2020 ◽  
Vol 738 ◽  
pp. 144475
Author(s):  
Kun Pang ◽  
Lin Hao ◽  
Zhenduo Shi ◽  
Bo Chen ◽  
Huiqing Pang ◽  
...  

1982 ◽  
Vol 106 (2) ◽  
pp. 111-118 ◽  
Author(s):  
J. Kochba ◽  
G. Ben-Hayyim ◽  
P. Spiegel-Roy ◽  
S. Saad ◽  
H. Neumann

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Siina Junnila ◽  
Arto Kokkola ◽  
Marja-Liisa Karjalainen-Lindsberg ◽  
Pauli Puolakkainen ◽  
Outi Monni

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