scholarly journals Evaluation of the use of untargeted metabolomics in the safety assessment of genetically modified crops

Metabolomics ◽  
2020 ◽  
Vol 16 (10) ◽  
Author(s):  
Mohamed Bedair ◽  
Kevin C. Glenn
Keyword(s):  
Analytical Methods ◽  
Safety Assessment ◽  
Genetically Modified ◽  
Plant Biotechnology ◽  
Compositional Analysis ◽  
Untargeted Metabolomics ◽  
Gm Crops ◽  
Feed Composition ◽  
Analytical Technique ◽  
Food And Feed

Abstract Background The safety assessment of foods and feeds from genetically modified (GM) crops includes the comparison of key characteristics, such as crop composition, agronomic phenotype and observations from animal feeding studies compared to conventional counterpart varieties that have a history of safe consumption, often including a near isogenic variety. The comparative compositional analysis of GM crops has been based on targeted, validated, quantitative analytical methods for the key food and feed nutrients and antinutrients for each crop, as identified by Organization of Economic Co-operation and Development (OCED). As technologies for untargeted metabolomic methods have evolved, proposals have emerged for their use to complement or replace targeted compositional analytical methods in regulatory risk assessments of GM crops to increase the number of analyzed metabolites. Aim of Review The technical opportunities, challenges and strategies of including untargeted metabolomics analysis in the comparative safety assessment of GM crops are reviewed. The results from metabolomics studies of GM and conventional crops published over the last eight years provide context to enable the discussion of whether metabolomics can materially improve the risk assessment of food and feed from GM crops beyond that possible by the Codex-defined practices used worldwide for more than 25 years. Key Scientific Concepts of Review Published studies to date show that environmental and genetic factors affect plant metabolomics profiles. In contrast, the plant biotechnology process used to make GM crops has little, if any consequence, unless the inserted GM trait is intended to alter food or feed composition. The nutritional value and safety of food and feed from GM crops is well informed by the quantitative, validated compositional methods for list of key analytes defined by crop-specific OECD consensus documents. Untargeted metabolic profiling has yet to provide data that better informs the safety assessment of GM crops than the already rigorous Codex-defined quantitative comparative assessment. Furthermore, technical challenges limit the implementation of untargeted metabolomics for regulatory purposes: no single extraction method or analytical technique captures the complete plant metabolome; a large percentage of metabolites features are unknown, requiring additional research to understand if differences for such unknowns affect food/feed safety; and standardized methods are needed to provide reproducible data over time and laboratories.

scholarly journals Safety Assessment of Food and Feed from GM Crops in Europe: Evaluating EFSA’s Alternative Framework for the Rat 90-day Feeding Study

2017 ◽  
Vol 65 (27) ◽  
pp. 5545-5560 ◽  
Author(s):  
Bonnie Hong ◽  
Yingzhou Du ◽  
Pushkor Mukerji ◽  
Jason M. Roper ◽  
Laura M. Appenzeller
Keyword(s):  
Safety Assessment ◽  
Gm Crops ◽  
Alternative Framework ◽  
Feeding Study ◽  
Food And Feed

scholarly journals Compositional Analysis of Genetically Modified (GM) Crops: Key Issues and Future Needs

2013 ◽  
Vol 61 (35) ◽  
pp. 8248-8253 ◽  
Author(s):  
Owen A. Hoekenga ◽  
Jannavi Srinivasan ◽  
Gerard Barry ◽  
Andrew Bartholomaeus
Keyword(s):  
Genetically Modified ◽  
Compositional Analysis ◽  
Gm Crops ◽  
Future Needs ◽  
Key Issues

EU regulation of genetically modified organisms: Food and feed, traceability and labelling

10.5912/jcb4 ◽  
1969 ◽  
Vol 9 (1) ◽  
Author(s):  
Geraldine Schofield
Keyword(s):  
European Commission ◽  
Food Chain ◽  
Genetically Modified Organisms ◽  
Animal Feed ◽  
Genetically Modified ◽  
Gm Crops ◽  
Eu Regulation ◽  
Food And Feed ◽  
The Eu

The European Commission has proposed two new regulations to deal with the labelling and traceability of genetically modified organisms (GMOs). These deal with both food and animal feed. The intention is to provide information to the consumer, to ensure transparency of GM ingredients in the food chain and to encourage the unblocking of an (unofficial) moratorium on GM crops. This paper describes where the proposals are in the EU system, the issues and the problems industry will face if they are implemented in their present format.

scholarly journals Analysis of gm crops allowed for using in the european union

2021 ◽  
Author(s):  
T. Tkachenko ◽  
◽  
V. Tsedyk ◽  
V. Kornienko ◽  
V. Ischenko ◽  
...  
Keyword(s):  
European Union ◽  
Raw Materials ◽  
Genetically Modified ◽  
Genetically Modified Crops ◽  
Gm Crops ◽  
The European Union ◽  
Genetically Modified Soybean ◽  
Gm Plants ◽  
Tiny Amount ◽  
Food And Feed

The development of biotechnology in the field of GMOs requires states to take specific decisions to regulate the spread of genetically modified crops. In the European Union all GM crops that circulation are subject to mandatory registration, which regulates the placing on the market and circulation of genetically modified raw materials, food and feed. The article presents systematized data about the registration of genetically modified soybean, maize and rapeseed in the European Union. It was established that most of the GM crops have introduced genes that give them tolerance to herbicides of different groups. The register of the European Union currently includes 12 events of soybean (GTS 40-3-2, A2704-12, Mon 89788, MON87705, DP 356043, A5547-127, FG 72, SYHTOH 2, DAS-44406-6, DAS-68416- 4, Mon 87708, BPS-CV127-9), 5 events of maize (MZHG0JG, DAS-40278-9, GA 21, NK 603, T 25), 3 events of rapeseed (GT 73, T45, TOPAS 19/2) with tolerance to herbicides. It has been shown that a significant number of registered GM plants have a combination of several events, including tolerance to herbicides and resistance to certain insects or improving quality features of crops. Among them are one event of soybean (DP305423-1), 9 events of maize (TC 1507, DP 4114-3, MON 87411-9, MON 87427, MON 88017, DAS59122-7, Bt 176, Bt 11, DAS 1507) and one event of rapeseed (MS8xRF3). Many GM crops (one event of soybean and 6 events of maize) have introduced genes that determine the plant's tolerance to insects. Only a tiny amount of GM crops are being with altered consumer or technological qualities. In the register of genetically modified crops, all events of GM crops are currently authorized for usage for food, supplements, feed and other product. А single event of maize (Mon 810), that was allowed for cultivation at the time of this analysis was at the stage of renewal of the permit.

A Review of the Characteristics, Properties and Methods for Quantification of Roxithromycin

2020 ◽  
Vol 16 ◽  
Author(s):  
Marcus Vinicius Martins Rubatino ◽  
Ana Laura Araújo Santos ◽  
Rayssa Araújo dos Santos ◽  
Magali Benjamim de Araújo
Keyword(s):  
Analytical Methods ◽  
Environmental Samples ◽  
Biological Fluids ◽  
Pharmaceutical Preparations ◽  
Gram Negative Bacteria ◽  
Analytical Technique ◽  
Detection Systems ◽  
Gram Positive Bacteria ◽  
Microbiological Characteristics ◽  
Biological And Environmental Samples

: Roxithromycin is one of the most frequently used macrolide antibiotics, a safe group of antimicrobials that acts against Gram-positive bacteria and some Gram-negative bacteria. It is sold in several countries in different dosage forms (tablets and capsules) and strengths (50, 100, 150 and 300 mg). Several analytical methods have been described to quantify roxithromycin in different matrices, such as biological and environmental samples and food. Identifying the main characteristics of the drugs and selecting appropriate analytical methods for their quantification are of paramount importance for understanding the behavior of drugs, metabolites and impurities. This review presents the physicalchemical and microbiological characteristics, properties as well as methods for quantification of roxithromycin in biological fluids, pharmaceutical preparations, food and environmental samples. HPLC coupled to various detection systems is the most used analytical technique to determine roxithromycin in these matrices. Although many analytical methods have been reported for the analysis of this drug, it is very important to include in this context a prospective view, in order to implement new analytical technologies for the quality control of this antimicrobial that contribute to the preservation of economic and environmental impacts.

scholarly journals Monarch butterfly and milkweed declines substantially predate the use of genetically modified crops

2019 ◽  
Vol 116 (8) ◽  
pp. 3006-3011 ◽  
Author(s):  
J. H. Boyle ◽  
H. J. Dalgleish ◽  
J. R. Puzey
Keyword(s):  
Genetically Modified ◽  
Danaus Plexippus ◽  
Genetically Modified Crops ◽  
Monarch Butterfly ◽  
The United States ◽  
Gm Crops ◽  
Herbicide Resistant ◽  
The Past ◽  
Scientific Attention ◽  
Herbicide Use

Monarch butterfly (Danaus plexippus) decline over the past 25 years has received considerable public and scientific attention, in large part because its decline, and that of its milkweed (Asclepias spp.) host plant, have been linked to genetically modified (GM) crops and associated herbicide use. Here, we use museum and herbaria specimens to extend our knowledge of the dynamics of both monarchs and milkweeds in the United States to more than a century, from 1900 to 2016. We show that both monarchs and milkweeds increased during the early 20th century and that recent declines are actually part of a much longer-term decline in both monarchs and milkweed beginning around 1950. Herbicide-resistant crops, therefore, are clearly not the only culprit and, likely, not even the primary culprit: Not only did monarch and milkweed declines begin decades before GM crops were introduced, but other variables, particularly a decline in the number of farms, predict common milkweed trends more strongly over the period studied here.

Environment and its Forms of Knowledge: The Regulation of Genetically Modified Crops in India

2021 ◽  
Vol 37 (2) ◽  
pp. 167-183
Author(s):  
Aniket Aga
Keyword(s):  
Power Relations ◽  
Genetically Modified ◽  
Genetically Modified Crops ◽  
Gm Crops ◽  
Regulatory Regime ◽  
Democratic Participation ◽  
Environment Protection ◽  
Policy Decisions ◽  
Inherent Ambiguity ◽  
Forms Of Knowledge

A fierce controversy over genetically modified (GM) crops has been raging in India for over two decades. Analyzing India’s regulatory regime for GM crops, this article focuses on the modes through which state bureaucracies know the environment. It argues that two epistemologies - scientific and legal-administrative – underpin environment protection. By unraveling the course of regulatory disputes, I demonstrate that bureaucracies are not just hierarchically divided but are also segmented by horizontal, functional specializations. There is thus an inherent ambiguity lodged between environment as a technical discourse and as statecraft. This ambiguity both fosters and constrains democratic participation in policy decisions and can even partially disrupt power relations in unanticipated ways.

BRAZILIAN GMO REGULATION: DOES IT HAVE AN ENVIRONMENTAL APPROACH?

2012 ◽  
Vol 14 (02) ◽  
pp. 1250013 ◽  
Author(s):  
DENISE GALLO PIZELLA ◽  
MARCELO PEREIRA DE SOUZA
Keyword(s):  
Decision Making ◽  
Risk Analysis ◽  
Environmental Impacts ◽  
Genetically Modified ◽  
Genetically Modified Crops ◽  
Gm Crops ◽  
Gm Crop ◽  
Institutional Issues ◽  
Institutional Aspects ◽  
Biosafety Evaluation

Brazil is the second largest producer of genetically modified crops (GM crops) and the National Technical Commission on Biosafety (CTNBio) the decision making agency on this matter. The country uses Risk Analysis (RA) and project EIA as tools for biosafety evaluation. This paper aims to review the appropriateness of these tools for evaluating the environmental impacts of GM crops, also considering institutional aspects. An overview of the process of release of GM crops in Brazil along with important operational and institutional aspects is provided. The results indicate that project EIA could be applied to GM crops in specific sites and RA could give support to the evaluation of GM crop itself. Regarding institutional issues, it is concluded that decisions should be made by the environmental bodies, and not by the CTNBio.

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