Association between endurance performance, oxidative stress, and antioxidant markers during a running training program in untrained men

2021 ◽  
Author(s):  
Cecília Segabinazi Peserico ◽  
Fabiana Andrade Machado
Keyword(s):  
Oxidative Stress ◽  
Training Program ◽  
Endurance Performance ◽  
Running Training ◽  
Antioxidant Markers

scholarly journals Are insulin-resistance and oxidative stress cause or consequence of aging

2020 ◽  
Vol 245 (14) ◽  
pp. 1260-1267
Author(s):  
Sylwia Dzięgielewska-Gęsiak ◽  
Dorota Stołtny ◽  
Alicja Brożek ◽  
Małgorzata Muc-Wierzgoń ◽  
Ewa Wysocka
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Antioxidant Status ◽  
Antioxidant Defense ◽  
Total Antioxidant Status ◽  
Thiobarbituric Acid ◽  
Elderly Individuals ◽  
Total Antioxidant ◽  
Antioxidant Defense Systems ◽  
Antioxidant Markers

Insulin resistance (IR) may be associated with oxidative stress and leads to cardiovascular disorders. Current research focuses on interplay between insulin-resistance indices and oxidant-antioxidant markers in elderly individuals with or without insulin-resistance. The assessment involved anthropometric data (weight, height, BMI, percentage of body fat (FAT)) and biochemical tests (glucose, lipids, serum insulin and plasma oxidant-antioxidant markers: Thiobarbituric Acid-Reacting Substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1) and total antioxidant status). Insulin resistance index (IR) assuming a cut-off point of 0.3 allows to divides groups into: insulin sensitive group (InsS) IR < 0,3 ( n = 35, median age 69.0 years) and insulin-resistant group (InsR) IR ≥ 0.3 ( n = 51, median age 71.0 years). Lipids and antioxidant defense system markers did not differentiate the investigated groups. In the InsR elderly group, the FAT was increased ( P < 0.000003) and TBARS ( P = 0.008) concentration decreased in comparison with InsS group. A positive correlation for SOD-1 and total antioxidant status ( P < 0.05; r =  0.434) and a negative correlation for TBARS and age ( P < 0.05 with r = −0.421) were calculated in InsR individuals. In elderly individuals, oxidative stress persists irrespective of insulin-resistance status. We suggest that increased oxidative stress may be consequence of old age. An insulin action identifies those at high risk for atherosclerosis, via congruent associations with oxidative stress and extra- and intra-cellular antioxidant defense systems. Thus, we maintain that insulin-resistance is not the cause of aging. Impact statement Insulin resistance is associated with oxidative stress leading to cardiovascular diseases. However, little research has been performed examining elderly individuals with or without insulin-resistance. We demonstrate that antioxidant defense systems alone is not able to abrogate insulin action in elderly individuals at high risk for atherosclerosis, whereas the combined oxidant-antioxidant markers (thiobarbituric acid-reacting substances (TBARS), Cu,Zn-superoxide dismutase (SOD-1), and total antioxidant status (TAS)) might be more efficient and perhaps produce better clinical outcome. In fact, a decrease in oxidative stress and strong interaction between antioxidant defense can be seen only among insulin-resistant elderly individuals. This is, in our opinion, valuable information for clinicians, since insulin-resistance is considered strong cardiovascular risk factor.

scholarly journals Oxidative Stress Indexes for Diagnosis of Health or Disease in Humans

2019 ◽  
Vol 2019 ◽  
pp. 1-32 ◽  
Author(s):  
Martha A. Sánchez-Rodríguez ◽  
Víctor Manuel Mendoza-Núñez
Keyword(s):  
Oxidative Stress ◽  
Human Health ◽  
Clinical Medicine ◽  
The State ◽  
Stress Index ◽  
Clinical Prognosis ◽  
Oxidative Stress Index ◽  
Health And Disease ◽  
Antioxidant Markers ◽  
The Relationship

Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favor of oxidants, that causes aging and disease. Many studies have been published that demonstrate the relationship between OS and human health and disease; however, the following questions arise: (i) how are we sure that the OS is present in a biological process? (ii) Is the OS reported in the different investigations equivalent? (iii) What are the best oxidant and antioxidant markers for OS diagnosis? (iv) Can we establish the types and the intensity of the OS? (v) Does OS index could be useful for research and/or application in clinical medicine? In this regard, several indexes have been proposed to measure OS in humans relative to the state of health and disease, among which the following can be highlighted: Oxidative Stress Index (OSI), Tiol Ratios (-SH/TT, -SS/-SH, and-SS/TT), Glutathione Ratio (GSSG/GSH), Oxidative Stress Score (OSS), and OXY-index. Therefore, the aim of this review is to present the state of the art of knowledge about OS indexes for diagnosis of health or disease in humans. We searched for articles in English or Spanish in the PubMed/MEDLINE and Scopus electronic databases published up until May 2019. The keywords used were “oxidative stress,” “index,” and “oxidative stress index.” It was identified 11479 records in both databases, and 490 articles were analyzed. Our review suggests that all indexes analyzed allow diagnose and differentiate the OS related to human health and disease. Also, the studies on OSI, Oxy-score, and OSS indexes have proven to be reliable, practical, and with clinical utility. However, it is necessary to continue with longitudinal studies, especially assess the usefulness of the indexes in the clinical prognosis, and make comparative studies between the different indexes.

Effects of photobiomodulation associated with endurance running training on oxidative stress in untrained men

2019 ◽  
Vol 16 (1) ◽  
pp. 129-136
Author(s):  
Cecília S. Peserico ◽  
Vânia D’Almeida ◽  
Vanessa Cavalcante-Silva ◽  
Joyce J. U. S. Yamamoto ◽  
Fabiana A. Machado
Keyword(s):  
Oxidative Stress ◽  
Endurance Running ◽  
Running Training

scholarly journals ADHERENCE TO SIX MONTHS OF INSTRUCTED MINIMALIST AND BAREFOOT RUNNING TRAINING

2016 ◽  
Vol 22 (3) ◽  
pp. 182-185 ◽  
Author(s):  
Ana Paula da Silva Azevedo ◽  
Clara Nóbrega ◽  
Alberto Carlos Amadio ◽  
Júlio Cerca Serrão
Keyword(s):  
Training Program ◽  
Drop Out ◽  
Intervention Programs ◽  
Dropping Out ◽  
Exercise Programs ◽  
Barefoot Running ◽  
Running Training ◽  
The Third ◽  
Supervised Exercise ◽  
Recreational Runners

ABSTRACT Introduction: The interest in minimalist and barefoot running is growing continuously. However, there is no data on how many runners drop out during this process. Objective: To describe the adhesion and dropout rates of a six-month instructed training program based on barefoot and minimalist footwear running. Methods: Thirty-four recreational runners participated in the study: 20 runners started the race training barefoot, while 14 runners were involved in training with minimalist footwear. Adhesion to intervention programs was evaluated through training spreadsheets and recording attendance at training sessions, while dropouts were evaluated at the end of training. A questionnaire was sent to participants who dropped out of the training, to obtain information related on why they had abandoned it. Results: Considering all participants (n=34), 41.2% of the runners completed six months with reduced plantar protection; 70% of all dropouts occurred in barefoot training; the main reasons for leaving the training were injury/pain (40%) and lack of time/suitable place for training (40%); and the majority of dropouts (50%) occurred in the first month of training. Barefoot training (n=20) showed 70% dropouts, 57.1% of them due to lack of time/suitable place for training; and 71.4% of the dropouts occurred in the first month of the intervention. The training with minimalist footwear (n=14) had fewer dropouts (42.9%) than the barefoot training, all of them due to injury/pain; 50% of them occurred in the third month of intervention. Conclusion: Dropouts usually occur at the beginning of training. Training involving barefoot running has more dropouts than training with minimalist footwear. Intervention programs lasting six months based on minimalist footwear/barefoot seems to have similar adhesion to other supervised exercise programs. The main reasons for dropping out are injury/pain and lack of time/suitable place to run.

Maintenance of Strength Gains While Performing Endurance Training in Oarswomen

1993 ◽  
Vol 18 (1) ◽  
pp. 104-115 ◽  
Author(s):  
G. J. Bell ◽  
D. G. Syrotuik ◽  
K. Attwood ◽  
H. A. Quinney
Keyword(s):  
Resistance Training ◽  
Training Program ◽  
Endurance Training ◽  
Endurance Performance ◽  
Lower Body ◽  
Resistance Training Program ◽  
Leg Press ◽  
Ventilation Threshold ◽  
Group 2 ◽  
Group 1

This study investigated the retention of strength gained after resistance training, while performing aerobic endurance training. Following a 10-week resistance training program (three times a week) that included maintenance aerobic endurance training (twice a week), 18 varsity oarswomen were matched on strength and randomly assigned to two groups: Group 1 performed maintenance resistance training once a week and Group 2 performed resistance training twice a week. Both groups performed endurance training four times a week during the 6-week maintenance resistance training program. There was a significant increase in strength (multiple-RM test) for three upper and three lower body exercises after the initial 10-week resistance training program. A further significant increase in two exercises (inclined leg press and knee flexion) were observed after 6 weeks of maintenance resistance training and endurance training in both groups. No further significant increases were observed in the four other exercises during maintenance strength training. These latter findings occurred at the same time that VO2max and ventilation threshold increased. These results suggest that strength gains can be maintained with resistance training once or twice a week while focusing on improving aerobic endurance performance without compromising the latter. Key words: repetition maximum, ventilation threshold, endurance performance

scholarly journals Effects of Self-Administered GH or IGF-1 Hormones on Resting Oxidative Stress and Antioxidant Markers in Men with or Without Resistance Exercise

2020 ◽  
Vol 27 (4) ◽  
pp. 14-17
Author(s):  
Heidar Mohammadjafari ◽  
Hamid Arazi ◽  
Nematollah Nemati ◽  
Tahereh Bagherpoor
Keyword(s):  
Oxidative Stress ◽  
Resistance Exercise ◽  
Peptide Hormone ◽  
Self Administration ◽  
Male Athletes ◽  
Stress Markers ◽  
History Of ◽  
Antioxidant Defense Systems ◽  
Antioxidant Markers

Abstract Introduction. Some athletes and non-athletes use peptide hormones to increase lean body mass and fat loss, but those effects on oxidative stress and antioxidant markers are unknown. The aim of this study was to show the physiological profile of oxidative stress and antioxidant markers in athletes and non-athletes following long-term self-administration of GH or IGF-1 Material and Methods. Seventy-five healthy young men with the history of peptide hormone (i.e., GH or IGF-1) use for at least 1 year (i.e., 3 to 4 times a year) or resistance exercise (RE) experience for at least 3 years volunteered to participate in this study and were divided into 5 selected groups including 1) GH use plus RE (GH+RE, n = 15), 2) IGF-1 use plus RE (IGF-1+RE, n = 15), 3) GH use (GH, n = 15), 4) IGF-1 use (IGF-1, n = 15), and 5) RE only (RE, n = 15). Blood sample was obtained one time in order to evaluate the resting concentration of oxidative stress markers including 8-hydroxy-2-deoxyguanosine (8-OHdG), malondialdehyde (MDA), nitric oxide (NO) and antioxidant defense systems (i.e., glutathione peroxidase [GPx], catalase [CAT], and glutamate [GLU]). Results. There were no significant (p > 0.05) differences among the groups in the 8-OHdG, MDA, NO, GPx, CAT, and GLU levels. Conclusions. Self-administration of peptide hormone and RE for at least 1 year is not accompanied by alterations in resting oxidative stress and the antioxidant system in male athletes and non-athletes.

Effect of endurance training on oxygen uptake kinetics during treadmill running

2000 ◽  
Vol 89 (5) ◽  
pp. 1744-1752 ◽  
Author(s):  
Helen Carter ◽  
Andrew M. Jones ◽  
Thomas J. Barstow ◽  
Mark Burnley ◽  
Craig Williams ◽  
...  
Keyword(s):  
Oxygen Uptake ◽  
Training Program ◽  
Endurance Training ◽  
Slow Component ◽  
Minute Ventilation ◽  
Lactate Concentration ◽  
Blood Lactate Concentration ◽  
Treadmill Running ◽  
Endurance Running ◽  
Running Training

The purpose of this study was to examine the effect of endurance training on oxygen uptake (V˙o 2) kinetics during moderate [below the lactate threshold (LT)] and heavy (above LT) treadmill running. Twenty-three healthy physical education students undertook 6 wk of endurance training that involved continuous and interval running training 3–5 days per week for 20–30 min per session. Before and after the training program, the subjects performed an incremental treadmill test to exhaustion for determination of the LT and the V˙o 2 max and a series of 6-min square-wave transitions from rest to running speeds calculated to require 80% of the LT and 50% of the difference between LT and maximal V˙o 2. The training program caused small (3–4%) but significant increases in LT and maximalV˙o 2 ( P < 0.05). TheV˙o 2 kinetics for moderate exercise were not significantly affected by training. For heavy exercise, the time constant and amplitude of the fast component were not significantly affected by training, but the amplitude of theV˙o 2 slow component was significantly reduced from 321 ± 32 to 217 ± 23 ml/min ( P< 0.05). The reduction in the slow component was not significantly correlated to the reduction in blood lactate concentration ( r = 0.39). Although the reduction in the slow component was significantly related to the reduction in minute ventilation ( r = 0.46; P < 0.05), it was calculated that only 9–14% of the slow component could be attributed to the change in minute ventilation. We conclude that theV˙o 2 slow component during treadmill running can be attenuated with a short-term program of endurance running training.

Carcinogen sodium arsenite disrupts antioxidant and redox homeostasis in Drosophila melanogaster

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Aghogho Oyibo ◽  
Amos O. Abolaji ◽  
Oyeronke A. Odunola
Keyword(s):  
Oxidative Stress ◽  
Drosophila Melanogaster ◽  
Sodium Arsenite ◽  
Environmental Contaminants ◽  
Redox Homeostasis ◽  
Exposure Period ◽  
Acetylcholinesterase Activity ◽  
Glutathione S Transferase ◽  
Emergence Rate ◽  
Antioxidant Markers

Abstract Objectives The inadvertent exposure to environmental contaminants has been reported to induce cancer in different animal models. Here, we investigated the toxicity of Sodium Arsenite (SA), a Class I Carcinogen in Drosophila melanogaster. Methods Harwich fly strain (1–3 days old) of both sexes were orally exposed to SA (0, 0.0312, 0.0625 and 0.125 mM) for 14 days for survival study. Thereafter, 5 days exposure period was selected to assess the toxic effects of SA on oxidative stress and antioxidant markers. Results The results indicated that SA induced significant reduction in survival and emergence rate of flies. Furthermore, SA significantly increased Nitric Oxide (NO, nitrite and nitrate) and Hydrogen Peroxide (H2O2) levels in flies compared with control (p<0.05). In addition, SA inhibited catalase and glutathione-S-transferase (GST) activities, and depleted total thiol and glutathione (GSH) contents. Moreover, acetylcholinesterase activity significantly increased in flies treated with SA when compared with control. Conclusions Sodium arsenite-induced reduction in survival and emergence rates of flies occurred via the disruption of oxidative stress-antioxidant homeostasis in D. melanogaster.

scholarly journals Mindfulness Training Enhances Endurance Performance and Executive Functions in Athletes: An Event-Related Potential Study

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Jui-Ti Nien ◽  
Chih-Han Wu ◽  
Kao-Teng Yang ◽  
Yu-Min Cho ◽  
Chien-Heng Chu ◽  
...  
Keyword(s):  
Executive Functions ◽  
Training Program ◽  
Stroop Task ◽  
Endurance Performance ◽  
Sport Performance ◽  
Mindfulness Training ◽  
Event Related Potential ◽  
Control Group ◽  
Related Potentials ◽  
University Athletes

Mindfulness interventions have been linked to improved sport performance and executive functions; however, few studies have explored the effects of mindfulness on sport performance and executive functions simultaneously. This study sought to examine whether a mindfulness training program would affect both the endurance performance and executive functions of athletes. In addition, event-related potentials (ERPs) associated with the Stroop task were assessed to investigate the potential electrophysiological activation associated with the mindfulness training. Applying a quasiexperimental design, forty-six university athletes were recruited and assigned into a five-week mindfulness training program or a waiting list control group. For each participant, the mindfulness level, endurance performance assessed by a graded exercise test, executive functions assessed via Stroop task, and N2 component of ERPs were measured prior to and following the 5-week intervention. After adjusting for the preintervention scores as a covariate, it was found that the postintervention mindfulness level, exhaustion time, and Stroop task accuracy scores, regardless of task condition, of the mindfulness group were higher than those of the control group. The mindfulness group also exhibited a smaller N2 amplitude than the control group. These results suggest that the five-week mindfulness program can enhance the mindfulness level, endurance performance, and multiple cognitive functions, including executive functions, of university athletes. Mindfulness training may also reduce conflict monitoring in neural processes.

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