scholarly journals Correction to: Clinical-Dynamic Features of Affective Disorders Comorbid with Alcohol Dependence

2020 ◽  
Author(s):  
Svetlana N. Vasilieva ◽  
German G. Simutkin ◽  
Evgeny D. Schastnyy ◽  
Nikolay A. Bokhan
Keyword(s):  
Alcohol Dependence ◽  
Affective Disorders ◽  
Dynamic Features

Clinical-Dynamic Features of Affective Disorders Comorbid with Alcohol Dependence

2020 ◽  
Author(s):  
Svetlana N. Vasilieva ◽  
German G. Simutkin ◽  
Evgeny D. Schastnyy ◽  
Nikolay A. Bokhan
Keyword(s):  
Alcohol Dependence ◽  
Affective Disorders ◽  
Dynamic Features

scholarly journals PIP5K2A (rs10828317) polymorphism in patients with alcohol dependence and affective disorders

2021 ◽  
Vol 13 (3) ◽  
pp. 48-52
Author(s):  
E. V. Mikhalitskaya ◽  
N. M. Vyalova ◽  
O. Yu. Fedorenko ◽  
O. V. Roshchina ◽  
G. G. Simutkin ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Conformational Changes ◽  
Affective Disorders ◽  
Rating Scale ◽  
Modern Society ◽  
Structured Interview ◽  
Depression Symptoms ◽  
Obsessive Compulsive ◽  
Atypical Depression ◽  
Phosphatidylinositol 4

Alcohol dependence (AD) and affective disorders (ADs) are serious medical and socio-economic problems of modern society. It is hypothesized that both disorders share a common neurobiological basis. Phosphatidylinositol-4-phosphate-5-kinase type 2 alpha (PIP5K2A) plays an essential role in neuronal phosphoinositide signaling pathways. Nonsynonymous rs10828317 mutation of the PIP5K2A gene leads to conformational changes of the PIP5K2A protein and a decrease in the functional activity of this enzyme. In this study, we assessed the possibility of using the rs10828317 polymorphic variant of the PIP5K2A gene as a marker of AD and ADs.Objective: to study the associations of the PIP5K2A (rs10828317) polymorphism with AD and ADs clinical course.Patients and methods. We enrolled 255 patients with AD and 325 patients with ADs. 126 patients with AD and 71 patients with ADs underwent a comprehensive clinical, clinical-dynamic, psychodiagnostic assessment using a set of clinical scales and tests, including Structured Interview Guide For The Hamilton Depression Rating Scale, Seasonal Affective Disorders Version (SIGH-SAD), Alcohol Use Disorders Identification Test (AUDIT), The Obsessive-Compulsive Drinking Scale for craving in alcohol (OCDS).Results and discussion. PIP5K2A (rs10828317) polymorphism in patients with AD was associated with the OCDS mean score after the inpatient treatment; in patients with ADs - with the severity of atypical depression symptoms assessed by SIGH-SAD at the time of admission.Conclusion. The results of our pilot study indicate the involvement of PIP5K2A (rs10828317) polymorphism in the AD and ADs pathophysiology.

Affective Disorders with or Without Comorbid Alcohol Dependence: a Longitudinal Neuropsychological and Neuroimaging Investigation in Young Adults

2015 ◽  
Vol 30 ◽  
pp. 1238
Author(s):  
R.S.C. Lee ◽  
G. Dore ◽  
L. Juckes ◽  
J. Lagopoulos ◽  
S. Hatton ◽  
...  
Keyword(s):  
Young Adults ◽  
Alcohol Dependence ◽  
Affective Disorders

Biochemical and genetic markers in patients with alcohol dependence and affective disorders and their correlation with alcohol intake

2016 ◽  
Vol 33 (S1) ◽  
pp. S19-S20
Author(s):  
U. Preuss ◽  
F. Wurst
Keyword(s):  
Alcohol Use ◽  
Alcohol Dependence ◽  
Affective Disorders ◽  
Alcohol Intake ◽  
Bipolar Disorders ◽  
Cross Sectional Study ◽  
Emergency Rooms ◽  
Higher Alcohol ◽  
Cross Sectional ◽  
Alcohol Dependent

Rates of comorbid affective disorders in alcohol-dependent individuals are significant. Biomarkers of alcohol use may support the diagnosis of high and frequent alcohol use in these individuals. The aim of these analyses of the WHO-ISBRA Study on State and Trait Markers of Alcohol Use and Dependence is to compare biomarkers of alcohol use across individuals with and without comorbid alcohol dependence and affective disorders. Significantly, higher values of these biomarkers are hypothesized in individuals with comorbid disorders compared to alcohol dependence only. Assessment of Alcohol dependence and comorbid depression and bipolar disorders were conducted using an adapted version of the Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS). Altogether, n = 1863 individuals were included into the analyses, of whom n = 299 had a lifetime history of depression and n = 20 a bipolar disorder. Clinical characteristics like mean alcohol intake last month and biomarkers including ASAT, GGT, CDT, 5-HTOL/5-HIAA ratio and MAO-Activity were included into the analyses. Results indicate that AD only subjects had higher measures of all biomarkers compared to comorbid bipolar and depression subjects, while the latter had a higher alcohol intake during last month.Since this is a cross-sectional study, conducted in emergency rooms of several countries, this allegedly divergent result in alcohol intake in comorbid subjects compared to higher biomarkers in AD only subjects may indicate that drinking is more frequent in alcohol-dependent individuals while bipolar and depressed subjects may have more episodic pattern of alcohol intake. The latter may lead to shorter periods of intake compared to the chronic and frequent use of this substance in alcohol-dependent individuals and higher biomarkers of alcohol use.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Coherence parameters of cerebral bioelectric activity and blood serum levels of phosphorylated neurofilaments in comorbid alcohol dependence and affective disorders

2021 ◽  
pp. 5-11
Author(s):  
С.А. Галкин ◽  
О.В. Рощина ◽  
Н.И. Кисель ◽  
С.А. Иванова ◽  
Н.А. Бохан
Keyword(s):  
Functional Connectivity ◽  
Alcohol Dependence ◽  
Blood Serum ◽  
Affective Disorder ◽  
Affective Disorders ◽  
Right Hemisphere ◽  
Control Group ◽  
Bioelectric Activity ◽  
The Right ◽  
Phosphorylated Neurofilaments

Введение. Наряду со многими психическими расстройствами алкогольная зависимость и аффективные расстройства являются результатом взаимодействия генетических, социальных и экологических факторов, что сопровождается морфофункциональными изменениями в центральной нервной системе. Тем не менее, основные причины и механизмы развития коморбидности алкоголизма и аффективных расстройств остаются не до конца ясны. Цель исследования - определение функциональной связности и уровня фосфорилированных нейрофиламентов у пациентов с алкогольной зависимостью и коморбидностью алкогольной зависимости и аффективного расстройства. Методика. Обследовано 60 пациентов после детоксикации: 30 пациентов с алкогольной зависимостью и 30 пациентов с коморбидным течением алкогольной зависимости и аффективного расстройства. Контрольную группу составили 20 психически и соматически здоровых лиц, сопоставимых по полу и возрасту. Исследование биоэлектрической активности головного мозга проводилось при помощи 16-канального энцефалографа. Анализировались общие усредненные значения внутри - и межполушарной когерентности. В сыворотках крови определяли содержание фосфорилированных нейрофиламентов методом твердофазного иммуноферментного анализа на полистироловых планшетах, предварительно покрытых куриными пoликлональными антителами. Результаты. При межгрупповом анализе были выявлены статистически значимо более низкие значения когерентности в правой гемисфере у пациентов с коморбидностью алкогольной зависимости и аффективного расстройства по сравнению с пациентами, страдающими только алкогольной зависимостью. Были обнаружены также статистически значимо более высокие значения концентрации нейрофиламентов в группе пациентов с коморбидностью алкогольной зависимости и аффективного расстройства по сравнению со здоровой группой контроля. При сравнении групп пациентов между собой были обнаружены боле высокие значения концентрации нейрофиламентов у пациентов с коморбидностью алкогольной зависимости и аффективного расстройства на уровне тенденции. Заключение. Наличие коморбидности алкоголизма и аффективных расстройств приводят к нейрофизиологическим изменениям в виде снижения функциональной связности коры головного мозга, особенно в правой гемисфере, а также увеличению степени нейронального повреждения. Background. Similar to many mental disorders, alcohol dependence and affective disorders result from interaction of genetic, social, and environmental factors associated with morpho-functional alterations in the central nervous system. However, major causes and mechanisms of the development of comorbid alcoholism and affective disorders are not fully clear. The aim of this study was to determine the functional connectivity and levels of phosphorylated neurofilaments in patients with alcohol dependence and comorbid alcohol dependence and affective disorder. Methods. 60 patients were evaluated after detoxification, including 30 patients with alcohol dependence and 30 patients with comorbid alcohol dependence and affective disorder. The control group consisted of 20 sex- and age-matched, mentally and somatically healthy individuals. Brain bioelectric activity was recorded with a 16-channel encephalograph. Overall average values of intra- and inter-hemispheric coherence were analyzed. Blood serum concentration of phosphorylated neurofilaments was measured by solid-phase enzyme immunoassay on polystyrene plates pre-coated with chicken polyclonal antibodies. Results. The intergroup analysis showed that coherence values for the right hemisphere were significantly lower in patients with comorbid alcohol dependence and affective disorder compared to patients with alcohol dependence alone (p=0.018). Also, concentrations of neurofilaments were significantly higher in the patient group with comorbid alcohol dependence and affective disorder compared to the healthy control group (p=0.042). Comparison of patient groups showed that neurofilament concentrations had a tendency toward higher values in patients with comorbid alcohol dependence and affective disorder (p=0.092). Conclusion. The presence of comorbid alcoholism and affective disorders leads to neurophysiological alterations evident as reduced functional connectivity of the cerebral cortex, particularly in the right hemisphere, as well as to the increased degree of neuronal damage.

The ADH gene cluster SNP rs1789891 and temperamental dimensions in patients with alcohol dependence and affective disorders

2015 ◽  
Vol 56 (4) ◽  
pp. 420-427 ◽  
Author(s):  
Włodzimierz Oniszczenko ◽  
Janusz K. Rybakowski ◽  
Wojciech Ł. Dragan ◽  
Anna Grzywacz ◽  
Jerzy Samochowiec
Keyword(s):  
Alcohol Dependence ◽  
Gene Cluster ◽  
Affective Disorders ◽  
Adh Gene

scholarly journals Affective disorders, anxiety disorders and the risk of alcohol dependence and misuse

2011 ◽  
Vol 199 (3) ◽  
pp. 219-224 ◽  
Author(s):  
Wenbin Liang ◽  
Tanya Chikritzhs
Keyword(s):  
Anxiety Disorders ◽  
Alcohol Dependence ◽  
Affective Disorders ◽  
Retrospective Cohort ◽  
Regression Models ◽  
Alcohol Misuse ◽  
Well Being ◽  
Australian Population ◽  
Logistic Regression Models ◽  
Health And Well Being

BackgroundIt is unclear whether common affective disorders and anxiety disorders increase the risk of alcohol dependence and alcohol misuse.AimsTo investigate whether affective disorders and anxiety disorders increase the risk of alcohol dependence and alcohol misuse.MethodThis study is a retrospective cohort study based on data collected from the 2007 Australia Mental Health and Well-Being survey. Both Poisson and logistic regression models were used for multivariate analysis.ResultsParticipants with affective disorders (relative risk (RR) = 5.46, 95% CI 4.08–7.31 for alcohol dependence within 5 years of onset; RR = 2.77, 95% CI 1.93–3.99 after first 5 years) and anxiety disorders (RR = 3.33, 95% CI 2.37–4.68 for alcohol dependence within first 5 years of onset; RR = 3.56, 95% CI 2.72–4.64 after first 5 years) were at higher risk of alcohol misuse and alcohol dependence.ConclusionsCommon affective disorders and anxiety disorders may increase the risk of alcohol dependence and alcohol misuse among the Australian population.

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