scholarly journals PIP5K2A (rs10828317) polymorphism in patients with alcohol dependence and affective disorders

2021 ◽  
Vol 13 (3) ◽  
pp. 48-52
Author(s):  
E. V. Mikhalitskaya ◽  
N. M. Vyalova ◽  
O. Yu. Fedorenko ◽  
O. V. Roshchina ◽  
G. G. Simutkin ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Conformational Changes ◽  
Affective Disorders ◽  
Rating Scale ◽  
Modern Society ◽  
Structured Interview ◽  
Depression Symptoms ◽  
Obsessive Compulsive ◽  
Atypical Depression ◽  
Phosphatidylinositol 4

Alcohol dependence (AD) and affective disorders (ADs) are serious medical and socio-economic problems of modern society. It is hypothesized that both disorders share a common neurobiological basis. Phosphatidylinositol-4-phosphate-5-kinase type 2 alpha (PIP5K2A) plays an essential role in neuronal phosphoinositide signaling pathways. Nonsynonymous rs10828317 mutation of the PIP5K2A gene leads to conformational changes of the PIP5K2A protein and a decrease in the functional activity of this enzyme. In this study, we assessed the possibility of using the rs10828317 polymorphic variant of the PIP5K2A gene as a marker of AD and ADs.Objective: to study the associations of the PIP5K2A (rs10828317) polymorphism with AD and ADs clinical course.Patients and methods. We enrolled 255 patients with AD and 325 patients with ADs. 126 patients with AD and 71 patients with ADs underwent a comprehensive clinical, clinical-dynamic, psychodiagnostic assessment using a set of clinical scales and tests, including Structured Interview Guide For The Hamilton Depression Rating Scale, Seasonal Affective Disorders Version (SIGH-SAD), Alcohol Use Disorders Identification Test (AUDIT), The Obsessive-Compulsive Drinking Scale for craving in alcohol (OCDS).Results and discussion. PIP5K2A (rs10828317) polymorphism in patients with AD was associated with the OCDS mean score after the inpatient treatment; in patients with ADs - with the severity of atypical depression symptoms assessed by SIGH-SAD at the time of admission.Conclusion. The results of our pilot study indicate the involvement of PIP5K2A (rs10828317) polymorphism in the AD and ADs pathophysiology.

Calcium as a treatment option for alcohol dependence

2016 ◽  
Vol 33 (S1) ◽  
pp. S317-S317
Author(s):  
R. Schuster ◽  
A. Koopmann ◽  
F. Kiefer
Keyword(s):  
Serum Concentration ◽  
Alcohol Dependence ◽  
Treatment Option ◽  
Rating Scale ◽  
Clinical Sample ◽  
Plasma Concentrations ◽  
Obsessive Compulsive ◽  
Effective Treatment Option ◽  
Competing Interest ◽  
Molecular Mode

In the last couple of decades anti-craving drugs have been developed. Acamprosate was described as an effective treatment option to support alcohol abstinence with a low side effect profile. Moreover its molecular mode of action is highly controversial. Recently, calcium salt was described to be the active part of Acamprosate.Using a clinical sample of placebo (n = 10) vs. Acamprosate-treated (n = 19) abstinent alcohol-dependent patients, we measured calcium plasma concentrations after the 1st, 2nd and 3rd month after the treatment commenced. Before treatment, the same physiological calcium concentration of about 2.4 mmol/l was found in both groups respectively. We found significant correlations in the Acamprosate group while no correlations in the placebo group were observed.The very well regulated extracellular calcium serum concentration seems to get out of balance in association with the severity of alcohol dependence in inpatients during withdrawal.Accordingly, in another clinical sample (n = 57) we found a negative correlation between calcium serum concentration and craving (r2= 0.125; P = 0.011) on day 1 of detoxification. The measurement of craving was carried out by a self-rating scale, the Obsessive Compulsive Drinking Scale (OCDS). Furthermore a low calcium level correlated with high breathalyser readings and the number of alcohol inpatient detoxification's.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Structured Interview for Hoarding Disorder (SIHD)

2019 ◽  
Vol 35 (4) ◽  
pp. 512-520
Author(s):  
Caterina Novara ◽  
Paolo Cavedini ◽  
Stella Dorz ◽  
Susanna Pardini ◽  
Claudio Sica
Keyword(s):  
Convergent Validity ◽  
Structured Interview ◽  
Diagnostic Process ◽  
Schizophrenia Spectrum Disorders ◽  
Clinical Environment ◽  
Obsessive Compulsive ◽  
Rater Reliability ◽  
Hoarding Disorder ◽  
Compulsive Disorder ◽  
Schizophrenia Spectrum

Abstract. The Structured Interview for Hoarding Disorder (SIHD) is a semi-structured interview designed to assist clinicians in diagnosing a hoarding disorder (HD). This study aimed to validate the Italian version of the SIHD. For this purpose, its inter-rater reliability has been analyzed as well as its ability to differentiate HD from other disorders often comorbid. The sample was composed of 74 inpatients who had been diagnosed within their clinical environment: 9 with HD, 11 with obsessive-compulsive disorder (OCD) and HD, 22 with OCD, 19 with major depressive disorder (MDD), and 13 with schizophrenia spectrum disorders (SSD). The results obtained indicated “substantial” or “perfect” inter-rater reliability for all the core HD criteria, HD diagnosis, and specifiers. The SIHD differentiated between subjects suffering from and not suffering from a HD. Finally, the results indicated “good” convergent validity and high scores were shown in terms of both sensitivity and specificity for HD diagnosis. Altogether, the SIHD represents a useful instrument for evaluating the presence of HD and is a helpful tool for the clinician during the diagnostic process.

scholarly journals Obsessive–compulsive symptoms and information seeking during the Covid-19 pandemic

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alisa M. Loosen ◽  
Vasilisa Skvortsova ◽  
Tobias U. Hauser
Keyword(s):  
Mental Health ◽  
Information Seeking ◽  
Large Scale ◽  
Psychiatric Symptoms ◽  
Longitudinal Change ◽  
Depression Symptoms ◽  
Obsessive Compulsive ◽  
Related Information ◽  
Pandemic Wave

AbstractIncreased mental-health symptoms as a reaction to stressful life events, such as the Covid-19 pandemic, are common. Critically, successful adaptation helps to reduce such symptoms to baseline, preventing long-term psychiatric disorders. It is thus important to understand whether and which psychiatric symptoms show transient elevations, and which persist long-term and become chronically heightened. At particular risk for the latter trajectory are symptom dimensions directly affected by the pandemic, such as obsessive–compulsive (OC) symptoms. In this longitudinal large-scale study (N = 406), we assessed how OC, anxiety and depression symptoms changed throughout the first pandemic wave in a sample of the general UK public. We further examined how these symptoms affected pandemic-related information seeking and adherence to governmental guidelines. We show that scores in all psychiatric domains were initially elevated, but showed distinct longitudinal change patterns. Depression scores decreased, and anxiety plateaued during the first pandemic wave, while OC symptoms further increased, even after the ease of Covid-19 restrictions. These OC symptoms were directly linked to Covid-related information seeking, which gave rise to higher adherence to government guidelines. This increase of OC symptoms in this non-clinical sample shows that the domain is disproportionately affected by the pandemic. We discuss the long-term impact of the Covid-19 pandemic on public mental health, which calls for continued close observation of symptom development.

A comparison of the ‘Hamilton Rating Scale for Depression’ and the ‘Montgomery-Asberg Depression rating Scale’

1999 ◽  
Vol 11 (1) ◽  
pp. 34-37 ◽  
Author(s):  
I.P.A.M. Huijbrechts ◽  
P.M.J. Haffmans ◽  
K. Jonker ◽  
A. van Dijke ◽  
E. Hoencamp
Keyword(s):  
Clinical Practice ◽  
Clinical Global Impression ◽  
Rating Scale ◽  
Reliability And Validity ◽  
Structured Interview ◽  
Clinical Impression ◽  
Clinical Relationship ◽  
Hamilton Rating Scale ◽  
Depressive States

SummaryAlthough the Hamilton Rating Scale for Depression (HRSD) is the most frequently used rating scale for quantifying depressive states, it has been criticized for its reliability and its usability in clinical practice. This criticism is less applying to the Montgomery-Asberg Depression Rating Scale (MADRS). Goal of the present study is to investigate the reliability and validity, and clinical relationship between the HRSD and the MADRS. For 60 out-patients with diagnosed depression (DSM IV296.2x, 296.3x, 300.40 and 311.00), the HRSD and MADRS were scored at baseline and 6 weeks later by an independent rater according to a structured interview. Also the Clinical Global Impression (CGI) was assessed by a psychiatrist. Satisfying agreement was found between the totalscores (r= .75, p>.000 en r=.92, p>.000 respectively, at baseline and 6 weeks later). Furthermore agreement was found between the items of both scales, and these agree with the clinical impression. The reliability of the MADRS is more stable than the reliability of the HRSD (α = .6367 and α =.8900 vs α = .2193 and α = .8362 at baseline and at endpoint respectively). Considering the ease of scoring both scales in one interview and the widely international use of the HRSD, scoring both the HRSD and the MADRS to measure the severity of a depression seems to be an acceptabel covenant.

Examining depression symptoms within OCD: the role of experiential avoidance

2021 ◽  
pp. 1-14
Author(s):  
Morgan E. Browning ◽  
Nathaniel P. Van Kirk ◽  
Jason W. Krompinger
Keyword(s):  
Experiential Avoidance ◽  
Symptom Severity ◽  
Distress Tolerance ◽  
Past Research ◽  
Primary Diagnosis ◽  
Hierarchical Regression ◽  
Depression Symptoms ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Underlying Mechanisms

Abstract Background: Obsessive compulsive disorder (OCD) and depression commonly co-occur. Past research has evaluated underlying mechanisms of depression in the context of other diagnoses, but few to no studies have done this within OCD. Aims: This study examines the relationships between distress tolerance (DT), experiential avoidance (EA), depression, and OCD symptom severity across intensive/residential treatment (IRT) for OCD. It was hypothesized that all variables would be significantly moderately related and EA would emerge as a potential contributing factor to change in depression and OCD symptoms across IRT for OCD. Method: The sample included 311 participants with a primary diagnosis of OCD seeking IRT. Correlations were performed between all variables at both admission and discharge. A two-step hierarchical regression with change in OCD symptoms and change in DT in the first block and change in EA in the second block examined if change in EA explained change in depression above and beyond change in OCD and DT ability. Results: At both admission and discharge, higher EA, lower DT, and higher OCD symptom severity were significantly associated with more depressive symptoms. Change in EA explained a significant amount of variance in change in depression above and beyond change in OCD symptom severity and change in DT. Conclusions: This study expands past results within an OCD sample, emphasizing EA as an important treatment target in OCD. Future studies could utilize samples from other treatment contexts, use a measure of EA specific to OCD, and utilize a longitudinal model that takes temporal precedence into account.

What Do They Want From My Life? Parent-Child Relationships as Perceived by Druze Adolescents in Israel

2018 ◽  
Vol 34 (3) ◽  
pp. 261-281
Author(s):  
Randa Abbas ◽  
Sherri P. Pataki ◽  
Vered Vaknin-Nusbaum ◽  
Salman Ilaiyan
Keyword(s):  
Family Relationships ◽  
Intergenerational Conflict ◽  
Modern Society ◽  
Phenomenological Approach ◽  
Structured Interview ◽  
The Past ◽  
Supportive Family ◽  
The Impact ◽  
Parent Child Relationships ◽  
Parent Child

This research examined Druze adolescents’ perception of their relationships with parents in Israel. Israeli Druze is a small group accounting for only 2% of Israel’s population. The Druze society is patriarchal; it demands absolute loyalty to the values of religion, family, and clan. Our goal was to explore the impact of increasing intercultural contact with modern Israeli society and the outside world on parent-child relationships in a traditional society that demands absolute loyalty and obedience to elders. The researchers used the phenomenological approach to understand parent-child relationships from the perspective of the adolescents themselves. Twelve Druze adolescents, six females and six males ranging in age from 16 to 18, completed a semi-structured interview in which they were asked to describe their relationships with parents. Participants were prompted to describe a recent conflict, if any, and the way in which the conflict was resolved, as well as a positive and a negative interaction with parents in the past year. Thematic analyses revealed intergenerational conflict related to perceived acculturation gaps. Other consistent themes portrayed supportive parent-child relationships and the adolescents’ commitment to Druze heritage. Overall, findings suggest that although increasing exposure to modern society may lead to intergenerational conflict, Druze adolescents remained grounded in supportive family relationships and their religious heritage.

scholarly journals Prevalence and Influencing Factors of Anxiety and Depression Symptoms Amongst Surgical Nurses During COVID-19 Pandemic: A Large-Scale Cross-Sectional Study

2020 ◽  
Author(s):  
Chun-Xia Ren ◽  
De-Cun Zhou ◽  
Yin-Guang Fan ◽  
Bao-Zhu Li ◽  
Wan-Fei Zhang ◽  
...  
Keyword(s):  
Social Support ◽  
Depressive Symptoms ◽  
Influencing Factors ◽  
Rating Scale ◽  
Depression Scale ◽  
Anxiety And Depression ◽  
Depression Symptoms ◽  
Cross Sectional ◽  
Self Rating ◽  
Surgical Nurses

Abstract BackgroundThe outbreak of novel 2019 coronavirus disease (COVID-19) has imposed an enormous physical and psychological pressure on people across the world. This study focused on evaluating the prevalence and influencing factors of anxiety and depression symptoms in surgical nurses during the epidemic in China. MethodA cross-sectional, multicenter quantitative study was conducted in Anhui province (China) from March 3, 2020 to March 19, 2020, with a questionnaire package which consisted of general information questionnaire，Zung's self-rating anxiety scale (SAS), Zung's self-rating Depression Scale (SDS) and social support rating scale (SSRS). A total of 3600 surgical nurses participated in the survey by Wechat and QQ. Data were analysed using multiple linear regression models. ResultsA total of 3492 surgical nurses from 12tertiary hospitals and 12 secondary hospitals in one province of mainland China completed the survey. The prevalence rates of anxiety symptoms and depressive symptoms were 24.83% and 22.39%, respectively. The average level of anxiety and depression of surgical nurses were higher than that of the Chinese norm (P< 0.05).Levels of social support for surgical nurses were significantly negatively associated with the degree of anxiety (r = -0.630, P < 0.001) and depression (r = -0.578, P < 0.001). Fertility status (β = 1.469, P = 0.003), hospital (β = -0.611, P < 0.001), participation in care for COVID-19 patients (β = 2.229, P < 0.001), likelihood of being infected with COVID-19 (β = 1.146, P < 0.001), social support (β = -0.623, P < 0.001) were significantly influencing surgical nurses’ anxiety degree. Similarly, these characteristics were significantly associated with the odds of experiencing depression symptoms in surgical nurses. Divorce and widowed surgical nurses (β = -2.654, P < 0.001) were significantly more likely to experience depressive symptoms than single nurses. ConclusionIn this survey, we found that the surgical nurses had high anxiety and depression symptoms during the COVID-19 outbreak in China. The findings suggest that targeted psychological interventions to promote the mental health of surgical nurses with psychological problems need to be immediately implemented.

scholarly journals The Development of Indicators for Transformational Leadership of Undergraduate Students at Thailand National Sports University

2021 ◽  
Vol 11 (1) ◽  
pp. 94
Author(s):  
Thitipong Sukdee
Keyword(s):  
Transformational Leadership ◽  
Undergraduate Students ◽  
Goodness Of Fit ◽  
Rating Scale ◽  
Structured Interview ◽  
P Value ◽  
Sample Population ◽  
Research Instrument ◽  
Fit Index

This paper develops indicators for transformational leadership of undergraduate students at Thailand National Sports University. The development of these indicators was based on in-depth interviews with six informants. The research instrument was a semi-structured interview form. The data collected were inductively analyzed. The development of indicators was accomplished through the synthesis of the data and the conceptual framework for this research investigation. Evaluate indicators of Accuracy Standard Propriety Standard with of five experts was compared with the principle of 3.50, using the research instrument was an Evaluation Form and thence the verification of the quality of the congruence of the indicators. The sample population consisted of 4 5 0 undergraduate students at Thailand National Sports. The research instrument was a rating-scale questionnaire. Confirmatory factor analysis (CFA) was utilized in conjunction with reliance on the maximum likelihood estimation (MLE) technique. Findings were as follows: 1) In regard to the development of indicators for transformational leadership of undergraduate students at Thailand National Sports University, results were as follows: The aspect of idealized influence engendered eight keywords and twenty-two subtopics. The aspect of inspiration motivation exhibited six keywords and thirteen subtopics. The aspect of intellectual motivation evinced six keywords and fourteen subtopics. The aspect of individualized consideration displayed five keywords and eleven subtopics. 2) Assessing indicators for transformational leadership of undergraduate students at Thailand National Sports University All aspects were significantly higher than the threshold 3.50 at the .05 level. 3) The development of indicators for transformational leadership of undergraduate students at Thailand National Sports University were found to have twenty-five indicators. The verification of the quality of appropriateness for the indicators for transformational leadership of undergraduate students at Thailand National Sports University showed that chi-square (χ2) was at 552.93; (probability-value [p-value] at 0.000); degrees of freedom (df) at 271; relative χ2 at 2.04; goodness of fit index (GFI) at 0.91; adjusted goodness of fit index (AGFI) at 0.90; Normal Fit Index (NFI) at 0.99; Comparative Fit Index (CFI) at 0.99 and the root mean square error of approximation (RMSEA) at 0.04. It is concluded that transformational leadership of undergraduate students at Thailand National Sports is consistent with empirical data.

scholarly journals Central Pain in Parkinson’s Disease: Behavioral and Cognitive Characteristics

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
N. Vila-Chã ◽  
S. Cavaco ◽  
A. Mendes ◽  
A. Gonçalves ◽  
I. Moreira ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Performance ◽  
Rating Scale ◽  
Short Form ◽  
Structured Interview ◽  
Smoking Habits ◽  
Addictive Behaviors ◽  
Study Results ◽  
Compulsive Behaviors

Introduction. Pain is a major nonmotor symptom of Parkinson’s disease (PD), and central parkinsonian pain is the core feature of the putative Park pain subtype of PD. This study aimed to explore the cognitive and behavioral profile of PD patients with central parkinsonian pain. Material and Methods. A structured interview was used to identify and characterize pain in a cohort of 260 consecutive PD patients. The Ford classification of pain was applied. The Dementia Rating Scale-2 (DRS-2) and the Impulse Control Disorders in Parkinson’s Disease Short Form (QUIP-S) were administered, and patients’ smoking habits were recorded. The Unified Parkinson’s Disease Rating Scale (UPDRS) was used to assess motor and nonmotor symptoms in off and on conditions. Results. One hundred and eighty-eight patients (68%) reported pain; and in 41 (22%) of them, the pain was classified as central parkinsonian pain. PD patients with central parkinsonian pain had better cognitive performance in DRS-2 Initiation/Perseveration and Conceptualization subscales but reported more other compulsive behaviors (e.g., hobbyism, punding, and walkabout) and had more current smoking habits than those without pain or with non-central parkinsonian pain. Multiple logistic regression analyses revealed that the DRS-2 Conceptualization subscale, other compulsive behaviors, and smoking habits remained statistically associated with central parkinsonian pain even when other significant covariates were considered. Only patients with pain, regardless of type, had a gambling disorder. Discussion. The study results provide further evidence that pain revealed that patients with central parkinsonian pain are more likely to present compulsive or addictive behaviors, despite having more preserved cognitive performance. Patients with central parkinsonian pain appear to have a distinct phenotype of PD.

scholarly journals Case Report: Clinical and Pharmacokinetic Profile of Lithium Monotherapy in Exclusive Breastfeeding. A Follow-Up Case Series

2021 ◽  
Vol 12 ◽  
Author(s):  
Maria Luisa Imaz ◽  
Dolors Soy ◽  
Mercé Torra ◽  
Llüisa García-Esteve ◽  
Cristina Soler ◽  
...  
Keyword(s):  
Exclusive Breastfeeding ◽  
Rating Scale ◽  
Venous Blood ◽  
Case Series ◽  
Late Pregnancy ◽  
Structured Interview ◽  
Pharmacokinetic Data ◽  
Close Monitoring ◽  
Young Mania

Background: Most guidelines advise that women taking lithium should not breastfeed. The variation in transfer is just one reason behind this advice.Objectives: To present clinical and pharmacokinetic data of nine mother–infant pairs exposed to lithium monotherapy during late pregnancy and exclusive breastfeeding at the Perinatal Psychiatric Unit (2006–2018).Methods: We obtained sociodemographic data, medical risk factors, obstetric variables, and family and personal psychiatric history by semi-structured interview, and assessed maternal psychopathology with the Hamilton Depression Rating Scale and Young Mania Rating Scale. A senior neonatologist reviewed neonatal outcomes at birth using the Peripartum Events Scale. Paired maternal and cord blood and infant venous blood samples were collected. During the breastfeeding period, we monitored serum lithium and creatinine concentrations in mother–infant pairs at delivery, and at days 1–5, 7–11, 30, and 60 postpartum, and monthly until 6-months.Results: Lithium equilibrated completely across the placenta [1.13 (0.10), range (1.02–1.30)]. No women presented symptoms of postpartum lithium intoxication, two of the neonates presented transient hypotonia (22%). Lithium exposure was significantly less during breastfeeding than during late pregnancy, and serum lithium concentrations decreased up to 44% overtime from delivery to the first-month, and up to 60% to the third-month postpartum. There was no growth or developmental delay in the follow-up period. One woman had a manic episode with psychotic features at 45 days postpartum.Conclusions: In carefully selected women with bipolar disorder, lithium therapy when breastfeeding can be an appropriate option if coupled with close monitoring of the mother-infant pair.

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