Higher Levels of IgG3 Antibodies in Serum, But Not in CSF, Distinguish Multiple Sclerosis From Other Neurological Disorders

2022 ◽  
Author(s):  
Peter G. E. Kennedy ◽  
Michael W. Graner ◽  
Anthony Fringuello ◽  
Wenbo Zhou ◽  
Tiffany Pointon ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neurological Disorders

scholarly journals Self-management in neurological disorders: Systematic review of the literature and potential interventions in multiple sclerosis care

2011 ◽  
Vol 48 (9) ◽  
pp. 1087 ◽  
Author(s):  
Alex D. Rae-Grant ◽  
Aaron P. Turner ◽  
Alicia Sloan ◽  
Deborah Miller ◽  
James Hunziker ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Systematic Review ◽  
Neurological Disorders ◽  
Self Management ◽  
Review Of The Literature

scholarly journals Immune Parameters That Distinguish Multiple Sclerosis Patients from Patients with Other Neurological Disorders at Presentation

PLoS ONE ◽  
2015 ◽  
Vol 10 (8) ◽  
pp. e0135434 ◽  
Author(s):  
Athanasia Mouzaki ◽  
Maria Rodi ◽  
Nikolaos Dimisianos ◽  
Andreas Emmanuil ◽  
Dimitra Kalavrizioti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Neurological Disorders ◽  
Immune Parameters ◽  
Multiple Sclerosis Patients

scholarly journals Aptamer Applications in Neuroscience

2021 ◽  
Author(s):  
Meric Ozturk ◽  
Marit Nilsen-Hamilton ◽  
Muslum Ilgu
Keyword(s):  
Multiple Sclerosis ◽  
Amyotrophic Lateral Sclerosis ◽  
Nucleic Acid ◽  
Brain Tumors ◽  
Neurological Disorders ◽  
Neurological Diseases ◽  
Treatment Options ◽  
Health Community ◽  
Theranostic Applications ◽  
Lateral Sclerosis

Being the predominant cause of disability, neurological diseases have received much attention from the global health community. Over a billion people suffer from one of the following neurological disorders: dementia, epilepsy, stroke, migraine, meningitis, Alzheimer's disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, prion dis-ease, or brain tumors. Diagnosis and treatment options are limited for many of these diseases. Aptamers, being small and non-immunogenic nucleic acid molecules that are easy to chemically modify, offer potential diagnostic and theranostic applications to meet these needs. This review covers pioneer studies to apply aptamers, which show promise for future diagnostics and treatments of neurological disorders that pose increasingly dire worldwide health challenges.

scholarly journals Aptamer Applications in Neuroscience

2021 ◽  
Vol 14 (12) ◽  
pp. 1260
Author(s):  
Meric Ozturk ◽  
Marit Nilsen-Hamilton ◽  
Muslum Ilgu
Keyword(s):  
Multiple Sclerosis ◽  
Amyotrophic Lateral Sclerosis ◽  
Nucleic Acid ◽  
Brain Tumors ◽  
Global Health ◽  
Neurological Disorders ◽  
Neurological Diseases ◽  
Treatment Options ◽  
Health Community ◽  
Lateral Sclerosis

Being the predominant cause of disability, neurological diseases have received much attention from the global health community. Over a billion people suffer from one of the following neurological disorders: dementia, epilepsy, stroke, migraine, meningitis, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, prion disease, or brain tumors. The diagnosis and treatment options are limited for many of these diseases. Aptamers, being small and non-immunogenic nucleic acid molecules that are easy to chemically modify, offer potential diagnostic and theragnostic applications to meet these needs. This review covers pioneering studies in applying aptamers, which shows promise for future diagnostics and treatments of neurological disorders that pose increasingly dire worldwide health challenges.

The contribute of cerebrospinal fluid free light-chain assay in the diagnosis of multiple sclerosis and other neurological diseases in an Italian multicenter study

2021 ◽  
pp. 135245852110641
Author(s):  
Gaetano Bernardi ◽  
Tiziana Biagioli ◽  
Paola Malpassi ◽  
Teresa De Michele ◽  
Domizia Vecchio ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Neurological Disorders ◽  
Operating Characteristic ◽  
Neurological Diseases ◽  
Characteristic Curve ◽  
Oligoclonal Bands ◽  
Free Light Chains ◽  
Complementary Information ◽  
Combined Use

Background: Cerebrospinal fluid (CSF) free light chains (FLCs) can be an alternative assay to oligoclonal bands (OCBs) in inflammatory neurological disorders, but threshold has no consensus. Objective: To assess the diagnostic accuracy of CSF FLCs in multiple sclerosis (MS) and other neurological diseases. Methods: A total of 406 patients from five Italian centers. FLCs were measured in CSF and serum using Freelite MX assays on Optilite. Results: A total of 171 patients were diagnosed as MS, 154 non-inflammatory neurological diseases, 48 inflammatory central nervous system (CNS) diseases, and 33 peripheral neurological diseases. Both kFLC and λFLC indices were significantly higher in patients with MS compared to other groups ( p < 0.0001). The kFLC index ⩾ 6.4 is comparable to OCB for MS diagnosis (area under the receiver operating characteristic curve (AUC) = 0.876; sensitivity 83.6% vs 84.2%; specificity 88.5% vs 90.6%). λFLC index ⩾ 5 showed an AUC of 0.616, sensitivity of 33.3% and specificity of 90.6%. In all, 12/27 (44.4%) MS patients with negative OCB had kFLC index ⩾ 6.4. Interestingly, 37.5% of 24 patients with a single CSF IgG band showed high kFLC index and 12.5% positive λFLC index. Conclusion: Our findings support the diagnostic utility of FLC indices in MS and other CNS inflammatory disorders, suggesting a combined use of FLC and OCB to help clinicians with complementary information.

Neurology

2016 ◽  
pp. 153-166
Author(s):  
Kristine O’Phelan
Keyword(s):  
Multiple Sclerosis ◽  
Amyotrophic Lateral Sclerosis ◽  
Turner Syndrome ◽  
Neurological Disorders ◽  
Imaging Studies ◽  
Board Examination ◽  
Neurological Findings ◽  
The Common ◽  
Guillain Barré ◽  
Lateral Sclerosis

The purpose of the Oral Board Examination is to determine a candidate’s competency in neurosurgical disorders, but also neurological disorders, which may mimic neurosurgical conditions. It is not uncommon for a candidate to be presented imaging studies that clearly appear surgical; however, after carefully listening to the history and relevant neurological findings, it will become apparent that the imaging does not explain the patient’s symptoms. Some of the common neurological ailments that the Oral Board examinee needs to be well aware of include amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), Guillain-Barré syndrome, and Parsonage=Turner syndrome (brachial plexitis), some of which are covered either in this chapter or in other relevant chapters.

Neurological disorders

2013 ◽  
pp. 102-131
Author(s):  
Richard J. Hardie ◽  
Jon Poole
Keyword(s):  
Multiple Sclerosis ◽  
Side Effects ◽  
Neurological Disorders ◽  
Work Capacity ◽  
Job Applicants ◽  
Functional Abilities ◽  
Comorbid Illness ◽  
Precise Diagnosis ◽  
Job Title ◽  
Manual Handling

This chapter deals mainly with common acute and chronic neurological problems, particularly as they affect employees and job applicants. The complications of occupational exposure to neurotoxins and putative neurotoxins will also be covered in so far as they relate to the fitness of an exposed employee to continue working. In addition to a few well-known and common conditions, many uncommon but distinct neurological disorders may present at work or affect work capacity. Fitness for work in these disorders will be determined by the person’s functional abilities, any comorbid illness, the efficacy or side effects of the treatment, and psychological and social factors, rather than by the precise diagnosis. This will also need to be put into the context of the job in question, as the basic requirements for a manual labouring job may be completely different from something more intellectually demanding. Indeed, even an apparently precise diagnostic label such as multiple sclerosis (MS) can encompass a complete spectrum of disability, from someone who is entirely asymptomatic to another who is totally incapacitated. Similarly, the job title ‘production operative’ may be applied to someone who is sedentary or who undertakes heavy manual handling. Furthermore, reports by general practitioners, neurologists, or neurosurgeons may describe the symptoms, signs, and investigations in detail, but without analysing functional abilities. These colleagues may also fail to appreciate the workplace hazards, the responsibilities of the employer, or what scope exists for adaptations to the job or workplace.

scholarly journals Primary progressive multiple sclerosis to be treated with ocrelizumab: a mistaken case of cobalamin deficiency

2019 ◽  
Vol 12 (5) ◽  
pp. e229080 ◽  
Author(s):  
Sydney Feldman ◽  
Salman Aljarallah ◽  
Shiv Saidha
Keyword(s):  
Multiple Sclerosis ◽  
Neurological Disorders ◽  
Progressive Multiple Sclerosis ◽  
Cobalamin Deficiency ◽  
Vitamin B ◽  
Primary Progressive Multiple Sclerosis ◽  
Primary Progressive ◽  
Anti Cd20 ◽  
Mri Changes ◽  
Spine Mri

Cobalamin (vitamin B12) deficiency often manifests with neurologic symptoms and may rarely mimic multiple sclerosis (MS) among other neurological disorders. However, MRI changes associated with cobalamin deficiency are typically spinal predominant and distinct from MS-related changes. We report a case of a patient with cobalamin deficiency who was recommended by her primary neurologist to commence treatment with ocrelizumab, a potent anti-CD20 B-cell depleting monoclonal antibody, after being diagnosed with primary progressive MS. However, cervical spine MRI demonstrated changes classical of cobalamin deficiency including ‘inverted V sign’ signal hyperintensity and following parenteral cobalamin supplementation her neurological symptoms quickly and dramatically improved.

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