Bcl-2 Interacts with Beclin 1 and Regulates Autophagy in 7, 12-Dimethylbenz[a]anthracene-Induced Hamster Buccal-Pouch Squamous-Cell Tumorigenesis

2021 ◽  
Author(s):  
Qian Liu ◽  
Yang Liu ◽  
Shu-e Li ◽  
Jin-huan Geng
Keyword(s):  
Squamous Cell ◽  
Beclin 1 ◽  
Hamster Buccal Pouch

scholarly journals Angioarchitecture of squamous cell carcinoma from hamster buccal pouch: a scanning electron microscopy study

Scanning ◽  
2009 ◽  
Vol 31 (5) ◽  
pp. 188-194 ◽  
Author(s):  
Laura Beatriz Oliveira De Oliveira ◽  
Vinícius Faccin Bampi ◽  
Carolina Ferreira Gomes ◽  
Maria Antonieta Lopes De Souza
Keyword(s):  
Electron Microscopy ◽  
Scanning Electron Microscopy ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Microscopy Study ◽  
Electron Microscopy Study ◽  
Scanning Electron Microscopy Study ◽  
Hamster Buccal Pouch ◽  
Scanning Electron

scholarly journals Immunohistochemical Analysis of the Beclin-1 Expression Predicts the Progression of Oral Squamous Cell Carcinoma

2021 ◽  
Vol 18 (21) ◽  
pp. 11125
Author(s):  
Ida Barca ◽  
Chiara Mignogna ◽  
Daniela Novembre ◽  
Francesco Ferragina ◽  
Maria Giulia Cristofaro
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prognostic Index ◽  
Immunohistochemical Analysis ◽  
Tumour Cells ◽  
Beclin 1 ◽  
Immunohistochemical Techniques

Background: Autophagy is a cellular process responsible for maintaining homeostasis; a dysregulation of this process is involved in the development and progression of neoplasms. Beclin-1 is one of the major proteins linked to autophagy. However, the data regarding the association between the role of Beclin-1 and the progression of Oral Squamous Cell Carcinoma (OSCC) are rather low. For this reason, the objective of this study is to evaluate, through immunohistochemical techniques, the prognostic role of the expression of Beclin-1 autophagy marker in patients with OSCC. Methods: This is a single-centre retrospective study that includes patients with OSCC admitted to the Maxillofacial Unit of “Magna Graecia” University between January 2019 and September 2020. All the samples obtained from surgery were treated with anti Beclin-1 antibodies and subjected to immunohistochemical methods. Results: A total of 26 samples were analysed and the following variables were evaluated for each: percentage of positive Beclin-1 expression by tumour cells, signal strength of tumour cells, and total score. The variables considered were first normalised according to the D’Agostino and Pearson test, then analysed using the Pearson linear correlation coefficient: a statistically significant correlation was found between the parameters infiltration-intensity (p = 0.0088), infiltration-percent (p = 0.0123), intensity-total score (p = 0.0060). Conclusions: The immunohistochemical evaluation of Beclin-1 revealed a statistically significant correlation between the intensity of the molecule’s expression and a greater degree of infiltration of the neoplasm. Beclin-1 can, therefore, be considered a valid prognostic index of disease.

scholarly journals Tanshinone IIA induces cell death via Beclin-1-dependent autophagy in oral squamous cell carcinoma SCC-9 cell line

2018 ◽  
Vol 7 (2) ◽  
pp. 397-407 ◽  
Author(s):  
Ye Qiu ◽  
Conghua Li ◽  
Qinhua Wang ◽  
Xingqi Zeng ◽  
Ping Ji
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Death ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Cell Line ◽  
Squamous Cell ◽  
Beclin 1 ◽  
Tanshinone Iia

Deregulation of Beclin 1 in patients with tobacco-related oral squamous cell carcinoma

2012 ◽  
Vol 422 (4) ◽  
pp. 764-769 ◽  
Author(s):  
Vaishali Kapoor ◽  
Daizy Paliwal ◽  
S. Baskar Singh ◽  
Bidhu Kalyan Mohanti ◽  
Satya Narayan Das
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Beclin 1

Prognostic Significance of Beclin-1 Expression in Laryngeal Squamous Cell Carcinoma

2013 ◽  
Vol 19 (4) ◽  
pp. 771-777 ◽  
Author(s):  
Li Huang ◽  
Shuang Wang ◽  
Shi-Sheng Li ◽  
Xin-Ming Yang
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Prognostic Significance ◽  
Beclin 1

Chemopreventive effect of Toona sinensis leaf extract on 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch squamous cell carcinogenesis

2016 ◽  
Vol 70 ◽  
pp. 130-142 ◽  
Author(s):  
Wen-Chen Wang ◽  
Ching-Yi Chen ◽  
Hseng-Kuang Hsu ◽  
Li-Min Lin ◽  
Yuk-Kwan Chen
Keyword(s):  
Squamous Cell ◽  
Leaf Extract ◽  
Toona Sinensis ◽  
Hamster Buccal Pouch ◽  
Chemopreventive Effect
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