Effect of Chinese drugs for activating blood circulation and detoxifying on indices of thrombosis, inflammatory reaction, and tissue damage in a rabbit model of toxin-heat and blood stasis syndrome

2011 ◽  
Vol 19 (1) ◽  
pp. 42-47 ◽  
Author(s):  
Mei Xue ◽  
Hui-jun Yin ◽  
Cai-feng Wu ◽  
Xiao-juan Ma ◽  
Chun-yu Guo ◽  
...  
Keyword(s):  
Inflammatory Reaction ◽  
Tissue Damage ◽  
Blood Circulation ◽  
Blood Stasis ◽  
Rabbit Model ◽  
Blood Stasis Syndrome ◽  
Chinese Drugs

scholarly journals Chinese Herb and Formulas for Promoting Blood Circulation and Removing Blood Stasis and Antiplatelet Therapies

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Yue Liu ◽  
Hui-Jun Yin ◽  
Da-zhuo Shi ◽  
Ke-ji Chen
Keyword(s):  
Acute Coronary Syndromes ◽  
Blood Circulation ◽  
Adverse Reactions ◽  
Chinese Herb ◽  
Blood Stasis ◽  
Bleeding Risk ◽  
Blood Stasis Syndrome ◽  
The World ◽  
Close Relationship ◽  
Coronary Syndromes

Atherothrombosis, which directly threatens people's health and lives, is the main cause of morbidity and mortality all over the world. Platelets play a key role in the development of acute coronary syndromes (ACSs) and contribute to cardiovascular events. Oral antiplatelet drugs are a milestone in the therapy of cardiovascular atherothrombotic diseases. In recent years, many reports have shown the possibility that “resistance” to oral anti-platelet drugs and many adverse reactions, such as serious bleeding risk, which provides an impetus for developing new anti-platelet drugs possesses highly efficiency and fewer adverse effects. Study on the blood stasis syndrome and promoting blood circulation and removing blood stasis is the most active field of research of integration of traditional and western medicine in China. Blood-stasis syndrome and platelet activation have close relationship, many Chinese herb and formulas for promoting blood circulation and removing blood stasis possess definite anti-platelet effect. This paper covers the progress of anti-platelet mechanism of Chinese herb and formulas for promoting blood circulation and removing blood stasis and is to be deeply discussed in further research.

scholarly journals The Mechanism Research of Qishen Yiqi Formula by Module-Network Analysis

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Shichao Zheng ◽  
Yanling Zhang ◽  
Yanjiang Qiao
Keyword(s):  
Protein Interactions ◽  
Blood Circulation ◽  
Blood Stasis ◽  
Interaction Network ◽  
Enrichment Analysis ◽  
Small World ◽  
Blood Stasis Syndrome ◽  
Active Components ◽  
Scale Free ◽  
Topological Parameters

Qishen Yiqi formula (QSYQ) has the effect of tonifying Qi and promoting blood circulation, which is widely used to treat the cardiovascular diseases with Qi deficiency and blood stasis syndrome. However, the mechanism of QSYQ to tonify Qi and promote blood circulation is rarely reported at molecular or systems level. This study aimed to elucidate the mechanism of QSYQ based on the protein interaction network (PIN) analysis. The targets’ information of the active components was obtained from ChEMBL and STITCH databases and was further used to search against protein-protein interactions by String database. Next, the PINs of QSYQ were constructed by Cytoscape and were analyzed by gene ontology enrichment analysis based on Markov Cluster algorithm. Finally, based on the topological parameters, the properties of scale-free, small world, and modularity of the QSYQ’s PINs were analyzed. And based on function modules, the mechanism of QSYQ was elucidated. The results indicated that Qi-tonifying efficacy of QSYQ may be partly attributed to the regulation of amino acid metabolism, carbohydrate metabolism, lipid metabolism, and cAMP metabolism, while QSYQ improves the blood stasis through the regulation of blood coagulation and cardiac muscle contraction. Meanwhile, the “synergy” of formula compatibility was also illuminated.

scholarly journals THE EXPERIMENTAL STUDY OF CUPPING THERAPY INTERVENING THE RABBIT MODEL OF COLD STAGNATION LEADING TO BLOOD STASIS SYNDROME BASED ON THE BIOCHEMICAL CRITERION

2021 ◽  
Author(s):  
WEN-TAO LV ◽  
CHENG-HUI ZHU ◽  
XIANG-WEN MENG ◽  
HUI ZHI
Keyword(s):  
Growth Factor ◽  
Treatment Group ◽  
Epidermal Growth Factor ◽  
Peripheral Blood ◽  
Blood Stasis ◽  
Rabbit Model ◽  
Cupping Therapy ◽  
Blood Stasis Syndrome ◽  
Model Group ◽  
Epidermal Growth

Objective: Explore the partial mechanisms of cupping therapy by means of the cellular factors in the peripheral blood cells; methods: Replicate the rabbit model of cold stagnation leading to blood stasis by adopting the cold stimulation and randomly dividing 12 rabbits to three groups based on the weight. Observe the sign of the rabbits before and after cupping test, the content of the vascular endothelial growth factor (VEGF), epidermal growth factor (EGF)in the peripheral blood; Results: After replicated the model, the model group and the treatment group gradually appeared the sign of cold stagnation leading to blood stasis. After cupping treatment, the sign of cold stagnation leading to blood stasis of the rabbits gradually disappeared. Compared with the blank controlled group and the model group at the same time, the epidermal growth factor (EGF)in the peripheral blood of the treatment group was much higher after cupping and was statistically difference (p<0.05); Conclusion: The rabbit model of cold stagnation leading to blood stasis could be successfully replicated by the cold irritation; Cupping therapy could produce benign physical stimulation to the local skin through the expression of the cell factors, which might generate continuous weak stimulation, expand and improve the capillaries, thus formed the cascade reaction, and affected the entire microcirculation. Therefore this might be one of the mechanisms of “dredging collaterals”, effect that cupping therapy produced.

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