Mindfulness-based stress reduction alters brain activity for breast cancer survivors with chronic neuropathic pain: preliminary evidence from resting-state fMRI

2020 ◽  
Author(s):  
A. M. Smith ◽  
A. Leeming ◽  
Z. Fang ◽  
T. Hatchard ◽  
O. Mioduszewski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Neuropathic Pain ◽  
Cancer Survivors ◽  
Stress Reduction ◽  
Resting State ◽  
Breast Cancer Survivors ◽  
Brain Activity ◽  
Resting State Fmri ◽  
Preliminary Evidence ◽  
Chronic Neuropathic Pain

scholarly journals Neuropathic Pain in Breast Cancer Survivors: Using the ID Pain as a Screening Tool

2010 ◽  
Vol 39 (5) ◽  
pp. 882-889 ◽  
Author(s):  
Cielito Reyes-Gibby ◽  
Phuong Khanh Morrow ◽  
Michael I. Bennett ◽  
Mark P. Jensen ◽  
Sanjay Shete
Keyword(s):  
Breast Cancer ◽  
Neuropathic Pain ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Screening Tool

Patient-reported pain and other symptoms among breast cancer survivors: prevalence and risk factors

2020 ◽  
Vol 106 (6) ◽  
pp. 480-490
Author(s):  
Michele Divella ◽  
Luigi Vetrugno ◽  
Serena Bertozzi ◽  
Luca Seriau ◽  
Carla Cedolini ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Chronic Pain ◽  
Neuropathic Pain ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Breast Tissue ◽  
Shoulder Function ◽  
Breast Cancer Surgery ◽  
Patient Reported

Objective: To investigate the prevalence and risk factors associated with chronic pain and other symptoms related to breast cancer 6 months after surgery. Methods: In an observational study of 261 female breast cancer survivors treated between January 2017 and January 2018, patients were asked about their pain symptoms using a questionnaire that utilized the Numeric Rating Score (NRS) and the Douleur Neuropathique Score (DN4) for neuropathic pain; it also addressed phantom sensations and functional disorders on the ipsilateral shoulder. A total of 218 women completed the survey. Results: A total of 105 patients (48.17%) reported chronic pain. Of these, 64% rated the pain with an NRS of 1–3 and 35% with an NRS >3. Neuropathic pain was reported in 65% of the sample, phantom sensations in 12%, disorders of shoulder function in 16%, and web syndrome in 2%. Multivariable analyses showed that chronic pain (odds ratio [OR], 2.55; 95% confidence interval [CI], 1.094–5.942; p < 0.05) and neuropathic pain (OR, 2.988; 95% CI, 1.366–6.537; p < 0.05) were positively associated with surgical adverse events; phantom sensations were statistically associated with the weight of removed breast tissue (OR, 1.003; 95% CI, 1.001–1.005; p < 0.05). Conclusions: Our study highlights the need to employ specific tools capable of detecting different kinds of chronic pain after breast cancer surgery to improve pain prevention and treatment. Surgical complications and the weight of removed breast tissue emerged as 2 of the risk factors for chronic and neuropathic pain development in breast cancer survivors.

Feasibility of a Mindfulness-Based Stress Reduction Program for Early-Stage Breast Cancer Survivors

2010 ◽  
Vol 29 (2) ◽  
pp. 107-117 ◽  
Author(s):  
Cecile A. Lengacher ◽  
Versie Johnson-Mallard ◽  
Michelle Barta ◽  
Shirley Fitzgerald ◽  
Manolete S. Moscoso ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Survivors ◽  
Stress Reduction ◽  
Breast Cancer Survivors ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Reduction Program ◽  
Mindfulness Based Stress Reduction

Mindfulness based stress reduction (MBSR) to improve cardiovascular (CV) function and psychosocial outcomes in breast cancer survivors.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e24058-e24058
Author(s):  
Anne Hudson Blaes ◽  
Patricia Jewett ◽  
Prabhjot Nijjar ◽  
Susan Everson-Rose
Keyword(s):  
Breast Cancer ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Cancer Survivors ◽  
Stress Reduction ◽  
Breast Cancer Survivors ◽  
Psychosocial Outcomes ◽  
Ratio Measurement ◽  
The Impact

e24058 Background: Breast cancer survivors on aromatase inhibitors (AIs) can develop endothelial dysfunction, a measure of increased CV risk. Stress modifying techniques such as MBSR may improve CV function and quality of life (QOL). We present data of a pilot study assessing the impact of MBSR on endothelial dysfunction and psychosocial outcomes. Methods: 31 women with locally advanced breast cancer and taking an AI were randomized 1:1 to 8 weekly MBSR classes or wait-list control. Subjects with tobacco use, known hypertension or hyperlipidemia were excluded. Participants completed surveys and vascular testing at baseline and 10 weeks. With the COVID-19 pandemic, MBSR classes were held on a virtual platform. Endothelial function was measured using the Endo-PAT2000 system; reductions in EndoPAT ratio (<1.6) are indicative of worsening endothelial function and increased CV risk. Questionnaires included the CDC’s 4-item Healthy Days Core Module (HRQOL), Patient Health Questionnaire (PHQ)-8 for depression, the Perceived Stress Scale, and the Generalized Anxiety Disorder Scale (GAD-7). Functional test markers were compared between groups using t-tests. Results: Baseline mean age was 59 years, body mass index was 28.4 kg/m2, mean systolic blood pressure was 128.1 mmHg and cholesterol was 226.9 mg/dL. These measures did not differ between groups. Baseline EndoPAT ratio (0.60) and follow up (0.52) were low in all participants. As statewide COVID-19 cases spiked, 3/31 participants did not return for a second assessment, and for another 5 participants, one EndoPAT ratio measurement was not interpretable. Both groups showed a decline in EndoPat ratio pre-to-post, but the decline among MBSR participants (all of whom completed the intervention) was five times less than that observed among controls [Table]. Groups did not differ on QOL or psychosocial outcomes. Conclusions: Breast cancer survivors on AIs have endothelial dysfunction, a measure of increased CV risk. Stress reduction techniques, using virtual platforms, are feasible and acceptable to this patient population, and may help improve endothelial function. Further research and longer follow up is warranted in understanding the long-term impact of these interventions on CV risk and psychosocial well-being. [Table: see text]

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