Synthesis of Geraniol Esters in a Continuous-Flow Packed-Bed Reactor of Immobilized Lipase: Optimization of Process Parameters and Kinetic Modeling

In this study, the kinetic resolution of (R,S)-2-pentanol via transesterification to achieve S-2-pentanol, a key intermediate required in the synthesis of anti-Alzheimer drugs, was investigated in continuous-flow packed-bed reactors. The effects of residence time, substrate concentration, and operation time of the enzyme were investigated. Under steady state conditions, 50% conversion and enantiomeric excess of the substrate (eeS)>99% were achieved at a residence time of 0.04 min. Productivity of the continuous-flow process (1.341 mmol/min/g)was about 4 times higher than that of the corresponding batch process (0.363 mmol/min/g). In addition, the mathematical modeling of the packed-bed reactor was conductedusing an axial dispersion model. Ping Pong Bi Bi kinetics was used in this model. Design parameters were determined and the developed equations were solved using an algorithm for solving boundary value problems for ordinary differential equations by collocation (bvp4c) using MATLAB. The results, obtained from the model, fitted the experimental data very well.

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Continuous Production of Lipase-Catalyzed Biodiesel in a Packed-Bed Reactor: Optimization and Enzyme Reuse Study

Journal of Biomedicine and Biotechnology ◽

10.1155/2011/950725 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 22

Author(s):

Hsiao-Ching Chen ◽

Hen-Yi Ju ◽

Tsung-Ta Wu ◽

Yung-Chuan Liu ◽

Chih-Chen Lee ◽

...

Keyword(s):

Flow Rate ◽

Immobilized Lipase ◽

Continuous Production ◽

Packed Bed ◽

Packed Bed Reactor ◽

Molar Ratio ◽

System Response ◽

Biodiesel Synthesis ◽

Substrate Molar Ratio ◽

Molar Conversion

An optimal continuous production of biodiesel by methanolysis of soybean oil in a packed-bed reactor was developed using immobilized lipase (Novozym 435) as a catalyst in atert-butanol solvent system. Response surface methodology (RSM) and Box-Behnken design were employed to evaluate the effects of reaction temperature, flow rate, and substrate molar ratio on the molar conversion of biodiesel. The results showed that flow rate and temperature have significant effects on the percentage of molar conversion. On the basis of ridge max analysis, the optimum conditions were as follows: flow rate 0.1 mL/min, temperature52.1∘C, and substrate molar ratio 1 : 4. The predicted and experimental values of molar conversion were83.31±2.07% and82.81±.98%, respectively. Furthermore, the continuous process over 30 days showed no appreciable decrease in the molar conversion. The paper demonstrates the applicability of using immobilized lipase and a packed-bed reactor for continuous biodiesel synthesis.

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Rapid solvent-free esterification of conjugated linoleic acid and glycerol in a packed bed reactor containing an immobilized lipase

Studies in Surface Science and Catalysis - 12th International Congress on Catalysis, Proceedings of the 12th ICC ◽

10.1016/s0167-2991(00)80549-2 ◽

2000 ◽

pp. 3405-3410 ◽

Cited By ~ 1

Author(s):

Jose A. Arcos ◽

Charles G. Hill

Keyword(s):

Linoleic Acid ◽

Conjugated Linoleic Acid ◽

Immobilized Lipase ◽

Packed Bed ◽

Solvent Free ◽

Packed Bed Reactor

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Methyl Oleate Production in a Supported Sol–Gel Immobilized Lipase Packed Bed Reactor

Energy & Fuels ◽

10.1021/acs.energyfuels.5b00176 ◽

2015 ◽

Vol 29 (5) ◽

pp. 3168-3175 ◽

Cited By ~ 4

Author(s):

Sarah M. Meunier ◽

Amin R. Rajabzadeh ◽

Trevor G. Williams ◽

Raymond L. Legge

Keyword(s):

Methyl Oleate ◽

Immobilized Lipase ◽

Sol Gel ◽

Packed Bed ◽

Packed Bed Reactor

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The design and photoreaction kinetic modeling of a gas-phase titania foam packed bed reactor

Chemical Engineering Journal ◽

10.1016/j.cej.2007.02.018 ◽

2007 ◽

Vol 133 (1-3) ◽

pp. 317-323 ◽

Cited By ~ 20

Author(s):

A.O. Ibhadon ◽

I.M. Arabatzis ◽

P. Falaras ◽

D. Tsoukleris

Keyword(s):

Gas Phase ◽

Kinetic Modeling ◽

Packed Bed ◽

Packed Bed Reactor

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Electrochemical removal of copper from a simulated wastewater using a rotating tubular packed bed of woven screens electrode

Al-Qadisiyah Journal for Engineering Sciences ◽

10.30772/qjes.v12i2.601 ◽

2019 ◽

Vol 12 (2) ◽

pp. 127-134

Author(s):

Jenan Hussein Hemeidan ◽

Ali H. Abbar

Keyword(s):

Removal Efficiency ◽

Process Parameters ◽

Copper Concentration ◽

Rotation Speed ◽

Packed Bed ◽

Electrochemical Reactor ◽

Copper Removal ◽

A Value ◽

Optimization Of Process Parameters ◽

Simulated Wastewater

Copper removal from a simulated wastewater was investigated by using rotating tubular packed bed of woven screens electrode as a cathode in a new design of electrochemical reactor. Effects of electrolysis operating parameters like current (0.5–2.5 A), rotation speed (150–750 rpm), and initial copper concentration (100–500ppm) were investigated. Optimization of process parameters was carried out by adopting response surface methodology (RSM) combined with Box–Behnken Design (BBD) where copper removal efficiency was selected as a response function. The results indicated that current has the main effect on the copper removal efficiency followed by rotation speed and concentration. The results of regression analysis revealed that the experimental data could be fitted to a second-order polynomial model with a value of determination coefficient (R2) equal to 0.9894 and Fisher test at value of 51.57 for. The optimum conditions of the process parameters based on RSM method were an initial copper concentration of 205 ppm, current of 2.5A, and rotation speed of 750 rpm utilizing cathode composed of screens with mesh no. 30 where a final copper concentration less than 2 ppm was obtained after 30 min.

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