Effects of Zinc Supplementation and Deficiency on Bone Metabolism and Related Gene Expression in Rat

2010 ◽  
Vol 143 (1) ◽  
pp. 394-402 ◽  
Author(s):  
Jian-Yi Sun ◽  
Jian-Feng Wang ◽  
Nai-Tao Zi ◽  
Ming-Yan Jing ◽  
Xiao-Yan Weng
2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Shinichi Katsumata ◽  
Hiroshi Matsuzaki ◽  
Rie Katsumata-Tsuboi ◽  
Mariko Uehara ◽  
Kazuharu Suzuki

In this study, the effects of high phosphorus (P) diet on bone metabolism-related gene expression were investigated in young and aged mice. Twelve- and 80-week-old ddY male mice were divided into two groups, respectively, and fed a control diet containing 0.3% P or a high P diet containing 1.2% P. After 4 weeks of treatment, serum parathyroid hormone (PTH) concentration was significantly higher in the high P groups than in the control groups in both young and aged mice and was significantly higher in aged mice than in young mice fed the high P diet. High P diet significantly increased receptor activator of NF-κB ligand (RANKL) mRNA in the femur of both young and aged mice and significantly increased the RANKL/osteoprotegerin (OPG) mRNA ratio only in aged mice. High P diet significantly increased mRNA expression of transient receptor potential vanilloid type 6, calbindin-D9k, and plasma membrane Ca2+-ATPase 1b in the duodenum of both young and aged mice. These results suggest that high P diet increased RANKL mRNA expression in the femur and calcium absorption-related gene expression in the duodenum regardless of age. Furthermore, the high P diet-induced increase in PTH secretion might increase the RANKL/OPG mRNA ratio in aged mice.


Nutrition ◽  
2009 ◽  
Vol 25 (5) ◽  
pp. 581-589 ◽  
Author(s):  
Fusako Maehira ◽  
Ikuko Miyagi ◽  
Yukinori Eguchi

Meat Science ◽  
2017 ◽  
Vol 124 ◽  
pp. 84-94 ◽  
Author(s):  
Joël D'Astous-Pagé ◽  
Claude Gariépy ◽  
Richard Blouin ◽  
Simon Cliche ◽  
Brian Sullivan ◽  
...  

2020 ◽  
Vol 59 (4) ◽  
pp. 669-676 ◽  
Author(s):  
Pedro Negri ◽  
Leonor Ramirez ◽  
Silvina Quintana ◽  
Nicolas Szawarski ◽  
Matías D. Maggi ◽  
...  

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