The Therapeutic Role of Slit2 in Anti-fibrosis, Anti-inflammation and Anti-oxidative Stress in Rats with Coronary Heart Disease

Oxidative stress has been closely related with coronary artery disease. In coronary heart disease (CHD), an excess of reactive oxygen species (ROS) production generates endothelial cell and smooth muscle functional disorders, leading to a disequilibrium between the antioxidant capacity and prooxidants. ROS also leads to inflammatory signal activation and mitochondria-mediated apoptosis, which can promote and increase the occurrence and development of CHD. There are several kinds of antioxidative and small molecular systems of antioxidants, such as β-carotene, ascorbic acid, α-tocopherol, and reduced glutathione (GSH). Studies have shown that antioxidant treatment was effective and decreased the risk of CHD, but the effect of the treatment varies greatly. Traditional Chinese medicine (TCM) has been utilized for thousands of years in China and is becoming increasingly popular all over the world, especially for the treatments of cardiovascular diseases. This review will concentrate on the evidence of the action mechanism of TCM in preventing CHD by modulating oxidative stress-related signaling pathways.

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Functional Activity of Neutrophils in Diabetes Mellitus and Coronary Heart Disease: Role of Myeloperoxidase in the Development of Oxidative Stress

Bulletin of Experimental Biology and Medicine ◽

10.1007/s10517-012-1865-7 ◽

2012 ◽

Vol 154 (1) ◽

pp. 23-26 ◽

Cited By ~ 17

Author(s):

I. V. Gorudko ◽

V. A. Kostevich ◽

A. V. Sokolov ◽

E. V. Shamova ◽

I. V. Buko ◽

...

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Coronary Heart Disease ◽

Heart Disease ◽

Functional Activity

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Clinical Role of Antioxidants in the Treatment of Diseases

Nutraceutical and Functional Foods in Disease Prevention - Advances in Human Services and Public Health ◽

10.4018/978-1-5225-3267-5.ch013 ◽

2019 ◽

pp. 392-401 ◽

Cited By ~ 1

Author(s):

Kirti Rani

Keyword(s):

Oxidative Stress ◽

Coronary Heart Disease ◽

Heart Disease ◽

Clinical Role ◽

Free Radical Damage ◽

Potential Benefits ◽

Risk Of Cancer ◽

Radical Damage ◽

Wide Assortment

Antioxidants are our first line of defense against free radical damage and are critical for maintaining optimum healthcare. Although most of the present day research is focused on the potential benefits of antioxidant nutrients or supplements, it has become clear that the best protection against oxidative stress involves a wide assortment of interrelated antioxidants and antioxidant cofactors. Additionally, the combination of several suboptimal concentrations of these kinds of detoxifying supplements may have an additive or even synergistic role to decrease the risk of some of diseases which are caused by aging. Adequate intake of fruit and vegetables have essential antioxidants like B-carotene and vitamin C, which are reported for decreasing the risk of cancer and coronary heart disease (CHD).

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HIV, Metabolic Syndrome X, Inflammation, Oxidative Stress, and Coronary Heart Disease Risk : Role of Protease Inhibitor Exposure

Cardiovascular Toxicology ◽

10.1385/ct:4:3:303 ◽

2004 ◽

Vol 4 (3) ◽

pp. 303-316 ◽

Cited By ~ 25

Author(s):

Barry E. Hurwitz ◽

Nancy G. Klimas ◽

Maria M. Llabre ◽

Kevin J. Maher ◽

Jay S. Skyler ◽

...

Keyword(s):

Oxidative Stress ◽

Metabolic Syndrome ◽

Coronary Heart Disease ◽

Heart Disease ◽

Protease Inhibitor ◽

Coronary Heart Disease Risk ◽

Disease Risk ◽

Syndrome X ◽

Heart Disease Risk

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The Role of Oxidative Stress and Antioxidants in Occurrence of Myocardial Infarction and Chronic Heart Failure

Medical University ◽

10.2478/medu-2020-0019 ◽

2020 ◽

Vol 3 (4) ◽

pp. 155-164

Author(s):

N.A. Terekhina ◽

O.G. Goryacheva

Keyword(s):

Oxidative Stress ◽

Myocardial Infarction ◽

Heart Failure ◽

Coronary Heart Disease ◽

Uric Acid ◽

Antioxidant Enzymes ◽

Heart Disease ◽

Gamma Glutamyl Transferase ◽

Glutamyl Transferase

AbstractOxidative stress is one of the most important mechanisms of cardiovascular diseases, especially in heart failure. Mitochondrial dysfunction and inflammation play a major role in formation of free radicals and antioxidants. The association between oxidative stress, telomere biology and cell senescence plays the key role in cardiovascular pathology development. The paper considers role of pro-oxidant and antioxidant enzymes in heart pathology development. Specifically, the role of such antioxidant enzymes as glutathione peroxidase 3, catalase, and superoxide dismutase is described. The role of gamma-glutamyl transferase is emphasized as its activity increases significantly in cases of heart failure, coronary heart disease, stroke, arterial hypertensions, and arrhythmias. This article is a literature review of the effect of such antioxidants as alpha-tocopherol, ubiquinone, uric acid, and triiodothyronine on development of heart failure and myocardial infarction. A decrease in triiodothyronine concentration is a risk factor for coronary heart disease. High uric acid values in patients with myocardial infarction upon admission to the hospital are associated with a high risk of sudden death. The influence of such minerals such as zinc, copper, magnesium, selenium, potassium, sodium, calcium, and iron on heart failure development has been analyzed. The role of ceruloplasmin as an independent predictor of acute and chronic cardiac disorders cardiac events, mortality, and bad prognosis in patients with heart failure and myocardial infarction is examined. The authors demonstrate the influence of inflammation on heart failure development as well as association of inflammation with oxidative stress.

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