Functional Activity of Neutrophils in Diabetes Mellitus and Coronary Heart Disease: Role of Myeloperoxidase in the Development of Oxidative Stress

2012 ◽  
Vol 154 (1) ◽  
pp. 23-26 ◽  
Author(s):  
I. V. Gorudko ◽  
V. A. Kostevich ◽  
A. V. Sokolov ◽  
E. V. Shamova ◽  
I. V. Buko ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Functional Activity

scholarly journals The Role of Traditional Chinese Medicine in the Regulation of Oxidative Stress in Treating Coronary Heart Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Xinyu Yang ◽  
Tianmai He ◽  
Songjie Han ◽  
Xiaoyu Zhang ◽  
Yang Sun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Antioxidant Treatment ◽  
Molecular Systems ◽  
Artery Disease ◽  
Signal Activation

Oxidative stress has been closely related with coronary artery disease. In coronary heart disease (CHD), an excess of reactive oxygen species (ROS) production generates endothelial cell and smooth muscle functional disorders, leading to a disequilibrium between the antioxidant capacity and prooxidants. ROS also leads to inflammatory signal activation and mitochondria-mediated apoptosis, which can promote and increase the occurrence and development of CHD. There are several kinds of antioxidative and small molecular systems of antioxidants, such as β-carotene, ascorbic acid, α-tocopherol, and reduced glutathione (GSH). Studies have shown that antioxidant treatment was effective and decreased the risk of CHD, but the effect of the treatment varies greatly. Traditional Chinese medicine (TCM) has been utilized for thousands of years in China and is becoming increasingly popular all over the world, especially for the treatments of cardiovascular diseases. This review will concentrate on the evidence of the action mechanism of TCM in preventing CHD by modulating oxidative stress-related signaling pathways.

scholarly journals The Role of Endothelial Microparticle in Coronary Heart Disease as The Complications of Diabetes Mellitus

2019 ◽  
Vol 4 (1) ◽  
pp. 31-39
Author(s):  
Eka Fithra Elfi ◽  
Yose Ramda Ilhami ◽  
Eryati Darwin
Keyword(s):  
Nitric Oxide ◽  
Diabetes Mellitus ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Endothelial Dysfunction ◽  
Cell Activation ◽  
Inflammatory Factors ◽  
Endothelial Cell Activation ◽  
Complications Of Diabetes

  Coronary heart disease (CHD) is caused by obstruction of coronary blood flow due to endothelial dysfunction triggered by various genetic and non-genetic risk factors such as hyperlipidemia, hypertension, hyperglycemia and obesity. Endothelial cell activation due to hyperglycaemia in diabetes mellitus induces production of pro-inflammatory factors that damage the cell membrane triggering the formation of membrane particles called microparticles. Endothe-lial microparticles contain proteins including endothelial nitric oxide synthase (eNOS) which plays a role in the production of nitric oxide (NO). To determine the role of microparticles in the occurrence of coro-nary heart disease in diabetes mellitus due to endothelial dysfunction, a study was conducted by comparing the levels of eNOS and NO in DM patients who had CHD with DM patients who had no CHD. Blood samples from 20 DM patients who had CHD and 20 DM patients who had no CHD of the outpatients in Cardiology Department and Inter-nal Medicine department of regional public hospital were included in this study. All patients were fulfilled inclusion and exclusion criteria and diagnosed by the appropriate specialist. The eNOS and NO lev-els were measured using the ELISA method. The results of this study show that eNOS levels in the group of DM patients who had CHD (21,292±12,415 ng/ml) were significantly lower (p <0.05) than those in the group of DM patients who had no CHD (29,721±11,952 ng/ml). Nitric oxide levels in DM patients who had CHD (0,053±0,021 nmol/ μl) were not statistically different to the levels in DM patients who had no CHD (0,047±0,032 nmol/μl). From the results of this study we concluded that endothelial microparticle protein eNOS plays a role in the occurrence of CHD due to the complications of diabetes mellitus 

Clinical Role of Antioxidants in the Treatment of Diseases

2019 ◽  
pp. 392-401 ◽  
Author(s):  
Kirti Rani
Keyword(s):  
Oxidative Stress ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Clinical Role ◽  
Free Radical Damage ◽  
Potential Benefits ◽  
Risk Of Cancer ◽  
Radical Damage ◽  
Wide Assortment

Antioxidants are our first line of defense against free radical damage and are critical for maintaining optimum healthcare. Although most of the present day research is focused on the potential benefits of antioxidant nutrients or supplements, it has become clear that the best protection against oxidative stress involves a wide assortment of interrelated antioxidants and antioxidant cofactors. Additionally, the combination of several suboptimal concentrations of these kinds of detoxifying supplements may have an additive or even synergistic role to decrease the risk of some of diseases which are caused by aging. Adequate intake of fruit and vegetables have essential antioxidants like B-carotene and vitamin C, which are reported for decreasing the risk of cancer and coronary heart disease (CHD).

HIV, Metabolic Syndrome X, Inflammation, Oxidative Stress, and Coronary Heart Disease Risk : Role of Protease Inhibitor Exposure

2004 ◽  
Vol 4 (3) ◽  
pp. 303-316 ◽  
Author(s):  
Barry E. Hurwitz ◽  
Nancy G. Klimas ◽  
Maria M. Llabre ◽  
Kevin J. Maher ◽  
Jay S. Skyler ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Protease Inhibitor ◽  
Coronary Heart Disease Risk ◽  
Disease Risk ◽  
Syndrome X ◽  
Heart Disease Risk

scholarly journals The role of arterial hypertension in the patterns and outcomes of hospitalizations at a multidisciplinary emergency care hospital

2004 ◽  
Vol 10 (3) ◽  
pp. 155-158
Author(s):  
N. F. Plavunov ◽  
V. V. Stepanova ◽  
Yu. L. Karaulova ◽  
Yn. V. Kotovskaya ◽  
Zh. .. Kobalava ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Myocardial Infarction ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Arterial Hypertension ◽  
Emergency Care ◽  
Care Hospital ◽  
Circulatory Disorders ◽  
Actual Prevalence

The role of arterial hypertension (AH) in the pattern and outcomes of hospitalizations at a multidisciplinary emergency care hospital was analyzed, by using annual statistical reports and 0199 statistical cards on patients with AH, admitted to the therapeutic, cardiological, and neurological units of City Clinical Hospital No. 64 in 2000-2001. The bulk of patients with AH comprised above 60-year-old individuals having complications and concomitant diseases (most commonly coronary heart disease, diabetes mellitus, obesity, chronic bronchi!is). AH was the background disease in most patients admitted to the hospital for myocardial infarction and acute cerebral circulatory disorders, There arc great differences in the incidence of AH, as evidenced by annual final statistical reports (3.6 %) and individual Statistical forms (23.4 %), which leads to the underestimation of the actual prevalence of AG in inpatient practice.

The Role of Oxidative Stress and Antioxidants in Occurrence of Myocardial Infarction and Chronic Heart Failure

2020 ◽  
Vol 3 (4) ◽  
pp. 155-164
Author(s):  
N.A. Terekhina ◽  
O.G. Goryacheva
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Heart Failure ◽  
Coronary Heart Disease ◽  
Uric Acid ◽  
Antioxidant Enzymes ◽  
Heart Disease ◽  
Gamma Glutamyl Transferase ◽  
Glutamyl Transferase

AbstractOxidative stress is one of the most important mechanisms of cardiovascular diseases, especially in heart failure. Mitochondrial dysfunction and inflammation play a major role in formation of free radicals and antioxidants. The association between oxidative stress, telomere biology and cell senescence plays the key role in cardiovascular pathology development. The paper considers role of pro-oxidant and antioxidant enzymes in heart pathology development. Specifically, the role of such antioxidant enzymes as glutathione peroxidase 3, catalase, and superoxide dismutase is described. The role of gamma-glutamyl transferase is emphasized as its activity increases significantly in cases of heart failure, coronary heart disease, stroke, arterial hypertensions, and arrhythmias. This article is a literature review of the effect of such antioxidants as alpha-tocopherol, ubiquinone, uric acid, and triiodothyronine on development of heart failure and myocardial infarction. A decrease in triiodothyronine concentration is a risk factor for coronary heart disease. High uric acid values in patients with myocardial infarction upon admission to the hospital are associated with a high risk of sudden death. The influence of such minerals such as zinc, copper, magnesium, selenium, potassium, sodium, calcium, and iron on heart failure development has been analyzed. The role of ceruloplasmin as an independent predictor of acute and chronic cardiac disorders cardiac events, mortality, and bad prognosis in patients with heart failure and myocardial infarction is examined. The authors demonstrate the influence of inflammation on heart failure development as well as association of inflammation with oxidative stress.

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