An Insight into Cholangiocarcinoma and Recent Advances in its Treatment

2022 ◽  
Author(s):  
Rakesh Sahu ◽  
Praveen Sharma ◽  
Ajay Kumar
Keyword(s):  
Recent Advances ◽  
Insight Into

Nucleosome dynamics

2006 ◽  
Vol 73 ◽  
pp. 109-119 ◽  
Author(s):  
Chris Stockdale ◽  
Michael Bruno ◽  
Helder Ferreira ◽  
Elisa Garcia-Wilson ◽  
Nicola Wiechens ◽  
...  
Keyword(s):  
High Resolution ◽  
Chromatin Structure ◽  
Current Knowledge ◽  
Dynamic Properties ◽  
Structure And Dynamics ◽  
Nucleosome Dynamics ◽  
Sharp Focus ◽  
Recent Advances ◽  
Insight Into ◽  
Chromatin Structure And Dynamics

In the 30 years since the discovery of the nucleosome, our picture of it has come into sharp focus. The recent high-resolution structures have provided a wealth of insight into the function of the nucleosome, but they are inherently static. Our current knowledge of how nucleosomes can be reconfigured dynamically is at a much earlier stage. Here, recent advances in the understanding of chromatin structure and dynamics are highlighted. The ways in which different modes of nucleosome reconfiguration are likely to influence each other are discussed, and some of the factors likely to regulate the dynamic properties of nucleosomes are considered.

Gotta catch ‘em all: the microscale quest to understand cancer biology

2016 ◽  
Vol 8 (12) ◽  
pp. 1203-1207 ◽  
Author(s):  
Zhenwei Ma ◽  
Christopher Moraes
Keyword(s):  
Cancer Biology ◽  
Recent Advances ◽  
Cancer Initiation ◽  
Insight Into

We highlight recent advances in the innovative use of microscale engineered technologies to gain new insight into the integrative biophysical mechanisms that drive cancer initiation and progression.

scholarly journals A Mini Review: Recent Advances in Surface Modification of Porous Silicon

Materials ◽  
2018 ◽  
Vol 11 (12) ◽  
pp. 2557 ◽  
Author(s):  
Seo Lee ◽  
Jae Kang ◽  
Dokyoung Kim
Keyword(s):  
Surface Modification ◽  
Porous Silicon ◽  
Wide Spectrum ◽  
Basic Research ◽  
Recent Advances ◽  
Developed Surface ◽  
The Many ◽  
Insight Into ◽  
Biomedical Fields

Porous silicon has been utilized within a wide spectrum of industries, as well as being used in basic research for engineering and biomedical fields. Recently, surface modification methods have been constantly coming under the spotlight, mostly in regard to maximizing its purpose of use. Within this review, we will introduce porous silicon, the experimentation preparatory methods, the properties of the surface of porous silicon, and both more conventional as well as newly developed surface modification methods that have assisted in attempting to overcome the many drawbacks we see in the existing methods. The main aim of this review is to highlight and give useful insight into improving the properties of porous silicon, and create a focused description of the surface modification methods.

scholarly journals Dislocation–grain boundary interactions: recent advances on the underlying mechanisms studied via nanoindentation testing

2021 ◽  
Author(s):  
Farhan Javaid ◽  
Habib Pouriayevali ◽  
Karsten Durst
Keyword(s):  
Grain Boundary ◽  
Mechanical Response ◽  
Displacement Curve ◽  
Ambient Conditions ◽  
Recent Advances ◽  
Slip Transfer ◽  
Depth Analysis ◽  
Dislocation Interactions ◽  
Underlying Mechanisms ◽  
Insight Into

Abstract To comprehend the mechanical behavior of a polycrystalline material, an in-depth analysis of individual grain boundary (GB) and dislocation interactions is of prime importance. In the past decade, nanoindentation emerged as a powerful tool to study the local mechanical response in the vicinity of the GB. The improved instrumentation and test protocols allow to capture various GB–dislocation interactions during the nanoindentation in the form of strain bursts on the load–displacement curve. Moreover, the interaction of the plastic zone with the GB provides important insight into the dislocation transmission effects of distinct grain boundaries. Of great importance for the analysis and interpretation of the observed effects are microstructural investigations and computational approaches. This review paper focused on recent advances in the dislocation–GB interactions and underlying mechanisms studied via nanoindentation, which includes GB pop-in phenomenon, localized grain movement under ambient conditions, and an analysis of the slip transfer mechanism using theoretical treatments and simulations. Graphical abstract

Bone Grafts: An Overview of Bone Remodeling, Types and Recent Advances

2021 ◽  
pp. 6101-6105
Author(s):  
Gopala Krishna Ganta ◽  
Rama Krishna Alla ◽  
Kamala Cheruvu ◽  
Bharathi Ram Guduri
Keyword(s):  
Bone Graft ◽  
Bone Remodeling ◽  
Gold Standard ◽  
Bone Grafts ◽  
Form And Function ◽  
Recent Advances ◽  
And Function ◽  
Insight Into

Bone grafts are often used to retrieve the lost bone in the most acceptable, technical and skilful manner that enables to restore the form and function of the bone. Numerous bone graft materials have been developed to fill and/or remodel the bony defects. Though, autografts were considered to be the gold standard among the grafts available; they have got some inherent disadvantages. The current research is more focused on allografts, which addressed the problems associated with autografts. This article provides an insight into the remodeling process, and various types of bone grafts currently available. Also, the emphasis was given on the recent advances of the bone grafts.

Advanced Turbulent Combustion Physics and Applications

2021 ◽  
Keyword(s):  
Graduate Students ◽  
Turbulent Combustion ◽  
Current Knowledge ◽  
Supersonic Flows ◽  
Solid Fuels ◽  
Recent Advances ◽  
The World ◽  
Insight Into

Explore a thorough and up to date overview of the current knowledge, developments and outstanding challenges in turbulent combustion and application. The balance among various renewable and combustion technologies are surveyed, and numerical and experimental tools are discussed along with recent advances. Covers combustion of gaseous, liquid and solid fuels and subsonic and supersonic flows. This detailed insight into the turbulence-combustion coupling with turbulence and other physical aspects, shared by a number of the world leading experts in the field, makes this an excellent reference for graduate students, researchers and practitioners in the field.

Becoming Human: the Archaeological Challenge

2007 ◽  
Author(s):  
COLIN RENFREW
Keyword(s):  
Human Development ◽  
Homo Sapiens ◽  
Cognitive Archaeology ◽  
Recent Advances ◽  
Insight Into

This chapter discusses the attempts of pinpointing the origins of humans, i.e. Homo sapiens sapiens. Due to the recent advances in archaeology, specifically in archaeogenetics, it has been determined that the Homo sapiens sapiens originated in Africa 200,000 years ago, and that the speciation phase of human development occurred before that time. The chapter shows that cognitive archaeology would need to analyse more carefully the nature of mind, as well as seek further insight into the processes that underlie the achievements that characterise those different trajectories of development and change.

scholarly journals Recent Advances in Understanding the Genetic Architecture of Autism

2020 ◽  
Vol 21 (1) ◽  
pp. 289-304 ◽  
Author(s):  
Caroline M. Dias ◽  
Christopher A. Walsh
Keyword(s):  
Genetic Architecture ◽  
De Novo ◽  
Clinical Care ◽  
Copy Number Variants ◽  
Autism Spectrum ◽  
Loss Of Function ◽  
Single Nucleotide Variants ◽  
Single Nucleotide ◽  
Recent Advances ◽  
Insight Into

Recent advances in understanding the genetic architecture of autism spectrum disorder have allowed for unprecedented insight into its biological underpinnings. New studies have elucidated the contributions of a variety of forms of genetic variation to autism susceptibility. While the roles of de novo copy number variants and single-nucleotide variants—causing loss-of-function or missense changes—have been increasingly recognized and refined, mosaic single-nucleotide variants have been implicated more recently in some cases. Moreover, inherited variants (including common variants) and, more recently, rare recessive inherited variants have come into greater focus. Finally, noncoding variants—both inherited and de novo—have been implicated in the last few years. This work has revealed a convergence of diverse genetic drivers on common biological pathways and has highlighted the ongoing importance of increasing sample size and experimental innovation. Continuing to synthesize these genetic findings with functional and phenotypic evidence and translating these discoveries to clinical care remain considerable challenges for the field.

scholarly journals Where Do AQP4 Antibodies Fit in the Pathogenesis of NMO?

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Makoto Kinoshita ◽  
Yuji Nakatsuji
Keyword(s):  
Neuromyelitis Optica ◽  
Essential Role ◽  
Convincing Evidence ◽  
Controversial Issues ◽  
Dependent Manner ◽  
Specific Disease ◽  
Disease Marker ◽  
Recent Advances ◽  
Insight Into ◽  
Aqp4 Antibody

Recent advances in the field of neuromyelitis optica (NMO) research provided convincing evidence that anti-AQP4 antibody (AQP4-Ab) not only serves as a highly specific disease marker, but also plays an essential role in the pathogenesis of the disease. Although it is now widely recognized that AQP4-Ab induces astrocytic necrosis in a complement-dependent manner, additional triggers are also suspected as a prerequisite for the development of the disease. Unraveling these unresolved aspects of the disease will provide substantial insight into still controversial issues in the pathogenesis of NMO.

Sign in / Sign up

Export Citation Format

Share Document