Association between OPG, RANK and RANKL gene polymorphisms and susceptibility to acute coronary syndrome in Korean population

The purpose of this study was to determine whether relationships exist among protein cytokines, cytokine gene polymorphisms, and symptoms of potential acute coronary syndrome (ACS). Participants included 438 patients presenting to the emergency department (ED) whose symptoms triggered a cardiac evaluation (206 ruled in and 232 ruled out for ACS). Presence or absence of 13 symptoms was recorded upon arrival. Levels of tumor necrosis factor α (TNF-α), interleukin (IL)-6, and IL-18 were measured for all patients. A pilot analysis of 85 patients (ACS = 49; non-ACS = 36) genotyped eight single-nucleotide polymorphisms (SNPs; four TNF and four IL6 SNPs). Logistic regression models were tested to determine whether cytokines or SNPs predicted symptoms. Increased levels of TNF-α and IL-6 were associated with a decreased likelihood of chest discomfort for all patients. Increased levels of IL-6 were associated with a lower likelihood of chest discomfort and chest pressure for ACS patients, and an increased likelihood of shoulder and upper back pain for non-ACS patients. Elevated IL-18 was associated with an increased likelihood of sweating in patients with ACS. Of the four TNF SNPs, three were associated with shortness of breath, lightheadedness, unusual fatigue, and arm pain. In all, protein cytokines and TNF polymorphisms were associated with 11 of 13 symptoms assessed. Future studies are needed to determine the predictive ability of cytokines and related SNPs for a diagnosis of ACS or to determine whether biomarkers can identify patients with specific symptom clusters.

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Do CYP2C19 and ABCB1 gene polymorphisms and low CYP3A4 isoenzyme activity have an impact on stent implantation complications in acute coronary syndrome patients?

Pharmacogenomics and Personalized Medicine ◽

10.2147/pgpm.s143250 ◽

2017 ◽

Vol Volume 10 ◽

pp. 243-245 ◽

Cited By ~ 2

Author(s):

Eric Rytkin ◽

Karin B Mirzaev ◽

Elena A Grishina ◽

Valeriy V Smirnov ◽

Kristina A Ryzhikova ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Stent Implantation ◽

Gene Polymorphisms ◽

Coronary Syndrome ◽

Em Gene

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W13-P-011 Interleukin-1 gene cluster and interleukin-6 gene polymorphisms and increase in C-reactive protein levels in patients with acute coronary syndrome

Atherosclerosis Supplements ◽

10.1016/s1567-5688(05)80348-4 ◽

2005 ◽

Vol 6 (1) ◽

pp. 88

Author(s):

G. Latkovskis ◽

N. Licis ◽

D. Juhnevica ◽

S. Jegere ◽

A. Maca ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Gene Cluster ◽

Interleukin 6 ◽

Gene Polymorphisms ◽

Interleukin 1 ◽

C Reactive Protein ◽

Protein Levels ◽

Reactive Protein ◽

Coronary Syndrome

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The c.52 A/G and c.773 A/G Genetic Variants in the UTR′3 of the LDLR Gene Are Associated with the Risk of Acute Coronary Syndrome and Lower Plasma HDL-Cholesterol Concentration

Biomolecules ◽

10.3390/biom10101381 ◽

2020 ◽

Vol 10 (10) ◽

pp. 1381

Author(s):

Gilberto Vargas-Alarcon ◽

Oscar Perez-Mendez ◽

Julian Ramirez-Bello ◽

Rosalinda Posadas-Sanchez ◽

Hector Gonzalez-Pacheco ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

High Risk ◽

Gene Polymorphisms ◽

Plasma Lipids ◽

Critical Role ◽

Density Lipoprotein ◽

Cholesterol Concentration ◽

Ldlr Gene ◽

Coronary Syndrome ◽

Lipids Profile

Dyslipidemia has a substantial role in the development of acute coronary syndrome (ACS). Low-density lipoprotein receptor (LDLR) plays a critical role in plasma lipoprotein hemostasis, which is involved in the formation of atherosclerotic plaque. This study aimed to evaluate whether LDLR gene polymorphisms are significantly associated with ACS and the plasma lipids profile. Three LDLR gene polymorphisms located in the UTR′3 region (c.*52 A/G, c.*504 A/G, and c.* 773 A/G) were determined using TaqMan genotyping assays in a group of 618 ACS patients and 666 healthy controls. Plasma lipids profile concentrations were determined by enzymatic/colorimetric assays. Under co-dominant and recessive models, the c.*52 A allele of the c.*52 A/G polymorphism was associated with a higher risk of ACS (OR = 2.02, pCCo-dom = 0.033, and OR = 2.00, pCRes = 0.009, respectively). In the same way, under co-dominant and recessive models, the c.*773 G allele of the c.*773 A/G polymorphism was associated with a high risk of ACS (OR = 2.04, pCCo-dom = 0.027, and OR = 2.01, pCRes = 0.007, respectively). The “AAG” haplotype was associated with a high risk of ACS (OR = 1.22, pC = 0.016). The c.*52 AA genotype showed a lower HDL-C concentration than individuals with the GG genotype. In addition, carriers of c.*773 GG genotype carriers had a lower concentration of the high-density lipoprotein-cholesterol (HDL-C) than subjects with the AA genotype. Our data suggest the association of the LDLRc.*773 A/G and LDLR c.*52 A/G polymorphisms with both the risk of developing ACS and with a lower concentration of HDL-C in the study population.

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