scholarly journals The Kinetics of Two-Step Ellagitannin Extraction from the By-products of Selected Processed Fruits of the family Rosaceae

2021 ◽  
Author(s):  
Agnieszka Milczarek ◽  
Michał Sójka ◽  
Robert Klewicki
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Fruit Species ◽  
Definite Effect ◽  
Extraction Step ◽  
The Family ◽  
The Mean ◽  
Berry Fruits ◽  
Kinetics Of ◽  
Molecular Weight Fractions

AbstractThe paper presents the kinetics of two-step ellagitannin (ET) extraction with an aqueous acetone solution from two technological types of pomace from selected berry fruits of the Rosaceae family. ETs were identified and quantified using HPLC–MS and HPLC–DAD. The results revealed the extraction kinetics of total ETs, their high and low molecular weight fractions (≤ 1569 Da and > 1569 Da), and individual ETs characteristic of the examined fruits. ET extraction proceeded at a faster rate in the first step, regardless of the tested pomace. For all pomace variants, the mean extraction half time t1/2 was 48 min in the first step and 70 min in the second step. The fruit species and the technological type of pomace were not found to exert a definite effect on the kinetics of ET extraction. Statistical analysis demonstrated that the molecular weight of ETs did not influence the kinetics of their extraction, either. It was shown that the technological type of pomace had a significant impact on the extraction rate of both low molecular weight (LMW) and high molecular weight (HMW) ETs in the first extraction step, with the mean t1/2 being 44 min for pomace from juice production and 63 min for pomace from puree production.

Applications of Algal Polysaccharides and Derivatives in Therapeutic and Agricultural Fields

2019 ◽  
Vol 25 (11) ◽  
pp. 1187-1199 ◽  
Author(s):  
Soukaina Bouissil ◽  
Guillaume Pierre ◽  
Zainab El Alaoui-Talibi ◽  
Philippe Michaud ◽  
C. El Modafar ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Wound Dressing ◽  
Chemical Processes ◽  
Bioactive Molecules ◽  
Present Review ◽  
Agricultural Fields ◽  
Low Molecular Weight ◽  
Molecular Weight Fractions ◽  
Algal Polysaccharides ◽  
Agricultural Fertilizer

Background: Recently, researchers have given more and more consideration to natural polysaccharides thanks to their huge properties such as stability, biodegradability and biocompatibility for food and therapeutics applications. Methods: a number of enzymatic and chemical processes were performed to generate bioactive molecules, such as low molecular weight fractions and oligosaccharides derivatives from algal polysaccharides. Results: These considerable characteristics allow algal polysaccharides and their derivatives such as low molecular weight polymers and oligosaccharides structures to have great potential to be used in lots of domains, such as pharmaceutics and agriculture etc. Conclusion: The present review describes the mains polysaccharides structures from Algae and focuses on the currents agricultural (fertilizer, bio-elicitor, stimulators, signaling molecules and activators) and pharmaceutical (wound dressing, tissues engineering and drugs delivery) applications by using polysaccharides and/or their oligosaccharides derivatives obtained by chemical, physical and enzymatic processes.

scholarly journals Effect of ageing on plasma lipoprotein(a) levels

2002 ◽  
Vol 39 (3) ◽  
pp. 237-240 ◽  
Author(s):  
Harukuni Akita ◽  
Miyao Matsubara ◽  
Hitoshi Shibuya ◽  
Hirotoshi Fuda ◽  
Hitoshi Chiba
Keyword(s):  
Molecular Weight ◽  
Coronary Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
The Elderly ◽  
Low Molecular Weight ◽  
Lipoprotein A ◽  
Significant Difference ◽  
The Mean ◽  
Japanese Subjects

Background Lipoprotein(a) [Lp(a)] is a risk factor for atherosclerosis and increases with age. The purpose of this study was to determine the effect of ageing on Lp(a) for three different apo(a) phenotypes. Methods We measured plasma Lp(a) concentrations in 551 unrelated Japanese subjects (20-88 years of age). We performed statistical analyses separately for three apo(a) phenotypes: the low-molecular-weight (LMW) phenotype with the F, B or S1 isoform, the intermediate-molecular-weight (IMW) phenotype with the S2 isoform and the high-molecular-weight (HMW) phenotype with the S3 or S4 isoform. Results For each phenotype, the mean plasma Lp(a) concentration and the frequency of Lp(a) concentrations ≥ 250 mg/L increased with age. Further, a statistically significant difference was always found between the younger subjects (20-39 years of age) and the elderly (over 60 years). The frequency of coronary heart disease increased with age, particularly for the LMW and IMW phenotypes. Conclusions We conclude that ageing elevates plasma Lp(a) concentrations, which may have a role in the prevalence of coronary heart disease in the elderly, especially those with the LMW or IMW phenotypes.

scholarly journals Evaluation and Management of Women who Have Experienced Stillbirth in Their Previous Pregnancies

2019 ◽  
pp. 1
Author(s):  
Erdem Fadiloglu ◽  
Atakan Tanacan ◽  
Canan Unal ◽  
Mehmet Sinan Beksac
Keyword(s):  
Risk Factors ◽  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Low Dose ◽  
Methylenetetrahydrofolate Reductase ◽  
Post Partum ◽  
Subsequent Pregnancy ◽  
Low Molecular Weight ◽  
Mthfr Polymorphisms ◽  
The Mean

<p><strong>Objective:</strong> To evaluate the subsequent pregnancy outcomes of women who have experienced unexplained stillbirth in their previous gestations.</p><p><strong>Study Design:</strong> This retrospective cohort consisted of 14 pregnancies who had stillbirth (without known risk factors) in their previous pregnancies. These patients had been included in a special preconceptional care program to be evaluated in terms of etiological risk factors for stillbirth. At least one of the risk factors, such as methylenetetrahydrofolate reductase (MTHFR) polymorphisms, hereditary thrombophilias and autoimmune problems, were defined in this study population. After detection of pregnancy, the patients were administered low-dose low-molecular-weight heparin (LMWH) (enoxaparin, 1×2000 Anti-XA IU/0.2 mL/day), low-dose salicylic acid (100 mg/day) and low-dose corticosteroid (methylprednisolone, 1×4 mg/day orally) in necessary cases.</p><p><strong>Results:</strong> Out of 14 pregnancies, 4 (28.5%) ended up with miscarriages at 9, 11, 11 and 15 gestational weeks, respectively. The remaining 10 pregnancies ended up with alive deliveries. The mean gestational week at birth was 36.4±0.51, while the mean birthweight was 2882±381.01 g. Out of 10 pregnancies, only one was diagnosed as IUGR. Only two newborn necessitated hospitalization in the neonatal intensive care unit (NICU) due to respiratory problems. Both newborns were discharged from the NICU without any further complication at the post-partum 5th day. </p><p><strong>Conclusion:</strong> Patients with a prior stillbirth should be screened for MTHFR polymorphisms, autoimmune problems and hereditary thrombophilias, especially in case of absence of any etiological factor. Management of these patients with low-dose aspirin, low-dose low molecular weight heparin and corticosteroids seemed to be beneficial for increasing live birth rates and avoiding obstetric complications.</p>

Kinetics of the reaction of the first metabolite of fenitropan with some low molecular weight thiols

1989 ◽  
Vol 26 (3) ◽  
pp. 253-259 ◽  
Author(s):  
Gabor Gullner ◽  
Gyula Josepovits ◽  
Gyula Mikite
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight ◽  
Kinetics Of

Microporous Bio-Membrane Materials Based on High Molecular Weight Polylactide and Low Molecular Weight Poly(ethylene glycol)

2012 ◽  
Vol 567 ◽  
pp. 123-126
Author(s):  
Teng Fei Shen ◽  
Man Geng Lu ◽  
Li Yan Liang
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
High Weight ◽  
Low Molecular Weight ◽  
Poly Ethylene Glycol ◽  
Degradation Rates ◽  
Degradation Behaviors ◽  
The Mean ◽  
Poly Ethylene ◽  
Lower Glass Transition Temperature

In this work, microporous membrane biomaterials based on high weight molecular polylactide (PLA) and low molecular weight poly(ethylene glycol) (PEG) using rapid solvent evaporation method were prepared and investigated. The effect of PEG segments added on the thermal and degradation behaviors was studied. According to the results, produced PLA/PEG biomaterial has lower glass transition temperature (Tg)in comparison with neat PLA. It was also found that the degradation rates of the PLA/PEG biomaterials were significantly increased with adding of PEG, which explained by increasing hydrophilic groups. For better porous fixation, CL-blocked polyisocyanate (CL-bp), which was synthesized from reaction of isophorone diisocyanate (IPDI) with dimethylol propionic acid (DMPA) and Trimethylolpropane (TMP) followed by addition of caprolactam (CL), were introduced. The microporous forms were observed by the scanning electron microscope (SEM), which showed the mean diameters of prepared PLA/PEG microporous were around 10μm.

Characterization of Elution Chromatography Fractions from CIS-Polybutadiene by GPC

1970 ◽  
Vol 43 (6) ◽  
pp. 1439-1450 ◽  
Author(s):  
W. V. Smith ◽  
S. Thiruvengada
Keyword(s):  
Molecular Weight ◽  
Molecular Weight Distribution ◽  
Weight Distribution ◽  
Low Molecular Weight ◽  
Molecular Weight Distributions ◽  
Weight Distributions ◽  
Log Normal ◽  
Analytical Fractionation ◽  
Molecular Weight Fractions ◽  
Elution Chromatography

Abstract A preparative fractionation of about 23 g of a commercial cis-polybutadiene rubber is described. The method employed was a solvent elution chromatographic method with very little temperature gradient. The molecular weight distributions of the fractions obtained were determined by an analytical fractionation of 20 mg of polymer. The method was similar to the preparative fractionation and involved solvent elution chromatography. The fractions obtained were assayed for quantity, molecular weight, and molecular weight distribution by GPC. The low molecular weight fractions of the preparative fractionation had molecular weight distributions which could be closely approximated by two log normal distributions, the low molecular weight component having the narrower width. The ratio of weight to number average molecular weight was found to be about 1.1 for these samples. The higher molecular weight fractions could also be approximated by two log normal distributions; however, in these fractions the low molecular weight component had a very broad distribution but constituted only a small portion of the sample. The widths of the GPC curves of the fractions correlate satisfactorily with the molecular weight distributions found by the analytical refractionations. The GPC width is a sensitive criterion of the width of the molecular weight distribution even when only two columns are used. It is felt that the analytical fractionation procedure presented gives more detailed information on the molecular weight distribution than is easily obtainable from an ordinary GPC curve.

Kinetics of inhibition of purified bovine neutrophil matrix metalloproteinase 9 by low–molecular-weight inhibitors

2009 ◽  
Vol 70 (5) ◽  
pp. 633-639 ◽  
Author(s):  
Gregory A. Bannikov ◽  
Jeffrey Lakritz ◽  
Christopher Premanandan ◽  
John S. Mattoon ◽  
Eric J. Abrahamsen
Keyword(s):  
Molecular Weight ◽  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Low Molecular Weight ◽  
Kinetics Of ◽  
Metalloproteinase 9 ◽  
Kinetics Of Inhibition ◽  
Bovine Neutrophil
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