Endocrine Regulation of Extra-skeletal Organs by Bone-derived Secreted Protein and the effect of Mechanical Stimulation

Bone serves as the support for body and provide attachment points for the muscles. The musculoskeletal system is the basis for the human body to complete exercise. Studies believe that bone is not only the basis for constructing structures, but also participates in the regulation of organs outside bone. The realization of this function is closely related to the protein secreted by bone. Whether bone can realize their positions in the human body is also related to their secretion. Bone-derived proteins provide a medium for the targeted regulation of bones on organs, making the role of bone in human body more profound and concrete. Mechanical stimulation effects the extra-skeletal organs by causing quantitative changes in bone-derived factors. When bone receives mechanical stimulation, the nichle of bone responds, and the secretion of various factors changes. However, whether the proteins secreted by bone can interfere with disease requires more research. In this review article, we will first introduce the important reasons and significance of the in-depth study on bone-derived secretory proteins, and summarize the locations, structures and functions of these proteins. These functions will not only focus on the bone metabolism process, but also be reflected in the cross-organ regulation. We specifically explain the role of typical bone-derived secretory factors such as osteocalcin (OCN), osteopontin (OPN), sclerostin (SOST) and fibroblast growth factor 23 (FGF23) in different organs and metabolic processes, then establishing the relationship between them and diseases. Finally, we will discuss whether exercise or mechanical stimulation can have a definite effect on bone-derived secretory factors. Understanding their important role in cross-organ regulation is of great significance for the treatment of diseases, especially for the elderly people with more than one basic disease.

Are Housing Prices Sustainable in 35 Large and Medium-Sized Chinese Cities? A Study Based on the Cheap Talk Game and Dynamic GMM

Focusing on the rapid rise of China’s housing prices in recent years, in this paper, we construct a model using the cheap talk game that centers on how information receivers in a market make inferences about the true state of the information based on the cost-free signals they receive and then make decisions based on these inferences, which in turn affect market equilibrium. By constructing a cheap talk game model of house prices, we examine the correlation between market expectations, economic fundamentals, and individual housing purchase decisions. Then, we conduct an empirical analysis using the dynamic GMM method based on the panel data of 35 large and medium-sized cities in China. The analysis reveals that: (1) when the whole of society expects housing prices to rise, housing prices will rise regardless of the true state of economic fundamentals; (2) when information on economic fundamentals is accurate and reliable, home buyers tend to make purchase decisions based on such information, thus maximizing the utility of society as a whole; but when information on economic fundamentals is unreliable, home buyers tend to make purchase decisions according to their own housing price expectations, which is not conducive to the optimization of the utility of society as a whole; (3) the empirical results also reveal that expectations are a non-negligible factor in the rise of housing prices, and the coefficient of expectations exceeds that of each economic fundamental; this demonstrates the investment-driven attribute of the housing market in China. At the same time, economic fundamentals have a definite effect on housing prices, which implies that the rise of housing prices in China is supported by objective conditions.

Research on Application Technology of Self Melting Ice Fine Surface Treatment

The construction of the expressway network has brought great convenience to the people’s travel, and it also brings the hidden danger of driving safety, especially the snow and ice problem in winter which threatens the safety of the people’s life and property. In order to solve the problem of dark(black)ice on the pavement safely, quickly, efficiently and conveniently, this study has developed a self melting ice fine surface treatment technology with the combination of the preventive maintenance mask technology and the self melting ice technology, which will have a definite effect on the deicing technology of the highway pavement in winter.

The Kinetics of Two-Step Ellagitannin Extraction from the By-products of Selected Processed Fruits of the family Rosaceae

The paper presents the kinetics of two-step ellagitannin (ET) extraction with an aqueous acetone solution from two technological types of pomace from selected berry fruits of the Rosaceae family. ETs were identified and quantified using HPLC–MS and HPLC–DAD. The results revealed the extraction kinetics of total ETs, their high and low molecular weight fractions (≤ 1569 Da and > 1569 Da), and individual ETs characteristic of the examined fruits. ET extraction proceeded at a faster rate in the first step, regardless of the tested pomace. For all pomace variants, the mean extraction half time t1/2 was 48 min in the first step and 70 min in the second step. The fruit species and the technological type of pomace were not found to exert a definite effect on the kinetics of ET extraction. Statistical analysis demonstrated that the molecular weight of ETs did not influence the kinetics of their extraction, either. It was shown that the technological type of pomace had a significant impact on the extraction rate of both low molecular weight (LMW) and high molecular weight (HMW) ETs in the first extraction step, with the mean t1/2 being 44 min for pomace from juice production and 63 min for pomace from puree production.

Short-Term Deterministic Solar Irradiance Forecasting Considering a Heuristics-Based, Operational Approach

Solar energy is an economic and clean power source subject to natural variability, while energy storage might attenuate it, ultimately, effective and operationally feasible forecasting techniques for energy management are needed for better grid integration. This work presents a novel deterministic forecast method considering: irradiance pattern classification, Markov chains, fuzzy logic and an operational approach. The method developed was applied in a rolling manner for six years to a target location with no prior data to assess performance and its changes as new local data becomes available. Clearness index, diffuse fraction and irradiance hourly forecasts are analyzed on a yearly basis but also for 20 day types, and compared against smart persistence. Results show the proposed method outperforms smart persistence by ~10% for clearness index and diffuse fraction on the base case, but there are significant differences across the 20 day types analyzed, reaching up to +60% for clear days. Forecast lead time has the greatest impact in forecasting performance, which is important for any practical implementation. Seasonality in data gaps or rejected data can have a definite effect in performance assessment. A novel, comprehensive and detailed analysis framework was shown to present a better assessment of forecasters’ performance.

Clubhouse Model of Psychiatric Rehabilitation in China to Promote Recovery of People With Schizophrenia: A Systematic Review and Meta-Analysis

Background: Whether the clubhouse model of psychiatric rehabilitation is well-implemented in China and whether patients with schizophrenia successfully achieve symptom remission and functional recovery through engaging in the clubhouse remain unclear.Methods: Seven electronic databases were searched for relevant articles from inception to April 21, 2021. Quality assessment, data synthesis, and subgroup analysis were performed on the included studies.Results: Seven randomized controlled studies with 682 participants were included in the present meta-analysis. The clubhouse model of psychiatric rehabilitation has a significant effect on promoting the remission of psychiatric symptoms, especially negative symptoms. However, it does not show a definite effect on promoting recovery of positive symptoms. The clubhouse model of psychiatric rehabilitation has a significant effect on promoting social functioning recovery, reducing the family burden, improving the quality of life, and promoting the remission of depressive and anxiety symptoms of patients with schizophrenia in China.Conclusions: Our findings suggest that the clubhouse model of psychiatric rehabilitation can promote the remission of symptoms and functional recovery of Chinese with schizophrenia. It may be suitable to address the urgent need for better mental health services in China.

Physical properties of raspberry and orange flavoured fruit syrups

In the case of fruit syrups, consumers prefer thicker, deep-coloured ones because they remind them of good old homemade ones. Physical properties – as viscosity, colour, refractive index, soluble solid content (SSC), and electrical impedance - of fruit syrups flavoured with raspberry or orange juice were determined. The change of the measured physical properties was determined in three different experiments: 1. evaluating the effect of sugar and sweetener content 2. evaluating the effect of fruit juice composition and 3. evaluating the effect of sugar content on syrups containing raspberry or orange juice only. Variations in fruit and sugar content had a definite effect on the physical properties of squashes. Viscosity, SSC value, refractive index, and impedance magnitude increased with increasing sugar content and decreased with replacement of sugar with sweeteners although colour characteristics were defined mostly by the colorant added to the squash. Changes in the fruit composition of syrups could influence viscosity, refractive index, and SSC values but the magnitude of impedance showed little changes for all samples. The characteristics of squashes containing only raspberry or orange juice and different sugar content did not follow any trends, which emphasized that additives had a significant effect on the physical properties.

Some Clinical Features and Supportive Therapies in Covid-19 Patients Died in Hajar Hospital, Tehran, Iran

Objective: Due to the spread of Coronavirus Disease 2019 (COVID-19) worldwide and the resulting mortality as well as the lack of definitive treatment for this disease, various non-invasive and invasive drugs and treatments have been used around the world for reducing the effects of this disease or accelerating the treatment process, but the positive and definite effect of none of these methods has been confirmed and they have been effective only in some cases. This study aims to investigate some clinical features and supportive therapies in deceased COVID-19 patients in Iran. Methods: This descriptive-analytical retrospective study was conducted on 100 Covid-19 patients died in Hajar Hospital in Tehran, Iran from February to September 2020. They were divided into two groups of with and without underlying diseases. After coordination and obtaining the necessary permission and informed consent, information was collected from the medical files of samples. Results: Mechanical ventilation, vasoconstrictor injection and blood products had been used as supportive therapies in deceased patients, where ventilation use (n=62, 62%) was significantly higher (P=0.01) compared to vasoconstrictor injection (n=28, 28%) and blood products (n=13, 13%). Most of deceased patients had an underlying diseases (79%). Hypertension, diabetes and heart problems were the most common underlying diseases. The disease severity, clinical manifestations, and mortality rate of deceased patients with cardiovascular diseases, diabetes and hypertension were significantly different compared to those with other underlying diseases (P= 0.01). The age and gender of deceased patients had no significant relationship with the use of any supportive therapies (P≥0.01), but had a significant relationship with the underlying diseases (P≤0.01). Conclusion: The treatment methods that are the definite needs of the patient and have more favorable effects on the recovery process have a high value in the treatment of COVID-19 patients. These patients need to use supportive therapies for purposeful and effective treatment. Mechanical ventilation is more important than injecting vasoconstrictors or using blood products.

Effect of DDAVP on Platelet Activation and Platelet-Derived Microparticle Generation

Background The way by which 1-deamino-8-D-arginine vasopressin (DDAVP) acts on platelets remains unclear. Data from the literature tend to show that there is no definite effect on platelet activation, but recent work has suggested that a subtype of platelets, activated by the combined action of collagen and thrombin, was triggered by DDAVP. Moreover, platelet microparticles (PMPs), which have been shown to be procoagulant, have rarely been studied in this context. The goal of this study was to analyze the effects of DDAVP on PMPs' release through platelet activation. Methods Fifteen out of 18 consecutive patients undergoing a therapeutic test with DDAVP were included. They were suffering from factor VIII deficiency or from von Willebrand disease. The expression of P-selectin and PAC-1 binding on platelets and the numbers of circulating PMPs were evaluated ex vivo before and after DDAVP infusion. Peripheral blood was collected on CTAD to limit artifactual platelet activation. Results DDAVP induced a significant decrease of platelet counts and volume. Only small changes of P-selectin expression and PAC-1 binding were observed. Considering PMPs, two populations of patients could be defined, respectively, with (120%, n = 6) or without (21%, n = 7) an increase of PMPs after DDAVP. The decrease in platelet counts and volume remained significant in the group of responders. Conclusion This study shows that DDAVP induces the generation/release of PMPs in some patients with factor VIII deficiency and von Willebrand disease 1 hour after DDAVP infusion.

The effect of textual glosses on L2 vocabulary acquisition: A meta-analysis

Despite the growing interest in incorporating textual glosses into second language (L2) reading in hypermedia and paper media, no agreements have been reached as to whether and what extent a textual gloss facilitates L2 learners’ vocabulary acquisition in hypermedia and paper media. The present study meta-analysed the overall effects of textual glosses and different glossing types (i.e. language, location, and mode) on L2 vocabulary acquisition, as well as the moderation effects on the variability of L2 vocabulary acquisition effect sizes. Based on a comprehensive search, 20 studies involving 2,291 participants that have quantitatively documented the changes of L2 vocabulary gains through a pre-and-post textual glosses design were identified and coded in order to retrieve moderator variables. The results show the following: (1) textual glossing has a medium effect on L2 vocabulary acquisition; (2) the effect of textual glosses on L2 vocabulary acquisition persists over time; (3) glossing location and glossing mode significantly impact the effect of textual glosses on L2 vocabulary acquisition but glossing language has no definite effect; and (4) outcome measure is the only moderator variable among the three influencing factors on vocabulary acquisition. These results are further discussed with reference to existing studies and theory of second language acquisition.