scholarly journals The role of nitric oxide and its donors in uterus contractility regulation

1998 ◽  
Vol 47 (1) ◽  
pp. 58-63
Author(s):  
V. V. Abramchenko ◽  
L. A. Sherbina ◽  
S. V. Nikitin ◽  
A. V. Nikitin ◽  
T. U. Kuzminih
Keyword(s):  
Nitric Oxide ◽  
Uterine Contraction ◽  
Therapeutic System ◽  
Uterine Contractility ◽  
Uterine Activity ◽  
The Status ◽  
Interruption Management ◽  
And Function ◽  
Pregnancy Interruption

This article presents comprehensive data on uterine contractility regulation by nitric oxide, including systematized contemporary data on the status and function of the human nitroxidergic vasodilator system, and our experience in threat of pregnancy interruption management by nitroglycerin given with the transdermal therapeutic system Deponit 5 (Schwarz Pharma, Germany). To control contractile uterine activity in pregnant women with pathologic preliminary period, the authors successfully used sublingual application of Nitrolingual aerosol (G. Pohl-Boskamp GmbH and Co, Germany) with prolongation of the effect by the Deponit system 5. As little as five minutes after aerosol application tocography revealed a decrease in uterine contraction frequency, duration and intensity. By effecting post- and preloading and lowering the resistance of spiral arteries, vasodilators provided increased intensity of placenta circulation, which had a great importance for anteintranatal care of the fetus and newborn. The advantages of nitric oxide donator application in obstetrics were also demonstrated.

NADPH-diaphorase-positive nerves and the role of nitric oxide in CGRP relaxation of uterine contraction

Peptides ◽  
1993 ◽  
Vol 14 (3) ◽  
pp. 637-641 ◽  
Author(s):  
Ronald L. Shew ◽  
Raymond E. Papka ◽  
Daniel L. McNeill ◽  
John A. Yee
Keyword(s):  
Nitric Oxide ◽  
Uterine Contraction ◽  
Nadph Diaphorase

scholarly journals The role of nitric oxide on matrix metalloproteinase 2 (MMP2) and MMP9 in placenta and fetus from diabetic rats

Reproduction ◽  
2007 ◽  
Vol 134 (4) ◽  
pp. 605-613 ◽  
Author(s):  
M C Pustovrh ◽  
A Jawerbaum ◽  
V White ◽  
E Capobianco ◽  
R Higa ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Structural Changes ◽  
Diabetic Rats ◽  
Matrix Metalloproteinase 2 ◽  
No Donor ◽  
Diaphorase Activity ◽  
Nos Inhibitor ◽  
And Function ◽  
Fetal Organs

Matrix metalloproteinases (MMPs) play an important role in tissue remodeling that accompanies the rapid growth, differentiation, and structural changes of the placenta and several fetal organs. In the present study, we investigated whether the diabetic maternal environment may alter the regulatory homeostasis exerted by nitric oxide (NO) on MMPs activity in the feto-placental unit from rats at midgestation. We found that NADPH-diaphorase activity, which reflects the distribution and activity of NO synthases (NOS), was increased in both placenta and fetuses from diabetic rats when compared with controls. In addition, while a NO donor enhanced MMP2 and MMP9 activities, a NOS inhibitor reduced these activities in the maternal side of the placenta from control rats. This regulatory effect of NO was only observed on MMP9 in the diabetic group. On the other hand, the NO donor did not modify MMP2 and MMP9 activities, while the NOS inhibitor reduced MMP9 activity in the fetal side of both control and diabetic placentas. In the fetuses, MMP2 was enhanced by the NO donor and reduced by the NO inhibitor in both fetuses from control and diabetic rats. Overall, this study demonstrates that NO is able to modulate the activation of MMPs in the feto-placental unit, and provides supportive evidence that increased NOS activity leads to NO overproduction in the feto-placental unit from diabetic rats, an alteration closely related to the observed MMPs dysregulation that may have profound implications in the formation and function of the placenta and the fetal organs.

scholarly journals Autoregulatory Role of Endothelium-derived Nitric Oxide (NO) on Lipopolysaccharide-induced Vascular Inducible NO Synthase Expression and Function

2004 ◽  
Vol 280 (8) ◽  
pp. 7236-7243 ◽  
Author(s):  
Phuong A. Vo ◽  
Bhavini Lad ◽  
James A. P. Tomlinson ◽  
Stephanie Francis ◽  
Amrita Ahluwalia
Keyword(s):  
Nitric Oxide ◽  
No Synthase ◽  
Inducible No Synthase ◽  
And Function

scholarly journals DISORIENTASI PENDIDIKAN MADRASAH DI INDONESIA

2017 ◽  
Vol 3 (1) ◽  
pp. 61
Author(s):  
Hasan Basri
Keyword(s):  
School Culture ◽  
Secular Education ◽  
The Family ◽  
The Status ◽  
The Will ◽  
And Function ◽  
Changing Schools ◽  
Further Development

Madrasah in the Middle East has known eight or nine centuries before madrasah in Indonesia, which emerged as a reaction to the reform movement as well as a response to the policy of Dutch colonizers secular education. Madrasah got a decent place in Indonesia after rising SKB 3 minister (Minister of Interior, Minister of Education and Culture, and the Minister of Religious Affairs) in 1975, where madrasas equated with other schools in terms of the status of the diploma, graduates continuing education opportunities and changing schools. In a further development, the school as disoriented. It is caused by two things: first, a paradigm shift towards sekularistik. Education implementation has marred even be interpreted as a partial instead of a holistic paradigm as desired by Islam. Supposedly, the madrasa education as a whole should make Islam as a principle in the determination of educational objectives, the formulation of the curriculum and standard of value of science and the learning process, including determining the qualifications of teachers and school culture that will be developed in the madrasas. Second, the functional institutional weakness as a result of shifting the orientation and function of the family and their influence and societal demands materialistic-hedonistic.The weakness seen in a mess madrasa curriculum, not optimal role of teachers as well as school culture that is not in line with the will of Islam.

scholarly journals The Role of Glycocalyx and Caveolae in Vascular Homeostasis and Diseases

2021 ◽  
Vol 11 ◽  
Author(s):  
Simone Regina Potje ◽  
Tiago Dal-Cin Paula ◽  
Michele Paulo ◽  
Lusiane Maria Bendhack
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Cardiovascular Diseases ◽  
Endothelial Glycocalyx ◽  
Special Focus ◽  
Oxygen Species ◽  
Vascular Homeostasis ◽  
Structure Synthesis ◽  
And Function

This review highlights recent findings about the role that endothelial glycocalyx and caveolae play in vascular homeostasis. We describe the structure, synthesis, and function of glycocalyx and caveolae in vascular cells under physiological and pathophysiological conditions. Special focus will be given in glycocalyx and caveolae that are associated with impaired production of nitric oxide (NO) and generation of reactive oxygen species (ROS). Such alterations could contribute to the development of cardiovascular diseases, such as atherosclerosis, and hypertension.

scholarly journals EVALUATION OF THE STATUS OF SALIVARY NITRIC OXIDE IN PATIENTS WITH DENTAL CARIES

2012 ◽  
Vol 02 (02) ◽  
pp. 06-09 ◽  
Author(s):  
Mithra N. Hegde ◽  
Suchetha Kumari ◽  
Nidarsh Hegde ◽  
Shilpa Shetty ◽  
Keyword(s):  
Nitric Oxide ◽  
Dental Caries ◽  
Risk Group ◽  
Saliva Sample ◽  
High Risk Group ◽  
Control Group ◽  
No Production ◽  
High Caries Risk ◽  
The Status

AbstractThe aim of the present study is to evaluate the status of salivary nitric oxide in patients with dental caries. The study consisted of 80 individuals. According to DFMT index, the subjects were divided into control group (DMFT=0) and study group (DMFT>5). Saliva sample was collected from each subject. Nitric oxide concentration was measured as total nitrates and nitrites by the Griess reaction method. The results of this study show that the presence of NO and its metabolites in saliva of adults with natural healthy teeth is significantly higher compared to high risk group, suggesting the protective role of NO in relation to caries. From the study it can be concluded that highly significant increase of nitrates and nitrites in stimulated saliva of high caries risk group could be the host defense response opposing bacterial growth. The obtained results support the role of NO as modulator of bacterial proliferation and suggest that increased NO production might contribute to lower caries incidence in adults.

scholarly journals ROLE OF NITRIC OXIDE AND ARGINASE IN THE PATHOGENESIS OF ORAL CANCER

2012 ◽  
Vol 02 (02) ◽  
pp. 14-17
Author(s):  
Nidarsh D. Hegde ◽  
Suchetha Kumari ◽  
Mithra N. Hegde ◽  
Shilpa Shetty
Keyword(s):  
Nitric Oxide ◽  
Oral Cancer ◽  
The Body ◽  
Arginase Activity ◽  
Oxide Degradation ◽  
Griess Reaction ◽  
Normal Individuals ◽  
The Status ◽  
Nitric Oxide Concentration

AbstractThe aim of the present study is to evaluate the status of serum nitric oxide and arginase activity in oral cancerous condition. The study consisted of 80 individuals. The subjects were divided into normal individuals and individuals with oral cancer. Blood sample was collected from each subject and serum separated. Nitric oxide concentration was measured as total nitrates and nitrites by the Griess reaction method and arginase activity was estimated by diacetylmonoxime method.The results of this study showed significantly increased levels of nitric oxide and arginase activity in oral cancerous condition when compared to normal individuals. From the study it can be concluded that during carcinogenesis and tumor progression, the level of nitric oxide and arginase activity increases. This could result from a generalized increased nitric oxide synthesis throughout the body of the cancer patient or reflect increased nitric oxide degradation promoted by oxidative stress.

scholarly journals Role of nitric oxide in placental vascular development and function

Placenta ◽  
2011 ◽  
Vol 32 (11) ◽  
pp. 797-805 ◽  
Author(s):  
B.J. Krause ◽  
M.A. Hanson ◽  
P. Casanello
Keyword(s):  
Nitric Oxide ◽  
Vascular Development ◽  
And Function

scholarly journals Glycyrrhizin as a Nitric Oxide Regulator in Cancer Chemotherapy

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5762
Author(s):  
Minsu Kim ◽  
Seok Chan Park ◽  
Dong Yun Lee
Keyword(s):  
Nitric Oxide ◽  
Multidrug Resistance ◽  
Tumor Microenvironment ◽  
Cancer Chemotherapy ◽  
Active Compound ◽  
Potential Role ◽  
No Production ◽  
Therapeutic Benefits ◽  
And Function

Chemotherapy is used widely for cancer treatment; however, the evolution of multidrug resistance (MDR) in many patients limits the therapeutic benefits of chemotherapy. It is important to overcome MDR for enhanced chemotherapy. ATP-dependent efflux of drugs out of cells is the main mechanism of MDR. Recent studies have suggested that nitric oxide (NO) can be used to overcome MDR by inhibiting the ATPase function of ATP-dependent pumps. Several attempts have been made to deliver NO to the tumor microenvironment (TME), however there are limitations in delivery. Glycyrrhizin (GL), an active compound of licorice, has been reported to both reduce the MDR effect by inhibiting ATP-dependent pumps and function as a regulator of NO production in the TME. In this review, we describe the potential role of GL as an NO regulator and MDR inhibitor that efficiently reduces the MDR effect in cancer chemotherapy.

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