Introduction/Objective. Nonclassical celiac disease (CD) is characterized by
a very heterogeneous and non-specific clinical presentation. The aim of this
study was to determine the basic symptoms and clinical signs of this CD
subtype in children and adolescents Methods. The study was based on a sample
of 58 children and adolescent, 38 female and 20 male, ages 1.75 to 17.75
(10.01 ? 4.62) years with a nonclassical CD diagnosed according to the
ESPGHAN criteria from 1990 and 2012. Results. Except four patients who were
between the ages of 1.75 to 2.50 years, all others were older than three
years. The main clinical symptoms and signs suggestive of non-classical CB
were anemia caused by iron deficiency (48.28%), short stature (34.48%), and
intermittent abdominal pain (18.97%), anorexia with stagnation or weight loss
(13.79%), and chronic constipation (6.90%). One symptom or a sign of the
disease had 30 patients, 15 two and 13 three. In addition, 12 patients had
dental enamel hypoplasia, 18 sideropenia without anemia and 5 mild isolated
hypertransaminasemia. A gluten-free diet, apart from the dental enamel
hypoplasia, has resulted in the withdrawal of all indicators of the disease.
Conclusion. The main symptoms and clinical signs of nonclassical CD in
children and adolescents were iron deficiency anemia, short stature and
intermittent abdominal pain, and less frequently anorexia with stagnation or
weight loss and chronic constipation. Excluding dental enamel hypoplasia, a
gluten-free diet leads to a complete recovery of the patient.
NF1 microduplication first clinical report: association with mild mental retardation, early onset of baldness and dental enamel hypoplasia?
