Mild Exercise Differently Affects Proteostasis and Oxidative Stress on Motor Areas During Neurodegeneration: A Comparative Study of Three Treadmill Running Protocols

The fruit and pericarp of Zanthoxylum schinifolium (ZS) have been used in traditional medicine; however, few studies have characterized ZS fruit and pericarp. Therefore, in the present study, we evaluated the safety of ZS fruit (ZSF) and pericarp (ZSP) extracts and compared their bioactivity. To evaluate the safety of ZSF and ZSP, mutagenicity, cytotoxicity, and oxidative stress assays were performed and nontoxic concentration ranges were obtained. ZSP was found to be superior to ZSF in terms of its antimutagenic, antioxidant, and anti-inflammatory activities. In the S9 mix, the mutation inhibition rate of ZSP was close to 100% at concentrations exceeding 625 µg·plate-1 for both the TA98 and TA100 strains. ZSP exhibited efficient DPPH (IC50 = 75.6 ± 6.1 µg·mL−1) and ABTS (IC50 = 57.4 ± 6 µg·mL−1) scavenging activities. ZSP inhibited the release of cytokines, involved in IL-1β (IC50 = 134.4 ± 7.8), IL-6 (IC50 = 262.8 ± 11.2), and TNF-α (IC50 = 223.8 ± 5.8). These results indicate that ZSP contains a higher amount of biochemicals than ZSF, or that ZSP contains unique biochemicals. In conclusion, for certain physiological activities, the use of ZSP alone may be more beneficial than the combined use of ZSF and ZSP.

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Comparative study of the effect of obesity on lipid profiles levels, insulin resistance and oxidative stress in adolescents

International Journal of Medical Research and Review ◽

10.17511/ijmrr.2015.i9.172 ◽

2015 ◽

Vol 3 (9) ◽

pp. 919-924

Author(s):

Dr N. Sundaraveena ◽

◽

Dr. T. Santhi ◽

Dr. T. Uma ◽

◽

...

Keyword(s):

Oxidative Stress ◽

Insulin Resistance ◽

Comparative Study ◽

Lipid Profiles ◽

And Oxidative Stress

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Effects of Exercise Intensity on Postexercise Endothelial Function and Oxidative Stress

Oxidative Medicine and Cellular Longevity ◽

10.1155/2015/723679 ◽

2015 ◽

Vol 2015 ◽

pp. 1-8 ◽

Cited By ~ 20

Author(s):

Conor McClean ◽

Ryan A. Harris ◽

Malcolm Brown ◽

John C. Brown ◽

Gareth W. Davison

Keyword(s):

Oxidative Stress ◽

Shear Rate ◽

Endothelial Function ◽

Acute Exercise ◽

Venous Blood ◽

Random Order ◽

Treadmill Running ◽

Lipid Hydroperoxides ◽

Artery Flow ◽

And Oxidative Stress

Purpose. To measure endothelial function and oxidative stress immediately, 90 minutes, and three hours after exercise of varying intensities.Methods. Sixteen apparently healthy men completed three exercise bouts of treadmill running for 30 minutes at 55%V˙O2max(mild); 20 minutes at 75%V˙O2max(moderate); or 5 minutes at 100%V˙O2max(maximal) in random order. Brachial artery flow-mediated dilation (FMD) was assessed with venous blood samples drawn for measurement of endothelin-1 (ET-1), lipid hydroperoxides (LOOHs), and lipid soluble antioxidants.Results. LOOH increased immediately following moderate exercise (P<0.05). ET-1 was higher immediately after exercise and 3 hours after exercise in the mild trial compared to maximal one (P<0.05). Transient decreases were detected forΔFMD/ShearAUCfrom baseline following maximal exercise, but it normalised at 3 hours after exercise (P<0.05). Shear rate was higher immediately after exercise in the maximal trial compared to mild exercise (P<0.05). No changes in baseline diameter, peak diameter, absolute change in diameter, or FMD were observed following any of the exercise trials (P>0.05).Conclusions. Acute exercise at different intensities elicits varied effects on oxidative stress, shear rate, and ET-1 that do not appear to mediate changes in endothelial function measured by FMD.

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