Growth factor-eluting technologies for bone tissue engineering

2015 ◽  
Vol 6 (2) ◽  
pp. 184-194 ◽  
Author(s):  
Ethan Nyberg ◽  
Christina Holmes ◽  
Timothy Witham ◽  
Warren L. Grayson
Keyword(s):  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Tissue Engineering ◽  
Bone Tissue

Osteoinductive Small Molecules: Growth Factor Alternatives for Bone Tissue Engineering

2013 ◽  
Vol 19 (19) ◽  
pp. 3420-3428 ◽  
Author(s):  
Aja Aravamudhan ◽  
Daisy M. Ramos ◽  
Jonathan Nip ◽  
Aditi Subramanian ◽  
Roshan James ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factor ◽  
Small Molecules ◽  
Bone Tissue Engineering ◽  
Bone Tissue

scholarly journals Human DPSCs fabricate vascularized woven bone tissue: a new tool in bone tissue engineering

2017 ◽  
Vol 131 (8) ◽  
pp. 699-713 ◽  
Author(s):  
Francesca Paino ◽  
Marcella La Noce ◽  
Alessandra Giuliani ◽  
Alfredo De Rosa ◽  
Serena Mazzoni ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Growth Factor ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Dental Pulp ◽  
3D Structure ◽  
Growth Curves ◽  
Woven Bone

Human dental pulp stem cells (hDPSCs) are mesenchymal stem cells that have been successfully used in human bone tissue engineering. To establish whether these cells can lead to a bone tissue ready to be grafted, we checked DPSCs for their osteogenic and angiogenic differentiation capabilities with the specific aim of obtaining a new tool for bone transplantation. Therefore, hDPSCs were specifically selected from the stromal–vascular dental pulp fraction, using appropriate markers, and cultured. Growth curves, expression of bone-related markers, calcification and angiogenesis as well as an in vivo transplantation assay were performed. We found that hDPSCs proliferate, differentiate into osteoblasts and express high levels of angiogenic genes, such as vascular endothelial growth factor and platelet-derived growth factor A. Human DPSCs, after 40 days of culture, give rise to a 3D structure resembling a woven fibrous bone. These woven bone (WB) samples were analysed using classic histology and synchrotron-based, X-ray phase-contrast microtomography and holotomography. WB showed histological and attractive physical qualities of bone with few areas of mineralization and neovessels. Such WB, when transplanted into rats, was remodelled into vascularized bone tissue. Taken together, our data lead to the assumption that WB samples, fabricated by DPSCs, constitute a noteworthy tool and do not need the use of scaffolds, and therefore they are ready for customized regeneration.

Central Growth Factor Loaded Depots in Bone Tissue Engineering Scaffolds for Enhanced Cell Attraction

2017 ◽  
Vol 23 (15-16) ◽  
pp. 762-772 ◽  
Author(s):  
Mandy Quade ◽  
Sven Knaack ◽  
Ashwini Rahul Akkineni ◽  
Anastasia Gabrielyan ◽  
Anja Lode ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Engineering Scaffolds

Nickel doped nanohydroxyapatite: vascular endothelial growth factor inducing biomaterial for bone tissue engineering

RSC Advances ◽  
2015 ◽  
Vol 5 (89) ◽  
pp. 72515-72528 ◽  
Author(s):  
B. Anu Priya ◽  
K. Senthilguru ◽  
T. Agarwal ◽  
S. N. Gautham Hari Narayana ◽  
S. Giri ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Vascular Endothelial ◽  
Effective Option ◽  
Vegf Pathway ◽  
Endothelial Growth Factor

Biomaterial induced activation of vascular endothelial growth factor (VEGF) pathway for angiogenesis is now gaining recognition as an effective option for tissue engineering.

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