Protective effects of Gymnaster koraiensis extract on high fat diet-induced fatty liver in mice

2020 ◽  
Author(s):  
Soo Young Choe ◽  
Yoonhee Seo ◽  
Chae Young Bang ◽  
Seok Hoon Woo ◽  
Moonkyu Kang
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Protective Effects ◽  
High Fat

Preventive effect of total glycosides from Ligustri Lucidi Fructus against nonalcoholic fatty liver in mice

2015 ◽  
Vol 70 (9-10) ◽  
pp. 237-241 ◽  
Author(s):  
Nianyun Yang ◽  
Yiwen Zhang ◽  
Jianming Guo
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Inflammatory Responses ◽  
Regulatory Element ◽  
Lipid Synthesis ◽  
Protective Effects ◽  
Model Group ◽  
High Fat ◽  
Nonalcoholic Fatty Liver ◽  
Element Binding Protein

Abstract The protective effects of the total glycosides from Ligustri Lucidi Fructus against nonalcoholic fatty liver (NAFL) in mice were investigated. Liver injury was induced by the administration of high fat diet for 60 days. During this period, the model group received high fat diet only; the treatment groups received various drugs plus high fat diet. Compared with the model group, the total glycosides significantly decreased the contents of triglyceride (TG) and cholesterol (TC), as well as the activities of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the serum. Moreover, the contents of TG and TC in liver tissue and the liver index were reduced. Histological findings also confirmed antisteatosis. Compared with the model group, total glycosides significantly reduced the levels of the sterol regulatory element binding protein-1c (SREBP-1c) and liver X receptor-a (LXR-α) protein, and down-regulated the expression of SREBP-1c, LXR-α and interleukin-6 (IL-6) mRNA in the liver. These results suggest that the total glycosides are effective in the treatment of NAFL of mice. Their mode of action is associated with inhibiting SREBP-1c, LXR-α and IL-6 mRNA, reducing lipid synthesis factor SREBP-1c and LXR-α protein and gene expression, suppressing inflammatory responses, then decreasing serum lipid and hepatic lipid.

scholarly journals Protective effects of saffron extract and crocin supplementation on fatty liver tissue of high-fat diet-induced obese rats

2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Maryam Mashmoul ◽  
Azrina Azlan ◽  
Norhafizah Mohtarrudin ◽  
Barakatun Nisak Mohd Yusof ◽  
Huzwah Khaza’ai ◽  
...  
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Liver Tissue ◽  
Protective Effects ◽  
High Fat ◽  
Obese Rats ◽  
Saffron Extract

Protective effects of Sapindus mukorossi Gaertn against fatty liver disease induced by high fat diet in rats

2014 ◽  
Vol 450 (1) ◽  
pp. 685-691 ◽  
Author(s):  
Qiuxian Peng ◽  
Qin Zhang ◽  
Wei Xiao ◽  
Meng Shao ◽  
Qin Fan ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Protective Effects ◽  
High Fat

scholarly journals Modulation of Gut Microbiota by Lonicera caerulea L. Berry Polyphenols in a Mouse Model of Fatty Liver Induced by High Fat Diet

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3213 ◽  
Author(s):  
Shusong Wu ◽  
Ruizhi Hu ◽  
Hironobu Nakano ◽  
Keyu Chen ◽  
Ming Liu ◽  
...  
Keyword(s):  
Mouse Model ◽  
Gut Microbiota ◽  
Fatty Liver ◽  
Relative Abundance ◽  
High Fat Diet ◽  
Rrna Gene ◽  
Protective Effects ◽  
High Fat ◽  
Lonicera Caerulea ◽  
Alcoholic Fatty Liver

Polyphenols from the Lonicera caerulea L. berry have shown protective effects on experimental non-alcoholic fatty liver disease (NAFLD) in our previous studies. As endotoxins from gut bacteria are considered to be the major trigger of inflammation in NAFLD, this study aims to clarify the regulatory effects of L. caerulea L. berry polyphenols (LCBP) on gut microbiota in a high fat diet (HFD)-induced mouse model. C57BL/6N mice were fed with a normal diet, HFD, or HFD containing 0.5–1% of LCBP for 45 days. The results revealed that supplementation with LCBP decreased significantly the levels of IL-2, IL-6, MCP-1, and TNF-α in serum, as well as endotoxin levels in both serum and liver in HFD-fed mice. Fecal microbiota characterization by high throughput 16S rRNA gene sequencing revealed that a HFD increased the Firmicutes/Bacteroidetes ratio, and LCBP reduced this ratio by increasing the relative abundance of Bacteroides, Parabacteroides, and another two undefined bacterial genera belonging to the order of Bacteroidales and family of Rikenellaceae, and also by decreasing the relative abundance of six bacterial genera belonging to the phylum Firmicutes, including Staphylococcus, Lactobacillus, Ruminococcus, and Oscillospira. These data demonstrated that LCBP potentially attenuated inflammation in NAFLD through modulation of gut microbiota, especially the ratio of Firmicutes to Bacteroidetes.

scholarly journals Effect of Kelussia odoratissima Mozaff extract on PNPLA3 gene expression in non-alcoholic fatty liver and control rats

2021 ◽  
pp. 335-345
Keyword(s):  
Gene Expression ◽  
Treatment Group ◽  
Fatty Liver ◽  
High Fat Diet ◽  
Blood Lipids ◽  
Control Group ◽  
Protective Effects ◽  
High Fat ◽  
Biochemical Tests ◽  
Alcoholic Fatty Liver

Background and Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with such symptoms as steatosis, fibrosis, and liver cirrhosis. Kelussia has attracted assiduous attention due to its protective effects on the liver. The PNPLA3 gene is mainly expressed in the liver and plays a major role in the degradation rate of hepatic triglycerides. Therefore, the present study aimed to assess the effect of Kelussia extract on PNPLA3 gene expression in rats with fatty liver and healthy rats. Materials and Methods: This experimental study was conducted on 24 male Wistar rats in the control group (no treatment), obese group (which received a high-fat diet), treatment group 1 (which received a high-fat diet with Kelussia extract 400 mg/kg) and treatment group 2 (a high-fat diet with Kelussia extract 800 mg/kg) for six weeks. Blood samples were taken from rats and the factors of (LDL, HDL, Cholesterol, Triglyceride, and fasting sugar) were measured. After sampling the rat liver, the effect of Kelussia on PNPLA3 gene expression was investigated using the Real-time reverse transcription-polymerase chain reaction (RT-PCR) technique and analyzed in SPSS software (version 22). Results: Based on the results, Kelussia extract at a dose of 800 mg/kg resulted in a more dramatic decrease in PNPLA3 gene expression in rats with fatty liver, compared to a dose of 400 mg /kg, and this reduction was statistically significant, compared to the fatty liver group (P<0.05). The results of biochemical tests confirmed liver improvement in the rats treated with Kelussia extract at a dose of 800 mg/kg. Conclusion: It can be said that Kelussia had a beneficial effect on the reduction of blood lipids; moreover, it reduces the accumulation of triglycerides in the liver and improves the tissue structure of the liver by reducing the expression of PNPLA3 gene; therefore, with more studies, it can be considered a supplement to reduce blood lipids.

scholarly journals Lentinan Protects against Nonalcoholic Fatty Liver Disease by Reducing Oxidative Stress and Apoptosis via the PPARα Pathway

Metabolites ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. 55
Author(s):  
Tingyi Du ◽  
Qin Fang ◽  
Zhihao Zhang ◽  
Chuanmeng Zhu ◽  
Renfan Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
Chow Diet ◽  
Protective Effects ◽  
High Fat ◽  
Nonalcoholic Fatty Liver

Aim: Lentinan (LNT), a type of polysaccharide derived from Lentinus edodes, has manifested protective effects during liver injury and hepatocellular carcinoma, but little is known about its effects on nonalcoholic fatty liver disease (NAFLD). This study aimed to investigate whether LNT can affect the progression of NAFLD and the associated mechanisms. Methods: C57BL/6J mice were fed a normal chow diet or a high-fat diet (HFD) with or without LNT (6 mg/kg/d). AML12 cells were exposed to 200 μM palmitate acid (PA) with or without LNT (5 μg/mL). Results: After 21 wk of the high-fat diet, LNT significantly decreased plasma triglyceride levels and liver lipid accumulation, reduced excessive reactive oxygen species production, and subsequently attenuated hepatic apoptosis in NAFLD mice. These effects were associated with increased PPARα levels, a decreased Bax/Bcl-2 ratio, and enhancement of the antioxidant defense system in vivo. Similar effects were also observed in cultured cells. More importantly, these protective effects of LNT on palmitate acid-treated AML12 cells were almost abolished by PPARα knockdown. Conclusion: In conclusion, this study demonstrates that LNT may ameliorate hepatic steatosis and decrease oxidative stress and apoptosis by activating the PPARα pathway and is a potential drug target for NAFLD.

Protective Effects of Oral Lactobacillus rhamnosus on Liver Steatosis in Rats on High-Fat Diet

2020 ◽  
Vol 19 (3) ◽  
pp. 353-358
Author(s):  
Sevan Çetin Özbek ◽  
Mendane Saka ◽  
Nesrin Turhan ◽  
Elvan Hortaç Iştar ◽  
Cenk Mirza ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Aspartate Aminotransferase ◽  
High Fat Diet ◽  
Histopathological Examination ◽  
Control Diet ◽  
Liver Steatosis ◽  
Diet Group ◽  
Protective Effects ◽  
High Fat ◽  
Nonalcoholic Fatty Liver

The purpose of this study was to investigate the effect of probiotic on fatty liver and metabolic endotoxemia in rats on high-fat diet. The rats were divided into three groups and fed one of the three diets (standard or control diet, high-fat diet, or high-fat+probiotic diet) for 16 weeks. At the end of this period, blood samples of the rats were taken and the liver tissue was removed for histopathology. There was an increase in the activities of both aspartate aminotransferase and alanine aminotransferase in the livers of rats on high-fat diet. However, only the rise in aspartate aminotransferase was blunted by incorporation of probiotics to the high-fat diet. Histopathological examination revealed 62.5% hepatosteatosis in high fat diet group and 12.5% in high-fat+probiotic diet group. In conclusion, the protective effect of probiotic supplement on liver steatosis caused by high-fat diet was histopathologically demonstrated; however, its effect on liver enzymes, inflammatory markers, and metabolic endotoxin was not observed. There is a need for further studies in terms of both dose and strain to recommend the use of probiotics in nonalcoholic fatty liver disease.

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