Therapeutic possibility of human fetal cartilage-derived progenitor cells in rat arthritis model

2015 ◽  
Vol 12 (S2) ◽  
pp. 147-154 ◽  
Author(s):  
Su Jeong Lee ◽  
Hyun Ju Oh ◽  
Minh-Dung Truong ◽  
Kyi Beom Lee ◽  
Jiyoung Kim ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Arthritis Model ◽  
Therapeutic Possibility

scholarly journals Myeloid skewing in murine autoimmune arthritis occurs in hematopoietic stem and primitive progenitor cells

Blood ◽  
2012 ◽  
Vol 120 (11) ◽  
pp. 2203-2213 ◽  
Author(s):  
Kwadwo A. Oduro ◽  
Fang Liu ◽  
Qing Tan ◽  
Chan-Kyu Kim ◽  
Olga Lubman ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Myeloid Cell ◽  
Autoimmune Arthritis ◽  
Dependent Manner ◽  
Wild Type ◽  
Hematopoietic Stem ◽  
Arthritis Model ◽  
Pathologic State

Abstract Skewing toward myeloid cell production is often observed in chronic inflammation and autoimmune diseases. Herein, we determined whether persistent myeloid activation and proinflammatory output occurring in pathologic conditions is at the level of hematopoietic stem and primitive progenitor cells (HSPPCs). By using a mouse arthritis model, we found that even though HSPPCs in arthritis still retained the capacity to differentiate into different lineages, they acquired enhanced in vitro and in vivo propensity in a disease-dependent manner to generate myeloid cells, the key perpetrators of tissue damage in arthritis. This myeloid skewing was cell intrinsic, as arthritic HSPPCs up-regulate myeloid-specific transcripts including S100a8. Exogenous S100a8 promoted myeloid cell output from wild-type HSPPCs, suggesting mechanistic involvement of this gene in the myeloid priming that occurs in arthritic HSPPCs. Therefore, our results indicate that in arthritic mice, HSPPCs adopt a pathologic state that favors disease persistence.

Wnt signaling pathway regulates the differentiation of hepatic progenitor cells

2010 ◽  
Vol 34 (8) ◽  
pp. S41-S41
Author(s):  
Yang Bi ◽  
Yun He ◽  
Tingyu Li ◽  
Tao Feng ◽  
Tongchuan He
Keyword(s):  
Wnt Signaling ◽  
Progenitor Cells ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Hepatic Progenitor Cells

Human thymic epithelial cells maintain long-term survival of clonogenic myeloid and erythroid progenitor cells in vitro

2000 ◽  
Vol 111 (1) ◽  
pp. 363-370 ◽  
Author(s):  
Katsuto Takenaka ◽  
Mine Harada ◽  
Tomoaki Fujisaki ◽  
Koji Nagafuji ◽  
Shinichi Mizuno ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Progenitor Cells ◽  
Thymic Epithelial Cells ◽  
Erythroid Progenitor ◽  
Term Survival ◽  
Long Term Survival ◽  
Erythroid Progenitor Cells

“Blastosphere”: A new culture method for human fetal hepatic progenitor cells

2001 ◽  
Vol 120 (5) ◽  
pp. A542-A543
Author(s):  
T HIROSE ◽  
K YASUCHIKA ◽  
T FUJIKAWA ◽  
H FUJII ◽  
S OE ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Culture Method ◽  
Hepatic Progenitor Cells
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