Collagen Patches Impregnated with Antimicrobial Agents Have High Local Antimicrobial Efficacy and Achieve Effective Tissue Gluing

Infection ◽  
2001 ◽  
Vol 29 (1) ◽  
pp. 27-31 ◽  
Author(s):  
S. Baar ◽  
C. Schörner ◽  
M. Röllinghoff ◽  
M. Radespiel-Tröger ◽  
H.P. Hümmer ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Antimicrobial Efficacy

scholarly journals Evaluation of Antimicrobial Efficacy of Triphala Oral Spray in Patients Undergoing Orthodontic Treatment- A Randomized Clinical Trial

2021 ◽  
pp. 24-29
Author(s):  
Nishi Malviya ◽  
Nilima Thosar ◽  
Nilesh Rathi ◽  
Monika Khubchandani ◽  
V. G. Meshram
Keyword(s):  
Orthodontic Treatment ◽  
Antimicrobial Agents ◽  
Periodontal Diseases ◽  
Drug Formulation ◽  
Microbial Load ◽  
Antimicrobial Efficacy ◽  
Microbial Count ◽  
Oral Streptococci ◽  
Post Intervention ◽  
Plaque Score

Background: Malocclusion is one of the most susceptible causes of the development of periodontal diseases and dental caries in young individuals undergoing fixed orthodontic treatment. It provides a surface area for the accumulation of food particles, which further leads to plaque formation. Various mechanical and chemical aids are used regularly to decrease the microbial load and accumulation of plaque. Chemical adjuncts such as chlorhexidine mouthwash are widely used as antimicrobial agents that have significant efficacy against oral Streptococci and Actinomyces species. Herbal agents have replaced conventional medications due to the development of antibiotic resistance. Among herbal medicaments, Triphala is the well-known drug formulation that can be used as an adjuvant for commercially available chemical aid. Chlorhexidine mouth wash requires the assistance of the caregivers. Therefore, there is a need for a newer modality to maintain oral hygiene in patients undertaking orthodontic corrections. Objectives: 1. To evaluate the antimicrobial efficacy of Triphala oral spray on Streptococcus mutants levels in children undergoing orthodontic treatment. 2. To evaluate the efficacy of Triphala oral spray in reducing dental plaque in children undergoing orthodontic treatment. 3. To evaluate the efficacy of Triphala oral spray reducing gingivitis in children undergoing orthodontic treatment. Methodology: A randomized control trial will be done among – participants with the age group of 10 to 15 years of age. A total of 25 children were included in the study. The participants will be told to use the spray two times a day for one week. After 7 days, plaque index and the gingival index will be re-recorded, and plaque samples will be collected for post-intervention microbial analysis. Results: Triphala-based oral spray will effectively reduce plaque score, reduce gingival inflammation, and show inhibitory effects on microbial count. Conclusion: Triphala oral spray can be used as an adjuvant by the orthodontic patients for reduction of the microbial load. It also provides better acceptability by the children as it does not require any assistance of the caregivers.

scholarly journals Assessment of the half-life of cationic periodontal pocket irrigation

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Tugrul Kirtiloglu ◽  
Ilker Keskiner ◽  
Murathan Sahin ◽  
Banu Kirtiloglu ◽  
Safak Aygul ◽  
...  
Keyword(s):  
Electrical Activity ◽  
Half Life ◽  
Antimicrobial Agents ◽  
Dynamic Imaging ◽  
Thallium 201 ◽  
Periodontal Pocket ◽  
Antimicrobial Efficacy ◽  
Clearance Time ◽  
Selection Of

Abstract Background The concentration and persisting time of antimicrobial agents in the periodontal pockets are important factors for their antimicrobial efficacy. Increased clearance time in the periodontal pocket is a significant criterion for the selection of intrapocket irrigants. The aim of this study was to estimate the clearance time of a cationic agent from the periodontal pocket. Methods Thallium-201(Tl-201) was chosen as a tracer to simulate the clearance of cationic substance because of its electrical activity. Twenty patients with periodontitis and probing depths 6 to 9 mm were included in this study. In each patient, 3 Mega Becquerel (MBq) of Tl-201 were inserted into the periodontal pocket. Dynamic imaging was performed and clearance of radioactivity was measured. Results Clearance of radioactivity was 67.1 ± 16.9, 83.1 ± 13.9, 90.4 ± 10.4, 93.39 ± 8.0% at 30, 60, 90 and 120 min, respectively. Half-life of wash-out was determined as 20.3 ± 10.2 min. Conclusion The results of this study demonstrate that the half-life of the cationic solution applied subgingivally was approximately 20 min and labelling of oral irrigants with radiotracers may be used to determine their clearance in further research.

scholarly journals Evaluation of Antimicrobial Efficacy of Three Combinations of Different Antibiotics against Microorganisms in Gingival Abscess – An in Situ Study

2019 ◽  
pp. 1-7
Author(s):  
Viral Maru Pravin ◽  
Farhin Katge ◽  
Manohar Poojari ◽  
Shilpa K. Shetty
Keyword(s):  
Antimicrobial Agents ◽  
Anaerobic Bacteria ◽  
Antimicrobial Efficacy ◽  
Permanent Teeth ◽  
Primary Tooth ◽  
Dental Arch ◽  
Tooth Root ◽  
Root Canals ◽  
In Situ Study

Background: It is important to maintain primary dentition in the dental arch to facilitate the development of permanent teeth, in spite of teeth with infected root canals. Antimicrobial agents have been used, but, even a broad spectrum antibiotic could not eradicate all the bacteria from the periapical lesions. An in situ study was carried out with the aim to evaluate the antimicrobial efficacy of combinations antibiotics against microorganisms in a gingival abscess or primary tooth root canals. Methodology: Thirty children with gingival abscess secondary to pulp infection or infected primary tooth root canals were randomly selected for the study. Swabs of gingival abscess microbial content were used for development of bacteria in suitable media containing three combinations of antibiotics, under aerobic and anaerobic incubation. Ciprofloxacin, Minocycline were used with metronidazole, ornidazole, tinidazole antibiotics to form three different combinations. The antimicrobial efficacy was measured in terms of the diameter of the zone of inhibition around the antibiotic discs. Results: The three combinations of antibiotics exhibit equivalent efficacy for aerobic as well as anaerobic bacteria, and the difference in efficacy between them was not statistically significant (p > 0.05). There was no difference in pair-wise significance between the groups. Conclusion: In view of the equivalent antibacterial activity of the three classes, towards the two types of bacteria, a group containing ornidazole was found to be superior with more favorable side effect profile compared to metronidazole.

Copper Nanoparticles

2021 ◽  
pp. 370-390
Author(s):  
Ubaid Rasool ◽  
Davoodbasha Mubarak Ali ◽  
Hemalatha S.
Keyword(s):  
Silver Nanoparticles ◽  
Copper Oxide ◽  
Copper Nanoparticles ◽  
Water Purification ◽  
Metallic Nanoparticles ◽  
Bacterial Infections ◽  
Noble Metals ◽  
Antimicrobial Agents ◽  
Metallic Copper ◽  
Antimicrobial Efficacy

Nanoparticles are also proving a great alternative to antibiotics in combating the deadly bacterial infections. Copper nanoparticles, in particular, are being utilized as antimicrobial agents as well as their interaction with other particles helps to improve the antimicrobial efficacy. Compared to other metallic nanoparticles, copper nanoparticles are highly reactive, and their small size allows them to be used in different areas. When exposed to air, copper nanoparticles form copper oxide, and to prevent this oxidation, silica and carbon are utilized to coat copper nanoparticles. Metallic copper nanoparticles have been used in place of silver nanoparticles and other noble metals as anti-infective agents and also utilized in in water purification.

Essential oil from Zanthoxylum tingoassuiba loaded into multilamellar liposomes useful as antimicrobial agents

2009 ◽  
pp. 1-8 ◽  
Author(s):  
C. B. Detoni ◽  
E. C. M. Cabral-Albuquerque ◽  
S. V. A. Hohlemweger ◽  
C. Sampaio ◽  
T. F. Barros ◽  
...  
Keyword(s):  
Essential Oil ◽  
Antimicrobial Agents ◽  
Multilamellar Liposomes
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