scholarly journals Evaluation of Antimicrobial Efficacy of Triphala Oral Spray in Patients Undergoing Orthodontic Treatment- A Randomized Clinical Trial

2021 ◽  
pp. 24-29
Author(s):  
Nishi Malviya ◽  
Nilima Thosar ◽  
Nilesh Rathi ◽  
Monika Khubchandani ◽  
V. G. Meshram
Keyword(s):  
Orthodontic Treatment ◽  
Antimicrobial Agents ◽  
Periodontal Diseases ◽  
Drug Formulation ◽  
Microbial Load ◽  
Antimicrobial Efficacy ◽  
Microbial Count ◽  
Oral Streptococci ◽  
Post Intervention ◽  
Plaque Score

Background: Malocclusion is one of the most susceptible causes of the development of periodontal diseases and dental caries in young individuals undergoing fixed orthodontic treatment. It provides a surface area for the accumulation of food particles, which further leads to plaque formation. Various mechanical and chemical aids are used regularly to decrease the microbial load and accumulation of plaque. Chemical adjuncts such as chlorhexidine mouthwash are widely used as antimicrobial agents that have significant efficacy against oral Streptococci and Actinomyces species. Herbal agents have replaced conventional medications due to the development of antibiotic resistance. Among herbal medicaments, Triphala is the well-known drug formulation that can be used as an adjuvant for commercially available chemical aid. Chlorhexidine mouth wash requires the assistance of the caregivers. Therefore, there is a need for a newer modality to maintain oral hygiene in patients undertaking orthodontic corrections. Objectives: 1. To evaluate the antimicrobial efficacy of Triphala oral spray on Streptococcus mutants levels in children undergoing orthodontic treatment. 2. To evaluate the efficacy of Triphala oral spray in reducing dental plaque in children undergoing orthodontic treatment. 3. To evaluate the efficacy of Triphala oral spray reducing gingivitis in children undergoing orthodontic treatment. Methodology: A randomized control trial will be done among – participants with the age group of 10 to 15 years of age. A total of 25 children were included in the study. The participants will be told to use the spray two times a day for one week. After 7 days, plaque index and the gingival index will be re-recorded, and plaque samples will be collected for post-intervention microbial analysis. Results: Triphala-based oral spray will effectively reduce plaque score, reduce gingival inflammation, and show inhibitory effects on microbial count. Conclusion: Triphala oral spray can be used as an adjuvant by the orthodontic patients for reduction of the microbial load. It also provides better acceptability by the children as it does not require any assistance of the caregivers.

Decreasing Cariogenic Bacteria with a Natural, Alternative Prevention Therapy utilizing Phytochemistry (Plant Extracts)

2011 ◽  
Vol 36 (1) ◽  
pp. 55-64 ◽  
Author(s):  
Y Ramakrishna ◽  
H Goda ◽  
MS Baliga ◽  
AK Munshi
Keyword(s):  
Pathogenic Bacteria ◽  
Antimicrobial Agents ◽  
Periodontal Diseases ◽  
Treatment Options ◽  
Biologically Active ◽  
Oral Microbiota ◽  
Toxic Exposure ◽  
Oral Diseases ◽  
Cariogenic Bacteria ◽  
Traditional Medicines

The association between the oral microbiota and oral diseases is well established. Various antimicrobial agents including antibiotics are commercially available against oral pathogenic bacteria. For the reasons of antibiotic resistance, their adverse effects and financial considerations in the developing countries, there is a need for alternate preventive and curative treatment options that are also safe, effective and economical. Traditional medicines have been used since ancient times for the treatment of oral diseases including dental caries, periodontal diseases that affect the majority of the population and can affect a person's overall health. Natural phytochemicals are certain organic components isolated from plants and some of these extracts are considered to be beneficial to health. They serve as antioxidants, enhance immune response,provide protection against oral cancer and other diseases and also repair DNA damage caused by smoking and other toxic exposure, and detoxify carcinogens. The natural products derived from medicinal plants have proven to be an abundant source of biologically active compounds, many of which have been the basis for the development of new lead chemicals for pharmaceuticals.They are considered to be good alternatives to synthetic chemicals. This article presents a review of natural alternatives derived from plants and plant products that can serve as a prevention and treatment option against cariogenic bacteria.

Collagen Patches Impregnated with Antimicrobial Agents Have High Local Antimicrobial Efficacy and Achieve Effective Tissue Gluing

Infection ◽  
2001 ◽  
Vol 29 (1) ◽  
pp. 27-31 ◽  
Author(s):  
S. Baar ◽  
C. Schörner ◽  
M. Röllinghoff ◽  
M. Radespiel-Tröger ◽  
H.P. Hümmer ◽  
...  
Keyword(s):  
Antimicrobial Agents ◽  
Antimicrobial Efficacy

scholarly journals Microbial load of healthcare wastes in Aba Metropolis, Abia State

2021 ◽  
Vol 3 (1) ◽  
pp. 17-23
Author(s):  
Elendu, C. Onwuchekwa ◽  
Anaele, C. C. ◽  
Emeonye, O. P. ◽  
Felix C. J. ◽  
Ikechukwu-Okoroezi, J. ◽  
...  
Keyword(s):  
Viable Count ◽  
Microbial Load ◽  
Microbial Count ◽  
Unique Contribution ◽  
Healthcare Facilities ◽  
Healthcare Waste ◽  
Microbiological Techniques ◽  
Hospital Wastes ◽  
Laboratory Waste ◽  
The Government

Introduction: Healthcare waste is the total waste both solid and liquid from healthcare establishment and laboratories. A hospital produces waste by giving their services to the patients. Purpose: This study examined the microbial load of waste from selected healthcare facilities in Aba metropolis, Abia State. Methodology: Tenfold serial dilution was used for processing of all the samples. After the dilutions, exactly 0.5ml of each the sample was planted on the media using the spread plate method and evaluated using the standard microbiological techniques. Results: The viable count (TVC) ranged from 1.0×103cfu/g to 0.3×108cfu/g, coliform count (TCC) ranged from 0.4×102 cfu/g to 4.2×104 cfu/g, staphylococcal count (TSC) ranged from 1.0×101 cfu/g to 1.4×102 and fungal counts ranged from 2.0×102 cfu/g to 0.8×103cfu/g in the microbial count of various waste samples within the Aba metropolis, Abia State. The laboratory waste had the highest microbial counts, followed by the Out-patient department waste and the least was the pharmaceutical waste. The microorganisms isolated from the hospital wastes were Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus niger, A. Fumigatus, Candida albicans and among others. Unique contribution to theory, practice and policy: This research has revealed that healthcare waste contained pathogens with high microbial load densities, suggesting that the hospital wastes may pose a major health and environmental threat, if not properly managed. The study recommends that, the government should ensure that there is a policy on hospital waste management in line with recommended international best practices, which should be monitored and enforced. 

scholarly journals IMMUNOLOGICAL AND PATHOPHYSIOLOGICAL LAWS OF LOCAL IMMUNITY ORAL CAVITY PREVENTION OF INFLAMMATORY COMPLICATIONS OF TREATMENT OF DENTOALVEOLAR ANOMALIES

2018 ◽  
Vol 22 (1) ◽  
pp. 25-28
Author(s):  
Pavel Aleksandrovich Zheleznyi ◽  
K. S Shchelkunov ◽  
S. P Zheleznyi ◽  
A. P Zheleznaia ◽  
Y. N Belousov
Keyword(s):  
Orthodontic Treatment ◽  
Antimicrobial Agents ◽  
Immunoglobulin A ◽  
Interleukin 4 ◽  
Activity Levels ◽  
Local Immunity ◽  
Immunomodulatory Agents ◽  
Periodontal Tissues ◽  
Mixed Saliva ◽  
Secretory Immunoglobulin

The state of local immunity oral factors in orthodontic treatment with fixed structures in 192 people aged 18-25 years. The mixed saliva was determined lysozyme activity levels of secretory immunoglobulin A, interleukin 1в and interleukin 4 dynamics. It was found that orthodontic treatment leads to activation of the inflammatory process in periodontal tissues, effective therapy which should be based on the integrated use of antimicrobial agents and immunomodulatory agents.

scholarly journals Antibacterial agent-releasing scaffolds in dental tissue engineering

2021 ◽  
Vol 13 (1) ◽  
pp. 43-47
Author(s):  
Zahra Gholami ◽  
Shirin Hasanpour ◽  
Samira Sadigh ◽  
Sana Johari ◽  
Zahra Shahveghar ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Antimicrobial Agents ◽  
Periodontal Diseases ◽  
Base Material ◽  
Antimicrobial Activities ◽  
Synthesis Process ◽  
Oral Diseases ◽  
Dental Tissue ◽  
Inflammatory Reactions ◽  
Dental Tissue Engineering

It seems quite challenging in tissue engineering to synthesize a base material with a range of essential activities, including biocompatibility, nontoxicity, and antimicrobial activities. Various types of materials are synthesized to solve the problem. This study aimed to provide the latest relevant information for practitioners about antibacterial scaffolds in dental tissue engineering. The PubMed search engine was used to review the relevant studies with a combination of the following terms as search queries: tissue engineering, scaffolds, antimicrobial, dentistry, dental stem cells, and oral diseases. It is noteworthy to state that only the terms related to tissue engineering in dentistry were considered. The antimicrobial scaffolds support the local tissue regeneration and prevent adverse inflammatory reactions; however, not all scaffolds have such positive characteristics. To resolve this potential defect, different antimicrobial agents are used during the synthesis process. Innovative methods in guided tissue engineering are actively working towards new ways to control oral and periodontal diseases.

scholarly journals Cone Beam Computed Tomography Study on the Incidence of Endodontic Filling Biomaterials Resorption in Patients With/Without Orthodontic Treatment

2021 ◽  
Vol 6 (2) ◽  
pp. 103-107
Author(s):  
Eugen Bud ◽  
Mariana Păcurar ◽  
Alexandru Vlasa ◽  
Cristina Bica ◽  
Krisztina Martha ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Orthodontic Treatment ◽  
Periodontal Diseases ◽  
Correct Diagnosis ◽  
Cone Beam ◽  
Total Length ◽  
Lower Jaw ◽  
Starting Point ◽  
Study Population ◽  
The Mean

Abstract Background: The differential diagnosis of endodontic and periodontal diseases can sometimes be clinically difficult, but it is vital to establish a correct diagnosis so that predictable treatment can be offered. Aim: The aim of this study was to highlight the prevalence of endo-periodontal lesions in the frontal dental group of the lower jaw depending on the degree of bone resorption as well as endodontic filling resorption in different patients, some of them with orthodontic treatment, using conical beam computed tomography (CBCT). Materials and methods: A number of 31 CBCT imaging volumes and the medical records of these patients were selected for analysis by an experienced examiner. The sites selected for analysis were divided into two subgroups, one where the endodontic treatment was performed with Endomethasone™ (Colthene, Creteil, France) (7 patients), and the other where it was performed with Adseal™ (Meta Biomed, Seoul, South Korea) (6 patients). Results: The mean age of the study population was 24.1 years, and 35.8% presented previous orthodontic treatment in their medical history. There were no statistically significant differences (p = 0.54) between groups regarding the length of the endodontic filling, the Endomethasone group showing a total length of 11.24 millimeters while the Adseal group showed a total length of 10.85 millimeters. Conclusions: The image obtained in clinical situations in which patients present combined endodontic-periodontal lesions is of real help because in many cases, with the help of CBCT, the starting point of a combined lesion can be highlighted, whether it is endodontic or periodontal.

scholarly journals Clinical and immunological studies of periodontal inflammatory complications at orthodontic treatment using fixed appliances

2014 ◽  
Vol 95 (1) ◽  
pp. 80-82
Author(s):  
G R Khaliullina ◽  
S L Blashkova
Keyword(s):  
Immune Response ◽  
Orthodontic Treatment ◽  
Inflammatory Diseases ◽  
Periodontal Diseases ◽  
Orthodontic Appliances ◽  
Periodontal Inflammation ◽  
Fixed Orthodontic Appliances ◽  
Fixed Appliances ◽  
Orthodontic Devices

The review of clinical and immunologic studies of periodontal inflammatory diseases is presented. At present, the most effective tools for treatment of malocclusions are fixed orthodontic appliances (dental braces), but the use of fixed appliances complicates the oral hygiene, predisposes to periodontal and gum inflammation. The rate of complications diagnosed during orthodontic treatment stays high. The principles of periodontal inflammatory diseases (gingivitis, periodontitis) treatment are closely related with the causes and mechanisms of periodontal inflammation. Patients who receive orthodontic treatment using braces should be treated as a group with a high risk for inflammatory periodontal diseases. The orthodontic devices stimulate the directed reorganization of periodontal structures achieving optimal aesthetic and functional standards. Physiology of periodontium restructuring is largely determined by the local and general health before, during and after the orthodontic treatment. This article surveys the mechanisms of periodontal damage, highlighting the important role of immune response. So far, only anecdotal descriptions of immune response on the stages of orthodontic treatment are published.

scholarly journals Microbiological Assessment of Wheat and Buckwheat Sprouting Process

2022 ◽  
Vol 51 (4) ◽  
pp. 795-804
Author(s):  
Mariya Zenkova ◽  
Ludmila Melnikova
Keyword(s):  
Antimicrobial Agents ◽  
Food Poisoning ◽  
Antimicrobial Properties ◽  
Medicinal Herbs ◽  
Microbial Count ◽  
Microbiological Contamination ◽  
Advantages And Disadvantages ◽  
Long Term Storage ◽  
Term Storage

Introduction. Sprouted grain can cause food poisoning, since inappropriate conditions can promote the growth of pathogenic microorganisms on the grain surface. As a result, products of long-term storage use thermally-treated sprouted grain, the parameters of which depend on the initial bacteria content. There are different ways to reduce bacterial contamination of sprouted grain, each of which has its own advantages and disadvantages. Natural substances with antimicrobial properties, such as medicinal herbs, can serve as decontaminators. However, no scientific research has been performed so far to determine the exact temperature of grain sprouting to minimize its microbiological contamination. The research objective was to investigate the effect of antimicrobial agents and sprouting conditions on the microflora of wheat and buckwheat grain. Study objects and methods. The study featured wheat grain and green buckwheat grain. A set of experiments was performed to define the effect of antimicrobial agents and sprouting conditions on the quantity of mesophilic aerobic and facultative anaerobic microorganisms (QMAFAnM), molds, and yeasts. During sprouting at 10–30°C for 90 h, the grain was irrigated with distilled water, potassium permanganate solution (KMnO4), calendula infusion, and celandine i nfusion. QMAFAnM and the count of molds and yeasts were determined by standard methods; the qualitative analysis of the microflora was based on their morphological and cultural characteristics. Results and discussion. Microflora development during sprouting of wheat and buckwheat grains was controlled by selecting appropriate conditions and grain treatment methods. The herbal infusions for sprouting reduced the total microbial insemination of grain during sprouting by 52–68%; the calendula infusion reduced the contamination with molds by 47–51%, yeasts – by 100%. Conclusion. The research revealed the total microbial count and the count of mold and yeast colonies in dry sprouted grain. The optimal temperature of sprouting wheat and buckwheat was 20 ± 2°C in the infusion of medicinal herbs: it minimized the microflora of sprouted grain and reduced the sprouting time to 46 h. Calendula infusion could be recommended for commercial use in order reduce the microbiological contamination of sprouted grain. The initial microbial population of the product was found to affect the mode of heat treatment in long-term storage products.

scholarly journals Antimicrobial Efficacy Assessment of Human Derived Composite Amnion-Chorion Membrane

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nathan D. Palanker ◽  
Chun-Teh Lee ◽  
Robin L. Weltman ◽  
Gena D. Tribble ◽  
Ransome van der Hoeven ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Antimicrobial Properties ◽  
Antimicrobial Efficacy ◽  
Oral Streptococci ◽  
Time Points ◽  
Traditional Assessment ◽  
Efficacy Assessment ◽  
Collagen Membranes ◽  
Porcine Pericardium

Abstract Human derived composite amnion-chorion membrane (ACM) has been used to facilitate wound healing due to reported anti-inflammatory properties and promotion of cell proliferation. This study aimed to assess the antimicrobial properties of the ACM using novel methods to visualize the antimicrobial efficacy of membranes in situ at different time points. Porcine Pericardium Collagen Membranes (PPCM) served as membrane controls. Circular pieces of the membranes were used in three different assays: insert, agar contact and glass-bottom well assays. Streptococcus gordonii were spotted onto the membranes and the plates were subsequently centrifuged to ensure direct bacterial contact with the membranes in the insert and agar contact assays, thus better mimicking bacterial adherence in the oral cavity. After incubation at 37 °C for 8, 24, and 48 hours, the membranes were dyed with the Live/Dead BacLight Bacterial Viability fluorescence stain and analyzed via confocal microscopy. The results demonstrated that the ACM completely inhibited bacterial growth at all time points, whereas the PPCM did not demonstrate any antimicrobial properties. Within the limits of this study, the ACM showed extremely high antimicrobial efficacy against oral streptococci. In addition, our methods may be useful in assessing antimicrobial properties for biomaterials with minimum diffusion ability, when traditional assessment methods are not applicable.

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